Bernhard Hennig

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Nutrition can modulate the toxicity of environmental pollutants: implications in risk assessment and human health
    Bernhard Hennig
    University of Kentucky Superfund Research Program, Lexington, Kentucky 40536, USA
    Environ Health Perspect 120:771-4. 2012
  2. ncbi request reprint Introductory comments: nutrition, environmental toxins and implications in prevention and intervention of human diseases
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture and Graduate Centers for Nutritional Sciences and Toxicology, University of Kentucky, Lexington, KY 40536, USA
    J Nutr Biochem 18:161-2. 2007
  3. ncbi request reprint Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K/Akt and ERK1/2 signaling
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 40536 0200, USA
    J Nutr Biochem 17:766-72. 2006
  4. ncbi request reprint Modification of environmental toxicity by nutrients: implications in atherosclerosis
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture, Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Cardiovasc Toxicol 5:153-60. 2005
  5. pmc Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, 900 S Limestone, Lexington, KY 40536, USA
    Environ Health Perspect 115:493-5. 2007
  6. ncbi request reprint Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Room 591, Wethington Health Sciences Bldg, 900 S Limestone, Lexington, KY 40536 0200, USA
    Nutr Metab Cardiovasc Dis 17:162-9. 2007
  7. ncbi request reprint Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence
    Bernhard Hennig
    Cell Nutrition Group, Department of Animal Sciences, University of Kentucky, Lexington 40506 0054, USA
    Toxicol Appl Pharmacol 181:174-83. 2002
  8. ncbi request reprint PCB-induced oxidative stress in endothelial cells: modulation by nutrients
    Bernhard Hennig
    Cell Nutrition Group, Department of Animal Sciences, University of Kentucky, Lexington, KY 40546, USA
    Int J Hyg Environ Health 205:95-102. 2002
  9. pmc Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells
    Wen Huang
    Dept of Neurosurgery, Univ of Kentucky, Lexington, 40536, USA
    Am J Physiol Heart Circ Physiol 298:H1136-45. 2010
  10. pmc PPARalpha and PPARgamma effectively protect against HIV-induced inflammatory responses in brain endothelial cells
    Wen Huang
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, Kentucky, USA
    J Neurochem 107:497-509. 2008

Collaborators

Detail Information

Publications83

  1. pmc Nutrition can modulate the toxicity of environmental pollutants: implications in risk assessment and human health
    Bernhard Hennig
    University of Kentucky Superfund Research Program, Lexington, Kentucky 40536, USA
    Environ Health Perspect 120:771-4. 2012
    ..Much of the emerging evidence suggests that nutrition can modulate the toxicity of environmental pollutants, which may alter human risks associated with toxicant exposures...
  2. ncbi request reprint Introductory comments: nutrition, environmental toxins and implications in prevention and intervention of human diseases
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture and Graduate Centers for Nutritional Sciences and Toxicology, University of Kentucky, Lexington, KY 40536, USA
    J Nutr Biochem 18:161-2. 2007
  3. ncbi request reprint Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K/Akt and ERK1/2 signaling
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 40536 0200, USA
    J Nutr Biochem 17:766-72. 2006
    ..These data indicate that both PI3K/Akt- and ERK1/2-mediated proinflammatory signaling events are critical in LA-induced endothelial cell activation and vascular inflammation...
  4. ncbi request reprint Modification of environmental toxicity by nutrients: implications in atherosclerosis
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture, Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Cardiovasc Toxicol 5:153-60. 2005
    ..More research is needed to understand observed interactions of PCB toxicity with nutritional interventions...
  5. pmc Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, 900 S Limestone, Lexington, KY 40536, USA
    Environ Health Perspect 115:493-5. 2007
    ..It is becoming increasingly clear that nutrition can modulate the toxicity of environmental pollutants...
  6. ncbi request reprint Environmental toxicity, nutrition, and gene interactions in the development of atherosclerosis
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Room 591, Wethington Health Sciences Bldg, 900 S Limestone, Lexington, KY 40536 0200, USA
    Nutr Metab Cardiovasc Dis 17:162-9. 2007
    ..Thus, the concept that nutrition may modify or ameliorate the toxicity of environmental chemicals may have implications for understanding the complex interaction of environmental toxicity and disease development...
  7. ncbi request reprint Proinflammatory properties of coplanar PCBs: in vitro and in vivo evidence
    Bernhard Hennig
    Cell Nutrition Group, Department of Animal Sciences, University of Kentucky, Lexington 40506 0054, USA
    Toxicol Appl Pharmacol 181:174-83. 2002
    ..An intact AhR may be necessary for the observed PCB-induced responses. These findings suggest that activation of the AhR can be an underlying mechanism of atherosclerosis mediated by certain environmental contaminants...
  8. ncbi request reprint PCB-induced oxidative stress in endothelial cells: modulation by nutrients
    Bernhard Hennig
    Cell Nutrition Group, Department of Animal Sciences, University of Kentucky, Lexington, KY 40546, USA
    Int J Hyg Environ Health 205:95-102. 2002
    ....
  9. pmc Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells
    Wen Huang
    Dept of Neurosurgery, Univ of Kentucky, Lexington, 40536, USA
    Am J Physiol Heart Circ Physiol 298:H1136-45. 2010
    ..These results indicate that the senescence of brain endothelial cells may predispose to the HIV-induced upregulation of inflammatory mediators and the disruption of the barrier function at the level of the brain endothelium...
  10. pmc PPARalpha and PPARgamma effectively protect against HIV-induced inflammatory responses in brain endothelial cells
    Wen Huang
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, Kentucky, USA
    J Neurochem 107:497-509. 2008
    ..The present data suggest that targeting PPAR signaling may provide a novel therapeutic approach to attenuate HIV-1-induced local inflammatory responses in brain endothelial cells...
  11. pmc NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells
    Sung Yong Eum
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, KY 40536, USA
    Toxicol Appl Pharmacol 240:299-305. 2009
    ..Due to its role in leukocyte infiltration, induction of CAMs may contribute to PCB-induced cerebrovascular disorders and neurotoxic effects in the CNS...
  12. pmc Deficiency of telomerase activity aggravates the blood-brain barrier disruption and neuroinflammatory responses in a model of experimental stroke
    Bei Zhang
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci Res 88:2859-68. 2010
    ..Our study suggests that TERT deficiency can predispose to the development of stroke in an experimental model of this disease...
  13. ncbi request reprint Involvement of CYP 2C9 in mediating the proinflammatory effects of linoleic acid in vascular endothelial cells
    Saraswathi Viswanathan
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 40546 0215, USA
    J Am Coll Nutr 22:502-10. 2003
    ..We investigated the role of CYP-mediated mechanisms of linoleic acid metabolism in endothelial cell activation by examining the effects of linoleic acid or its oxidized metabolites such as LTX and leukotoxin diol (LTD)...
  14. pmc Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression
    Yean Jung Choi
    Department of Neurosurgery, University of Kentucky, Lexington, 40536, USA
    Environ Health Perspect 118:976-81. 2010
    ..The main route of exposure to PCBs is through the gastrointestinal tract; however, little is known about the effects of PCBs on intestinal epithelial barrier functions...
  15. pmc Polychlorinated biphenyl-induced VCAM-1 expression is attenuated in aortic endothelial cells isolated from caveolin-1 deficient mice
    Sung Gu Han
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 40536, USA
    Toxicol Appl Pharmacol 246:74-82. 2010
    ..Our data demonstrate a critical role of functional caveolae in the activation and dysfunction of endothelial cells by coplanar PCBs...
  16. ncbi request reprint Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells
    Ibolya E Andras
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    J Cereb Blood Flow Metab 25:1159-70. 2005
    ..Because claudins constitute the major backbone of tight junctions, the present data are relevant to the disturbances of the BBB in the course of HIV-1 infection...
  17. ncbi request reprint Methamphetamine potentiates HIV-1 Tat protein-mediated activation of redox-sensitive pathways in discrete regions of the brain
    Govinder Flora
    Department of Surgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Exp Neurol 179:60-70. 2003
    ..Such synergistic proinflammatory stimulation may have significant implications in HIV-infected patients who abuse drugs...
  18. ncbi request reprint Zinc deficiency induces vascular pro-inflammatory parameters associated with NF-kappaB and PPAR signaling
    Huiyun Shen
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    J Am Coll Nutr 27:577-87. 2008
    ..Marginal intake of dietary zinc can be associated with increased risk of cardiovascular diseases. In the current study we hypothesized that vascular dysfunction and associated inflammatory events are activated during a zinc deficient state...
  19. ncbi request reprint HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation
    Hong Pu
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky Medical Center, Kentucky 40536, USA
    J Cereb Blood Flow Metab 25:1325-35. 2005
    ..These results indicate that Tat-induced oxidative stress can play an important role in affecting the integrity of the BBB through the ERK 1/2 pathway...
  20. ncbi request reprint Nicotine attenuates oxidative stress, activation of redox-regulated transcription factors and induction of proinflammatory genes in compressive spinal cord trauma
    R Ravikumar
    Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Brain Res Mol Brain Res 124:188-98. 2004
    ..The present results indicate that nicotine administration can attenuate the oxidative injury to spinal cords and suggest that neuronal nicotinic receptors can be attractive targets for neuroprotective therapy...
  21. ncbi request reprint Interplay between epidermal growth factor receptor and Janus kinase 3 regulates polychlorinated biphenyl-induced matrix metalloproteinase-3 expression and transendothelial migration of tumor cells
    Sung Yong Eum
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky, Lexington, USA
    Mol Cancer Res 4:361-70. 2006
    ....
  22. ncbi request reprint Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction
    Gudrun Reiterer
    Department of Surgery, College of Agriculture, University of Kentucky, Lexington, KY 40546 0215, USA
    J Nutr 134:771-5. 2004
    ..These data suggest that quercetin has potent antioxidative and anti-inflammatory properties and protects endothelial cells against linoleic acid-mediated cell dysfunction...
  23. pmc The role of fatty acids and caveolin-1 in tumor necrosis factor alpha-induced endothelial cell activation
    Lei Wang
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington KY 40536, USA
    Metabolism 57:1328-39. 2008
    ....
  24. pmc Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent
    Zuzana Majkova
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 0200, USA
    Toxicol Appl Pharmacol 237:1-7. 2009
    ..Intact caveolae are required for these processes both in vivo and in vitro. This further supports a key role for caveolae in vascular inflammation induced by persistent organic pollutants...
  25. ncbi request reprint Zinc modulates PPARgamma signaling and activation of porcine endothelial cells
    Purushothaman Meerarani
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 40546 0215, USA
    J Nutr 133:3058-64. 2003
    ..These data suggest that zinc plays a critical role in PPARgamma signaling in linoleic acid-induced endothelial cell activation and indicate that PPARgamma signaling is impaired during zinc deficiency...
  26. ncbi request reprint HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain
    Hong Pu
    Department of Surgery Neurosurgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Mol Cell Neurosci 24:224-37. 2003
    ..These data demonstrate that intracerebral administration of Tat can induce profound proinflammatory effects in the brain, leading to monocyte infiltration...
  27. pmc PPARα and PPARγ protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling
    Wen Huang
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, Kentucky, USA
    FASEB J 25:3979-88. 2011
    ..Overall, our results indicate that ERK1/2, Akt, and cav-1 are involved in the regulatory mechanisms of PPAR-mediated protection against HIV-1-induced MMP-9 expression in brain endothelial cells...
  28. ncbi request reprint PPARalpha ligands reduce PCB-induced endothelial activation: possible interactions in inflammation and atherosclerosis
    Xabier Arzuaga
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 40536 0200, USA
    Cardiovasc Toxicol 7:264-72. 2007
    ....
  29. ncbi request reprint The role of caveolin-1 in PCB77-induced eNOS phosphorylation in human-derived endothelial cells
    Eun Jin Lim
    Molecular and Cell Nutrition Laboratory, University of Kentucky, Lexington, KY 40536 0200, USA
    Am J Physiol Heart Circ Physiol 293:H3340-7. 2007
    ..Our data provide evidence that caveolae may play a critical role in regulating vascular endothelial cell activation and toxicity induced by persistent environmental pollutants such as coplanar PCBs...
  30. pmc Coplanar polychlorinated biphenyl-induced CYP1A1 is regulated through caveolae signaling in vascular endothelial cells
    Eun Jin Lim
    Molecular and Cell Nutrition Laboratory, Department of Chemistry, College of Agriculture, University of Kentucky, Lexington, KY 40536, USA
    Chem Biol Interact 176:71-8. 2008
    ..This may have implications in understanding mechanisms of inflammatory diseases induced by environmental pollutants...
  31. pmc PPARalpha and PPARgamma attenuate HIV-induced dysregulation of tight junction proteins by modulations of matrix metalloproteinase and proteasome activities
    Wen Huang
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky Medical Center, 593 Wethington Bldg, 900 S Limestone, Lexington, KY 40536, USA
    FASEB J 23:1596-606. 2009
    ..The present data indicate that down-regulation of MMP and proteasome activities constitutes a novel mechanism of PPAR-induced protections against HIV-induced disruption of brain endothelial cells...
  32. ncbi request reprint HIV-Tat protein induces P-glycoprotein expression in brain microvascular endothelial cells
    Kentaro Hayashi
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurochem 93:1231-41. 2005
    ..These results suggest that Tat-induced overexpression of P-gp in brain microvessels may have significant implications for the development of resistance to HAART and may be a contributing factor for low efficacy of HAART in the CNS...
  33. pmc HIV-1-induced amyloid beta accumulation in brain endothelial cells is attenuated by simvastatin
    Ibolya E Andras
    Department of Neurosurgery, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Mol Cell Neurosci 43:232-43. 2010
    ..These results suggest that HIV-1 may directly contribute to Abeta accumulation at the BBB level. In addition, statins may protect against increased Abeta levels associated with HIV-1 infection in the brain...
  34. doi request reprint Alumina nanoparticles induce expression of endothelial cell adhesion molecules
    Elizabeth Oesterling
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536, USA
    Toxicol Lett 178:160-6. 2008
    ..These data show that alumina nanoparticles can elicit a proinflammatory response and thus present a cardiovascular disease risk...
  35. pmc Changing ratios of omega-6 to omega-3 fatty acids can differentially modulate polychlorinated biphenyl toxicity in endothelial cells
    Lei Wang
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington 40536, USA
    Chem Biol Interact 172:27-38. 2008
    ..The present studies suggest that NF-kappaB is a critical player in the regulation of PCB-induced inflammatory markers as modulated by omega-6 and omega-3 fatty acids...
  36. ncbi request reprint HIV-TAT protein upregulates expression of multidrug resistance protein 1 in the blood-brain barrier
    Kentaro Hayashi
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    J Cereb Blood Flow Metab 26:1052-65. 2006
    ..These results indicate that Tat exposure can lead to alterations of the BBB functions and decrease HAART efficacy in the CNS through overexpression of drug efflux transporters...
  37. pmc Caveolin-1 regulates human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling
    Yu Zhong
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 28:7788-96. 2008
    ..Thus, caveolin-1 may provide an effective target to protect against Tat-induced HBMEC dysfunction and the disruption of the BBB in HIV-1-infected patients...
  38. pmc Intact lipid rafts regulate HIV-1 Tat protein-induced activation of the Rho signaling and upregulation of P-glycoprotein in brain endothelial cells
    Yu Zhong
    Department of Neurosurgery, Molecular Neuroscience and Vascular Biology Laboratory, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Cereb Blood Flow Metab 30:522-33. 2010
    ..The present data indicate the critical function of intact lipid rafts and the Rho signaling in HIV-1-mediated upregulation of P-gp and potential development of drug resistance in brain endothelial cells...
  39. ncbi request reprint Limited role of COX-2 in HIV Tat-induced alterations of tight junction protein expression and disruption of the blood-brain barrier
    Hong Pu
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky, Lexington, KY 40536, USA
    Brain Res 1184:333-44. 2007
    ..These results suggest only a limited role of COX-2 overexpression in the loss of tight junction integrity and the BBB breakdown in HIV-related brain diseases...
  40. pmc Reductive dechlorination of 3,3',4,4'-tetrachlorobiphenyl (PCB77) using palladium or palladium/iron nanoparticles and assessment of the reduction in toxic potency in vascular endothelial cells
    Karthik Venkatachalam
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, United States
    J Hazard Mater 159:483-91. 2008
    ..The data strongly suggest that the dechlorination system used in this study markedly reduced the proinflammatory activity of PCB77, a persistent organic pollutant...
  41. pmc Role of caveolin-1 in EGCG-mediated protection against linoleic-acid-induced endothelial cell activation
    Yuanyuan Zheng
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, 40536 0200, USA
    J Nutr Biochem 20:202-9. 2009
    ..Our data provide evidence that caveolae may play a critical role in regulating vascular endothelial cell activation and protection by flavonoids such as EGCG...
  42. ncbi request reprint Cyclooxygenase-2 is involved in HIV-1 Tat-induced inflammatory responses in the brain
    Govinder Flora
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky, Lexington KY 40536, USA
    Neuromolecular Med 8:337-52. 2006
    ..Such alterations may play an important role in the development of brain inflammatory reactions in HIV-infected patients and contribute to the development of neurological complications in the course of HIV-1 infection...
  43. ncbi request reprint Cholesterol attenuates linoleic acid-induced endothelial cell activation
    Purushothaman Meerarani
    Department of Animal Sciences, the Graduate Center for Nutritional Sciences, University of Kentucky, Lexington 40546 0215, USA
    Metabolism 52:493-500. 2003
    ..Our data suggest that signaling pathways linked to endothelial cell activation by prooxidant and proinflammatory insults may be influenced by cellular cholesterol levels...
  44. pmc Polychlorinated biphenyls disrupt blood-brain barrier integrity and promote brain metastasis formation
    Melissa Seelbach
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Environ Health Perspect 118:479-84. 2010
    ..However, the effects of PCBs on the development of tumor metastases are not fully understood...
  45. pmc Simvastatin protects against amyloid beta and HIV-1 Tat-induced promoter activities of inflammatory genes in brain endothelial cells
    Ibolya E Andras
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky Medical Center, 593 Wethington Bldg, 900 S Limestone, Lexington, KY 40536, USA
    Mol Pharmacol 73:1424-33. 2008
    ..In addition, simvastatin may provide a beneficial influence by reducing these effects at the BBB level...
  46. ncbi request reprint Proinflammatory synergism of ethanol and HIV-1 Tat protein in brain tissue
    Govinder Flora
    Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Exp Neurol 191:2-12. 2005
    ..Such potentiation of proinflammatory stimulation may further contribute to CNS pathology in HIV-infected patients who are alcohol abusers...
  47. ncbi request reprint Methamphetamine activates DNA binding of specific redox-responsive transcription factors in mouse brain
    Yong Woo Lee
    Division of Neurosurgery, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurosci Res 70:82-9. 2002
    ..These results suggest that METH-induced oxidative stress may trigger the molecular signaling pathways via specific and selective activation of AP-1 and CREB...
  48. doi request reprint Epigallocatechin gallate-mediated protection against tumor necrosis factor-α-induced monocyte chemoattractant protein-1 expression is heme oxygenase-1 dependent
    Yuanyuan Zheng
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY 40536 0200, USA
    Metabolism 59:1528-35. 2010
    ..These data suggest that the protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling...
  49. pmc Induction of gene pattern changes associated with dysfunctional lipid metabolism induced by dietary fat and exposure to a persistent organic pollutant
    Xabier Arzuaga
    Molecular and Cell Nutrition Laboratory, Department of Animal and Food Sciences, University of Kentucky, Lexington, KY 40536, USA
    Toxicol Lett 189:96-101. 2009
    ..These results provide insight into molecular mechanisms of how dietary fat can interact with environmental pollutants to compromise lipid metabolism...
  50. ncbi request reprint Arachidonic acid increases choline acetyltransferase activity in spinal cord neurons through a protein kinase C-mediated mechanism
    Malgorzata Chalimoniuk
    Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurochem 90:629-36. 2004
    ..These results indicate that the AA-evoked increase in ChAT activity in spinal cord neurons is mediated by PKC, presumably at the transcriptional level...
  51. pmc Cerebrovascular toxicity of PCB153 is enhanced by binding to silica nanoparticles
    Bei Zhang
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, USA
    J Neuroimmune Pharmacol 7:991-1001. 2012
    ..This study provides the first evidence that binding to NPs increases cerebrovascular toxicity of environmental toxicants, such as PCB153...
  52. pmc Caveolae: a regulatory platform for nutritional modulation of inflammatory diseases
    Joseph Layne
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 60536, USA
    J Nutr Biochem 22:807-11. 2011
    ..Thus, nutritional modulation of caveolae-mediated signaling events may provide an opportunity to ameliorate inflammatory signaling pathways capable of promoting the formation of vascular diseases, including atherosclerosis...
  53. pmc Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature
    Lei Chen
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Neurosurgery, University of Kentucky Medical Center, 593 Wethington Bldg, 900 S Limestone, Lexington, KY 40536, USA
    J Neuroimmune Pharmacol 3:286-95. 2008
    ..These results indicate that cerebral vasculature can be affected by nano-alumina. In addition, our data indicate that alterations of mitochondrial functions may be the underlying mechanism of nano-alumina toxicity...
  54. ncbi request reprint Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells
    Gudrun Reiterer
    Graduate Center for Nutritional Sciences, College of Agriculture, University of Kentucky, Lexington, KY 40546 0215, USA
    J Nutr 134:1711-5. 2004
    ..Our data demonstrate the importance of zinc in PPAR signaling and the requirement of zinc for the anti-inflammatory properties of PPARalpha and -gamma agonists...
  55. ncbi request reprint Zinc deficiency increases plasma lipids and atherosclerotic markers in LDL-receptor-deficient mice
    Gudrun Reiterer
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, 40546, USA
    J Nutr 135:2114-8. 2005
    ..These data also suggest that adequate zinc may be a critical component in protective PPAR signaling during atherosclerosis...
  56. pmc Quercetin blocks caveolae-dependent pro-inflammatory responses induced by co-planar PCBs
    Yean Jung Choi
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington KY 40536 0200, USA
    Environ Int 36:931-4. 2010
    ..Our results suggest that inflammatory pathways induced by co-planar PCBs can be down-regulated by the dietary flavonoid quercetin through mechanisms associated with functional caveolae...
  57. ncbi request reprint Mechanisms of the blood-brain barrier disruption in HIV-1 infection
    Michal Toborek
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    Cell Mol Neurobiol 25:181-99. 2005
    ..In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging...
  58. pmc Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls
    Zuzana Majkova
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40536 0200, USA
    Toxicol Appl Pharmacol 251:41-9. 2011
    ..Our data implicate A₄/J₄-NPs as mediators of omega-3 fatty acid-mediated protection against the endothelial toxicity of coplanar PCBs...
  59. ncbi request reprint Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells
    Pachaikani Ramadass
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington 40546 0215, USA
    Toxicol Sci 76:212-9. 2003
    ..These data suggest that protective effects of EGCG and quercetin are initiated upstream from CYP1A1 and that these flavonoids may be of value for inhibiting the toxic effects of PCBs on vascular endothelial cells...
  60. ncbi request reprint PCB 104-induced proinflammatory reactions in human vascular endothelial cells: relationship to cancer metastasis and atherogenesis
    Wangsun Choi
    Department of Surgery, University of Kentucky, Lexington, Kentucky 40536, USA
    Toxicol Sci 75:47-56. 2003
    ..We hypothesize that these proinflammatory processes may contribute to the development of cancer metastasis and/or atherogenesis in patients exposed to PCBs...
  61. pmc Titanium dioxide nanoparticles increase inflammatory responses in vascular endothelial cells
    Sung Gu Han
    Superfund Research Program, University of Kentucky, Lexington, KY 40536, USA
    Toxicology 306:1-8. 2013
    ..These data indicate that TiO2 NPs can induce endothelial inflammatory responses via redox-sensitive cellular signaling pathways...
  62. pmc EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2-regulated genes
    Sung Gu Han
    Superfund Research Program, University of Kentucky, Lexington, KY 40536 0200, USA
    Toxicol Appl Pharmacol 261:181-8. 2012
    ..These data suggest that EGCG can inhibit AhR regulated genes and induce Nrf2-regulated antioxidant enzymes, thus providing protection against PCB-induced inflammatory responses in endothelial cells...
  63. ncbi request reprint HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells
    Ibolya E Andras
    Department of Surgery, University of Kentucky, Lexington, Kentucky, USA
    J Neurosci Res 74:255-65. 2003
    ..Because tight junction proteins are critical for the barrier function of the BBB, such alterations can lead to disturbances of the BBB integrity and contribute to HIV trafficking into the brain...
  64. ncbi request reprint HIV-Tat protein induces oxidative and inflammatory pathways in brain endothelium
    Michal Toborek
    Department of Surgery, Animal Sciences and Neurology, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurochem 84:169-79. 2003
    ..These changes can directly lead to disruption of the BBB. Thus, Tat can play an important role in the development of detrimental vascular changes in the brains of HIV-infected patients...
  65. pmc The role of caveolae in endothelial cell dysfunction with a focus on nutrition and environmental toxicants
    Zuzana Majkova
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY, USA
    J Cell Mol Med 14:2359-70. 2010
    ....
  66. ncbi request reprint VEGF regulates PCB 104-mediated stimulation of permeability and transmigration of breast cancer cells in human microvascular endothelial cells
    Sung Yong Eum
    Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Exp Cell Res 296:231-44. 2004
    ..These results indicate that PCB 104 may contribute to tumor metastasis by inducing VEGF overexpression that stimulates endothelial hyperpermeability and transendothelial migration of cancer cells...
  67. pmc Dietary fat interacts with PCBs to induce changes in lipid metabolism in mice deficient in low-density lipoprotein receptor
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture and Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536 0200, USA
    Environ Health Perspect 113:83-7. 2005
    ..These findings have implications for understanding the interactions of nutrients with environmental contaminants on the pathology of inflammatory diseases such as atherosclerosis...
  68. ncbi request reprint Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signaling
    Viswanathan Saraswathi
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
    J Lipid Res 45:794-804. 2004
    ..LA exposure resulted in increased nitrotyrosine levels, as observed by Western blotting and immunofluorescence. Our data suggest that the proinflammatory effects of LA can be mediated through calcium and peroxynitrite signaling...
  69. ncbi request reprint Zinc deficiency alters lipid metabolism in LDL receptor deficient mice treated with rosiglitazone
    Huiyun Shen
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 40536, USA
    J Nutr 137:2339-45. 2007
    ..These data suggest that in this atherogenic mouse model treated with RSG, lipid metabolism can be compromised during zinc deficiency and that adequate dietary zinc may be considered during therapy with the antidiabetic medicine RSG...
  70. ncbi request reprint The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells
    Ibolya E Andras
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Cereb Blood Flow Metab 27:1431-43. 2007
    ..These findings indicate the opposite effects of the NMDA and AMPA/KA receptors on occludin phosphorylation and disruption of the BBB functions...
  71. doi request reprint Flavonoids protect against intercellular adhesion molecule-1 induction by benzo[a]pyrene
    Elizabeth Oesterling Owens
    Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 0200, USA
    Bull Environ Contam Toxicol 83:4-7. 2009
    ..These data suggest that selected bioactive compounds can decrease proinflammatory properties of environmental chemicals such as B[a]P...
  72. ncbi request reprint 2,2',4,6,6'-pentachlorobiphenyl (PCB 104) induces apoptosis of human microvascular endothelial cells through the caspase-dependent activation of CREB
    Yong Woo Lee
    Department of Surgery, University of Kentucky, Lexington, KY 40536, USA
    Toxicol Appl Pharmacol 189:1-10. 2003
    ..These results suggest that PCB-induced death of human microvascular endothelial cells is mediated, at least in part, via the caspase-dependent apoptotic pathways and that the selective activation of CREB is involved in this process...
  73. ncbi request reprint Measurement of inflammatory properties of fatty acids in human endothelial cells
    Michal Toborek
    Department of Surgery, Division of Neurosurgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    Methods Enzymol 352:198-219. 2002
  74. ncbi request reprint Emerging issues: nutritional awareness in environmental toxicology
    Bernhard Hennig
    Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, 200 W P Garrigus Building, Lexington, KY 40546 0215, USA
    J Nutr Biochem 15:194-5. 2004
    ..Nutrition may provide the most sensible means to develop primary prevention strategies of diseases associated with environmental toxicology...
  75. pmc Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway
    Elizabeth Oesterling
    Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536 0200, USA
    Toxicol Appl Pharmacol 232:309-16. 2008
    ....
  76. pmc Gene expression profile in interleukin-4-stimulated human vascular endothelial cells
    Yong Woo Lee
    Department of Surgery Division of Neurosurgery, University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky 40536, USA
    Mol Med 10:19-27. 2004
    ..In addition, a better understanding of IL-4-induced vascular injury at the level of gene expression could lead to the identification of new therapeutic strategies for atherosclerosis...
  77. ncbi request reprint Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells
    Michal Toborek
    Department of Surgery, University of Kentucky Medical Center, Lexington 40536, USA
    Am J Clin Nutr 75:119-25. 2002
    ..However, the specific effects of fatty acids on inflammatory responses in endothelial cells are not fully understood...
  78. ncbi request reprint c-Src is the primary signaling mediator of polychlorinated biphenyl-induced interleukin-8 expression in a human microvascular endothelial cell line
    Sung Yong Eum
    Molecular Neuroscience and Vascular Biology Laboratory, Department of Surgery and College of Agriculture, University of Kentucky, 900 South Limestone, Lexington, KY 40536, USA
    Toxicol Sci 92:311-20. 2006
    ..These stimulatory effects of dominant-positive c-src were abrogated by mutagenesis of AP-1- and NF-kappaB-binding sites in the IL-8 promoter...
  79. ncbi request reprint Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver "stem-like" cells
    Lenka Umannová
    Laboratory of Cytokinetics, Institute of Biophysics, 62165 Brno, Czech Republic
    Toxicol Sci 99:79-89. 2007
    ....
  80. ncbi request reprint Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells
    Yong Woo Lee
    Department of Surgery, University of Kentucky Medical Center, Lexington 40536, USA
    Am J Physiol Heart Circ Physiol 284:H185-92. 2003
    ..These results demonstrate that IL-4-dependent MCP-1 induction in HUVEC is mediated by redox-regulated STAT1 activation...
  81. ncbi request reprint Methamphetamine-induced TNF-alpha gene expression and activation of AP-1 in discrete regions of mouse brain: potential role of reactive oxygen intermediates and lipid peroxidation
    Govinder Flora
    Departments of Surgery, University of Kentucky, Lexington 40536, USA
    Neuromolecular Med 2:71-85. 2002
    ..Furthermore, these data provide evidence for the role of oxidative stress in the neurotoxic effects of METH...
  82. ncbi request reprint Apoptosis of spinal cord neurons by preventing depletion nicotine attenuates arachidonic acid-induced of neurotrophic factors
    Rosario Garrido
    Department of Surgery, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA
    J Neurotrauma 20:1201-13. 2003
    ..These results suggest that arachidonic acid can induce apoptosis of spinal cord neurons by depletion of neurotrophic factors and that nicotine can protect against these effects through the nAChRalpha7-mediated pathway...
  83. ncbi request reprint Nicotine upregulates nerve growth factor expression and prevents apoptosis of cultured spinal cord neurons
    Rosario Garrido
    Department of Surgery, University of Kentucky Medical Center, 800 Rose Street, Lexington, KY 40536, USA
    Neurosci Res 47:349-55. 2003
    ..The present results indicate that increased expression of NGF may be an important element of the neuroprotective effects of nicotine in injured spinal cord neurons...