ERIK HENRIKSEN

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. doi request reprint The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA Electronic address
    Mol Cell Endocrinol 378:15-22. 2013
  2. doi request reprint Effects of H2O2 on insulin signaling the glucose transport system in mammalian skeletal muscle
    Erik J Henriksen
    Department of Physiology, Muscle Metabolism Laboratory, University of Arizona College of Medicine, Tucson, Arizona, USA
    Methods Enzymol 528:269-78. 2013
  3. ncbi request reprint Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Curr Drug Targets 7:1435-41. 2006
  4. ncbi request reprint Dysregulation of glycogen synthase kinase-3 in skeletal muscle and the etiology of insulin resistance and type 2 diabetes
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology and Arizona Diabetes Program, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Curr Diabetes Rev 6:285-93. 2010
  5. ncbi request reprint Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes
    Erik J Henriksen
    Department of Physiology, Muscle Metabolism Laboratory, University of Arizona College of Medicine, P O Box 210093, Tucson, AZ 85721 0093, USA
    Free Radic Biol Med 40:3-12. 2006
  6. pmc Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Metabolism 56:931-8. 2007
  7. ncbi request reprint Improvement of insulin sensitivity by antagonism of the renin-angiotensin system
    Erik J Henriksen
    Department of Physiology, Ina E Gittings Bldg 93, University of Arizona, Tucson, AZ 85721 0093, USA
    Am J Physiol Regul Integr Comp Physiol 293:R974-80. 2007
  8. doi request reprint The high-fat-fed lean Zucker rat: a spontaneous isocaloric model of fat-induced insulin resistance associated with muscle GSK-3 overactivity
    Erik J Henriksen
    Department of Physiology, Univeristy of Arizona, Tucson, AZ 85721 0093, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1813-21. 2008
  9. pmc Oxidative stress and the etiology of insulin resistance and type 2 diabetes
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Free Radic Biol Med 51:993-9. 2011
  10. doi request reprint The Physiology undergraduate major in the University of Arizona College of Medicine: past, present, and future
    Erik J Henriksen
    Department of Physiology, University of Arizona College of Medicine, Tucson, 85721, USA
    Adv Physiol Educ 35:103-9. 2011

Research Grants

Collaborators

  • S Jacob
  • Vitoon Saengsirisuwan
  • William H Dantzler
  • Betsy B Dokken
  • Veronika Somoza
  • Craig S Stump
  • J R Sowers
  • Allan S Wagman
  • Mary K Teachey
  • Julie A Sloniger
  • Cody J Diehl
  • John S Kim
  • Andrew M Lemieux
  • Katherine A Lindborg
  • Matthew P O'Keefe
  • Oliver Hasselwander
  • Maggie K Diamond-Stanic
  • Tara L Archuleta
  • Nicholas B Harrell
  • Tyson R Kinnick
  • Elizabeth M Marchionne
  • Narissara Lailerd
  • Marc E Tischler
  • Elizabeth M Muellenbach
  • Markus Matuschek
  • Elizabeth A Muellenbach
  • Guenther J Dietze
  • Antoni R Macko
  • Tatiana Ort
  • Felipe R Perez
  • Sara R Sanders
  • Klaus Kraemer
  • Arne Ptock
  • David B Ring
  • Randi B Weinstein
  • Mujalin Prasonnarong
  • Alan N Beneze
  • Gaby Andersen
  • Robert Gerwien
  • Nancy J Gifford
  • Andrew Eisen
  • Chaivat Toskulkao
  • Lance H Baumgard
  • Dane Goff
  • Thomas Maier
  • Sylvia T Ma
  • Isa Samuels
  • Mary Ellen Wernette Hammond
  • Kirk W Johnson
  • Stephen D Harrison
  • Zachary C Taylor
  • John M Nuss
  • Trina Slabiak
  • Martin J Klatt
  • John W Reeder
  • Christle Layton
  • Jennifer Robinson
  • Michelle Heffner
  • Julie T Crawford
  • Noura Eleid
  • Bianca Durando
  • Suzy Rudinsky
  • Matthew O'Keefe
  • Catherine LeCesne
  • Erik B Youngblood

Detail Information

Publications47

  1. doi request reprint The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA Electronic address
    Mol Cell Endocrinol 378:15-22. 2013
    ....
  2. doi request reprint Effects of H2O2 on insulin signaling the glucose transport system in mammalian skeletal muscle
    Erik J Henriksen
    Department of Physiology, Muscle Metabolism Laboratory, University of Arizona College of Medicine, Tucson, Arizona, USA
    Methods Enzymol 528:269-78. 2013
    ..By varying the glucose oxidase concentration in the medium, target ranges of steady-state H2O2 concentrations (30-90 μM) can be attained for up to 6h, with subsequent assessment of cellular signaling and glucose transport activity...
  3. ncbi request reprint Role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Curr Drug Targets 7:1435-41. 2006
    ....
  4. ncbi request reprint Dysregulation of glycogen synthase kinase-3 in skeletal muscle and the etiology of insulin resistance and type 2 diabetes
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology and Arizona Diabetes Program, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Curr Diabetes Rev 6:285-93. 2010
    ..GSK-3 remains an important target for interventions designed to improve insulin action in obesity-associated insulin resistance and type 2 diabetes...
  5. ncbi request reprint Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes
    Erik J Henriksen
    Department of Physiology, Muscle Metabolism Laboratory, University of Arizona College of Medicine, P O Box 210093, Tucson, AZ 85721 0093, USA
    Free Radic Biol Med 40:3-12. 2006
    ..These studies highlight the effectiveness of combining endurance exercise training and antioxidants in beneficially modulating the molecular defects in insulin action observed in insulin-resistant skeletal muscle...
  6. pmc Short-term in vitro inhibition of glycogen synthase kinase 3 potentiates insulin signaling in type I skeletal muscle of Zucker Diabetic Fatty rats
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Metabolism 56:931-8. 2007
    ....
  7. ncbi request reprint Improvement of insulin sensitivity by antagonism of the renin-angiotensin system
    Erik J Henriksen
    Department of Physiology, Ina E Gittings Bldg 93, University of Arizona, Tucson, AZ 85721 0093, USA
    Am J Physiol Regul Integr Comp Physiol 293:R974-80. 2007
    ..Collectively, these findings support targeting the RAS in the design of interventions to improve metabolic and cardiovascular function in conditions of insulin resistance associated with prediabetes and type 2 diabetes...
  8. doi request reprint The high-fat-fed lean Zucker rat: a spontaneous isocaloric model of fat-induced insulin resistance associated with muscle GSK-3 overactivity
    Erik J Henriksen
    Department of Physiology, Univeristy of Arizona, Tucson, AZ 85721 0093, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1813-21. 2008
    ....
  9. pmc Oxidative stress and the etiology of insulin resistance and type 2 diabetes
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Free Radic Biol Med 51:993-9. 2011
    ..Strategies to prevent and ameliorate oxidative stress remain important in the overall treatment of insulin resistance and type 2 diabetes...
  10. doi request reprint The Physiology undergraduate major in the University of Arizona College of Medicine: past, present, and future
    Erik J Henriksen
    Department of Physiology, University of Arizona College of Medicine, Tucson, 85721, USA
    Adv Physiol Educ 35:103-9. 2011
    ....
  11. pmc Chronic renin inhibition with aliskiren improves glucose tolerance, insulin sensitivity, and skeletal muscle glucose transport activity in obese Zucker rats
    Elizabeth M Marchionne
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, 85721 0093, USA
    Am J Physiol Regul Integr Comp Physiol 302:R137-42. 2012
    ..These data support the strategy of targeting the RAS to improve both blood pressure regulation and insulin action in conditions of insulin resistance...
  12. ncbi request reprint Modulation of metabolic control by angiotensin converting enzyme (ACE) inhibition
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721 0093, USA
    J Cell Physiol 196:171-9. 2003
    ..These data support the concept that ACE inhibitors can beneficially modulate glucose control in insulin-resistant states, possibly through a NO-dependent effect of bradykinin and/or antagonism of ATII action on skeletal muscle...
  13. ncbi request reprint Exercise training and antioxidants: relief from oxidative stress and insulin resistance
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson 85721 0093, USA
    Exerc Sport Sci Rev 31:79-84. 2003
    ..This review will address the hypothesis that exercise training and the antioxidant R-(+)-lipoic acid interact at the level of insulin signaling to enhance glucose transport in insulin-resistant skeletal muscle...
  14. ncbi request reprint Modulation of muscle insulin resistance by selective inhibition of GSK-3 in Zucker diabetic fatty rats
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, Ina E Gittings Building 93, University of Arizona College of Medicine, Tucson, AZ 85721, USA
    Am J Physiol Endocrinol Metab 284:E892-900. 2003
    ..This unique approach may hold promise as a pharmacological treatment against insulin resistance of skeletal muscle glucose disposal...
  15. ncbi request reprint Invited review: Effects of acute exercise and exercise training on insulin resistance
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721 0093, USA
    J Appl Physiol (1985) 93:788-96. 2002
    ....
  16. ncbi request reprint Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats
    E J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ, USA
    Hypertension 38:884-90. 2001
    ....
  17. ncbi request reprint Isomer-specific actions of conjugated linoleic acid on muscle glucose transport in the obese Zucker rat
    Erik J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona, Tucson 85721, USA
    Am J Physiol Endocrinol Metab 285:E98-E105. 2003
    ..In the obese Zucker rat, the c9,t11 isomer of CLA is metabolically neutral...
  18. ncbi request reprint ACE inhibition and glucose transport in insulinresistant muscle: roles of bradykinin and nitric oxide
    E J Henriksen
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721 0093, USA
    Am J Physiol 277:R332-6. 1999
    ..Moreover, this modulation of insulin action by BK is likely mediated through B(2) receptors and by an increase in nitric oxide production and/or action in skeletal muscle tissue...
  19. ncbi request reprint Antihypertensive agent moxonidine enhances muscle glucose transport in insulin-resistant rats
    E J Henriksen
    Department of Physiology, University of Arizona, Tucson 85721 0093, USA
    Hypertension 30:1560-5. 1997
    ....
  20. ncbi request reprint Stimulation by alpha-lipoic acid of glucose transport activity in skeletal muscle of lean and obese Zucker rats
    E J Henriksen
    Department of Physiology, University of Arizona, Tucson 85721 0093, USA
    Life Sci 61:805-12. 1997
    ....
  21. ncbi request reprint Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker rat
    Mary K Teachey
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson 85721 0093, USA
    Metabolism 52:1167-74. 2003
    ..These findings support a significant interaction between low doses of CLA and R-ALA for enhancement of insulin action on skeletal muscle glucose transport, possibly via reductions in muscle oxidative stress and in lipid storage...
  22. ncbi request reprint Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats
    Vitoon Saengsirisuwan
    Department of Physiology, University of Arizona College of Medicine, Tucson 85721 0093, USA
    Am J Physiol Endocrinol Metab 287:E529-36. 2004
    ..These results indicate that the improvements of insulin action in insulin-resistant skeletal muscle after R-ALA or ET, alone and in combination, were associated with increases in IRS-1 protein expression and IRS-1 associated with p85...
  23. ncbi request reprint Effects of exercise training and antioxidant R-ALA on glucose transport in insulin-sensitive rat skeletal muscle
    Vitoon Saengsirisuwan
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona, College of Medicine, Tucson, Arizona 85721 0093, USA
    J Appl Physiol 92:50-8. 2002
    ..These results indicate that the beneficial interactive effects of ET and R-ALA on skeletal muscle insulin action observed previously in insulin-resistant obese Zucker rats are not apparent in insulin-sensitive lean Zucker rats...
  24. pmc Metabolic interactions of AGE inhibitor pyridoxamine and antioxidant alpha-lipoic acid following 22 weeks of treatment in obese Zucker rats
    Elizabeth M Muellenbach
    Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721, USA
    Life Sci 84:563-8. 2009
    ..This study was designed to ascertain whether these unique interactive effects of PYR and LA remain manifest following longer-term (22-week) treatment...
  25. ncbi request reprint Oxidative stress-induced insulin resistance in rat skeletal muscle: role of glycogen synthase kinase-3
    Betsy B Dokken
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721 0093, USA
    Am J Physiol Endocrinol Metab 294:E615-21. 2008
    ..Moreover, a small, but significant, portion of this oxidative stress-induced insulin resistance is associated with a reduced insulin-mediated suppression of the active form of GSK-3beta...
  26. pmc Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant alpha-lipoic acid on insulin resistance in the obese Zucker rat
    Elizabeth A Muellenbach
    Department of Physiology, Muscle Metabolism Laboratory, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Metabolism 57:1465-72. 2008
    ..Collectively, these results document a beneficial interaction of the antioxidant R-ALA and the AGE inhibitor PM in the treatment of whole-body and skeletal muscle insulin resistance in obese Zucker rats...
  27. ncbi request reprint Acute selective glycogen synthase kinase-3 inhibition enhances insulin signaling in prediabetic insulin-resistant rat skeletal muscle
    Betsy B Dokken
    Dept of Physiology, Univ of Arizona College of Medicine, P O Box 210093, Tucson, AZ 85721 0093, USA
    Am J Physiol Endocrinol Metab 288:E1188-94. 2005
    ..These effects of GSK3 inhibition on insulin action are greater in type I muscle than in type IIb muscle from these insulin-resistant animals...
  28. ncbi request reprint Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle
    Narissara Lailerd
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tuscon, USA
    Metabolism 53:101-7. 2004
    ..1 mmol/L) modestly improved in vitro insulin action on skeletal muscle glucose transport in both lean and obese Zucker rats. These results indicate that one potential site of action of SVS is the skeletal muscle glucose transport system...
  29. ncbi request reprint Modulation of insulin resistance and hypertension by voluntary exercise training in the TG(mREN2)27 rat
    Tyson R Kinnick
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, Arizona 85721 0093, USA
    J Appl Physiol 93:805-12; discussion 797. 2002
    ..These data indicate that the male heterozygous TG(mREN2)27 rat is a model of both hypertension and insulin resistance. Importantly, both of these defects can be beneficially modified by voluntary exercise training...
  30. ncbi request reprint Enhanced insulin action on glucose transport and insulin signaling in 7-day unweighted rat soleus muscle
    Matthew P O'Keefe
    Department of Physiology, University of Arizona, Tucson, AZ 85721 0093, USA
    J Appl Physiol 97:63-71. 2004
    ..However, PI3-kinase-independent mechanisms must also play a small role in this adaptive response to HS...
  31. ncbi request reprint Selective angiotensin II receptor antagonism enhances whole-body insulin sensitivity and muscle glucose transport in hypertensive TG(mREN2)27 rats
    Julie A Sloniger
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Metabolism 54:1659-68. 2005
    ....
  32. pmc Direct inhibition by angiotensin II of insulin-dependent glucose transport activity in mammalian skeletal muscle involves a ROS-dependent mechanism
    Maggie K Diamond-Stanic
    Muscle Metabolism Laboratory, Department of Physiology and Arizona Diabetes Program, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Arch Physiol Biochem 116:88-95. 2010
    ..These results indicate that Ang II inhibits distal insulin signalling and insulin-stimulated glucose transport in isolated mammalian skeletal muscle, and that this effect is partially mediated by ROS...
  33. ncbi request reprint Voluntary exercise training enhances glucose transport but not insulin signaling capacity in muscle of hypertensive TG(mREN2)27 rats
    Andrew M Lemieux
    Dept of Physiology, Univ of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    J Appl Physiol 99:357-62. 2005
    ..However, this adaptive response in muscle occurs independently of modifications in the proximal elements of the insulin signaling cascade...
  34. ncbi request reprint Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat
    Julie A Sloniger
    Muscle Metabolism Laboratory, Dept of Physiology, Ina E Gittings Bldg 93, Univ of Arizona, Tucson, AZ 85721 0093, USA
    Am J Physiol Endocrinol Metab 288:E1074-81. 2005
    ..Collectively, these data provide the first evidence that the insulin resistance of the hypertensive male heterozygous TG(mREN2)27 rat can be attributed to specific defects in the insulin-signaling pathway in skeletal muscle...
  35. pmc Roles of insulin signalling and p38 MAPK in the activation by lithium of glucose transport in insulin-resistant rat skeletal muscle
    Antoni R Macko
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721, USA
    Arch Physiol Biochem 114:331-9. 2008
    ..As in insulin-sensitive muscle, the lithium-induced activation of glucose transport in insulin-resistant skeletal muscle is dependent on the engagement of p38 MAPK...
  36. ncbi request reprint Chronic selective glycogen synthase kinase-3 inhibition enhances glucose disposal and muscle insulin action in prediabetic obese Zucker rats
    Betsy B Dokken
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, PO Box 210093, Tucson, AZ 85721 0093, USA
    Am J Physiol Endocrinol Metab 291:E207-13. 2006
    ..These results provide further evidence that selective targeting of GSK-3 in muscle may be an effective intervention for the treatment of obesity-associated insulin resistance...
  37. ncbi request reprint Essential role of p38 MAPK for activation of skeletal muscle glucose transport by lithium
    Nicholas B Harrell
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721, USA
    Arch Physiol Biochem 113:221-7. 2007
    ..Importantly, we have documented an essential role of p38 MAPK phosphorylation in the action lithium on the glucose transport system in isolated mammalian skeletal muscle...
  38. ncbi request reprint Oxidant stress and skeletal muscle glucose transport: roles of insulin signaling and p38 MAPK
    John S Kim
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Free Radic Biol Med 41:818-24. 2006
    ....
  39. ncbi request reprint Effects of specific conjugated linoleic acid isomers on growth characteristics in obese Zucker rats
    Sara R Sanders
    Department of Animal Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Lipids 39:537-43. 2004
    ..e., reduced arachidonic acid content), but the ability of CLA to manipulate body composition in obese Zucker rats remains questionable...
  40. pmc Oxidant stress-induced loss of IRS-1 and IRS-2 proteins in rat skeletal muscle: role of p38 MAPK
    Tara L Archuleta
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721 0093, USA
    Free Radic Biol Med 47:1486-93. 2009
    ....
  41. ncbi request reprint The metabolic syndrome: role of skeletal muscle metabolism
    Craig S Stump
    MU Diabetes and Cardiovascular Research Center, Columbia, Missouri, USA
    Ann Med 38:389-402. 2006
    ..Strategies will include adequate physical activity and maintaining a healthy weight, but may also require specific pharmacologic interventions...
  42. ncbi request reprint Development of whole-body and skeletal muscle insulin resistance after one day of hindlimb suspension
    Matthew P O'Keefe
    Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85721, USA
    Metabolism 53:1215-22. 2004
    ..However, activation of p38 MAPK may play a role in this response...
  43. ncbi request reprint Metabolic properties of vasodilating beta blockers: management considerations for hypertensive diabetic patients and patients with the metabolic syndrome
    Stephan Jacob
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    J Clin Hypertens (Greenwich) 6:690-6; quiz 697. 2004
    ..Clinical evidence is reviewed for the use of vasodilating beta blockers in the treatment of hypertension and in reducing cardiovascular risk in the diabetic population...
  44. ncbi request reprint Differential half-maximal effects of human insulin and its analogs for in situ glucose transport and protein synthesis in rat soleus muscle
    Randi B Weinstein
    Department of Biochemistry and Molecular Biophysics, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Metabolism 51:1065-70. 2002
    ..These data suggest that this approach for studying insulin responsiveness in a single muscle in situ may be a useful tool for investigating insulin signaling in muscle in vivo...
  45. ncbi request reprint Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo
    David B Ring
    Chiron Corporation, Emeryville, California, USA
    Diabetes 52:588-95. 2003
    ..Collectively, our results suggest that these selective GSK-3 inhibitors may be useful as acute-acting therapeutics for the treatment of the insulin resistance of type 2 diabetes...
  46. doi request reprint Angiotensin-converting enzyme in skeletal muscle: sentinel of blood pressure control and glucose homeostasis
    Guenther J Dietze
    Hypertension and Diabetes Research Unit, Max Grundig Clinic, Buehl, Germany
    J Renin Angiotensin Aldosterone Syst 9:75-88. 2008
    ..This concept also provides a unifying explanation for the beneficial effects of ACE-inhibitors and Angiotensin II receptor antagonists in the treatment of hypertension and insulin resistance...
  47. ncbi request reprint Alterations in soleus muscle gene expression associated with a metabolic endpoint following exercise training by lean and obese Zucker rats
    Tatiana Ort
    CuraGen Corporation, Branford, Connecticut, USA
    Physiol Genomics 29:302-11. 2007
    ..These findings could guide the development of pharmaceutical "exercise mimetics" in the treatment of insulin-resistant, prediabetic, or Type 2 diabetic individuals...

Research Grants3

  1. Glycogen Synthase Kinase-3 and Muscle Insulin Resistance
    ERIK HENRIKSEN; Fiscal Year: 2007
    ..abstract_text> ..