Research Topics
Species | Joshua L HermsenSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Phenotyping Clostridium septicum infection: a surgeon's infectious diseaseJoshua L Hermsen
Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792, USA
J Surg Res 148:67-76. 2008..Whether disease phenotype is affected by malignant status is not known. Surgical treatment is used frequently but its impact on survival has not been examined in a cohort >30 patients...
Parenteral nutrition maintains pulmonary IgA antibody transport capacity, but not active transport, following injuryYoshifumi Sano
Department of Surgery, University of Wisconsin Madison, College of Medicine, Public Health, Madison, WI, USA
Am J Surg 198:105-9. 2009..This work investigates the effect of type/route of nutrition on lung IgA and its transport protein, polymeric immunoglobulin receptor (pIgR), after injury...
Parenteral feeding depletes pulmonary lymphocyte populationsJoshua L Hermsen
Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
JPEN J Parenter Enteral Nutr 33:535-40. 2009..The objectives of this study are to characterize lung T-cell populations following parenteral feeding and to study distribution patterns of transferred donor lung T cells in recipient mice...
Proinflammatory cytokine surge after injury stimulates an airway immunoglobulin a increaseMark A Jonker
Veterans Administration Surgical Services, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA
J Trauma 69:843-8. 2010..We investigated the local and systemic kinetics of TNF-α, IL-1β, and IL-6 after injury in mice. We also hypothesized that injection of exogenous TNF-α, IL-1β, and IL-6 would replicate the airway IgA response to injury...
Small intestine mucosal immune system response to injury and the impact of parenteral nutritionMark A Jonker
Surgical Service and Department of Surgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
Surgery 151:278-86. 2012..We investigated the small intestine (SI) IgA response to injury and the role of TNF-α, IL-1β, IL-6, and PN/DES...
Injury induces localized airway increases in pro-inflammatory cytokines in humans and miceMark A Jonker
Surgical Services, William S Middleton Memorial Veterans Hospital, Madison, WI 53792, USA
Surg Infect (Larchmt) 12:49-56. 2011..We investigated the injury effect on airway and serum concentrations to determine the source of the cytokines involved in the airway IgA response...
Parenteral nutrition induces organ specific alterations in polymeric immunoglobulin receptor levelsYoshifumi Sano
Department of Surgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, Wisconsin, USA
J Surg Res 149:236-42. 2008..Our prior work shows that parenteral nutrition (PN) impairs both airway and small intestine mucosal immunity by reducing T and B cells and IgA levels. This work examines intestinal and respiratory tissue-specific pIgR responses to PN...
Food fight! Parenteral nutrition, enteral stimulation and gut-derived mucosal immunityJoshua L Hermsen
Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
Langenbecks Arch Surg 394:17-30. 2009..DISCUSSION: This article reviews the relationships between type and route of nutrition and gut-derived mucosal immunity in both the clinical and laboratory settings...
Clostridium difficile infection: a surgical disease in evolutionJoshua L Hermsen
Department of Surgery, University of Wisconsin Madison College of Medicine and Public Health, 600 Highland Avenue, H4 736 CSC, Madison, WI 53792 7375, USA
J Gastrointest Surg 12:1512-7. 2008..However, such studies commonly lack denominators over which to index this rise. There is also concern in the literature that disease virulence is increasing...
Parenteral nutrition inhibits tumor necrosis factor-alpha-mediated IgA response to injuryJoshua L Hermsen
Department of Surgery, University of Wisconsin Madison College of Medicine and Public Health, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53792 7375, USA
Surg Infect (Larchmt) 9:33-40. 2008..We have shown that PN alters levels of lung and nasal passage IgA and several IgA-stimulating cytokines. We hypothesized that TNF-alpha and IL-1beta blockade, as well as PN, would blunt the airway IgA response to injury...
Retrievable inferior vena cava filters in high-risk trauma and surgical patients: factors influencing successful removalJoshua L Hermsen
Department of Surgery, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI 53792, USA
World J Surg 32:1444-9. 2008..A removable IVCF (R-IVCF) provides prophylaxis during a high-risk period while potentially eliminating long-term complications associated with a permanent IVCF. Factors influencing success of R-IVCF removal are ill-defined...
