Michelle L Hermiston

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint CD45: a critical regulator of signaling thresholds in immune cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, 94143, USA
    Annu Rev Immunol 21:107-37. 2003
  2. pmc B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency
    Vikas A Gupta
    Department of Medicine, Biomedical Sciences Graduate Program, Medical Scientist Training Program, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:2755-61. 2008
  3. pmc Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses
    Michelle L Hermiston
    Department of Pediatrics, Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:546-51. 2009
  4. pmc Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production
    Robyn E Mills
    Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA 94143
    J Immunol 194:3675-86. 2015
  5. ncbi request reprint The juxtamembrane wedge negatively regulates CD45 function in B cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143, USA
    Immunity 23:635-47. 2005
  6. pmc Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases
    Michelle L Hermiston
    Department of Pediatrics, The Howard Hughes Medical Institute, University of California, San Francisco, California 94143 0795, USA
    J Clin Invest 109:9-14. 2002
  7. pmc Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production
    David G T Hesslein
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:7012-7. 2006
  8. pmc CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Immunol Rev 228:288-311. 2009
  9. pmc Oncogenic Kras initiates leukemia in hematopoietic stem cells
    Amit J Sabnis
    Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
    PLoS Biol 7:e59. 2009

Research Grants

  1. Role of CD45 in Hematopoiesis and Lymphomagenesis
    Michelle Hermiston; Fiscal Year: 2005

Collaborators

Detail Information

Publications9

  1. ncbi request reprint CD45: a critical regulator of signaling thresholds in immune cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, 94143, USA
    Annu Rev Immunol 21:107-37. 2003
    ..Perturbation of this function may contribute to autoimmunity, immunodeficiency, and malignancy. Moreover, recent advances suggest that modulation of CD45 function can have therapeutic benefit in many disease states...
  2. pmc B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency
    Vikas A Gupta
    Department of Medicine, Biomedical Sciences Graduate Program, Medical Scientist Training Program, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:2755-61. 2008
    ..These results reveal a requirement for careful control of B cell signaling and cell death in preventing inappropriate lymphocyte activation and autoimmunity...
  3. pmc Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses
    Michelle L Hermiston
    Department of Pediatrics, Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:546-51. 2009
    ..Together, the data support a role for the CD45 wedge in regulation of T cell responses in vivo and suggest that its effects depend on cellular context...
  4. pmc Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production
    Robyn E Mills
    Department of Pediatrics, University of California San Francisco, San Francisco, CA 94143 Biomedical Sciences Graduate Program, University of California San Francisco, San Francisco, CA 94143
    J Immunol 194:3675-86. 2015
    ..We further demonstrate a novel role for TLR9 signal strength in central tolerance, providing insight into the interplay of disease-associated polymorphisms at a discrete step of systemic lupus erythematosus pathogenesis. ..
  5. ncbi request reprint The juxtamembrane wedge negatively regulates CD45 function in B cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143, USA
    Immunity 23:635-47. 2005
    ..Together, the results support a role for CD45 as a rheostat, with both positive and negative regulatory functions, that fine-tunes the signal transduction threshold at multiple checkpoints in B cell development...
  6. pmc Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases
    Michelle L Hermiston
    Department of Pediatrics, The Howard Hughes Medical Institute, University of California, San Francisco, California 94143 0795, USA
    J Clin Invest 109:9-14. 2002
  7. pmc Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production
    David G T Hesslein
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:7012-7. 2006
    ..These findings indicate that CD45-dependent regulation of ITAM-dependent signaling pathways is essential for NK cell-mediated cytokine production but not cytolytic activity...
  8. pmc CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Immunol Rev 228:288-311. 2009
    ....
  9. pmc Oncogenic Kras initiates leukemia in hematopoietic stem cells
    Amit J Sabnis
    Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
    PLoS Biol 7:e59. 2009
    ..We conclude that MPD-initiating activity is restricted to the HSC compartment in Kras(G12D) mice, and that distinct self-renewing populations with cooperating mutations emerge during cancer progression...

Research Grants1

  1. Role of CD45 in Hematopoiesis and Lymphomagenesis
    Michelle Hermiston; Fiscal Year: 2005
    ..These studies should provide important insights into the links between immune regulation, autoimmunity, and lymphoid malignancies as well as improve our understanding of the mechanisms governing immune surveillance. ..