Research Topics
Genomes and Genes | Kenneth HensleySummaryAffiliation: University of Oklahoma Health Sciences Center Country: USA Publications
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Publications
Reactive oxygen species and protein oxidation in aging: a look back, a look aheadKenneth Hensley
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
Arch Biochem Biophys 397:377-83. 2002..Emerging technologies, particularly proteomic technologies, are discussed that will facilitate further evolution in the field of reactive oxygen biochemistry...- Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detectionK Hensley
Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, Oklahoma, 73104, USA
Anal Biochem 251:187-95. 1997..A method of sample preparation wherein tyrosine analogs are enzymatically hydrolyzed from protein without the need for sample extraction, concentration, or derivatization is reported... - On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosisKenneth Hensley
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
Antioxid Redox Signal 8:2075-87. 2006..This review summarizes what has been learned to date from studies of mutant SOD1 transgenic animals and demonstrates that the G93A-SOD1 mouse in particular is a robust laboratory for the study of neuroinflammation and redox biochemistry... 
Detection of protein carbonyls by means of biotin hydrazide-streptavidin affinity methodsKenneth Hensley
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 73104, USA
Methods Mol Biol 536:457-62. 2009..Advantages of the biotin hydrazide-labeling technique are its sensitivity and its lack of reliance upon antibodies that inevitably suffer from nonspecific background noise and contaminating endogenous immunoglobulins...- Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosisKenneth Hensley
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Neurobiol Dis 14:74-80. 2003..Our data support a model wherein TNFalpha acts as a principal driver for neuroinflammation, while several co-stimulating cytokines and chemokines act to potentiate the TNFalpha effects... - Reactive oxygen species, cell signaling, and cell injuryK Hensley
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Free Radic Biol Med 28:1456-62. 2000..Introduction of antioxidant therapies into mainstream medicine is possible and promising, but will require significant advances in basic cell biology, pharmacology, and clinical bioanalysis... - New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicineKenneth Hensley
Free Radical Biology and Aging Research Program, Oklahoma Medical Reserach Foundation, Oklahoma City, OK 73104, USA
Free Radic Biol Med 36:1-15. 2004..The data argue for thorough experimental and epidemiological reappraisal of desmethyl tocopherols, especially within the contexts of cardiovascular disease and cancer biology... - Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondriaK Hensley
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73014, USA
Carcinogenesis 21:983-9. 2000.... - Measurement of 3-nitrotyrosine and 5-nitro-gamma-tocopherol by high-performance liquid chromatography with electrochemical detectionK Hensley
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
Free Radic Biol Med 28:520-8. 2000..Techniques are described for the determination of 3-nitro-tyrosine and 5-nitro-gamma-tocopherol in biological samples using high-performance liquid chromatography with electrochemical detection... - CPI-1189 inhibits interleukin 1beta-induced p38-mitogen-activated protein kinase phosphorylation: an explanation for its neuroprotective properties?K Hensley
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma 73104, USA
Neurosci Lett 281:179-82. 2000.... - Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosisKenneth Hensley
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
J Neurochem 82:365-74. 2002.... - The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic miceMelinda West
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
J Neurochem 91:133-43. 2004..Thus, TNFalpha antagonists and especially 5LOX inhibitors might offer new opportunities for treatment of ALS... 
Inhalation of environmental stressors & chronic inflammation: autoimmunity and neurodegenerationSandra E Gomez-Mejiba
Free Radical Biology and Aging Research Program, MS 21, 825 NE 13th Street, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, United States
Mutat Res 674:62-72. 2009....- Anti-inflammatory effects of tocopherol metabolitesPaula Grammas
Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Biochem Biophys Res Commun 319:1047-52. 2004..These results show that the anti-inflammatory effects of tocopherols are highly cell type-, stimulus-, and endpoint-dependent... - Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibitionRobert A Floyd
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
Mol Cell Biochem 234:195-203. 2002..This is considered to be the primary reason the size of the preneoplastic lesions are significantly decreased and why the nitrones are potent anti-carcinogenic agents in this model... - Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous systemCharlotte H Y Chung
Oklahoma Medical Research Foundation, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73118, USA
Biochemistry 46:3262-9. 2007..These results indicate LanCL1 is a glutathione binding protein possibly significant to neurodegenerative disease... - Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell culturesKenneth Hensley
Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
J Neurosci 30:2979-88. 2010..The results are discussed with reference to possible biochemical origins, paracrine functions, neurological significance, and pharmacological potential of lanthionyl compounds... - Immuno-spin trapping of protein and DNA radicals: "tagging" free radicals to locate and understand the redox processSandra E Gomez-Mejiba
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Free Radic Biol Med 46:853-65. 2009.... - Antioxidants in central nervous system diseases: preclinical promise and translational challengesChandrashekhar D Kamat
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
J Alzheimers Dis 15:473-93. 2008.... - Translational research involving oxidative stress and diseases of agingRobert A Floyd
Experimental Therapeutics, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Free Radic Biol Med 51:931-41. 2011.... - Nitrones, their value as therapeutics and probes to understand agingRobert A Floyd
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104 5046, USA
Mech Ageing Dev 123:1021-31. 2002..Stabilization of phosphorylation networks associated with checkpoint proteins could slow cell cycle processes and this could be the basis of the nitrones anti-senescent activity... - The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brainKelly S Williamson
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Nitric Oxide 6:221-7. 2002..The findings are discussed in reference to the neuroinflammatory hypothesis of AD and the possible role of gamma-tocopherol as a major lipid-phase scavenger of reactive nitrogen species... - Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targetsMolina Mhatre
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
J Alzheimers Dis 6:147-57. 2004..A discussion is made regarding the relevance of neuroinflammation to potential therapeutic implications for both ALS and AD... - Degree of modification of Ro60 by the lipid peroxidation by-product 4-hydroxy-2-nonenal may differentially induce Sjögren syndrome or systemic lupus erythematosus in BALB/c miceBiji T Kurien
Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Free Radic Biol Med 50:1222-33. 2011..Understanding the mechanism of this differential induction may help discriminate between these two autoimmune diseases... - Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLEAnil D'Souza
Department of Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
BMC Med Genet 9:62. 2008..Hence we investigated the effects of a genetic polymorphism of catalase on risk and severity of SLE in 48 pedigrees with African American ancestry... - A survey of sesamin and composition of tocopherol variability from seeds of eleven diverse sesame (Sesamum indicum L.) genotypes using HPLC-PAD-ECDKelly S Williamson
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Phytochem Anal 19:311-22. 2008..Statistical analysis was conducted and significant differences were observed among the 11 different sesame genotypes. This suggests that genetic, environmental and geographical factors influence sesamin and desmethyl tocopherol content... - Chronic thrombin exposure results in an increase in apolipoprotein-E levelsMolina Mhatre
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
J Neurosci Res 84:444-9. 2006..These findings suggest that thrombin released during brain injury may contribute to an increase in apolipoprotein-E levels. Such increase in Apolipoprotein-E4 isoform facilitates beta-amyloid deposition and cognitive deficits... - Nitrones as neuroprotectants and antiaging drugsRobert A Floyd
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
Ann N Y Acad Sci 959:321-9. 2002..On the basis of novel ideas about the action of secretory products formed by senescent cells on bystander cells, it is postulated that nitrones will mitigate these processes and that this may be the mechanism of their antiaging activity... - Oxidatively modified autoantigens in autoimmune diseasesBiji T Kurien
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, OK 73104, USA
Free Radic Biol Med 41:549-56. 2006.... - HPLC-electrochemical detection of tocopherol products as indicators of reactive nitrogen intermediatesKenneth Hensley
Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, Oklahoma City, OK 73104, USA
Methods Enzymol 396:171-82. 2005.... - Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseasesRobert A Floyd
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Neurobiol Aging 23:795-807. 2002..Novel therapeutics based on blocking neuron damaging neuroinflammatory processes show great promise for abating dementia progression although they have yet to make it to clinical practice... - Oxidized LDLs affect nitric oxide and radical generation in brain endothelial cellsLadan Hamdheydari
Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Biochem Biophys Res Commun 311:486-90. 2003..01). These data demonstrate that oxidized LDLs affect nitric oxide and radical generation in brain endothelial cells and could contribute to cerebrovascular dysfunction in Alzheimer's disease... - Sensitivity of protein tyrosine phosphatase activity to the redox environment, cytochrome C, and microperoxidaseScott J Salsman
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Antioxid Redox Signal 7:1078-88. 2005..Taken together, these data suggest that not only H2O2, but also a variety of redox-active metabolites and hemes can oxidatively inactivate PTPs with potentially profound implications for signal transduction... - Oxidative biochemical markers; clues to understanding aging in long-lived speciesR A Floyd
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
Exp Gerontol 36:619-40. 2001.... - Nitrone inhibition of age-associated oxidative damageR A Floyd
Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
Ann N Y Acad Sci 899:222-37. 2000.... - Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreadingR Hal Scofield
Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
Free Radic Biol Med 38:719-28. 2005..These data may suggest a hitherto unappreciated mechanism by which oxidative stress facilitates epitope spreading in SLE... - Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brainA Biegon
Lawrence Berkeley National Laboratory, Berkeley, California, USA Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
J Neurochem 82:924-34. 2002..Loss of NMDA receptor function in cortical and hippocampal regions may contribute to the cognitive deficits observed in diseases with a neuroinflammatory component, such as meningitis or Alzheimer's disease... - 5-HT3 antagonist ICS 205-930 enhances naltrexone's effects on ethanol intakeMolina Mhatre
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, 800, N E 13th Street, Oklahoma City, OK 73190 3000, USA
Eur J Pharmacol 491:149-56. 2004..The drug combination did not affect the food intake. These data suggest that 5-HT3 receptor antagonist ICS 205-930 may be used as an effective adjunct for pharmacotherapy of alcoholism... - Lipid oxidation enhances the function of activated protein CO Safa
Department of Cardiovascular Biology, Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
J Biol Chem 276:1829-36. 2001..Anti-phospholipid antibodies that block this process would therefore be expected to contribute to thrombus growth and disease... - C/EBP alpha:AP-1 leucine zipper heterodimers bind novel DNA elements, activate the PU.1 promoter and direct monocyte lineage commitment more potently than C/EBP alpha homodimers or AP-1D H Cai
Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Oncogene 27:2772-9. 2008..C/EBPalpha:cJun binds and activates the endogenous PU.1 promoter, providing one mechanism for induction of monopoiesis by this complex... - Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosisH Fai Poon
Department of Chemistry, University of Kentucky, Lexington KY 40506, USA
Free Radic Biol Med 39:453-62. 2005.... - Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosisMahmoud Kiaei
Department of Neurology and Neuroscience, Weill Medical College, Cornell University, New York Presbyterian Hospital, New York, New York 10021, USA
J Neurosci 26:2467-73. 2006..Both compounds also reduced interleukin (IL)-12p40, IL-1alpha, and IL-1beta and increased IL-RA and TGF-beta1 mRNA. Therefore, both thalidomide and lenalidomide bear promise as therapeutic interventions for the treatment of ALS... - Oxidative modification of proteins in cell signalingKenneth Hensley
Antioxid Redox Signal 7:523-5. 2005 - Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosisMarzia Perluigi
Department of Biochemical Sciences, University of Rome La Sapienza, Rome 00185, Italy
Free Radic Biol Med 38:960-8. 2005..These results support the role of oxidative stress as a major mechanism in the pathogenesis of ALS. Structural alteration and activity decline of functional proteins may consistently contribute to the neurodegeneration process in ALS... - SOD1 interacts directly with hemoglobin in vitroBiji T Kurien
Thromb Haemost 92:218-20. 2004
Research Grants
- HYDROXYNONENAL MODIFICATION OF SUPEROXIDE DISMUTASEKenneth Hensley; Fiscal Year: 2002..abstract_text> ..