Michelle L Hernandez

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased Influenza A virus cleavage and replication
    Matthew J Kesic
    Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, 104 Mason Farm Rd CB 7310, Chapel Hill, NC, 27599 7310, USA
    Respir Res 13:82. 2012
  2. pmc Vitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers
    Michelle L Hernandez
    Center for Environmental Medicine, Asthma, and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Free Radic Biol Med 60:56-62. 2013
  3. pmc Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers
    Michelle L Hernandez
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27516, USA
    J Allergy Clin Immunol 130:869-76.e2. 2012
  4. pmc The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery
    Anke Leichtle
    Department of Surgery Otolaryngology University of California, San Diego, 9500 Gilman Avenue, La Jolla, California 92093, USA
    BMC Immunol 10:45. 2009
  5. pmc Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge
    Michelle L Hernandez
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
    Inhal Toxicol 22:648-56. 2010
  6. pmc The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 124:1222-1228.e5. 2009
  7. doi request reprint Enhancement of systemic and sputum granulocyte response to inhaled endotoxin in people with the GSTM1 null genotype
    Madeline A Dillon
    Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7310, USA
    Occup Environ Med 68:783-5. 2011
  8. pmc Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone
    Michelle L Hernandez
    Center for Environmental Medicine Asthma and Lung Biology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 126:537-44.e1. 2010
  9. pmc Low-level ozone exposure induces airways inflammation and modifies cell surface phenotypes in healthy humans
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, 104 Mason Farm Road, Chapel Hill, NC 27599, USA
    Inhal Toxicol 22:593-600. 2010
  10. pmc Airway purinergic responses in healthy, atopic nonasthmatic, and atopic asthmatic subjects exposed to ozone
    Charles R Esther
    Pediatric Pulmonology, University of North Carolina at Chapel Hill, 27517, USA
    Inhal Toxicol 23:324-30. 2011

Collaborators

  • Haibo Zhou
  • James G Wagner
  • Qing Jiang
  • Jenny P Y Ting
  • Neil E Alexis
  • David B Peden
  • John C Lay
  • Philip A Bromberg
  • Bradford Harris
  • Robert B Devlin
  • David Diaz-Sanchez
  • Matthew J Kesic
  • Amy Auerbach
  • Madeline A Dillon
  • Charles R Esther
  • Anke Leichtle
  • Ilona Jaspers
  • Baiming Zou
  • William Reed
  • Steven Kleeberger
  • HOWARD KEHRL
  • Chong Kim
  • Milan Hazucha
  • Tsui Shan Lu
  • Kwang Pak
  • NICHOLAS J WEBSTER
  • Allen F Ryan
  • Steven R Kleeberger
  • Stephen I Wasserman

Detail Information

Publications11

  1. pmc Airway protease/antiprotease imbalance in atopic asthmatics contributes to increased Influenza A virus cleavage and replication
    Matthew J Kesic
    Center for Environmental Medicine, Asthma, and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, 104 Mason Farm Rd CB 7310, Chapel Hill, NC, 27599 7310, USA
    Respir Res 13:82. 2012
    ..These data suggest that disruption of the protease balance in asthmatics enhances activation and infection of influenza virus...
  2. pmc Vitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers
    Michelle L Hernandez
    Center for Environmental Medicine, Asthma, and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Free Radic Biol Med 60:56-62. 2013
    ..These results suggest that γT is a potential therapeutic candidate for prevention or treatment of neutrophilic airway inflammation in diseased populations...
  3. pmc Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers
    Michelle L Hernandez
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27516, USA
    J Allergy Clin Immunol 130:869-76.e2. 2012
    ..It is unknown whether this sensitivity is due to dysregulated inflammatory responses after LPS exposure in atopic asthmatic patients...
  4. pmc The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery
    Anke Leichtle
    Department of Surgery Otolaryngology University of California, San Diego, 9500 Gilman Avenue, La Jolla, California 92093, USA
    BMC Immunol 10:45. 2009
    ..The ME inflammatory response to NTHi was examined in wild-type (WT) and TRIF-/- mice by qPCR, gene microarray, histopathology and bacterial culture...
  5. pmc Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge
    Michelle L Hernandez
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
    Inhal Toxicol 22:648-56. 2010
    ....
  6. pmc The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 124:1222-1228.e5. 2009
    ..Ozone is known to cause an immediate decrease in lung function and increased airway inflammation. However, it is not known whether GSTM1 modulates these ozone responses in vivo in human subjects...
  7. doi request reprint Enhancement of systemic and sputum granulocyte response to inhaled endotoxin in people with the GSTM1 null genotype
    Madeline A Dillon
    Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7310, USA
    Occup Environ Med 68:783-5. 2011
    ..To determine if the GSTM1 null genotype is a risk factor for increased inflammatory response to inhaled endotoxin...
  8. pmc Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone
    Michelle L Hernandez
    Center for Environmental Medicine Asthma and Lung Biology, University of North Carolina School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 126:537-44.e1. 2010
    ..Ozone causes an immediate decrease in lung function and increased airway inflammation. The role of atopy and asthma in modulation of ozone-induced inflammation has not been determined...
  9. pmc Low-level ozone exposure induces airways inflammation and modifies cell surface phenotypes in healthy humans
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, 104 Mason Farm Road, Chapel Hill, NC 27599, USA
    Inhal Toxicol 22:593-600. 2010
    ..These findings need to be replicated in a similar experiment that includes a control air exposure...
  10. pmc Airway purinergic responses in healthy, atopic nonasthmatic, and atopic asthmatic subjects exposed to ozone
    Charles R Esther
    Pediatric Pulmonology, University of North Carolina at Chapel Hill, 27517, USA
    Inhal Toxicol 23:324-30. 2011
    ..Ozone exposure triggers airway inflammatory responses that may be influenced by biologically active purine metabolites...
  11. pmc The effect of environmental oxidative stress on airway inflammation
    Amy Auerbach
    Center for Environmental Medicine, Asthma and Lung Biology, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina 27516, USA
    Curr Opin Allergy Clin Immunol 12:133-9. 2012
    ..This article reviews the data regarding the effects of air pollution on the innate immune response and potential clinical and treatment implications of how genetic polymorphisms affect this response...