Kyung Sun Heo

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. doi request reprint Glucagon-like peptide-1 and its cardiovascular effects
    Kyung Sun Heo
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    Curr Atheroscler Rep 14:422-8. 2012
  2. pmc Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity
    Kyung Sun Heo
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 33:321-9. 2013
  3. pmc p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction
    Nhat Tu Le
    University of Rochester School of Medicine and Dentistry, Aab Cardiovascular Research Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Circ Res 110:536-50. 2012
  4. pmc De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis
    Kyung Sun Heo
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Circ Res 112:911-23. 2013
  5. pmc PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation
    Kyung Sun Heo
    Aab Cardiovascular Research Institute, University of Rochester, Rochester, NY 14642, USA
    J Cell Biol 193:867-84. 2011
  6. pmc Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction
    Kyung Sun Heo
    Aab Cardiovascular Research Institute, University of Rochester, NY, USA
    Circ J 75:2722-30. 2011
  7. pmc MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation
    Eugene Chang
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 117:2527-37. 2011

Collaborators

Detail Information

Publications7

  1. doi request reprint Glucagon-like peptide-1 and its cardiovascular effects
    Kyung Sun Heo
    Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box CVRI, Rochester, NY 14642, USA
    Curr Atheroscler Rep 14:422-8. 2012
    ....
  2. pmc Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity
    Kyung Sun Heo
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Arterioscler Thromb Vasc Biol 33:321-9. 2013
    ..The aim of the study is to elucidate the regulatory mechanisms for these 2 different functions, especially with respect to endothelial inflammation...
  3. pmc p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction
    Nhat Tu Le
    University of Rochester School of Medicine and Dentistry, Aab Cardiovascular Research Institute, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Circ Res 110:536-50. 2012
    ..The regulatory mechanism governing ERK5/CHIP interaction is unknown...
  4. pmc De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis
    Kyung Sun Heo
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Circ Res 112:911-23. 2013
    ..Disturbed flow induces proinflammatory and apoptotic responses in endothelial cells, causing them to become dysfunctional and subsequently proatherogenic...
  5. pmc PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation
    Kyung Sun Heo
    Aab Cardiovascular Research Institute, University of Rochester, Rochester, NY 14642, USA
    J Cell Biol 193:867-84. 2011
    ..We propose a novel mechanism for p53 SUMOylation mediated by the PKCζ-PIASy interaction during d-flow-mediated EC apoptosis, which has potential relevance to early events of atherosclerosis...
  6. pmc Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction
    Kyung Sun Heo
    Aab Cardiovascular Research Institute, University of Rochester, NY, USA
    Circ J 75:2722-30. 2011
    ..In addition, we highlight several mechanisms contributing to endothelial dysfunction, focusing on the relations between flow patterns and activation of reactive oxygen species generating enzymes...
  7. pmc MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation
    Eugene Chang
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 117:2527-37. 2011
    ..Our study shows that MK2 SUMOylation is a new mechanism for regulating actin filament dynamics in ECs...