Research Topics
| SEAN P HENNESSYSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Quality of Medicaid and Medicare data obtained through Centers for Medicare and Medicaid Services (CMS)Sean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
Med Care 45:1216-20. 2007..The Centers for Medicare and Medicaid Services (CMS) now make data from the Medicaid and Medicare programs available for research. Prior research has identified important issues in Medicaid data obtained from a commercial vendor...
Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measuresSean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Clin Epidemiol 60:911-8. 2007..A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis...- Effectiveness of a two-part educational intervention to improve hypertension control: a cluster-randomized trialSean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Pharmacotherapy 26:1342-7. 2006..To measure the effectiveness of a multifaceted educational intervention to improve ambulatory hypertension control... - Use of health care databases in pharmacoepidemiologySean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, 19104 6021, USA
Basic Clin Pharmacol Toxicol 98:311-3. 2006.... - Comparative cardiac safety of low-dose thioridazine and low-dose haloperidolSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Br J Clin Pharmacol 58:81-7. 2004..To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol... - Retrospective drug utilization review, prescribing errors, and clinical outcomesSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
JAMA 290:1494-9. 2003..However, it has not been shown to improve clinical outcomes or reduce the rate of potential prescribing errors, known as "exceptions.".. - Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative dataSean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
BMJ 325:1070. 2002..To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls... - Risk of venous thromboembolism from oral contraceptives containing gestodene and desogestrel versus levonorgestrel: a meta-analysis and formal sensitivity analysisS Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Contraception 64:125-33. 2001..In the absence of a definitive answer, this apparent increased risk, together with its uncertainty and small magnitude and its important consequences, should be considered when selecting an OC for a given woman... - Descriptive analyses of the integrity of a US Medicaid claims databaseSean Hennessy
Center for Clinical Epidemiology, Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 12:103-11. 2003..To examine the integrity of six Medicaid databases for use in pharmacoepidemiology research... - Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims dataSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 19:555-62. 2010..This study examined the positive predictive value (PPV) of hospitalization and emergency department encounter diagnoses in identifying SD/VA events originating in the outpatient setting... - Potential limitations of electronic database studies of prescription non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) and risk of myocardial infarction (MI)Leonard Ilkhanoff
Department of Medicine, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 14:513-22. 2005..Further studies-preferably randomized trials-are needed to address the risk-benefit ratio of NANSAID use... - Diagnostic codes for sudden cardiac death and ventricular arrhythmia functioned poorly to identify outpatient events in EPIC's General Practice Research DatabaseSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 17:1131-6. 2008.... - Instantaneous preference was a stronger instrumental variable than 3- and 6-month prescribing preference for NSAIDsSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Epidemiol 61:1285-8. 2008..We sought to compare the correlations between different IV measures with exposure... - Cisapride and ventricular arrhythmiaSean Hennessy
Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Br J Clin Pharmacol 66:375-85. 2008..We aimed to examine the association between cisapride and ventricular arrhythmia, and examine the relationship to dose and CYP3A4 inhibitors... 
Increased risk of digoxin toxicity following hospitalizationKevin Haynes
Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 18:28-35. 2009..The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin...- Patient reported receipt of medication instructions for warfarin is associated with reduced risk of serious bleeding eventsJoshua P Metlay
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
J Gen Intern Med 23:1589-94. 2008..Adverse drug events are an important cause of preventable hospitalizations... - Antidiabetic action of bezafibrate in a large observational databaseJames H Flory
1Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Diabetes Care 32:547-51. 2009..The purpose of this study was to test the hypothesis that bezafibrate, an approved fibrate, can prevent or delay type 2 diabetes... - Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibioticsBrian L Strom
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
N Engl J Med 349:1628-35. 2003..The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics... - Fibrate/Statin initiation in warfarin users and gastrointestinal bleeding riskHedi Schelleman
Center for Clinical Epidemiology and Biostatistics and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, USA
Am J Med 123:151-7. 2010..To evaluate whether initiation of a fibrate or statin increases the risk of hospitalization for gastrointestinal bleeding in warfarin users... - Hospitalization costs associated with warfarin-related bleeding events among older community-dwelling adultsMichelle M Kim
Department of Health Care Management, Wharton School of Business, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 19:731-6. 2010.... - Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID--warfarin co-prescribing as a test caseBrian L Strom
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Pennsylvania 19104 6021, USA
J Am Med Inform Assoc 17:411-5. 2010..Studies that have looked at the effectiveness of computerized decision support systems to prevent drug-drug interactions have reported modest results because of low response by the providers to the automated alerts... - Cardiovascular safety of ADHD medications: rationale for and design of an investigator-initiated observational studySean Hennessy
Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 19:934-41. 2010.... - Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trialBrian L Strom
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Arch Intern Med 170:1578-83. 2010..The effectiveness of computerized physician order entry (CPOE) systems has been modest, largely because clinicians frequently override electronic alerts... - Exogenous estrogen does not attenuate the association between rofecoxib and myocardial infarction in perimenopausal womenKelly C Wade
Department of Pediatrics, Children s Hospital of Philadelphia Newborn Care, Pennsylvania Hospital, 800 Spruce St, Philadelphia, PA 19107, USA
J Cardiovasc Pharmacol 57:194-200. 2011..19; 95% CI, 0.91–1.57). Although estrogen use was associated with a lower risk of MI, it did not seem to attenuate the association between rofecoxib and MI... - Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug eventsCharles E Leonard
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
J Clin Epidemiol 61:561-71. 2008..We sought to examine the validity of specific hospital discharge codes in identifying drug toxicity precipitating hospitalization, among elderly users of high-risk medications... - Validity and comparison of two measures of days supply in Medicaid claims dataRobert Gross
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 17:1029-32. 2008..The two measures should yield the same duration, but if not, the preferred method is unknown... - Chronic statin therapy and the risk of colorectal cancerYu Xiao Yang
Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 17:869-76. 2008..We sought to clarify whether long-term statin therapy has a chemopreventive effect on the risk of colorectal cancer (CRC) in a large, population-representative cohort... - Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patientsYu Xiao Yang
Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
Gastroenterology 127:1044-50. 2004..We aimed to determine whether insulin therapy might increase the risk of colorectal cancer among type 2 diabetes mellitus patients... - Medication safety in older adults: home-based practice patternsJoshua P Metlay
Penn Program for the Reduction in Medication Errors, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania 19104, USA
J Am Geriatr Soc 53:976-82. 2005..To identify the current state of medication-taking practices of community-dwelling older adults on high-risk medications... - Type 2 diabetes mellitus and the risk of colorectal cancerYu Xiao Yang
Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Clin Gastroenterol Hepatol 3:587-94. 2005..However, epidemiologic evidence for this association is inconclusive. We conducted a population-based study to clarify this association... - Is there cross-reactivity between penicillins and cephalosporins?Andrea J Apter
Division of Pulmonary, Allergy Critical Care Medicine, Department of Medicine, Philadelphia, PA, USA
Am J Med 119:354.e11-9. 2006..We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions... - Enhancement of medication recall using medication pictures and lists in telephone interviewsStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
Pharmacoepidemiol Drug Saf 12:1-8. 2003..To determine the effect of reading medication lists and providing medication pictures on recall of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) during telephone interviews in a case-control study... - Natural supplements for H1N1 influenza: retrospective observational infodemiology study of information and search activity on the InternetShawndra Hill
Operations and Information Management, The Wharton School, University of Pennsylvania, 3730 Walnut Street, Philadelphia, PA 19104, USA
J Med Internet Res 13:e36. 2011..As the incidence of H1N1 increases, the lay public may turn to the Internet for information about natural supplements for prevention and treatment... - Chronic proton pump inhibitor therapy and the risk of colorectal cancerYu Xiao Yang
Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
Gastroenterology 133:748-54. 2007.... - Parenteral ketorolac and risk of myocardial infarctionStephen E Kimmel
Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Pharmacoepidemiol Drug Saf 11:113-9. 2002..To examine the effects of ketorolac, a non-aspirin non-steroidal anti-inflammatory drug (NANSAID) with antiplatelet properties, on the risk of in-hospital myocardial infarction (MI)... - Adverse events associated with prolonged antibiotic useSharon B Meropol
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:523-32. 2008.... - Effectiveness of an information technology intervention to improve prophylactic antibacterial use in the postoperative periodKevin Haynes
Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Am Med Inform Assoc 18:164-8. 2011..Electronic order sets have shown promise as a means of integrating guideline information with electronic order entry systems and facilitating safer, more effective care... - The ineffectiveness of retrospective drug utilization reviewSean Hennessy
Center for Clinical Epidemiology and Biostatistics, Center for Education and Research on Therapeutics, University of Pennsylvania, USA
LDI Issue Brief 9:1-4. 2003..This Issue Brief summarizes a landmark study that suggests that retrospective DUR has had no measurable effects on outpatient drug use or clinical outcomes in the Medicaid program... - Represcription of penicillin after allergic-like eventsAndrea J Apter
Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA
J Allergy Clin Immunol 113:764-70. 2004..72%). Represcription of penicillin to such patients is more frequent than anticipated... - Epidemiologic studies of adverse effects of anti-retroviral drugs: how well is statistical power reportedScott D Halpern
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Pharmacoepidemiol Drug Saf 14:155-61. 2005..Future research is needed to determine whether the observed paucity of industry-sponsored observational studies of anti-retroviral ADEs extends to other clinical areas, and if so, to identify the causes of this phenomenon... - Proton-pump inhibitor use and the risk for community-acquired pneumoniaMonika Sarkar
University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
Ann Intern Med 149:391-8. 2008..Recent studies suggest that proton-pump inhibitors (PPIs) may increase the risk for community-acquired pneumonia (CAP)... - On the estimation and use of propensity scores in case-control and case-cohort studiesRoger Månsson
Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
Am J Epidemiol 166:332-9. 2007..Researchers considering using propensity scores in case-control or case-cohort studies should consider the potential for artifactual effect modification and their reduced ability to control for potential confounding factors... - PDUFA reauthorization--drug safety's golden moment of opportunity?Sean Hennessy
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
N Engl J Med 356:1703-4. 2007
Research Grants
- RISK FACTORS FOR PHENYTOIN TOXICITYSean Hennessy; Fiscal Year: 2005..abstract_text> ..