Brian P Hermann
Affiliation: University of Texas at San Antonio
Hermann B, Cheng K, Singh A, Roa De La Cruz L, Mutoji K, Chen I, et al
. The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids. Cell Rep. 2018;25:1650-1667.e8 pubmed publisher
Hermann B, Mutoji K, Velte E, Ko D, Oatley J, Geyer C, et al
. Transcriptional and translational heterogeneity among neonatal mouse spermatogonia. Biol Reprod. 2015;92:54 pubmed publisher
Benavides Garcia R, Joachim R, Pina N, Mutoji K, Reilly M, Hermann B. Granulocyte colony-stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy. Fertil Steril. 2015;103:270-80.e8 pubmed publisher
..G-CSF treatment might be an effective adjuvant therapy to preserve male fertility in cancer patients receiving sterilizing treatments. ..
Mecklenburg J, Hermann B. Mechanisms Regulating Spermatogonial Differentiation. Results Probl Cell Differ. 2016;58:253-87 pubmed publisher
..This chapter reviews the current literature pertaining to spermatogonial differentiation with an emphasis on the mechanisms controlling stem cell fate decisions and early differentiation events in the life of a spermatogonium. ..
Lovelace D, Gao Z, Mutoji K, Song Y, Ruan J, Hermann B. The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia. Development. 2016;143:1893-906 pubmed publisher
..Together, these data reveal the full profile of PLZF and SALL4 regulatory targets in undifferentiated spermatogonia, including SSCs, which will help elucidate mechanisms controlling the earliest cell fate decisions in spermatogenesis. ..
Mutoji K, Singh A, Nguyen T, Gildersleeve H, Kaucher A, Oatley M, et al
. TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis. Biol Reprod. 2016;95:117 pubmed
..Taken together, these results demonstrate functional heterogeneity among mouse undifferentiated spermatogonia and point to key biological characteristics that distinguish SSCs from progenitor spermatogonia. ..
Kotzur T, Benavides Garcia R, Mecklenburg J, Sanchez J, Reilly M, Hermann B. Granulocyte colony-stimulating factor (G-CSF) promotes spermatogenic regeneration from surviving spermatogonia after high-dose alkylating chemotherapy. Reprod Biol Endocrinol. 2017;15:7 pubmed publisher
..Together, these results clarify that G-CSF protects spermatogenesis after alkylating chemotherapy by stimulating proliferation of surviving spermatogonia, and indicate it may be useful as a retrospective fertility-restoring treatment. ..