Brittney Shea Herbert

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier
    Cheryl M Lewis
    Hamon Center for Therapeutic Oncology Research and Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Breast Cancer Res Treat 99:103-15. 2006
  2. ncbi request reprint A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Cancer Res 63:1914-9. 2003
  3. ncbi request reprint Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors
    Brittney Shea Herbert
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
    Oncogene 21:638-42. 2002
  4. ncbi request reprint p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
    Oncogene 21:7897-900. 2002
  5. ncbi request reprint Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Oncogene 22:433-44. 2003
  6. doi request reprint Analysis of telomeres and telomerase
    Brittney Shea Herbert
    The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Protoc Cell Biol . 2003
  7. ncbi request reprint Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
    Brittney Shea Herbert
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Oncogene 24:5262-8. 2005
  8. ncbi request reprint Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
    Hong Zhang
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Oncogene 23:6193-8. 2004
  9. ncbi request reprint Telomere dysfunction in aging and cancer
    David Gilley
    Department of Medical and Molecular Genetics, The Indiana University Cancer Center, Indiana University School of Medicine, 975 West Walnut St, IB 242, Indianapolis, IN 46202 5251, USA
    Int J Biochem Cell Biol 37:1000-13. 2005
  10. ncbi request reprint Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells
    Mihaela Velicescu
    University of Southern California Norris Comprehensive Cancer Center, Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90089 9181, USA
    Cancer Res 63:5813-20. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier
    Cheryl M Lewis
    Hamon Center for Therapeutic Oncology Research and Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 9039, USA
    Breast Cancer Res Treat 99:103-15. 2006
    ....
  2. ncbi request reprint A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Cancer Res 63:1914-9. 2003
    ....
  3. ncbi request reprint Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors
    Brittney Shea Herbert
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
    Oncogene 21:638-42. 2002
    ..The results suggest that the oligonucleotide N3'-->P5' phosphoramidates, and particularly thio-phosphoramidates, might be further developed as selective anti-telomerase reagents...
  4. ncbi request reprint p16(INK4a) inactivation is not required to immortalize human mammary epithelial cells
    Brittney Shea Herbert
    Department of Cell Biology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, TX 75390 9039, USA
    Oncogene 21:7897-900. 2002
    ..These findings support the concept that the so-called M0 stage represents a cell culture stress-induced growth arrest and that hTERT is sufficient to immortalize HMECs when cultured under adequate conditions...
  5. ncbi request reprint Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells
    Ruben D Ramirez
    Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Oncogene 22:433-44. 2003
    ..These results suggest that the differentiation pathways in Cdk4-overexpressing cells remain intact...
  6. doi request reprint Analysis of telomeres and telomerase
    Brittney Shea Herbert
    The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Curr Protoc Cell Biol . 2003
    ..These assays can be used to study the in vitro cellular effects of aging and cancer treatments on telomere biology and telomerase activity...
  7. ncbi request reprint Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
    Brittney Shea Herbert
    Department of Cell Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9039, USA
    Oncogene 24:5262-8. 2005
    ..These results suggest that the lipid-conjugated thio-phosphoramidates could be important for improved pharmacodynamics of telomerase inhibitors in cancer therapy...
  8. ncbi request reprint Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
    Hong Zhang
    Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Oncogene 23:6193-8. 2004
    ....
  9. ncbi request reprint Telomere dysfunction in aging and cancer
    David Gilley
    Department of Medical and Molecular Genetics, The Indiana University Cancer Center, Indiana University School of Medicine, 975 West Walnut St, IB 242, Indianapolis, IN 46202 5251, USA
    Int J Biochem Cell Biol 37:1000-13. 2005
    ..Herein, we provide an overview of the emerging knowledge of telomere dysfunction and how it relates to possible links between aging and cancer...
  10. ncbi request reprint Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells
    Mihaela Velicescu
    University of Southern California Norris Comprehensive Cancer Center, Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90089 9181, USA
    Cancer Res 63:5813-20. 2003
    ..Reestablishment or emergence of ploidy stability, which is not always dependent on telomerase activation, is necessary for acquisition of the potential to achieve replicative immortality...
  11. ncbi request reprint Factors impacting human telomere homeostasis and age-related disease
    David Gilley
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, United States
    Mech Ageing Dev 129:27-34. 2008
    ....
  12. ncbi request reprint Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent
    Sergei M Gryaznov
    Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA
    Nucleosides Nucleotides Nucleic Acids 26:1577-9. 2007
    ..GRN163L is currently in Phase I and Phase I/II clinical studies in patients with solid tumors and CLL, respectively...
  13. ncbi request reprint Shared environmental factors associated with telomere length maintenance in elderly male twins
    Nazmul Huda
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Aging Cell 6:709-13. 2007
    ..0025 and 0.002, respectively). Our results emphasize that shared environmental factors can have a primary impact on telomere length maintenance in elderly humans...
  14. ncbi request reprint Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol
    Brittney Shea Herbert
    Department of Medical and Molecular Genetics, Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    Nat Protoc 1:1583-90. 2006
    ..These modified TRAP assays can be accomplished within 4 h (from lysis of samples to analysis of telomerase products)...
  15. ncbi request reprint Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells
    Jaime Gomez-Millan
    Department of Radiation Oncology, Radiation and Cancer Biology Laboratory, Indiana University School of Medicine, Indianapolis, IN 46202 5251, USA
    Int J Radiat Oncol Biol Phys 67:897-905. 2007
    ..Our goal was to test whether the treatment with GRN163L enhances sensitivity to irradiation (IR) in MDA-MB-231 breast cancer cells...
  16. ncbi request reprint Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer
    Amelia E Hochreiter
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202 5251, USA
    Clin Cancer Res 12:3184-92. 2006
    ..The aim of this study was to address the breast cancer translational potential of the novel telomerase inhibitor, GRN163L...
  17. ncbi request reprint Novel short oligonucleotide conjugates as inhibitors of human telomerase
    Krisztina Pongracz
    Geron Corporation, Menlo Park, California 94025, USA
    Nucleosides Nucleotides Nucleic Acids 22:1627-9. 2003
    ....
  18. ncbi request reprint Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model
    Benjamin K Canales
    Department of Urology, University of Minnesota, Minneapolis, MN 55455, USA
    Urol Oncol 24:141-51. 2006
    ..Determine the efficacy and timing of small molecule oligonucleotide-based inhibitors to the enzyme telomerase in an in vitro model of androgen-independent, osseous prostate cancer...