Michelle L Hermiston

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Immunol Rev 228:288-311. 2009
  2. pmc B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency
    Vikas A Gupta
    Department of Medicine, Biomedical Sciences Graduate Program, Medical Scientist Training Program, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:2755-61. 2008
  3. ncbi request reprint CD45: a critical regulator of signaling thresholds in immune cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, 94143, USA
    Annu Rev Immunol 21:107-37. 2003
  4. pmc Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses
    Michelle L Hermiston
    Department of Pediatrics, Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:546-51. 2009
  5. pmc Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases
    Michelle L Hermiston
    Department of Pediatrics, The Howard Hughes Medical Institute, University of California, San Francisco, California 94143 0795, USA
    J Clin Invest 109:9-14. 2002
  6. ncbi request reprint The juxtamembrane wedge negatively regulates CD45 function in B cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143, USA
    Immunity 23:635-47. 2005
  7. pmc Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production
    David G T Hesslein
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:7012-7. 2006

Collaborators

Detail Information

Publications7

  1. pmc CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, CA 94143, USA
    Immunol Rev 228:288-311. 2009
    ....
  2. pmc B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency
    Vikas A Gupta
    Department of Medicine, Biomedical Sciences Graduate Program, Medical Scientist Training Program, University of California San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:2755-61. 2008
    ..These results reveal a requirement for careful control of B cell signaling and cell death in preventing inappropriate lymphocyte activation and autoimmunity...
  3. ncbi request reprint CD45: a critical regulator of signaling thresholds in immune cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, 94143, USA
    Annu Rev Immunol 21:107-37. 2003
    ..Perturbation of this function may contribute to autoimmunity, immunodeficiency, and malignancy. Moreover, recent advances suggest that modulation of CD45 function can have therapeutic benefit in many disease states...
  4. pmc Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses
    Michelle L Hermiston
    Department of Pediatrics, Medicine, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:546-51. 2009
    ..Together, the data support a role for the CD45 wedge in regulation of T cell responses in vivo and suggest that its effects depend on cellular context...
  5. pmc Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases
    Michelle L Hermiston
    Department of Pediatrics, The Howard Hughes Medical Institute, University of California, San Francisco, California 94143 0795, USA
    J Clin Invest 109:9-14. 2002
  6. ncbi request reprint The juxtamembrane wedge negatively regulates CD45 function in B cells
    Michelle L Hermiston
    Department of Pediatrics, University of California, San Francisco, San Francisco, California 94143, USA
    Immunity 23:635-47. 2005
    ..Together, the results support a role for CD45 as a rheostat, with both positive and negative regulatory functions, that fine-tunes the signal transduction threshold at multiple checkpoints in B cell development...
  7. pmc Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production
    David G T Hesslein
    Department of Microbiology and Immunology and Cancer Research Institute, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:7012-7. 2006
    ..These findings indicate that CD45-dependent regulation of ITAM-dependent signaling pathways is essential for NK cell-mediated cytokine production but not cytolytic activity...