Research Topics
Species | James HermanSummaryAffiliation: University of Cincinnati Country: USA Publications
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Publications
Neural regulation of the stress response: glucocorticoid feedback mechanismsJ P Herman
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, OH, USA
Braz J Med Biol Res 45:292-8. 2012..Thus, rather than having a single, defined feedback 'switch', control of the stress response requires a wide-reaching feedback 'network' that coordinates HPA activity to suit the overall needs of multiple body systems...- Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical stress integrationJames P Herman
Department of Psychiatry, University of Cincinnati, Psychiatry North, Bldg 43, UC E, 2nd Fl, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
Ann N Y Acad Sci 1018:35-45. 2004..As such, these neurons are positioned to summate limbic inputs into net inhibitory tone on the PVN and may thus play a major role in HPA dysfunction seen in affective disease states and aging... - Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axisJames P Herman
Department of Psychiatry, Psychiatry North, ML 0506 2170 East Galbraith Road, University of Cincinnati College of Medicine, OH 45237 0506, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:1201-13. 2005.... - Hypothalamic-pituitary-adrenal axis, glucocorticoids, and neurologic diseaseJames P Herman
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45237 0506, USA
Neurol Clin 24:461-81, vi. 2006..This review highlights the importance of controlling stress and consequent stress hormone secretion in the context of neurologic disease states... - Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsivenessJames P Herman
Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
Front Neuroendocrinol 24:151-80. 2003..Imbalances among these limbic pathways and homeostatic sensors are likely to underlie hypothalamo-pituitary-adrenocortical dysfunction associated with numerous disease processes... 
The role of the posterior medial bed nucleus of the stria terminalis in modulating hypothalamic-pituitary-adrenocortical axis responsiveness to acute and chronic stressDennis C Choi
Neuroscience Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Psychoneuroendocrinology 33:659-69. 2008..The data further suggest that acute versus chronic stress integration are subserved by different brain circuitry...
The anteroventral bed nucleus of the stria terminalis differentially regulates hypothalamic-pituitary-adrenocortical axis responses to acute and chronic stressDennis C Choi
Neuroscience Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Endocrinology 149:818-26. 2008....- Regulation of forebrain GABAergic stress circuits following lesion of the ventral subiculumNancy K Mueller
Department of Psychiatry, University of Cincinnati, 2170 E. Galbraith Road, Cincinnati, OH 45237-0506, USA
Brain Res 1116:132-42. 2006.... - Mifepristone decreases depression-like behavior and modulates neuroendocrine and central hypothalamic-pituitary-adrenocortical axis responsiveness to stressAynara C Wulsin
Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA
Psychoneuroendocrinology 35:1100-12. 2010..Overall the data suggest that drugs targeting the glucocorticoid receptor may ameliorate stress dysfunction associated with depressive illness... - Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stressMiyuki Tauchi
Neuroscience Graduate Program, Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237 0506, USA
Exp Neurol 210:458-66. 2008..Overall, our data suggest that brain GLP-1 modulates HPA axis activity within the context of chronic stress, perhaps at the level of the adrenal gland... - Heterogeneity of neuroendocrine stress responses in aging rat strainsTracy M Segar
University of Cincinnati, Department of Psychiatry, Cincinnati, OH 45237, USA
Physiol Behav 96:6-11. 2009..The results suggest that these older rat strains may be useful models to further assess individual differences in neuroendocrine aging... - Norepinephrine-gamma-aminobutyric acid (GABA) interaction in limbic stress circuits: effects of reboxetine on GABAergic neuronsJames P Herman
Department of Psychiatry, University of Cincinnati Medical Center, JPH, BB, Cincinnati, Ohio 45267-0559, USA
Biol Psychiatry 53:166-74. 2003.... - The role of the forebrain glucocorticoid receptor in acute and chronic stressAmy R Furay
Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Endocrinology 149:5482-90. 2008..Overall, the data are consistent with an essential role of the forebrain GR in coordinating endocrine responses to stimuli of a psychological origin... - Deficient hippocampal c-fos expression results in reduced anxiety and altered response to chronic stress in female miceJill M Slane McQuade
Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, OH 45267, USA
Neurosci Lett 403:125-30. 2006..These findings suggest that hippocampal c-fos plays a role in gender-dependent response to stress... - Chronic stress-induced neurotransmitter plasticity in the PVNJonathan N Flak
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
J Comp Neurol 517:156-65. 2009..These changes could lead to an enhanced capacity for excitation in these neurons, contributing to chronic stress-induced hyperreactivity of stress effector systems in the brain... - Role of glucocorticoids in tuning hindbrain stress integrationRong Zhang
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
J Neurosci 30:14907-14. 2010.... - Stressor-selective role of the ventral subiculum in regulation of neuroendocrine stress responsesNancy K Mueller
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237-0506, USA
Endocrinology 145:3763-8. 2004.... - Chronic stress plasticity in the hypothalamic paraventricular nucleusJames P Herman
Department of Psychiatry, University of Cincinnati, Cincinnati, OH, USA
Prog Brain Res 170:353-64. 2008..Overall, the PVN is uniquely situated to coordinate responses of multiple stress effector systems in the face of prolonged stimulation, and likely plays a role in both adaptation and pathology associated with chronic stress... - Organization and regulation of paraventricular nucleus glutamate signaling systems: N-methyl-D-aspartate receptorsDana R Ziegler
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267 0559, USA
J Comp Neurol 484:43-56. 2005.... - Distribution of vesicular glutamate transporter mRNA in rat hypothalamusDana R Ziegler
Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267-0559, USA
J Comp Neurol 448:217-29. 2002..Our data support a major role for hypothalamic glutamatergic neurons in regulation of all aspects of hypothalamic function... - Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nucleiMiyuki Tauchi
Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, United States
J Chem Neuroanat 36:144-9. 2008..GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays... - Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stressRyan Jankord
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237 0506, USA
Ann N Y Acad Sci 1148:64-73. 2008.... - Forebrain origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus: differential inputs to the anterior versus posterior subregionsYvonne M Ulrich-Lai
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Comp Neurol 519:1301-19. 2011..The results suggest that PVN subregions are influenced by varying amounts and sources of forebrain glutamatergic regulation, consistent with functional differentiation of glutamate projections... - Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of functionJason G Barrera
Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45237, USA
J Neurosci 31:3904-13. 2011..Moreover, they suggest that this role is distinct from that of circulating GLP-1 as a short-term satiation signal. Therefore, it may be possible to tailor GLP-1-based therapies for the prevention and/or treatment of obesity... - HPA axis dampening by limited sucrose intake: reward frequency vs. caloric consumptionYvonne M Ulrich-Lai
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
Physiol Behav 103:104-10. 2011..Moreover, the results support the contention that naturally rewarding behaviors are a physiological means to produce stress relief... - Pleasurable behaviors reduce stress via brain reward pathwaysYvonne M Ulrich-Lai
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45237, USA
Proc Natl Acad Sci U S A 107:20529-34. 2010..These findings provide a clearer understanding of the motivation for consuming palatable foods during times of stress and influence therapeutic strategies for the prevention and/or treatment of obesity and other stress-related disorders... - Chronic stress, energy balance and adiposity in female ratsMatia B Solomon
Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, United States
Physiol Behav 102:84-90. 2011..Overall, the data indicate that in female rats, chronic stress prevents high fat diet related increases in body weight, but does not prevent high fat diet induced increases in adiposity when compared to chow-fed females... - Stress activation of IL-6 neurons in the hypothalamusRyan Jankord
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237 1625, USA
Am J Physiol Regul Integr Comp Physiol 299:R343-51. 2010..In summary, results show that IL-6 neurons of the HNS are a recruited component of the response to psychological stress... - GluR5-mediated glutamate signaling regulates hypothalamo-pituitary-adrenocortical stress responses at the paraventricular nucleus and median eminenceNathan K Evanson
University of Cincinnati Graduate Program in Neuroscience, Cincinnati, OH, United States of America
Psychoneuroendocrinology 34:1370-9. 2009..Together, these findings provide evidence for glutamate-mediated signaling in control of CRH release at the PVN and median eminence, mediated by way of kainate-preferring receptor complexes... - Glucocorticoid regulation of preproglucagon transcription and RNA stability during stressRong Zhang
Departments of Psychiatry and Internal Medicine, University of Cincinnati, Cincinnati, OH 45237, USA
Proc Natl Acad Sci U S A 106:5913-8. 2009.... - Sex differences in psychopathology: of gonads, adrenals and mental illnessMatia B Solomon
Department of Psychiatry, University of Cincinnati, Genome, Research Institute, Reading, OH 45237, USA
Physiol Behav 97:250-8. 2009..Overall, the preclinical research suggests that selective ER modulators targeting ERbeta may be an attractive alternative or adjunct treatment to currently prescribed antidepressants or anxiolytics... - Bed nucleus of the stria terminalis subregions differentially regulate hypothalamic-pituitary-adrenal axis activity: implications for the integration of limbic inputsDennis C Choi
Neuroscience Program and Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
J Neurosci 27:2025-34. 2007.... - Daily limited access to sweetened drink attenuates hypothalamic-pituitary-adrenocortical axis stress responsesYvonne M Ulrich-Lai
Department of Psychiatry, University of Cincinnati, 2170 East Galbraith Road, Reading, Ohio 45237 0506, USA
Endocrinology 148:1823-34. 2007..Collectively the results support the hypothesis that the intake of palatable substances represents an endogenous mechanism to dampen physiological stress responses... - Comparative analysis of ACTH and corticosterone sampling methods in ratsTorsten P Vahl
Dept of Internal Medicine, Division of Endocrinology and Metabolism, Univ of Cincinnati, 2170 E Galbraith Rd, Bldg 43, Rm 315, Cincinnati, OH 45237, USA
Am J Physiol Endocrinol Metab 289:E823-8. 2005..However, collection of blood under pentobarbital sodium or CO2 anesthesia is likely to confound the results of stress studies when ACTH is an important endpoint... - Local circuit regulation of paraventricular nucleus stress integration: glutamate-GABA connectionsJames P Herman
Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Avenue, Cincinnati, OH 45267 0559, USA
Pharmacol Biochem Behav 71:457-68. 2002..Local circuits are likely the primary integrators of anticipatory stress responses, and may indeed be the focus of HPA dysfunction seen with aging or affective disease... - Role of the paraventricular nucleus microenvironment in stress integrationJames P Herman
Department of Psychiatry, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
Eur J Neurosci 16:381-5. 2002..The current state of knowledge reveals the paraventricular nucleus to be a dynamic entity, capable of integrating diverse classes of signals into control of adrenocortical activation... - Stress and amphetamine induce Fos expression in medial prefrontal cortex neurons containing glucocorticoid receptorsMichelle M Ostrander
Department of Psychiatry, University of Cincinnati, Med Sci Bldg, Rm G551, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
Brain Res 990:209-14. 2003..These findings suggest exposure to amphetamine activates the same medial prefrontal cortex regions responsible for integration of responses to stress, and suggest the potential for AP1-glucocorticoid cross-talk in these cell populations... - Stress integration after acute and chronic predator stress: differential activation of central stress circuitry and sensitization of the hypothalamo-pituitary-adrenocortical axisHelmer F Figueiredo
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
Endocrinology 144:5249-58. 2003.... - Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesionsNeil M Richtand
Cincinnati Veterans Affairs Medical Center, Psychiatry Service V116A, Cincinnati, OH, USA
Neuropsychopharmacology 31:77-89. 2006..Additionally, these data support the use of low-dose risperidone in psychosis prevention, and suggest the possibility that higher risperidone doses could be less effective in this application... - Hypoactivity of the hypothalamo-pituitary-adrenocortical axis during recovery from chronic variable stressMichelle M Ostrander
Department of Psychiatry, University of Cincinnati, Ohio 45237, USA
Endocrinology 147:2008-17. 2006.... - Limbic and HPA axis function in an animal model of chronic neuropathic painYvonne M Ulrich-Lai
Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45140, USA
Physiol Behav 88:67-76. 2006..These results suggest that increased nociceptive sensitivity during chronic pain is associated with alterations in the limbic system, but is dissociated from HPA axis activation... - Stress activation of cortex and hippocampus is modulated by sex and stage of estrusHelmer F Figueiredo
Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
Endocrinology 143:2534-40. 2002..Taken together, this study indicates that cortical structures are differentially stress activated in females depending on the phase of the estrous cycle, perhaps in a progesterone-dependent fashion... - Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signalingNathan K Evanson
Department of Psychiatry, University of Cincinnati, GRI E205 ML 0506, 2170 E Galbraith Road, Cincinnati, Ohio 45237, USA
Endocrinology 151:4811-9. 2010..These data support the hypothesis that glucocorticoid-induced fast feedback inhibition of the HPA axis is mediated by a nongenomic signaling mechanism that involves endocannabinoid signaling at the level of the PVN... - Estrogen potentiates adrenocortical responses to stress in female ratsHelmer F Figueiredo
Department of Psychiatry, University of Cincinnati, Genome Research Institute, Psychiatry North, ML 0506, Bldg 43, 2nd Floor, 2170 East Galbraith Road, Reading, OH 45237 0506, USA
Am J Physiol Endocrinol Metab 292:E1173-82. 2007..These results suggest that enhanced adrenal sensitive to ACTH is an important physiological mechanism mediating E(2)-related glucocorticoid hypersecretion in stressed females... - Chronic social stress in the visible burrow system modulates stress-related gene expression in the bed nucleus of the stria terminalisDennis C Choi
Neuroscience Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Physiol Behav 89:301-10. 2006.... - Role of the ventral subiculum in stress integrationJames P Herman
Department of Psychiatry, Neurobiology and Anatomy, University of Cincinnati, 2170 East Galbraith Road, Cincinnati, OH 45237 0506, United States
Behav Brain Res 174:215-24. 2006..Overall, the present state of knowledge indicates that the role of the subiculum in stress integration is complex, and likely involves interactions of stress-relevant subicular output with limbic-hypothalamic stress-integrative circuits... - Decrements in nuclear glucocorticoid receptor (GR) protein levels and DNA binding in aged rat hippocampusErin K Murphy
Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0559, USA
Endocrinology 143:1362-70. 2002..Diminished GR signaling capacity may attenuate the beneficial effects of glucocorticoids on hippocampal regulation of memory and stress integration... - Chronic stress induces adrenal hyperplasia and hypertrophy in a subregion-specific mannerYvonne M Ulrich-Lai
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237 0506, USA
Am J Physiol Endocrinol Metab 291:E965-73. 2006..These chronic stress-induced changes in adrenal growth and function may have implications for patients with stress-related disorders... - The medial prefrontal cortex differentially regulates stress-induced c-fos expression in the forebrain depending on type of stressorHelmer F Figueiredo
Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0559, USA
Eur J Neurosci 18:2357-64. 2003..Taken together, this study indicates that the medial prefrontal cortex differentially regulates cellular activation of specific stress-related brain regions, thus exerting stressor-dependent inhibition of the HPA axis... - Activity-dependent modulation of neurotransmitter innervation to vasopressin neurons of the supraoptic nucleusNancy K Mueller
Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45237-0506, USA
Endocrinology 146:348-54. 2005.... - Changes in central sodium and not osmolarity or lactate induce panic-like responses in a model of panic disorderAndre I Molosh
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neuropsychopharmacology 35:1333-47. 2010..These data show that hypertonic sodium, but not hyper-osmolarity or changes in lactate, is the key stimulus that provokes panic attacks in panic disorder, and is consistent with human studies... - Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodentsStephen C Benoit
Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
J Clin Invest 119:2577-89. 2009..These results suggest that many of the deleterious effects of high-fat diets, specifically those enriched with palmitic acid, are CNS mediated via PKC-theta activation, resulting in reduced insulin activity... - Neural regulation of endocrine and autonomic stress responsesYvonne M Ulrich-Lai
Department of Psychiatry, University of Cincinnati, Ohio 45237 0506, USA
Nat Rev Neurosci 10:397-409. 2009.... - Acid-sensing by the T cell death-associated gene 8 (TDAG8) receptor cloned from rat brainJennifer McGuire
Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, OH 45237, USA
Biochem Biophys Res Commun 386:420-5. 2009..Our results open up new areas of investigation into the relevance of TDAG8 in pH homeostasis and pathological states associated with acid-base dys-regulation in the brain such as ischemia and panic disorder... - Traumatic brain injury regulates adrenocorticosteroid receptor mRNA levels in rat hippocampusDeanna L McCullers
Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40536, USA
Brain Res 947:41-9. 2002..Regulation of MR and GR expression following TBI may influence hippocampal neuron viability by modulating glucocorticoid signaling after injury... - CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressorsKimberly P Kinzig
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 23:6163-70. 2003..Although diverse neural circuits must necessarily process disparate stressors, the current data implicate a role for the GLP-1 system as a critical mediator of multiple stress responses... - Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis functionDaniela Cota
Group of Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
Endocrinology 148:1574-81. 2007.... - Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairmentEric M Blalock
Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0298, USA
J Neurosci 23:3807-19. 2003.... - Stability of neuroendocrine and behavioral responsiveness in aging Fischer 344/Brown-Norway hybrid ratsJohn W Kasckow
Psychiatry Service, Cincinnati Veterans Affairs Medical Center, Ohio 45220, USA
Endocrinology 146:3105-12. 2005..The lack of a correlation between HPA axis measures and emotional as well as fear conditioning-related behaviors indicates that corticosteroid dysfunction may not predict age-related behavioral deficits in this aging model... - GABAergic circuits and the stress hyporesponsive period in the rat: ontogeny of glutamic acid decarboxylase (GAD) 67 mRNA expression in limbic-hypothalamic stress pathwaysGersham Dent
Department of Biology, University of Delaware, Newark, DE 19716 2577, USA
Brain Res 1138:1-9. 2007..Overall, the data implicate forebrain GABA circuits in inhibition of HPA axis activity during the SHRP... - Strategies and methods for research on sex differences in brain and behaviorJill B Becker
Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109, USA
Endocrinology 146:1650-73. 2005..This article describes methods and procedures to assist scientists new to the field in designing and conducting experiments to investigate sex differences in research involving both laboratory animals and humans... - Optimally straight and optimally curved saccadesMark R Harwood
Department of Biology, City College of New York, City University of New York, New York, New York 10031, USA
J Neurosci 28:7455-7. 2008 - Dissociation of ACTH and glucocorticoidsStefan R Bornstein
Medical Faculty Carl Gustav Carus of the Technical University Dresden, Dresden, Germany
Trends Endocrinol Metab 19:175-80. 2008..The separation of adrenocorticotropic hormone and corticosteroid secretion is of clinical relevance and should be incorporated into our view on endocrine stress regulation...
Research Grants
- FUNCTIONAL ANATOMY OF LIMBIC-NEUROENDOCRINE CIRCUITSJames Herman; Fiscal Year: 2006..abstract_text> ..
- Glucocorticoid Receptor Mechanisms, Stress and AgingJames Herman; Fiscal Year: 2006..abstract_text> ..
- Brainstem Mechanisms of Stress RegulationJames Herman; Fiscal Year: 2007..The results of these studies are expected to establish a major role for GLP-1 systems in stress regulation, and identify the GLP-1 system as a target for future therapeutic interventions. ..
- PREDOCTORAL TRAINING PROGRAM IN THE NEUROSCIENCESJames Herman; Fiscal Year: 2007..D.) program. ..
- FUNCTIONAL ANATOMY OF LIMBIC-NEUROENDOCRINE CIRCUITSJames P Herman; Fiscal Year: 2010....
- Anatomical Plasticity and HPA Axis DysfunctionJames Herman; Fiscal Year: 2009..Overall, this project will provide critical new information on hypothalamic mechanisms mediating neuroendocrine dysfunction in affective disease states. ..
- GLUCOCORTICOID RECEPTOR MECHANISMS STRESS AND AGINGJames Herman; Fiscal Year: 1999..It is predicted that the results of this project will identify specific mechanisms responsible for impaired ACR regulation in aging and AD. ..
- FUNCTIONAL ANATOMY OF LIMBIC NEUROENDOCRINE CIRCUITSJames Herman; Fiscal Year: 2001..Together, these studies are expected to define the raphe of the hippocampus in stress processing, and indicate that dysfunction of this structure is a likely mitigating factor in depressive disorder and stress-related disease processes. ..
- Brainstem Mechanisms of Stress RegulationJames P Herman; Fiscal Year: 2010..Our studies are expected to provide preclinical data regarding new molecular targets for promoting stress resistance and adaptation. ..