Research Topics
| ERIK HENRIKSENSummaryAffiliation: University of Arizona Country: USA Publications
Research Grants
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Detail Information
Publications
The Physiology undergraduate major in the University of Arizona College of Medicine: past, present, and futureErik J Henriksen
Department of Physiology, University of Arizona College of Medicine, Tucson, 85721, USA
Adv Physiol Educ 35:103-9. 2011....
Modulation of metabolic control by angiotensin converting enzyme (ACE) inhibitionErik J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721 0093, USA
J Cell Physiol 196:171-9. 2003..These data support the concept that ACE inhibitors can beneficially modulate glucose control in insulin-resistant states, possibly through a NO-dependent effect of bradykinin and/or antagonism of ATII action on skeletal muscle...
Chronic renin inhibition with aliskiren improves glucose tolerance, insulin sensitivity, and skeletal muscle glucose transport activity in obese Zucker ratsElizabeth M Marchionne
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, 85721 0093, USA
Am J Physiol Regul Integr Comp Physiol 302:R137-42. 2012..These data support the strategy of targeting the RAS to improve both blood pressure regulation and insulin action in conditions of insulin resistance...- Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetesErik J Henriksen
Department of Physiology, Muscle Metabolism Laboratory, University of Arizona College of Medicine, P O Box 210093, Tucson, AZ 85721 0093, USA
Free Radic Biol Med 40:3-12. 2006..These studies highlight the effectiveness of combining endurance exercise training and antioxidants in beneficially modulating the molecular defects in insulin action observed in insulin-resistant skeletal muscle... - Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetesErik J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
Curr Drug Targets 7:1435-41. 2006.... - Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty ratsErik J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
Metabolism 56:931-8. 2007.... - Improvement of insulin sensitivity by antagonism of the renin-angiotensin systemErik J Henriksen
Department of Physiology, Ina E Gittings Bldg 93, University of Arizona, Tucson, AZ 85721 0093, USA
Am J Physiol Regul Integr Comp Physiol 293:R974-80. 2007..Collectively, these findings support targeting the RAS in the design of interventions to improve metabolic and cardiovascular function in conditions of insulin resistance associated with prediabetes and type 2 diabetes... - The high-fat-fed lean Zucker rat: a spontaneous isocaloric model of fat-induced insulin resistance associated with muscle GSK-3 overactivityErik J Henriksen
Department of Physiology, Univeristy of Arizona, Tucson, AZ 85721 0093, USA
Am J Physiol Regul Integr Comp Physiol 294:R1813-21. 2008.... - Dysregulation of glycogen synthase kinase-3 in skeletal muscle and the etiology of insulin resistance and type 2 diabetesErik J Henriksen
Muscle Metabolism Laboratory, Department of Physiology and Arizona Diabetes Program, University of Arizona College of Medicine, Tucson, AZ 85724, USA
Curr Diabetes Rev 6:285-93. 2010..GSK-3 remains an important target for interventions designed to improve insulin action in obesity-associated insulin resistance and type 2 diabetes... - Oxidative stress and the etiology of insulin resistance and type 2 diabetesErik J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
Free Radic Biol Med 51:993-9. 2011..Strategies to prevent and ameliorate oxidative stress remain important in the overall treatment of insulin resistance and type 2 diabetes... - Exercise training and antioxidants: relief from oxidative stress and insulin resistanceErik J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson 85721 0093, USA
Exerc Sport Sci Rev 31:79-84. 2003..This review will address the hypothesis that exercise training and the antioxidant R-(+)-lipoic acid interact at the level of insulin signaling to enhance glucose transport in insulin-resistant skeletal muscle... - Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker ratErik J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona, Tucson 85721, USA
Am J Physiol Endocrinol Metab 285:E98-E105. 2003..In the obese Zucker rat, the c9,t11 isomer of CLA is metabolically neutral... - Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker ratsE J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ, USA
Hypertension 38:884-90. 2001.... - ACE inhibition and glucose transport in insulinresistant muscle: roles of bradykinin and nitric oxideE J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721 0093, USA
Am J Physiol 277:R332-6. 1999..Moreover, this modulation of insulin action by BK is likely mediated through B(2) receptors and by an increase in nitric oxide production and/or action in skeletal muscle tissue... - Modulation of muscle insulin resistance by selective inhibition of GSK-3 in Zucker diabetic fatty ratsErik J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, Ina E Gittings Building 93, University of Arizona College of Medicine, Tucson, AZ 85721, USA
Am J Physiol Endocrinol Metab 284:E892-900. 2003..This unique approach may hold promise as a pharmacological treatment against insulin resistance of skeletal muscle glucose disposal... - Antihypertensive agent moxonidine enhances muscle glucose transport in insulin-resistant ratsE J Henriksen
Department of Physiology, University of Arizona, Tucson 85721 0093, USA
Hypertension 30:1560-5. 1997.... - Invited review: Effects of acute exercise and exercise training on insulin resistanceErik J Henriksen
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721 0093, USA
J Appl Physiol 93:788-96. 2002.... - Stimulation by alpha-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker ratsE J Henriksen
Department of Physiology, University of Arizona, Tucson 85721 0093, USA
Life Sci 61:805-12. 1997.... - Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker ratMary K Teachey
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson 85721-0093, USA
Metabolism 52:1167-74. 2003..These findings support a significant interaction between low doses of CLA and R-ALA for enhancement of insulin action on skeletal muscle glucose transport, possibly via reductions in muscle oxidative stress and in lipid storage... - Effects of exercise training and antioxidant R-ALA on glucose transport in insulin-sensitive rat skeletal muscleVitoon Saengsirisuwan
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona, College of Medicine, Tucson, Arizona 85721-0093, USA
J Appl Physiol 92:50-8. 2002..These results indicate that the beneficial interactive effects of ET and R-ALA on skeletal muscle insulin action observed previously in insulin-resistant obese Zucker rats are not apparent in insulin-sensitive lean Zucker rats... - Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker ratsVitoon Saengsirisuwan
Department of Physiology, University of Arizona College of Medicine, Tucson 85721 0093, USA
Am J Physiol Endocrinol Metab 287:E529-36. 2004..These results indicate that the improvements of insulin action in insulin-resistant skeletal muscle after R-ALA or ET, alone and in combination, were associated with increases in IRS-1 protein expression and IRS-1 associated with p85... - Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3Betsy B Dokken
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721 0093, USA
Am J Physiol Endocrinol Metab 294:E615-21. 2008..Moreover, a small, but significant, portion of this oxidative stress-induced insulin resistance is associated with a reduced insulin-mediated suppression of the active form of GSK-3beta... - Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscleBetsy B Dokken
Dept. of Physiology, Univ. of Arizona College of Medicine, P.O. Box 210093, Tucson, AZ 85721-0093, USA
Am J Physiol Endocrinol Metab 288:E1188-94. 2005..These effects of GSK3 inhibition on insulin action are greater in type I muscle than in type IIb muscle from these insulin-resistant animals... - Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant alpha-lipoic acid on insulin resistance in the obese Zucker ratElizabeth A Muellenbach
Department of Physiology, Muscle Metabolism Laboratory, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
Metabolism 57:1465-72. 2008..Collectively, these results document a beneficial interaction of the antioxidant R-ALA and the AGE inhibitor PM in the treatment of whole-body and skeletal muscle insulin resistance in obese Zucker rats... - Metabolic interactions of AGE inhibitor pyridoxamine and antioxidant alpha-lipoic acid following 22 weeks of treatment in obese Zucker ratsElizabeth M Muellenbach
Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721, USA
Life Sci 84:563-8. 2009..This study was designed to ascertain whether these unique interactive effects of PYR and LA remain manifest following longer-term (22-week) treatment... - Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscleNarissara Lailerd
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tuscon, USA
Metabolism 53:101-7. 2004..1 mmol/L) modestly improved in vitro insulin action on skeletal muscle glucose transport in both lean and obese Zucker rats. These results indicate that one potential site of action of SVS is the skeletal muscle glucose transport system... - Modulation of insulin resistance and hypertension by voluntary exercise training in the TG(mREN2)27 ratTyson R Kinnick
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721-0093, USA
J Appl Physiol 93:805-12; discussion 797. 2002..These data indicate that the male heterozygous TG(mREN2)27 rat is a model of both hypertension and insulin resistance. Importantly, both of these defects can be beneficially modified by voluntary exercise training... - Enhanced insulin action on glucose transport and insulin signaling in 7-day unweighted rat soleus muscleFelipe R Perez
Department of Physiology, University of Arizona, Tucson, AZ 85721-0093, USA
J Appl Physiol 97:63-71. 2004..However, PI3-kinase-independent mechanisms must also play a small role in this adaptive response to HS... - Selective angiotensin II receptor antagonism enhances whole-body insulin sensitivity and muscle glucose transport in hypertensive TG(mREN2)27 ratsJulie A Sloniger
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721-0093, USA
Metabolism 54:1659-68. 2005.... - Roles of insulin signalling and p38 MAPK in the activation by lithium of glucose transport in insulin-resistant rat skeletal muscleAntoni R Macko
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721, USA
Arch Physiol Biochem 114:331-9. 2008..As in insulin-sensitive muscle, the lithium-induced activation of glucose transport in insulin-resistant skeletal muscle is dependent on the engagement of p38 MAPK... - Direct inhibition by angiotensin II of insulin-dependent glucose transport activity in mammalian skeletal muscle involves a ROS-dependent mechanismMaggie K Diamond-Stanic
Muscle Metabolism Laboratory, Department of Physiology and Arizona Diabetes Program, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
Arch Physiol Biochem 116:88-95. 2010..These results indicate that Ang II inhibits distal insulin signalling and insulin-stimulated glucose transport in isolated mammalian skeletal muscle, and that this effect is partially mediated by ROS... - Voluntary exercise training enhances glucose transport but not insulin signaling capacity in muscle of hypertensive TG(mREN2)27 ratsAndrew M Lemieux
Dept. of Physiology, Univ. of Arizona College of Medicine, Tucson, AZ 85721-0093, USA
J Appl Physiol 99:357-62. 2005..However, this adaptive response in muscle occurs independently of modifications in the proximal elements of the insulin signaling cascade... - Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 ratJulie A Sloniger
Muscle Metabolism Laboratory, Dept. of Physiology, Ina E. Gittings Bldg. #93, Univ. of Arizona, Tucson, AZ 85721-0093, USA
Am J Physiol Endocrinol Metab 288:E1074-81. 2005..Collectively, these data provide the first evidence that the insulin resistance of the hypertensive male heterozygous TG(mREN2)27 rat can be attributed to specific defects in the insulin-signaling pathway in skeletal muscle... - Essential role of p38 MAPK for activation of skeletal muscle glucose transport by lithiumNicholas B Harrell
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721, USA
Arch Physiol Biochem 113:221-7. 2007..Importantly, we have documented an essential role of p38 MAPK phosphorylation in the action lithium on the glucose transport system in isolated mammalian skeletal muscle... - Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in prediabetic obese Zucker ratsBetsy B Dokken
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, PO Box 210093, Tucson, AZ 85721 0093, USA
Am J Physiol Endocrinol Metab 291:E207-13. 2006..These results provide further evidence that selective targeting of GSK-3 in muscle may be an effective intervention for the treatment of obesity-associated insulin resistance... - Effects of specific conjugated linoleic acid isomers on growth characteristics in obese Zucker ratsSara R Sanders
Department of Animal Sciences, University of Arizona, Tucson, Arizona 85721, USA
Lipids 39:537-43. 2004..e., reduced arachidonic acid content), but the ability of CLA to manipulate body composition in obese Zucker rats remains questionable... - Oxidant stress and skeletal muscle glucose transport: roles of insulin signaling and p38 MAPKJohn S Kim
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
Free Radic Biol Med 41:818-24. 2006.... - Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPKTara L Archuleta
Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
Free Radic Biol Med 47:1486-93. 2009.... - Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivoDavid B Ring
Chiron Corporation, Emeryville, California, USA
Diabetes 52:588-95. 2003..Collectively, our results suggest that these selective GSK-3 inhibitors may be useful as acute-acting therapeutics for the treatment of the insulin resistance of type 2 diabetes... - Development of whole-body and skeletal muscle insulin resistance after one day of hindlimb suspensionFelipe R Perez
U AZ Coll Med, Tucson
Metabolism 53:1215-22. 2004..However, activation of p38 MAPK may play a role in this response... - Metabolic properties of vasodilating beta blockers: management considerations for hypertensive diabetic patients and patients with the metabolic syndromeStephan Jacob
Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
J Clin Hypertens (Greenwich) 6:690-6; quiz 697. 2004..Clinical evidence is reviewed for the use of vasodilating beta blockers in the treatment of hypertension and in reducing cardiovascular risk in the diabetic population... - Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasisGuenther J Dietze
Hypertension and Diabetes Research Unit, Max Grundig Clinic, Buehl, Germany
J Renin Angiotensin Aldosterone Syst 9:75-88. 2008..This concept also provides a unifying explanation for the beneficial effects of ACE-inhibitors and Angiotensin II receptor antagonists in the treatment of hypertension and insulin resistance... - Differential half-maximal effects of human insulin and its analogs for in situ glucose transport and protein synthesis in rat soleus muscleRandi B Weinstein
U AZ, Tucson
Metabolism 51:1065-70. 2002..These data suggest that this approach for studying insulin responsiveness in a single muscle in situ may be a useful tool for investigating insulin signaling in muscle in vivo... - Alterations in soleus muscle gene expression associated with a metabolic endpoint following exercise training by lean and obese Zucker ratsTatiana Ort
CuraGen Corporation, Branford, Connecticut, USA
Physiol Genomics 29:302-11. 2007..These findings could guide the development of pharmaceutical "exercise mimetics" in the treatment of insulin-resistant, prediabetic, or Type 2 diabetic individuals... - The metabolic syndrome: role of skeletal muscle metabolismCraig S Stump
MU Diabetes and Cardiovascular Research Center, Columbia, Missouri, USA
Ann Med 38:389-402. 2006..Strategies will include adequate physical activity and maintaining a healthy weight, but may also require specific pharmacologic interventions...
Research Grants
- Glycogen Synthase Kinase-3 and Muscle Insulin ResistanceERIK HENRIKSEN; Fiscal Year: 2007..abstract_text> ..