Research Topics
Species | Michelle L HermistonSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
CD45: a critical regulator of signaling thresholds in immune cellsMichelle L Hermiston
Department of Pediatrics, University of California, San Francisco, 94143, USA
Annu Rev Immunol 21:107-37. 2003..Perturbation of this function may contribute to autoimmunity, immunodeficiency, and malignancy. Moreover, recent advances suggest that modulation of CD45 function can have therapeutic benefit in many disease states...
B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiencyVikas A Gupta
Department of Medicine, Biomedical Sciences Graduate Program, Medical Scientist Training Program, University of California San Francisco, San Francisco, CA 94143, USA
J Exp Med 205:2755-61. 2008..These results reveal a requirement for careful control of B cell signaling and cell death in preventing inappropriate lymphocyte activation and autoimmunity...- Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responsesMichelle L Hermiston
Department of Pediatrics, Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:546-51. 2009..Together, the data support a role for the CD45 wedge in regulation of T cell responses in vivo and suggest that its effects depend on cellular context... - The juxtamembrane wedge negatively regulates CD45 function in B cellsMichelle L Hermiston
Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143, USA
Immunity 23:635-47. 2005..Together, the results support a role for CD45 as a rheostat, with both positive and negative regulatory functions, that fine-tunes the signal transduction threshold at multiple checkpoints in B cell development... - Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatasesMichelle L Hermiston
Department of Pediatrics, The Howard Hughes Medical Institute, University of California, San Francisco, California 94143-0795, USA
J Clin Invest 109:9-14. 2002 - Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine productionDavid G T Hesslein
Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 103:7012-7. 2006..These findings indicate that CD45-dependent regulation of ITAM-dependent signaling pathways is essential for NK cell-mediated cytokine production but not cytolytic activity... - CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cellsMichelle L Hermiston
Department of Pediatrics, University of California, San Francisco, CA 94143, USA
Immunol Rev 228:288-311. 2009.... - Oncogenic Kras initiates leukemia in hematopoietic stem cellsAmit J Sabnis
Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA
PLoS Biol 7:e59. 2009..We conclude that MPD-initiating activity is restricted to the HSC compartment in Kras(G12D) mice, and that distinct self-renewing populations with cooperating mutations emerge during cancer progression...
Research Grants
- Role of CD45 in Hematopoiesis and LymphomagenesisMichelle Hermiston; Fiscal Year: 2005..These studies should provide important insights into the links between immune regulation, autoimmunity, and lymphoid malignancies as well as improve our understanding of the mechanisms governing immune surveillance. ..
- Interplay of Innate and Adaptive Immunity in Lupus PathogenesisMichelle L Hermiston; Fiscal Year: 2010..The results of these studies should provide new insight into the mechanisms of disease and reveal new targets for therapeutic intervention. ..