Research Topics
| SUSANNE MARGARETE HENNINGSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesisSusanne M Henning
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA Electronic address
J Nutr Biochem 23:1537-42. 2012..Our results suggest that the inhibition of tumor growth is due to GTP-mediated inhibition of oxidative stress and angiogenesis in the LAPC4 xenograft prostate tumor in SCID mice...- Arginine and antioxidant supplement on performance in elderly male cyclists: a randomized controlled trialSteve Chen
Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Int Soc Sports Nutr 7:13. 2010..Antioxidants may prevent nitric oxide inactivation by oxygen free radicals. The purpose of this study was to investigate the effects of an L-arginine and antioxidant supplement on exercise performance in elderly male cyclists... - Chemopreventive effects of tea in prostate cancer: green tea versus black teaSusanne M Henning
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Mol Nutr Food Res 55:905-20. 2011..This article will review in detail the available epidemiological and human clinical studies, as well as animal and basic mechanistic studies on GT and BT supporting a chemopreventive role in CaP... 
Antioxidant capacity and phytochemical content of herbs and spices in dry, fresh and blended herb paste formSusanne M Henning
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Int J Food Sci Nutr 62:219-25. 2011..However, there was no significant correlation between the AC and the concentration of chemical marker compounds. In summary, processed herbs contribute significant amounts of AC to the diet...- Strawberry consumption is associated with increased antioxidant capacity in serumSusanne M Henning
Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
J Med Food 13:116-22. 2010..In summary, daily consumption of strawberries resulted in a modest but significant increase in antioxidant capacity in a healthy population... - Nongallated compared with gallated flavan-3-ols in green and black tea are more bioavailableSusanne M Henning
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
J Nutr 138:1529S-1534S. 2008..Future intervention studies will need to focus on the bioactivity not only of green tea and BT PP but also of their metabolites and biotransformation products... 
Catechin content of 18 teas and a green tea extract supplement correlates with the antioxidant capacitySusanne M Henning
UCLA Center for Human Nutrition, School of Medicine, Warren Hall 14 166, 900 Veteran Avenue, Los Angeles, CA 90095, USA
Nutr Cancer 45:226-35. 2003..The large variation in flavanol content and ORAC value among various brands and types of tea provides critical information for investigators using tea in studies of nutrition and cancer prevention...- Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplementSusanne M Henning
Center for Human Nutrition, David Geffen School of Medicine and the Department of Biostatistics, School of Public Health, University of California, Los Angeles, 90095, USA
Am J Clin Nutr 80:1558-64. 2004..Additional in vivo studies are needed to examine the pharmacokinetic relation of absorption and antioxidant activity of tea polyphenols administered in the form of green or black tea or tea extract supplements... - Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individualsSusanne M Henning
Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
J Nutr Biochem 16:610-6. 2005..In future studies of dietary effects on the plasma antioxidant capacity, changes in plasma uric acid will need to be closely monitored... - Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjectsNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, Los Angeles California, USA
J Med Food 11:390-4. 2008..This study demonstrates that ellagitannin metabolites, delivered from pomegranate fruits, as PJ, POMxl, and POMxp, reach equivalent levels with a delay in time of maximum concentration of POMxp compared to PJ and POMxl... - Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivoMaryam R Sartippour
Center for Human Nutrition, Los Angeles, CA 90095 1742, USA
Int J Oncol 32:475-80. 2008..Further studies in humans are needed to confirm that angiogenesis can be inhibited by an ellagitannin-rich pomegranate extract administered orally as a dietary supplement... - Green tea polyphenols and metabolites in prostatectomy tissue: implications for cancer preventionPiwen Wang
Center for Human Nutrition, University of California Los Angeles, 90095, USA
Cancer Prev Res (Phila) 3:985-93. 2010.... - Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United StatesNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 56:1415-22. 2008..Although in vitro antioxidant potency does not prove in vivo biological activity, there is also consistent clinical evidence of antioxidant potency for the most potent beverages including both PJ and red wine... - Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2Naoko Kobayashi
Department of Urology, Division of Clinical Nutrition and Hematology-Oncology, University of California, Los Angeles School of Medicine, 90095-1738, USA
Clin Cancer Res 12:4662-70. 2006.... - Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanismMatthew B Rettig
Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA
Mol Cancer Ther 7:2662-71. 2008..Our study represents the first description of PE as a promising dietary agent for the prevention of the emergence of androgen independence that is driven in part by heightened NF-kappaB activity... - Absence of pomegranate ellagitannins in the majority of commercial Pomegranate extracts: implications for standardization and quality controlYanjun Zhang
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 57:7395-400. 2009..Future research is needed to assess the health impact of substituting ellagic acid for the complex mix of phytochemicals in a pomegranate extract dietary supplement... - Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist sizeDavid Heber
Center for Human Nutrition, University of California, Los Angeles, CA 90095, USA
J Agric Food Chem 55:10050-4. 2007..These studies demonstrate the safety of a pomegranate ellagitannin-enriched polyphenol dietary supplement in humans and provide evidence of antioxidant activity in humans... - Pistachio nuts reduce triglycerides and body weight by comparison to refined carbohydrate snack in obese subjects on a 12-week weight loss programZhaoping Li
Center for Human Nutrition, Warren Hall, Room 12 217, 900 Veteran Ave, Los Angeles, CA 90095, USA
J Am Coll Nutr 29:198-203. 2010..This study is designed to study the effects of pistachio snack consumption on body weight and lipid levels in obese participants under real-world conditions... - In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juiceNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Nutr Biochem 16:360-7. 2005..The superior bioactivity of PJ compared to its purified polyphenols illustrated the multifactorial effects and chemical synergy of the action of multiple compounds compared to single purified active ingredients... - Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate glandNavindra P Seeram
Center for Human Nutrition, Greater Los Angeles VA Medical Center, Los Angeles, California, USA
J Agric Food Chem 55:7732-7. 2007..This warrants future human tissue bioavailability studies and further clinical studies in men with CaP... - Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hoursNavindra P Seeram
Departments of Biomathematics and Human Genetics, University of California, Los Angeles, CA, USA
J Nutr 136:2481-5. 2006..Whether genetic polymorphisms in EA-metabolizing enzymes (e.g., catechol-O-methyl transferase and glucuronosyl transferase) are related to variations in response to PJ remains to be established... - Catechin and caffeine content of green tea dietary supplements and correlation with antioxidant capacityNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 54:1599-603. 2006..Reliable labeling information and standardized manufacturing practices, based on both chemical standardization and biological assays, are recommended for the quality control of botanical dietary supplements... - Pistachio skin phenolics are destroyed by bleaching resulting in reduced antioxidative capacitiesNavindra P Seeram
Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
J Agric Food Chem 54:7036-40. 2006..The destruction of bioactive phenolics in pistachio skins may negatively impact the potential health benefits arising from pistachio consumption... - The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cellsKun Gao
Center for Human Nutrition, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA
J Nutr Biochem 17:89-95. 2006.... - The combination of green tea and tamoxifen is effective against breast cancerMaryam R Sartippour
Department of Surgery, Center for Human Nutrition, University of California, Los Angeles, CA 90095-1782, USA
Carcinogenesis 27:2424-33. 2006..These results may lead to future improvements in breast cancer treatment and prevention... - Antioxidant-rich spice added to hamburger meat during cooking results in reduced meat, plasma, and urine malondialdehyde concentrationsZhaoping Li
University of California, Los Angeles Center for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Am J Clin Nutr 91:1180-4. 2010..Emerging science has shown the effect of oxidation products and inflammation on atherogenesis and carcinogenesis. Cooking hamburger meat can promote the formation of malondialdehyde that can be absorbed after ingestion... - Nonaminoglycoside compounds induce readthrough of nonsense mutationsLiutao Du
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Exp Med 206:2285-97. 2009..The two compounds also demonstrated readthrough activity in mdx mouse myotube cells carrying a nonsense mutation and induced significant amounts of dystrophin protein... - Antagonism of hypervitaminosis A-induced anterior neural tube closure defects with a methyl-donor deficiency in murine whole-embryo cultureJesús Santos-Guzmán
UCLA School of Public Health, Los Angeles, CA 90095, USA
J Nutr 133:3561-70. 2003..Biochemical measurements of metabolites in relevant pathways were performed. We propose that the amelioration of these malformations may be used to determine biochemical pathways critical for retinoid teratogenesis... - Bioavailability and antioxidant effects of orange juice components in humansAdrian A Franke
Cancer Research Center of Hawaii, University of Hawaii, Honolulu, 96813, USA
J Agric Food Chem 53:5170-8. 2005..We conclude from this pilot study that OJ is an excellent food source to enhance circulating concentrations of valuable hydrophilic as well as lipophilic phytochemicals... - Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumptionSusanne M Henning
Department of Pathology, VA West Los Angeles, CA 90073, USA
J Nutr 136:1839-43. 2006..001) and GT (P = 0.025) consumption relative to baseline serum This is the first human study to show that tea polyphenols and theaflavins are bioavailable in the prostate where they may be active in the prevention of prostate cancer... - Folate fortification, plasma folate, homocysteine and colorectal adenoma recurrenceMaria Elena Martinez
Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
Int J Cancer 119:1440-6. 2006..Our finding, suggesting that multivitamins or supplemental folate only benefit individuals with lower plasma folate concentrations, should be taken into consideration when designing and interpreting results of intervention studies... - Of the major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activityKun Gao
State Key Laboratory of Biocontrol, Department of Biochemistry and Center for Biopharmaceutical Research, College of Life Sciences, Sun Yatsen (Zhongshan) University, Guangzhou, China
J Nutr 136:52-7. 2006..In summary, fermentation by intestinal microbes of GT, BT, C+R, and S flavonoids resulted in the conversion to the same major phenolic acids...
Research Grants
- Bioavailability of Tea Polyphenols in Prostate CancerSusanne Henning; Fiscal Year: 2002..ODC enzyme activity will be determined measuring the release of 14C CO2 from 14C ornithine. These studies will provide information important in designing studies to critically test the role of dietary supplementation in prostate cancer. ..
- Tea Polyphenols in Chemoprevention of Prostate CancerSusanne Henning; Fiscal Year: 2007..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..
- Tea Polyphenols in Chemoprevention of Prostate CancerSUSANNE MARGARETE HENNING; Fiscal Year: 2011..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..