SUSANNE MARGARETE HENNING

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols
    Piwen Wang
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10202. 2010
  2. pmc Weight loss reduces breast ductal fluid estrogens in obese postmenopausal women: a single arm intervention pilot study
    Catherine L Carpenter
    Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Nutr J 11:102. 2012
  3. pmc Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Mol Nutr Food Res 57:483-93. 2013
  4. pmc Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Nutr Biochem 23:1537-42. 2012
  5. pmc Arginine and antioxidant supplement on performance in elderly male cyclists: a randomized controlled trial
    Steve Chen
    Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Int Soc Sports Nutr 7:13. 2010
  6. pmc Chemopreventive effects of tea in prostate cancer: green tea versus black tea
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Mol Nutr Food Res 55:905-20. 2011
  7. doi request reprint Antioxidant capacity and phytochemical content of herbs and spices in dry, fresh and blended herb paste form
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Int J Food Sci Nutr 62:219-25. 2011
  8. doi request reprint Strawberry consumption is associated with increased antioxidant capacity in serum
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Med Food 13:116-22. 2010
  9. pmc Nongallated compared with gallated flavan-3-ols in green and black tea are more bioavailable
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    J Nutr 138:1529S-1534S. 2008
  10. ncbi request reprint Catechin content of 18 teas and a green tea extract supplement correlates with the antioxidant capacity
    Susanne M Henning
    UCLA Center for Human Nutrition, School of Medicine, Warren Hall 14 166, 900 Veteran Avenue, Los Angeles, CA 90095, USA
    Nutr Cancer 45:226-35. 2003

Research Grants

  1. Bioavailability of Tea Polyphenols in Prostate Cancer
    Susanne Henning; Fiscal Year: 2002
  2. Tea Polyphenols in Chemoprevention of Prostate Cancer
    Susanne Henning; Fiscal Year: 2007
  3. Tea Polyphenols in Chemoprevention of Prostate Cancer
    Susanne Henning; Fiscal Year: 2009
  4. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2010
  5. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2011

Collaborators

Detail Information

Publications35

  1. pmc Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols
    Piwen Wang
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10202. 2010
    ..Although the susceptibility to EGCG treatment is largely dependent on cancer cell type, the particular cell viability and proliferation assays utilized may significantly influence quantitative results reported in the literature...
  2. pmc Weight loss reduces breast ductal fluid estrogens in obese postmenopausal women: a single arm intervention pilot study
    Catherine L Carpenter
    Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Nutr J 11:102. 2012
    ..Our purpose was to demonstrate feasibility and preliminarily evaluate serum-based and localized breast biomarker changes resulting from a weight loss intervention among obese postmenopausal women...
  3. pmc Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Mol Nutr Food Res 57:483-93. 2013
    ....
  4. pmc Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Nutr Biochem 23:1537-42. 2012
    ..Our results suggest that the inhibition of tumor growth is due to GTP-mediated inhibition of oxidative stress and angiogenesis in the LAPC4 xenograft prostate tumor in SCID mice...
  5. pmc Arginine and antioxidant supplement on performance in elderly male cyclists: a randomized controlled trial
    Steve Chen
    Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Int Soc Sports Nutr 7:13. 2010
    ..Antioxidants may prevent nitric oxide inactivation by oxygen free radicals. The purpose of this study was to investigate the effects of an L-arginine and antioxidant supplement on exercise performance in elderly male cyclists...
  6. pmc Chemopreventive effects of tea in prostate cancer: green tea versus black tea
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Mol Nutr Food Res 55:905-20. 2011
    ..This article will review in detail the available epidemiological and human clinical studies, as well as animal and basic mechanistic studies on GT and BT supporting a chemopreventive role in CaP...
  7. doi request reprint Antioxidant capacity and phytochemical content of herbs and spices in dry, fresh and blended herb paste form
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Int J Food Sci Nutr 62:219-25. 2011
    ..However, there was no significant correlation between the AC and the concentration of chemical marker compounds. In summary, processed herbs contribute significant amounts of AC to the diet...
  8. doi request reprint Strawberry consumption is associated with increased antioxidant capacity in serum
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Med Food 13:116-22. 2010
    ..In summary, daily consumption of strawberries resulted in a modest but significant increase in antioxidant capacity in a healthy population...
  9. pmc Nongallated compared with gallated flavan-3-ols in green and black tea are more bioavailable
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    J Nutr 138:1529S-1534S. 2008
    ..Future intervention studies will need to focus on the bioactivity not only of green tea and BT PP but also of their metabolites and biotransformation products...
  10. ncbi request reprint Catechin content of 18 teas and a green tea extract supplement correlates with the antioxidant capacity
    Susanne M Henning
    UCLA Center for Human Nutrition, School of Medicine, Warren Hall 14 166, 900 Veteran Avenue, Los Angeles, CA 90095, USA
    Nutr Cancer 45:226-35. 2003
    ..The large variation in flavanol content and ORAC value among various brands and types of tea provides critical information for investigators using tea in studies of nutrition and cancer prevention...
  11. ncbi request reprint Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine and the Department of Biostatistics, School of Public Health, University of California, Los Angeles, 90095, USA
    Am J Clin Nutr 80:1558-64. 2004
    ..Additional in vivo studies are needed to examine the pharmacokinetic relation of absorption and antioxidant activity of tea polyphenols administered in the form of green or black tea or tea extract supplements...
  12. ncbi request reprint Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Nutr Biochem 16:610-6. 2005
    ..In future studies of dietary effects on the plasma antioxidant capacity, changes in plasma uric acid will need to be closely monitored...
  13. pmc Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, Los Angeles California, USA
    J Med Food 11:390-4. 2008
    ..This study demonstrates that ellagitannin metabolites, delivered from pomegranate fruits, as PJ, POMxl, and POMxp, reach equivalent levels with a delay in time of maximum concentration of POMxp compared to PJ and POMxl...
  14. ncbi request reprint Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo
    Maryam R Sartippour
    Center for Human Nutrition, Los Angeles, CA 90095 1742, USA
    Int J Oncol 32:475-80. 2008
    ..Further studies in humans are needed to confirm that angiogenesis can be inhibited by an ellagitannin-rich pomegranate extract administered orally as a dietary supplement...
  15. pmc Green tea polyphenols and metabolites in prostatectomy tissue: implications for cancer prevention
    Piwen Wang
    Center for Human Nutrition, University of California Los Angeles, 90095, USA
    Cancer Prev Res (Phila) 3:985-93. 2010
    ....
  16. pmc Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2
    Naoko Kobayashi
    Department of Urology, Division of Clinical Nutrition and Hematology Oncology, University of California, Los Angeles School of Medicine, 90095 1738, USA
    Clin Cancer Res 12:4662-70. 2006
    ....
  17. doi request reprint Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 56:1415-22. 2008
    ..Although in vitro antioxidant potency does not prove in vivo biological activity, there is also consistent clinical evidence of antioxidant potency for the most potent beverages including both PJ and red wine...
  18. doi request reprint Absence of pomegranate ellagitannins in the majority of commercial Pomegranate extracts: implications for standardization and quality control
    Yanjun Zhang
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 57:7395-400. 2009
    ..Future research is needed to assess the health impact of substituting ellagic acid for the complex mix of phytochemicals in a pomegranate extract dietary supplement...
  19. pmc Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism
    Matthew B Rettig
    Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA
    Mol Cancer Ther 7:2662-71. 2008
    ..Our study represents the first description of PE as a promising dietary agent for the prevention of the emergence of androgen independence that is driven in part by heightened NF-kappaB activity...
  20. ncbi request reprint In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Nutr Biochem 16:360-7. 2005
    ..The superior bioactivity of PJ compared to its purified polyphenols illustrated the multifactorial effects and chemical synergy of the action of multiple compounds compared to single purified active ingredients...
  21. ncbi request reprint Catechin and caffeine content of green tea dietary supplements and correlation with antioxidant capacity
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 54:1599-603. 2006
    ..Reliable labeling information and standardized manufacturing practices, based on both chemical standardization and biological assays, are recommended for the quality control of botanical dietary supplements...
  22. ncbi request reprint Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size
    David Heber
    Center for Human Nutrition, University of California, Los Angeles, CA 90095, USA
    J Agric Food Chem 55:10050-4. 2007
    ..These studies demonstrate the safety of a pomegranate ellagitannin-enriched polyphenol dietary supplement in humans and provide evidence of antioxidant activity in humans...
  23. ncbi request reprint Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland
    Navindra P Seeram
    Center for Human Nutrition, Greater Los Angeles VA Medical Center, Los Angeles, California, USA
    J Agric Food Chem 55:7732-7. 2007
    ..This warrants future human tissue bioavailability studies and further clinical studies in men with CaP...
  24. ncbi request reprint Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours
    Navindra P Seeram
    Departments of Biomathematics and Human Genetics, University of California, Los Angeles, CA, USA
    J Nutr 136:2481-5. 2006
    ..Whether genetic polymorphisms in EA-metabolizing enzymes (e.g., catechol-O-methyl transferase and glucuronosyl transferase) are related to variations in response to PJ remains to be established...
  25. ncbi request reprint Pistachio skin phenolics are destroyed by bleaching resulting in reduced antioxidative capacities
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 54:7036-40. 2006
    ..The destruction of bioactive phenolics in pistachio skins may negatively impact the potential health benefits arising from pistachio consumption...
  26. ncbi request reprint Pistachio nuts reduce triglycerides and body weight by comparison to refined carbohydrate snack in obese subjects on a 12-week weight loss program
    Zhaoping Li
    Center for Human Nutrition, Warren Hall, Room 12 217, 900 Veteran Ave, Los Angeles, CA 90095, USA
    J Am Coll Nutr 29:198-203. 2010
    ..This study is designed to study the effects of pistachio snack consumption on body weight and lipid levels in obese participants under real-world conditions...
  27. ncbi request reprint The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells
    Kun Gao
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Nutr Biochem 17:89-95. 2006
    ....
  28. pmc Antioxidant-rich spice added to hamburger meat during cooking results in reduced meat, plasma, and urine malondialdehyde concentrations
    Zhaoping Li
    University of California, Los Angeles Center for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Am J Clin Nutr 91:1180-4. 2010
    ..Emerging science has shown the effect of oxidation products and inflammation on atherogenesis and carcinogenesis. Cooking hamburger meat can promote the formation of malondialdehyde that can be absorbed after ingestion...
  29. ncbi request reprint The combination of green tea and tamoxifen is effective against breast cancer
    Maryam R Sartippour
    Department of Surgery, Center for Human Nutrition, University of California, Los Angeles, CA 90095 1782, USA
    Carcinogenesis 27:2424-33. 2006
    ..These results may lead to future improvements in breast cancer treatment and prevention...
  30. ncbi request reprint Antagonism of hypervitaminosis A-induced anterior neural tube closure defects with a methyl-donor deficiency in murine whole-embryo culture
    Jesús Santos-Guzmán
    UCLA School of Public Health, Los Angeles, CA 90095, USA
    J Nutr 133:3561-70. 2003
    ..Biochemical measurements of metabolites in relevant pathways were performed. We propose that the amelioration of these malformations may be used to determine biochemical pathways critical for retinoid teratogenesis...
  31. pmc Nonaminoglycoside compounds induce readthrough of nonsense mutations
    Liutao Du
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Exp Med 206:2285-97. 2009
    ..The two compounds also demonstrated readthrough activity in mdx mouse myotube cells carrying a nonsense mutation and induced significant amounts of dystrophin protein...
  32. pmc Bioavailability and antioxidant effects of orange juice components in humans
    Adrian A Franke
    Cancer Research Center of Hawaii, University of Hawaii, Honolulu, 96813, USA
    J Agric Food Chem 53:5170-8. 2005
    ..We conclude from this pilot study that OJ is an excellent food source to enhance circulating concentrations of valuable hydrophilic as well as lipophilic phytochemicals...
  33. ncbi request reprint Tea polyphenols and theaflavins are present in prostate tissue of humans and mice after green and black tea consumption
    Susanne M Henning
    Department of Pathology, VA West Los Angeles, CA 90073, USA
    J Nutr 136:1839-43. 2006
    ..001) and GT (P = 0.025) consumption relative to baseline serum This is the first human study to show that tea polyphenols and theaflavins are bioavailable in the prostate where they may be active in the prevention of prostate cancer...
  34. ncbi request reprint Of the major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity
    Kun Gao
    State Key Laboratory of Biocontrol, Department of Biochemistry and Center for Biopharmaceutical Research, College of Life Sciences, Sun Yatsen Zhongshan University, Guangzhou, China
    J Nutr 136:52-7. 2006
    ..In summary, fermentation by intestinal microbes of GT, BT, C+R, and S flavonoids resulted in the conversion to the same major phenolic acids...
  35. ncbi request reprint Folate fortification, plasma folate, homocysteine and colorectal adenoma recurrence
    Maria Elena Martinez
    Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    Int J Cancer 119:1440-6. 2006
    ..Our finding, suggesting that multivitamins or supplemental folate only benefit individuals with lower plasma folate concentrations, should be taken into consideration when designing and interpreting results of intervention studies...

Research Grants6

  1. Bioavailability of Tea Polyphenols in Prostate Cancer
    Susanne Henning; Fiscal Year: 2002
    ..ODC enzyme activity will be determined measuring the release of 14C CO2 from 14C ornithine. These studies will provide information important in designing studies to critically test the role of dietary supplementation in prostate cancer. ..
  2. Tea Polyphenols in Chemoprevention of Prostate Cancer
    Susanne Henning; Fiscal Year: 2007
    ..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..
  3. Tea Polyphenols in Chemoprevention of Prostate Cancer
    Susanne Henning; Fiscal Year: 2009
    ..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..
  4. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2010
    ..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..
  5. Tea Polyphenols in Chemoprevention of Prostate Cancer
    SUSANNE MARGARETE HENNING; Fiscal Year: 2011
    ..The results will assist in designing dietary supplements for chemoprevention of early stages of prostate cancer or during watchful waiting. ..