Kenneth Hensley

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Reactive oxygen species and protein oxidation in aging: a look back, a look ahead
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Arch Biochem Biophys 397:377-83. 2002
  2. doi request reprint Detection of protein carbonyls by means of biotin hydrazide-streptavidin affinity methods
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA
    Methods Mol Biol 536:457-62. 2009
  3. ncbi request reprint On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    Kenneth Hensley
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Antioxid Redox Signal 8:2075-87. 2006
  4. ncbi request reprint New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Reserach Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 36:1-15. 2004
  5. ncbi request reprint Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Neurobiol Dis 14:74-80. 2003
  6. ncbi request reprint Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 82:365-74. 2002
  7. ncbi request reprint Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73014, USA
    Carcinogenesis 21:983-9. 2000
  8. ncbi request reprint Reactive oxygen species, cell signaling, and cell injury
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 28:1456-62. 2000
  9. ncbi request reprint CPI-1189 inhibits interleukin 1beta-induced p38-mitogen-activated protein kinase phosphorylation: an explanation for its neuroprotective properties?
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma 73104, USA
    Neurosci Lett 281:179-82. 2000
  10. ncbi request reprint Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detection
    K Hensley
    Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, Oklahoma, 73104, USA
    Anal Biochem 251:187-95. 1997

Research Grants

  1. HYDROXYNONENAL MODIFICATION OF SUPEROXIDE DISMUTASE
    Kenneth Hensley; Fiscal Year: 2002

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Reactive oxygen species and protein oxidation in aging: a look back, a look ahead
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Arch Biochem Biophys 397:377-83. 2002
    ..Emerging technologies, particularly proteomic technologies, are discussed that will facilitate further evolution in the field of reactive oxygen biochemistry...
  2. doi request reprint Detection of protein carbonyls by means of biotin hydrazide-streptavidin affinity methods
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA
    Methods Mol Biol 536:457-62. 2009
    ..Advantages of the biotin hydrazide-labeling technique are its sensitivity and its lack of reliance upon antibodies that inevitably suffer from nonspecific background noise and contaminating endogenous immunoglobulins...
  3. ncbi request reprint On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    Kenneth Hensley
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Antioxid Redox Signal 8:2075-87. 2006
    ..This review summarizes what has been learned to date from studies of mutant SOD1 transgenic animals and demonstrates that the G93A-SOD1 mouse in particular is a robust laboratory for the study of neuroinflammation and redox biochemistry...
  4. ncbi request reprint New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Reserach Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 36:1-15. 2004
    ..The data argue for thorough experimental and epidemiological reappraisal of desmethyl tocopherols, especially within the contexts of cardiovascular disease and cancer biology...
  5. ncbi request reprint Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Neurobiol Dis 14:74-80. 2003
    ..Our data support a model wherein TNFalpha acts as a principal driver for neuroinflammation, while several co-stimulating cytokines and chemokines act to potentiate the TNFalpha effects...
  6. ncbi request reprint Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 82:365-74. 2002
    ....
  7. ncbi request reprint Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73014, USA
    Carcinogenesis 21:983-9. 2000
    ....
  8. ncbi request reprint Reactive oxygen species, cell signaling, and cell injury
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 28:1456-62. 2000
    ..Introduction of antioxidant therapies into mainstream medicine is possible and promising, but will require significant advances in basic cell biology, pharmacology, and clinical bioanalysis...
  9. ncbi request reprint CPI-1189 inhibits interleukin 1beta-induced p38-mitogen-activated protein kinase phosphorylation: an explanation for its neuroprotective properties?
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma 73104, USA
    Neurosci Lett 281:179-82. 2000
    ....
  10. ncbi request reprint Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detection
    K Hensley
    Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, Oklahoma, 73104, USA
    Anal Biochem 251:187-95. 1997
    ..A method of sample preparation wherein tyrosine analogs are enzymatically hydrolyzed from protein without the need for sample extraction, concentration, or derivatization is reported...
  11. ncbi request reprint Measurement of 3-nitrotyrosine and 5-nitro-gamma-tocopherol by high-performance liquid chromatography with electrochemical detection
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Free Radic Biol Med 28:520-8. 2000
    ..Techniques are described for the determination of 3-nitro-tyrosine and 5-nitro-gamma-tocopherol in biological samples using high-performance liquid chromatography with electrochemical detection...
  12. ncbi request reprint The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice
    Melinda West
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 91:133-43. 2004
    ..Thus, TNFalpha antagonists and especially 5LOX inhibitors might offer new opportunities for treatment of ALS...
  13. ncbi request reprint Anti-inflammatory effects of tocopherol metabolites
    Paula Grammas
    Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Biochem Biophys Res Commun 319:1047-52. 2004
    ..These results show that the anti-inflammatory effects of tocopherols are highly cell type-, stimulus-, and endpoint-dependent...
  14. pmc Inhalation of environmental stressors & chronic inflammation: autoimmunity and neurodegeneration
    Sandra E Gomez-Mejiba
    Free Radical Biology and Aging Research Program, MS 21, 825 NE 13th Street, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, United States
    Mutat Res 674:62-72. 2009
    ....
  15. ncbi request reprint Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Mol Cell Biochem 234:195-203. 2002
    ..This is considered to be the primary reason the size of the preneoplastic lesions are significantly decreased and why the nitrones are potent anti-carcinogenic agents in this model...
  16. doi request reprint In vivo detection of free radicals using molecular MRI and immuno-spin trapping in a mouse model for amyotrophic lateral sclerosis
    Rheal A Towner
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 63:351-60. 2013
    ..This novel, noninvasive, in vivo diagnostic method can be applied to investigate the involvement of free radical mechanisms in ALS rodent models...
  17. ncbi request reprint Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system
    Charlotte H Y Chung
    Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73118, USA
    Biochemistry 46:3262-9. 2007
    ..These results indicate LanCL1 is a glutathione binding protein possibly significant to neurodegenerative disease...
  18. pmc Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures
    Kenneth Hensley
    Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Neurosci 30:2979-88. 2010
    ..The results are discussed with reference to possible biochemical origins, paracrine functions, neurological significance, and pharmacological potential of lanthionyl compounds...
  19. pmc Antioxidants in central nervous system diseases: preclinical promise and translational challenges
    Chandrashekhar D Kamat
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Alzheimers Dis 15:473-93. 2008
    ....
  20. pmc Immuno-spin trapping of protein and DNA radicals: "tagging" free radicals to locate and understand the redox process
    Sandra E Gomez-Mejiba
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 46:853-65. 2009
    ....
  21. pmc Translational research involving oxidative stress and diseases of aging
    Robert A Floyd
    Experimental Therapeutics, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 51:931-41. 2011
    ....
  22. ncbi request reprint The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain
    Kelly S Williamson
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Nitric Oxide 6:221-7. 2002
    ..The findings are discussed in reference to the neuroinflammatory hypothesis of AD and the possible role of gamma-tocopherol as a major lipid-phase scavenger of reactive nitrogen species...
  23. ncbi request reprint Nitrones, their value as therapeutics and probes to understand aging
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104 5046, USA
    Mech Ageing Dev 123:1021-31. 2002
    ..Stabilization of phosphorylation networks associated with checkpoint proteins could slow cell cycle processes and this could be the basis of the nitrones anti-senescent activity...
  24. pmc Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE
    Anil D'Souza
    Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    BMC Med Genet 9:62. 2008
    ..Hence we investigated the effects of a genetic polymorphism of catalase on risk and severity of SLE in 48 pedigrees with African American ancestry...
  25. pmc Degree of modification of Ro60 by the lipid peroxidation by-product 4-hydroxy-2-nonenal may differentially induce Sjögren syndrome or systemic lupus erythematosus in BALB/c mice
    Biji T Kurien
    Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 50:1222-33. 2011
    ..Understanding the mechanism of this differential induction may help discriminate between these two autoimmune diseases...
  26. ncbi request reprint Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets
    Molina Mhatre
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    J Alzheimers Dis 6:147-57. 2004
    ..A discussion is made regarding the relevance of neuroinflammation to potential therapeutic implications for both ALS and AD...
  27. pmc Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines
    Robert A Floyd
    Experimental Therapeutics, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 62:145-56. 2013
    ..There is much more research and development activity ongoing for various indications with the nitrones, alone or in combination with other active compounds, as briefly noted in this review. ..
  28. ncbi request reprint A survey of sesamin and composition of tocopherol variability from seeds of eleven diverse sesame (Sesamum indicum L.) genotypes using HPLC-PAD-ECD
    Kelly S Williamson
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Phytochem Anal 19:311-22. 2008
    ..Statistical analysis was conducted and significant differences were observed among the 11 different sesame genotypes. This suggests that genetic, environmental and geographical factors influence sesamin and desmethyl tocopherol content...
  29. pmc Chronic thrombin exposure results in an increase in apolipoprotein-E levels
    Molina Mhatre
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
    J Neurosci Res 84:444-9. 2006
    ..These findings suggest that thrombin released during brain injury may contribute to an increase in apolipoprotein-E levels. Such increase in Apolipoprotein-E4 isoform facilitates beta-amyloid deposition and cognitive deficits...
  30. ncbi request reprint Oxidatively modified autoantigens in autoimmune diseases
    Biji T Kurien
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, OK 73104, USA
    Free Radic Biol Med 41:549-56. 2006
    ....
  31. ncbi request reprint Nitrones as neuroprotectants and antiaging drugs
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Ann N Y Acad Sci 959:321-9. 2002
    ..On the basis of novel ideas about the action of secretory products formed by senescent cells on bystander cells, it is postulated that nitrones will mitigate these processes and that this may be the mechanism of their antiaging activity...
  32. ncbi request reprint Sensitivity of protein tyrosine phosphatase activity to the redox environment, cytochrome C, and microperoxidase
    Scott J Salsman
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Antioxid Redox Signal 7:1078-88. 2005
    ..Taken together, these data suggest that not only H2O2, but also a variety of redox-active metabolites and hemes can oxidatively inactivate PTPs with potentially profound implications for signal transduction...
  33. ncbi request reprint Oxidized LDLs affect nitric oxide and radical generation in brain endothelial cells
    Ladan Hamdheydari
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Biochem Biophys Res Commun 311:486-90. 2003
    ..01). These data demonstrate that oxidized LDLs affect nitric oxide and radical generation in brain endothelial cells and could contribute to cerebrovascular dysfunction in Alzheimer's disease...
  34. ncbi request reprint HPLC-electrochemical detection of tocopherol products as indicators of reactive nitrogen intermediates
    Kenneth Hensley
    Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, Oklahoma City, OK 73104, USA
    Methods Enzymol 396:171-82. 2005
    ....
  35. ncbi request reprint Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Neurobiol Aging 23:795-807. 2002
    ..Novel therapeutics based on blocking neuron damaging neuroinflammatory processes show great promise for abating dementia progression although they have yet to make it to clinical practice...
  36. ncbi request reprint Oxidative biochemical markers; clues to understanding aging in long-lived species
    R A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Exp Gerontol 36:619-40. 2001
    ....
  37. ncbi request reprint Nitrone inhibition of age-associated oxidative damage
    R A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
    Ann N Y Acad Sci 899:222-37. 2000
    ....
  38. ncbi request reprint Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading
    R Hal Scofield
    Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 38:719-28. 2005
    ..These data may suggest a hitherto unappreciated mechanism by which oxidative stress facilitates epitope spreading in SLE...
  39. doi request reprint Lanthionine ketimine ethyl ester partially rescues neurodevelopmental defects in unc-33 (DPYSL2/CRMP2) mutants
    Caleb Hubbard
    Department of Biological Sciences, Southwestern Oklahoma State University, Weatherford, Oklahoma, USA
    J Neurosci Res 91:1183-90. 2013
    ....
  40. ncbi request reprint Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain
    A Biegon
    Lawrence Berkeley National Laboratory, Berkeley, California, USA Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Neurochem 82:924-34. 2002
    ..Loss of NMDA receptor function in cortical and hippocampal regions may contribute to the cognitive deficits observed in diseases with a neuroinflammatory component, such as meningitis or Alzheimer's disease...
  41. ncbi request reprint 5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intake
    Molina Mhatre
    Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, 800, N E 13th Street, Oklahoma City, OK 73190 3000, USA
    Eur J Pharmacol 491:149-56. 2004
    ..The drug combination did not affect the food intake. These data suggest that 5-HT3 receptor antagonist ICS 205-930 may be used as an effective adjunct for pharmacotherapy of alcoholism...
  42. ncbi request reprint Lipid oxidation enhances the function of activated protein C
    O Safa
    Department of Cardiovascular Biology, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    J Biol Chem 276:1829-36. 2001
    ..Anti-phospholipid antibodies that block this process would therefore be expected to contribute to thrombus growth and disease...
  43. pmc C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1
    D H Cai
    Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Oncogene 27:2772-9. 2008
    ..C/EBPalpha:cJun binds and activates the endogenous PU.1 promoter, providing one mechanism for induction of monopoiesis by this complex...
  44. ncbi request reprint SOD1 interacts directly with hemoglobin in vitro
    Biji T Kurien
    Thromb Haemost 92:218-20. 2004
  45. ncbi request reprint Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis
    Marzia Perluigi
    Department of Biochemical Sciences, University of Rome La Sapienza, Rome 00185, Italy
    Free Radic Biol Med 38:960-8. 2005
    ..These results support the role of oxidative stress as a major mechanism in the pathogenesis of ALS. Structural alteration and activity decline of functional proteins may consistently contribute to the neurodegeneration process in ALS...
  46. ncbi request reprint Oxidative modification of proteins in cell signaling
    Kenneth Hensley
    Antioxid Redox Signal 7:523-5. 2005
  47. ncbi request reprint Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis
    H Fai Poon
    Department of Chemistry, University of Kentucky, Lexington KY 40506, USA
    Free Radic Biol Med 39:453-62. 2005
    ....
  48. ncbi request reprint Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis
    Mahmoud Kiaei
    Department of Neurology and Neuroscience, Weill Medical College, Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
    J Neurosci 26:2467-73. 2006
    ..Both compounds also reduced interleukin (IL)-12p40, IL-1alpha, and IL-1beta and increased IL-RA and TGF-beta1 mRNA. Therefore, both thalidomide and lenalidomide bear promise as therapeutic interventions for the treatment of ALS...

Research Grants1

  1. HYDROXYNONENAL MODIFICATION OF SUPEROXIDE DISMUTASE
    Kenneth Hensley; Fiscal Year: 2002
    ..abstract_text> ..