Ellen C Henry

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo
    E C Henry
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Arch Biochem Biophys 450:67-77. 2006
  2. pmc TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts
    Ellen C Henry
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Toxicol Sci 114:90-100. 2010
  3. pmc Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor
    E C Henry
    Department of Environmental Medicine, University of Rochester Medical Center, 575 Elmwood Ave, Box EHSC, Rochester, NY 14642, USA
    Arch Biochem Biophys 472:77-88. 2008
  4. ncbi request reprint Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis
    E C Henry
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Pharmacol 63:392-400. 2003
  5. pmc (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor
    Zhengyu Yin
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Biochemistry 48:336-45. 2009
  6. ncbi request reprint Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements
    Jun Guo Zhou
    Molecular Toxicology and Environmental Medicine Program, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Mol Pharmacol 63:915-24. 2003
  7. ncbi request reprint Effects of SH-modifying reagents on the rat hepatic Ah receptor: inhibition of ligand binding and transformation, and disruption of the ligand-receptor complex
    E C Henry
    Department of Biophysics, University of Rochester Medical Center, NY 14642
    Biochim Biophys Acta 964:361-76. 1988
  8. ncbi request reprint Expression and activity of aryl hydrocarbon receptors in development and cancer
    Thomas A Gasiewicz
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Crit Rev Eukaryot Gene Expr 18:279-321. 2008
  9. ncbi request reprint Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylation
    S Park
    Department of Environmental Medicine, School of Medicine, University of Rochester, New York 14642, USA
    Arch Biochem Biophys 381:302-12. 2000
  10. ncbi request reprint Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation
    E C Henry
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Mol Pharmacol 55:716-25. 1999

Collaborators

Detail Information

Publications12

  1. ncbi request reprint A potential endogenous ligand for the aryl hydrocarbon receptor has potent agonist activity in vitro and in vivo
    E C Henry
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Arch Biochem Biophys 450:67-77. 2006
    ..These data demonstrate that ITE is a potent AhR agonist in cell extracts, cultured cells, and intact animals, but does not cause the toxicity associated with the more stable xenobiotic ligand, TCDD...
  2. pmc TCDD and a putative endogenous AhR ligand, ITE, elicit the same immediate changes in gene expression in mouse lung fibroblasts
    Ellen C Henry
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Toxicol Sci 114:90-100. 2010
    ..Furthermore, if the difference in toxicity between TCDD and ITE is mediated by differences in gene expression, then it is likely that secondary changes enabled by the persistent TCDD, but not by the shorter lived ITE, are responsible...
  3. pmc Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor
    E C Henry
    Department of Environmental Medicine, University of Rochester Medical Center, 575 Elmwood Ave, Box EHSC, Rochester, NY 14642, USA
    Arch Biochem Biophys 472:77-88. 2008
    ..The ultimate response of the AhR also depends on how other portions of the receptor protein are functionally coupled to the initial ligand binding event...
  4. ncbi request reprint Agonist but not antagonist ligands induce conformational change in the mouse aryl hydrocarbon receptor as detected by partial proteolysis
    E C Henry
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Pharmacol 63:392-400. 2003
    ..We conclude that agonist ligands initiate structural alteration in AhR that is Arnt-dependent and at least partially involves the ligand-binding/Per-Arnt-Sim domain...
  5. pmc (-)-Epigallocatechin-3-gallate is a novel Hsp90 inhibitor
    Zhengyu Yin
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Biochemistry 48:336-45. 2009
    ..EGCG also modified the association of hsp90 with several cochaperones. Overall, these data indicate that EGCG is a novel hsp90 inhibitor. Further studies are needed to determine if this has a role in the antitumor actions of EGCG...
  6. ncbi request reprint Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements
    Jun Guo Zhou
    Molecular Toxicology and Environmental Medicine Program, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642, USA
    Mol Pharmacol 63:915-24. 2003
    ....
  7. ncbi request reprint Effects of SH-modifying reagents on the rat hepatic Ah receptor: inhibition of ligand binding and transformation, and disruption of the ligand-receptor complex
    E C Henry
    Department of Biophysics, University of Rochester Medical Center, NY 14642
    Biochim Biophys Acta 964:361-76. 1988
    ..Our results are in striking contrast to the effects of these reagents on steroid receptors, whose bound steroid hormone ligand is rapidly and reversibly displaced by lower concentrations of reagent.(ABSTRACT TRUNCATED AT 400 WORDS)..
  8. ncbi request reprint Expression and activity of aryl hydrocarbon receptors in development and cancer
    Thomas A Gasiewicz
    Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Crit Rev Eukaryot Gene Expr 18:279-321. 2008
    ..Here we describe the current understanding of how the AhR may function to regulate both normal and cancerous tissue growth and development...
  9. ncbi request reprint Regulation of DNA binding activity of the ligand-activated aryl hydrocarbon receptor by tyrosine phosphorylation
    S Park
    Department of Environmental Medicine, School of Medicine, University of Rochester, New York 14642, USA
    Arch Biochem Biophys 381:302-12. 2000
    ....
  10. ncbi request reprint Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation
    E C Henry
    Department of Environmental Medicine, University of Rochester, Rochester, New York 14642, USA
    Mol Pharmacol 55:716-25. 1999
    ..Together, these data indicate that the most potent antagonists bind the AhR with high affinity but cannot initiate receptor transformation and nuclear localization...
  11. ncbi request reprint DNA binding and transcriptional enhancement by purified TCDD.Ah receptor complex
    E C Henry
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York, 14642, USA
    Arch Biochem Biophys 339:305-14. 1997
    ..ligand complex itself is competent as a transcriptional enhancer without a requirement for other factors...
  12. pmc Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Sarah E Latchney
    Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Stem Cells Dev 20:313-26. 2011
    ....