James Herman

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis
    James P Herman
    Department of Psychiatry, Psychiatry North, ML 0506 2170 East Galbraith Road, University of Cincinnati College of Medicine, OH 45237 0506, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1201-13. 2005
  2. ncbi request reprint Neural regulation of the stress response: glucocorticoid feedback mechanisms
    J P Herman
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, OH, USA
    Braz J Med Biol Res 45:292-8. 2012
  3. ncbi request reprint Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration
    James P Herman
    Department of Psychiatry, University of Cincinnati, Psychiatry North, Bldg 43, UC E, 2nd Fl, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
    Ann N Y Acad Sci 1018:35-45. 2004
  4. ncbi request reprint Hypothalamic-pituitary-adrenal axis, glucocorticoids, and neurologic disease
    James P Herman
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45237 0506, USA
    Neurol Clin 24:461-81, vi. 2006
  5. ncbi request reprint Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness
    James P Herman
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Front Neuroendocrinol 24:151-80. 2003
  6. pmc The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic-pituitary-adrenocortical axis responsiveness to acute and chronic stress
    Dennis C Choi
    Neuroscience Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Psychoneuroendocrinology 33:659-69. 2008
  7. pmc The anteroventral bed nucleus of the stria terminalis differentially regulates hypothalamic-pituitary-adrenocortical axis responses to acute and chronic stress
    Dennis C Choi
    Neuroscience Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Endocrinology 149:818-26. 2008
  8. ncbi request reprint Regulation of forebrain GABAergic stress circuits following lesion of the ventral subiculum
    Nancy K Mueller
    Department of Psychiatry, University of Cincinnati, 2170 E Galbraith Road, Cincinnati, OH 45237 0506, USA
    Brain Res 1116:132-42. 2006
  9. doi request reprint Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress
    Aynara C Wulsin
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
    Psychoneuroendocrinology 35:1100-12. 2010
  10. pmc Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stress
    Miyuki Tauchi
    Neuroscience Graduate Program, Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237 0506, USA
    Exp Neurol 210:458-66. 2008

Research Grants

Detail Information

Publications63

  1. ncbi request reprint Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis
    James P Herman
    Department of Psychiatry, Psychiatry North, ML 0506 2170 East Galbraith Road, University of Cincinnati College of Medicine, OH 45237 0506, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1201-13. 2005
    ....
  2. ncbi request reprint Neural regulation of the stress response: glucocorticoid feedback mechanisms
    J P Herman
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, OH, USA
    Braz J Med Biol Res 45:292-8. 2012
    ..Thus, rather than having a single, defined feedback 'switch', control of the stress response requires a wide-reaching feedback 'network' that coordinates HPA activity to suit the overall needs of multiple body systems...
  3. ncbi request reprint Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integration
    James P Herman
    Department of Psychiatry, University of Cincinnati, Psychiatry North, Bldg 43, UC E, 2nd Fl, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
    Ann N Y Acad Sci 1018:35-45. 2004
    ..As such, these neurons are positioned to summate limbic inputs into net inhibitory tone on the PVN and may thus play a major role in HPA dysfunction seen in affective disease states and aging...
  4. ncbi request reprint Hypothalamic-pituitary-adrenal axis, glucocorticoids, and neurologic disease
    James P Herman
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45237 0506, USA
    Neurol Clin 24:461-81, vi. 2006
    ..This review highlights the importance of controlling stress and consequent stress hormone secretion in the context of neurologic disease states...
  5. ncbi request reprint Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness
    James P Herman
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Front Neuroendocrinol 24:151-80. 2003
    ..Imbalances among these limbic pathways and homeostatic sensors are likely to underlie hypothalamo-pituitary-adrenocortical dysfunction associated with numerous disease processes...
  6. pmc The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic-pituitary-adrenocortical axis responsiveness to acute and chronic stress
    Dennis C Choi
    Neuroscience Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Psychoneuroendocrinology 33:659-69. 2008
    ..The data further suggest that acute versus chronic stress integration are subserved by different brain circuitry...
  7. pmc The anteroventral bed nucleus of the stria terminalis differentially regulates hypothalamic-pituitary-adrenocortical axis responses to acute and chronic stress
    Dennis C Choi
    Neuroscience Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Endocrinology 149:818-26. 2008
    ....
  8. ncbi request reprint Regulation of forebrain GABAergic stress circuits following lesion of the ventral subiculum
    Nancy K Mueller
    Department of Psychiatry, University of Cincinnati, 2170 E Galbraith Road, Cincinnati, OH 45237 0506, USA
    Brain Res 1116:132-42. 2006
    ....
  9. doi request reprint Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stress
    Aynara C Wulsin
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
    Psychoneuroendocrinology 35:1100-12. 2010
    ..Overall the data suggest that drugs targeting the glucocorticoid receptor may ameliorate stress dysfunction associated with depressive illness...
  10. pmc Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stress
    Miyuki Tauchi
    Neuroscience Graduate Program, Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237 0506, USA
    Exp Neurol 210:458-66. 2008
    ..Overall, our data suggest that brain GLP-1 modulates HPA axis activity within the context of chronic stress, perhaps at the level of the adrenal gland...
  11. pmc Heterogeneity of neuroendocrine stress responses in aging rat strains
    Tracy M Segar
    University of Cincinnati, Department of Psychiatry, Cincinnati, OH 45237, USA
    Physiol Behav 96:6-11. 2009
    ..The results suggest that these older rat strains may be useful models to further assess individual differences in neuroendocrine aging...
  12. ncbi request reprint Norepinephrine-gamma-aminobutyric acid (GABA) interaction in limbic stress circuits: effects of reboxetine on GABAergic neurons
    James P Herman
    Department of Psychiatry, University of Cincinnati Medical Center, JPH, BB, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 53:166-74. 2003
    ....
  13. pmc The role of the forebrain glucocorticoid receptor in acute and chronic stress
    Amy R Furay
    Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Endocrinology 149:5482-90. 2008
    ..Overall, the data are consistent with an essential role of the forebrain GR in coordinating endocrine responses to stimuli of a psychological origin...
  14. ncbi request reprint Deficient hippocampal c-fos expression results in reduced anxiety and altered response to chronic stress in female mice
    Jill M Slane McQuade
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, OH 45267, USA
    Neurosci Lett 403:125-30. 2006
    ..These findings suggest that hippocampal c-fos plays a role in gender-dependent response to stress...
  15. doi request reprint Chronic stress-induced neurotransmitter plasticity in the PVN
    Jonathan N Flak
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Comp Neurol 517:156-65. 2009
    ..These changes could lead to an enhanced capacity for excitation in these neurons, contributing to chronic stress-induced hyperreactivity of stress effector systems in the brain...
  16. pmc Role of glucocorticoids in tuning hindbrain stress integration
    Rong Zhang
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Neurosci 30:14907-14. 2010
    ....
  17. ncbi request reprint Stressor-selective role of the ventral subiculum in regulation of neuroendocrine stress responses
    Nancy K Mueller
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237 0506, USA
    Endocrinology 145:3763-8. 2004
    ....
  18. pmc Chronic stress plasticity in the hypothalamic paraventricular nucleus
    James P Herman
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH, USA
    Prog Brain Res 170:353-64. 2008
    ..Overall, the PVN is uniquely situated to coordinate responses of multiple stress effector systems in the face of prolonged stimulation, and likely plays a role in both adaptation and pathology associated with chronic stress...
  19. ncbi request reprint Organization and regulation of paraventricular nucleus glutamate signaling systems: N-methyl-D-aspartate receptors
    Dana R Ziegler
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267 0559, USA
    J Comp Neurol 484:43-56. 2005
    ....
  20. ncbi request reprint Distribution of vesicular glutamate transporter mRNA in rat hypothalamus
    Dana R Ziegler
    Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    J Comp Neurol 448:217-29. 2002
    ..Our data support a major role for hypothalamic glutamatergic neurons in regulation of all aspects of hypothalamic function...
  21. pmc Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei
    Miyuki Tauchi
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, United States
    J Chem Neuroanat 36:144-9. 2008
    ..GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays...
  22. pmc Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress
    Ryan Jankord
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237 0506, USA
    Ann N Y Acad Sci 1148:64-73. 2008
    ....
  23. doi request reprint Forebrain origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus: differential inputs to the anterior versus posterior subregions
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Comp Neurol 519:1301-19. 2011
    ..The results suggest that PVN subregions are influenced by varying amounts and sources of forebrain glutamatergic regulation, consistent with functional differentiation of glutamate projections...
  24. pmc Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function
    Jason G Barrera
    Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Neurosci 31:3904-13. 2011
    ..Moreover, they suggest that this role is distinct from that of circulating GLP-1 as a short-term satiation signal. Therefore, it may be possible to tailor GLP-1-based therapies for the prevention and/or treatment of obesity...
  25. pmc HPA axis dampening by limited sucrose intake: reward frequency vs. caloric consumption
    Yvonne M Ulrich-Lai
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Physiol Behav 103:104-10. 2011
    ..Moreover, the results support the contention that naturally rewarding behaviors are a physiological means to produce stress relief...
  26. pmc Pleasurable behaviors reduce stress via brain reward pathways
    Yvonne M Ulrich-Lai
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45237, USA
    Proc Natl Acad Sci U S A 107:20529-34. 2010
    ..These findings provide a clearer understanding of the motivation for consuming palatable foods during times of stress and influence therapeutic strategies for the prevention and/or treatment of obesity and other stress-related disorders...
  27. doi request reprint Chronic stress, energy balance and adiposity in female rats
    Matia B Solomon
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, United States
    Physiol Behav 102:84-90. 2011
    ..Overall, the data indicate that in female rats, chronic stress prevents high fat diet related increases in body weight, but does not prevent high fat diet induced increases in adiposity when compared to chow-fed females...
  28. pmc Stress activation of IL-6 neurons in the hypothalamus
    Ryan Jankord
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237 1625, USA
    Am J Physiol Regul Integr Comp Physiol 299:R343-51. 2010
    ..In summary, results show that IL-6 neurons of the HNS are a recruited component of the response to psychological stress...
  29. pmc GluR5-mediated glutamate signaling regulates hypothalamo-pituitary-adrenocortical stress responses at the paraventricular nucleus and median eminence
    Nathan K Evanson
    University of Cincinnati Graduate Program in Neuroscience, Cincinnati, OH, United States of America
    Psychoneuroendocrinology 34:1370-9. 2009
    ..Together, these findings provide evidence for glutamate-mediated signaling in control of CRH release at the PVN and median eminence, mediated by way of kainate-preferring receptor complexes...
  30. pmc Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress
    Rong Zhang
    Departments of Psychiatry and Internal Medicine, University of Cincinnati, Cincinnati, OH 45237, USA
    Proc Natl Acad Sci U S A 106:5913-8. 2009
    ....
  31. doi request reprint Sex differences in psychopathology: of gonads, adrenals and mental illness
    Matia B Solomon
    Department of Psychiatry, University of Cincinnati, Genome, Research Institute, Reading, OH 45237, USA
    Physiol Behav 97:250-8. 2009
    ..Overall, the preclinical research suggests that selective ER modulators targeting ERbeta may be an attractive alternative or adjunct treatment to currently prescribed antidepressants or anxiolytics...
  32. ncbi request reprint Bed nucleus of the stria terminalis subregions differentially regulate hypothalamic-pituitary-adrenal axis activity: implications for the integration of limbic inputs
    Dennis C Choi
    Neuroscience Program and Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Neurosci 27:2025-34. 2007
    ....
  33. ncbi request reprint Daily limited access to sweetened drink attenuates hypothalamic-pituitary-adrenocortical axis stress responses
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Reading, Ohio 45237 0506, USA
    Endocrinology 148:1823-34. 2007
    ..Collectively the results support the hypothesis that the intake of palatable substances represents an endogenous mechanism to dampen physiological stress responses...
  34. ncbi request reprint Comparative analysis of ACTH and corticosterone sampling methods in rats
    Torsten P Vahl
    Dept of Internal Medicine, Division of Endocrinology and Metabolism, Univ of Cincinnati, 2170 E Galbraith Rd, Bldg 43, Rm 315, Cincinnati, OH 45237, USA
    Am J Physiol Endocrinol Metab 289:E823-8. 2005
    ..However, collection of blood under pentobarbital sodium or CO2 anesthesia is likely to confound the results of stress studies when ACTH is an important endpoint...
  35. ncbi request reprint Local circuit regulation of paraventricular nucleus stress integration: glutamate-GABA connections
    James P Herman
    Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Avenue, Cincinnati, OH 45267 0559, USA
    Pharmacol Biochem Behav 71:457-68. 2002
    ..Local circuits are likely the primary integrators of anticipatory stress responses, and may indeed be the focus of HPA dysfunction seen with aging or affective disease...
  36. ncbi request reprint Role of the paraventricular nucleus microenvironment in stress integration
    James P Herman
    Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Eur J Neurosci 16:381-5. 2002
    ..The current state of knowledge reveals the paraventricular nucleus to be a dynamic entity, capable of integrating diverse classes of signals into control of adrenocortical activation...
  37. ncbi request reprint Stress and amphetamine induce Fos expression in medial prefrontal cortex neurons containing glucocorticoid receptors
    Michelle M Ostrander
    Department of Psychiatry, University of Cincinnati, Med Sci Bldg, Rm G551, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Brain Res 990:209-14. 2003
    ..These findings suggest exposure to amphetamine activates the same medial prefrontal cortex regions responsible for integration of responses to stress, and suggest the potential for AP1-glucocorticoid cross-talk in these cell populations...
  38. ncbi request reprint Stress integration after acute and chronic predator stress: differential activation of central stress circuitry and sensitization of the hypothalamo-pituitary-adrenocortical axis
    Helmer F Figueiredo
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Endocrinology 144:5249-58. 2003
    ....
  39. pmc Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions
    Neil M Richtand
    Cincinnati Veterans Affairs Medical Center, Psychiatry Service V116A, Cincinnati, OH, USA
    Neuropsychopharmacology 31:77-89. 2006
    ..Additionally, these data support the use of low-dose risperidone in psychosis prevention, and suggest the possibility that higher risperidone doses could be less effective in this application...
  40. pmc Hypoactivity of the hypothalamo-pituitary-adrenocortical axis during recovery from chronic variable stress
    Michelle M Ostrander
    Department of Psychiatry, University of Cincinnati, Ohio 45237, USA
    Endocrinology 147:2008-17. 2006
    ....
  41. ncbi request reprint Limbic and HPA axis function in an animal model of chronic neuropathic pain
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45140, USA
    Physiol Behav 88:67-76. 2006
    ..These results suggest that increased nociceptive sensitivity during chronic pain is associated with alterations in the limbic system, but is dissociated from HPA axis activation...
  42. ncbi request reprint Stress activation of cortex and hippocampus is modulated by sex and stage of estrus
    Helmer F Figueiredo
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    Endocrinology 143:2534-40. 2002
    ..Taken together, this study indicates that cortical structures are differentially stress activated in females depending on the phase of the estrous cycle, perhaps in a progesterone-dependent fashion...
  43. pmc Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling
    Nathan K Evanson
    Department of Psychiatry, University of Cincinnati, GRI E205 ML 0506, 2170 E Galbraith Road, Cincinnati, Ohio 45237, USA
    Endocrinology 151:4811-9. 2010
    ..These data support the hypothesis that glucocorticoid-induced fast feedback inhibition of the HPA axis is mediated by a nongenomic signaling mechanism that involves endocannabinoid signaling at the level of the PVN...
  44. ncbi request reprint Estrogen potentiates adrenocortical responses to stress in female rats
    Helmer F Figueiredo
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, Psychiatry North, ML 0506, Bldg 43, 2nd Floor, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
    Am J Physiol Endocrinol Metab 292:E1173-82. 2007
    ..These results suggest that enhanced adrenal sensitive to ACTH is an important physiological mechanism mediating E(2)-related glucocorticoid hypersecretion in stressed females...
  45. ncbi request reprint Chronic social stress in the visible burrow system modulates stress-related gene expression in the bed nucleus of the stria terminalis
    Dennis C Choi
    Neuroscience Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Physiol Behav 89:301-10. 2006
    ....
  46. ncbi request reprint Role of the ventral subiculum in stress integration
    James P Herman
    Department of Psychiatry, Neurobiology and Anatomy, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237 0506, United States
    Behav Brain Res 174:215-24. 2006
    ..Overall, the present state of knowledge indicates that the role of the subiculum in stress integration is complex, and likely involves interactions of stress-relevant subicular output with limbic-hypothalamic stress-integrative circuits...
  47. ncbi request reprint Decrements in nuclear glucocorticoid receptor (GR) protein levels and DNA binding in aged rat hippocampus
    Erin K Murphy
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0559, USA
    Endocrinology 143:1362-70. 2002
    ..Diminished GR signaling capacity may attenuate the beneficial effects of glucocorticoids on hippocampal regulation of memory and stress integration...
  48. ncbi request reprint Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific manner
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237 0506, USA
    Am J Physiol Endocrinol Metab 291:E965-73. 2006
    ..These chronic stress-induced changes in adrenal growth and function may have implications for patients with stress-related disorders...
  49. ncbi request reprint The medial prefrontal cortex differentially regulates stress-induced c-fos expression in the forebrain depending on type of stressor
    Helmer F Figueiredo
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0559, USA
    Eur J Neurosci 18:2357-64. 2003
    ..Taken together, this study indicates that the medial prefrontal cortex differentially regulates cellular activation of specific stress-related brain regions, thus exerting stressor-dependent inhibition of the HPA axis...
  50. ncbi request reprint Activity-dependent modulation of neurotransmitter innervation to vasopressin neurons of the supraoptic nucleus
    Nancy K Mueller
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45237 0506, USA
    Endocrinology 146:348-54. 2005
    ....
  51. pmc Changes in central sodium and not osmolarity or lactate induce panic-like responses in a model of panic disorder
    Andre I Molosh
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Neuropsychopharmacology 35:1333-47. 2010
    ..These data show that hypertonic sodium, but not hyper-osmolarity or changes in lactate, is the key stimulus that provokes panic attacks in panic disorder, and is consistent with human studies...
  52. pmc Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    J Clin Invest 119:2577-89. 2009
    ..These results suggest that many of the deleterious effects of high-fat diets, specifically those enriched with palmitic acid, are CNS mediated via PKC-theta activation, resulting in reduced insulin activity...
  53. doi request reprint Neural regulation of endocrine and autonomic stress responses
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Ohio 45237 0506, USA
    Nat Rev Neurosci 10:397-409. 2009
    ....
  54. pmc Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brain
    Jennifer McGuire
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
    Biochem Biophys Res Commun 386:420-5. 2009
    ..Our results open up new areas of investigation into the relevance of TDAG8 in pH homeostasis and pathological states associated with acid-base dys-regulation in the brain such as ischemia and panic disorder...
  55. ncbi request reprint Traumatic brain injury regulates adrenocorticosteroid receptor mRNA levels in rat hippocampus
    Deanna L McCullers
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
    Brain Res 947:41-9. 2002
    ..Regulation of MR and GR expression following TBI may influence hippocampal neuron viability by modulating glucocorticoid signaling after injury...
  56. ncbi request reprint CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors
    Kimberly P Kinzig
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 23:6163-70. 2003
    ..Although diverse neural circuits must necessarily process disparate stressors, the current data implicate a role for the GLP-1 system as a critical mediator of multiple stress responses...
  57. ncbi request reprint Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function
    Daniela Cota
    Group of Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 148:1574-81. 2007
    ....
  58. ncbi request reprint Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    J Neurosci 23:3807-19. 2003
    ....
  59. ncbi request reprint Stability of neuroendocrine and behavioral responsiveness in aging Fischer 344/Brown-Norway hybrid rats
    John W Kasckow
    Psychiatry Service, Cincinnati Veterans Affairs Medical Center, Ohio 45220, USA
    Endocrinology 146:3105-12. 2005
    ..The lack of a correlation between HPA axis measures and emotional as well as fear conditioning-related behaviors indicates that corticosteroid dysfunction may not predict age-related behavioral deficits in this aging model...
  60. ncbi request reprint GABAergic circuits and the stress hyporesponsive period in the rat: ontogeny of glutamic acid decarboxylase (GAD) 67 mRNA expression in limbic-hypothalamic stress pathways
    Gersham Dent
    Department of Biology, University of Delaware, Newark, DE 19716 2577, USA
    Brain Res 1138:1-9. 2007
    ..Overall, the data implicate forebrain GABA circuits in inhibition of HPA axis activity during the SHRP...
  61. ncbi request reprint Strategies and methods for research on sex differences in brain and behavior
    Jill B Becker
    Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109, USA
    Endocrinology 146:1650-73. 2005
    ..This article describes methods and procedures to assist scientists new to the field in designing and conducting experiments to investigate sex differences in research involving both laboratory animals and humans...
  62. doi request reprint Optimally straight and optimally curved saccades
    Mark R Harwood
    Department of Biology, City College of New York, City University of New York, New York, New York 10031, USA
    J Neurosci 28:7455-7. 2008
  63. doi request reprint Dissociation of ACTH and glucocorticoids
    Stefan R Bornstein
    Medical Faculty Carl Gustav Carus of the Technical University Dresden, Dresden, Germany
    Trends Endocrinol Metab 19:175-80. 2008
    ..The separation of adrenocorticotropic hormone and corticosteroid secretion is of clinical relevance and should be incorporated into our view on endocrine stress regulation...

Research Grants34

  1. FUNCTIONAL ANATOMY OF LIMBIC-NEUROENDOCRINE CIRCUITS
    James Herman; Fiscal Year: 2006
    ..abstract_text> ..
  2. Glucocorticoid Receptor Mechanisms, Stress and Aging
    James Herman; Fiscal Year: 2006
    ..abstract_text> ..
  3. Brainstem Mechanisms of Stress Regulation
    James Herman; Fiscal Year: 2007
    ..The results of these studies are expected to establish a major role for GLP-1 systems in stress regulation, and identify the GLP-1 system as a target for future therapeutic interventions. ..
  4. PREDOCTORAL TRAINING PROGRAM IN THE NEUROSCIENCES
    James Herman; Fiscal Year: 2007
    ..D.) program. ..
  5. FUNCTIONAL ANATOMY OF LIMBIC-NEUROENDOCRINE CIRCUITS
    James P Herman; Fiscal Year: 2010
    ....
  6. Anatomical Plasticity and HPA Axis Dysfunction
    James Herman; Fiscal Year: 2009
    ..Overall, this project will provide critical new information on hypothalamic mechanisms mediating neuroendocrine dysfunction in affective disease states. ..
  7. GLUCOCORTICOID RECEPTOR MECHANISMS STRESS AND AGING
    James Herman; Fiscal Year: 1999
    ..It is predicted that the results of this project will identify specific mechanisms responsible for impaired ACR regulation in aging and AD. ..
  8. FUNCTIONAL ANATOMY OF LIMBIC NEUROENDOCRINE CIRCUITS
    James Herman; Fiscal Year: 2001
    ..Together, these studies are expected to define the raphe of the hippocampus in stress processing, and indicate that dysfunction of this structure is a likely mitigating factor in depressive disorder and stress-related disease processes. ..
  9. Brainstem Mechanisms of Stress Regulation
    James P Herman; Fiscal Year: 2010
    ..Our studies are expected to provide preclinical data regarding new molecular targets for promoting stress resistance and adaptation. ..