SEAN P HENNESSY

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Quality of Medicaid and Medicare data obtained through Centers for Medicare and Medicaid Services (CMS)
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Med Care 45:1216-20. 2007
  2. pmc Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Epidemiol 60:911-8. 2007
  3. ncbi request reprint Effectiveness of a two-part educational intervention to improve hypertension control: a cluster-randomized trial
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pharmacotherapy 26:1342-7. 2006
  4. ncbi request reprint Use of health care databases in pharmacoepidemiology
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, 19104 6021, USA
    Basic Clin Pharmacol Toxicol 98:311-3. 2006
  5. pmc Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Br J Clin Pharmacol 58:81-7. 2004
  6. ncbi request reprint Retrospective drug utilization review, prescribing errors, and clinical outcomes
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    JAMA 290:1494-9. 2003
  7. pmc Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    BMJ 325:1070. 2002
  8. ncbi request reprint Risk of venous thromboembolism from oral contraceptives containing gestodene and desogestrel versus levonorgestrel: a meta-analysis and formal sensitivity analysis
    S Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Contraception 64:125-33. 2001
  9. ncbi request reprint Descriptive analyses of the integrity of a US Medicaid claims database
    Sean Hennessy
    Center for Clinical Epidemiology, Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 12:103-11. 2003
  10. pmc Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 19:555-62. 2010

Research Grants

  1. RISK FACTORS FOR PHENYTOIN TOXICITY
    Sean Hennessy; Fiscal Year: 2005

Detail Information

Publications43

  1. ncbi request reprint Quality of Medicaid and Medicare data obtained through Centers for Medicare and Medicaid Services (CMS)
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Med Care 45:1216-20. 2007
    ..The Centers for Medicare and Medicaid Services (CMS) now make data from the Medicaid and Medicare programs available for research. Prior research has identified important issues in Medicaid data obtained from a commercial vendor...
  2. pmc Observed association between antidepressant use and pneumonia risk was confounded by comorbidity measures
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Clin Epidemiol 60:911-8. 2007
    ..A prior study suggested that antidepressants might increase the risk of hospitalization for pneumonia in the elderly. This study sought to confirm or refute this hypothesis...
  3. ncbi request reprint Effectiveness of a two-part educational intervention to improve hypertension control: a cluster-randomized trial
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pharmacotherapy 26:1342-7. 2006
    ..To measure the effectiveness of a multifaceted educational intervention to improve ambulatory hypertension control...
  4. ncbi request reprint Use of health care databases in pharmacoepidemiology
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, 19104 6021, USA
    Basic Clin Pharmacol Toxicol 98:311-3. 2006
    ....
  5. pmc Comparative cardiac safety of low-dose thioridazine and low-dose haloperidol
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research in Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Br J Clin Pharmacol 58:81-7. 2004
    ..To compare the rate of ventricular arrhythmia, sudden death and unexplained or unattended death among users of thioridazine and haloperidol...
  6. ncbi request reprint Retrospective drug utilization review, prescribing errors, and clinical outcomes
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    JAMA 290:1494-9. 2003
    ..However, it has not been shown to improve clinical outcomes or reduce the rate of potential prescribing errors, known as "exceptions."..
  7. pmc Cardiac arrest and ventricular arrhythmia in patients taking antipsychotic drugs: cohort study using administrative data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    BMJ 325:1070. 2002
    ..To examine the rates of cardiac arrest and ventricular arrhythmia in patients with treated schizophrenia and in non-schizophrenic controls...
  8. ncbi request reprint Risk of venous thromboembolism from oral contraceptives containing gestodene and desogestrel versus levonorgestrel: a meta-analysis and formal sensitivity analysis
    S Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Contraception 64:125-33. 2001
    ..In the absence of a definitive answer, this apparent increased risk, together with its uncertainty and small magnitude and its important consequences, should be considered when selecting an OC for a given woman...
  9. ncbi request reprint Descriptive analyses of the integrity of a US Medicaid claims database
    Sean Hennessy
    Center for Clinical Epidemiology, Department of Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 12:103-11. 2003
    ..To examine the integrity of six Medicaid databases for use in pharmacoepidemiology research...
  10. pmc Validation of diagnostic codes for outpatient-originating sudden cardiac death and ventricular arrhythmia in Medicaid and Medicare claims data
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 19:555-62. 2010
    ..This study examined the positive predictive value (PPV) of hospitalization and emergency department encounter diagnoses in identifying SD/VA events originating in the outpatient setting...
  11. ncbi request reprint Potential limitations of electronic database studies of prescription non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) and risk of myocardial infarction (MI)
    Leonard Ilkhanoff
    Department of Medicine, Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:513-22. 2005
    ..In the 'Confounding Assessment Analysis #2,' we also adjusted for body mass index (BMI) and physical activity. In the 'Interaction Assessment Analysis,' we stratified on aspirin use and repeated the latter analysis...
  12. pmc Diagnostic codes for sudden cardiac death and ventricular arrhythmia functioned poorly to identify outpatient events in EPIC's General Practice Research Database
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 17:1131-6. 2008
    ....
  13. pmc Instantaneous preference was a stronger instrumental variable than 3- and 6-month prescribing preference for NSAIDs
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:1285-8. 2008
    ..We sought to compare the correlations between different IV measures with exposure...
  14. pmc Cisapride and ventricular arrhythmia
    Sean Hennessy
    Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Br J Clin Pharmacol 66:375-85. 2008
    ..We aimed to examine the association between cisapride and ventricular arrhythmia, and examine the relationship to dose and CYP3A4 inhibitors...
  15. doi request reprint Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
    ..The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin...
  16. pmc Patient reported receipt of medication instructions for warfarin is associated with reduced risk of serious bleeding events
    Joshua P Metlay
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Gen Intern Med 23:1589-94. 2008
    ..Adverse drug events are an important cause of preventable hospitalizations...
  17. pmc Antidiabetic action of bezafibrate in a large observational database
    James H Flory
    1Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 32:547-51. 2009
    ..The purpose of this study was to test the hypothesis that bezafibrate, an approved fibrate, can prevent or delay type 2 diabetes...
  18. ncbi request reprint Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics
    Brian L Strom
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    N Engl J Med 349:1628-35. 2003
    ..The safety of sulfonamide nonantibiotics is unclear in patients with prior allergic reactions to sulfonamide antibiotics...
  19. pmc Fibrate/Statin initiation in warfarin users and gastrointestinal bleeding risk
    Hedi Schelleman
    Center for Clinical Epidemiology and Biostatistics and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Med 123:151-7. 2010
    ..To evaluate whether initiation of a fibrate or statin increases the risk of hospitalization for gastrointestinal bleeding in warfarin users...
  20. doi request reprint Hospitalization costs associated with warfarin-related bleeding events among older community-dwelling adults
    Michelle M Kim
    Department of Health Care Management, Wharton School of Business, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 19:731-6. 2010
    ....
  21. pmc Randomized clinical trial of a customized electronic alert requiring an affirmative response compared to a control group receiving a commercial passive CPOE alert: NSAID--warfarin co-prescribing as a test case
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Pennsylvania 19104 6021, USA
    J Am Med Inform Assoc 17:411-5. 2010
    ..Studies that have looked at the effectiveness of computerized decision support systems to prevent drug-drug interactions have reported modest results because of low response by the providers to the automated alerts...
  22. doi request reprint Cardiovascular safety of ADHD medications: rationale for and design of an investigator-initiated observational study
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 19:934-41. 2010
    ....
  23. doi request reprint Unintended effects of a computerized physician order entry nearly hard-stop alert to prevent a drug interaction: a randomized controlled trial
    Brian L Strom
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Arch Intern Med 170:1578-83. 2010
    ..The effectiveness of computerized physician order entry (CPOE) systems has been modest, largely because clinicians frequently override electronic alerts...
  24. pmc Exogenous estrogen does not attenuate the association between rofecoxib and myocardial infarction in perimenopausal women
    Kelly C Wade
    Department of Pediatrics, Children s Hospital of Philadelphia Newborn Care, Pennsylvania Hospital, 800 Spruce St, Philadelphia, PA 19107, USA
    J Cardiovasc Pharmacol 57:194-200. 2011
    ..19; 95% CI, 0.91–1.57). Although estrogen use was associated with a lower risk of MI, it did not seem to attenuate the association between rofecoxib and MI...
  25. doi request reprint Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:561-71. 2008
    ..We sought to examine the validity of specific hospital discharge codes in identifying drug toxicity precipitating hospitalization, among elderly users of high-risk medications...
  26. doi request reprint Validity and comparison of two measures of days supply in Medicaid claims data
    Robert Gross
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 17:1029-32. 2008
    ..The two measures should yield the same duration, but if not, the preferred method is unknown...
  27. ncbi request reprint Chronic statin therapy and the risk of colorectal cancer
    Yu Xiao Yang
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 17:869-76. 2008
    ..We sought to clarify whether long-term statin therapy has a chemopreventive effect on the risk of colorectal cancer (CRC) in a large, population-representative cohort...
  28. ncbi request reprint Insulin therapy and colorectal cancer risk among type 2 diabetes mellitus patients
    Yu Xiao Yang
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia 19104 6021, USA
    Gastroenterology 127:1044-50. 2004
    ..We aimed to determine whether insulin therapy might increase the risk of colorectal cancer among type 2 diabetes mellitus patients...
  29. ncbi request reprint Medication safety in older adults: home-based practice patterns
    Joshua P Metlay
    Penn Program for the Reduction in Medication Errors, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 53:976-82. 2005
    ..To identify the current state of medication-taking practices of community-dwelling older adults on high-risk medications...
  30. ncbi request reprint Type 2 diabetes mellitus and the risk of colorectal cancer
    Yu Xiao Yang
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Clin Gastroenterol Hepatol 3:587-94. 2005
    ..However, epidemiologic evidence for this association is inconclusive. We conducted a population-based study to clarify this association...
  31. ncbi request reprint Is there cross-reactivity between penicillins and cephalosporins?
    Andrea J Apter
    Division of Pulmonary, Allergy Critical Care Medicine, Department of Medicine, Philadelphia, PA, USA
    Am J Med 119:354.e11-9. 2006
    ..We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions...
  32. ncbi request reprint Enhancement of medication recall using medication pictures and lists in telephone interviews
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics, University of Pennsylvania School of Medicine, 717 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 12:1-8. 2003
    ..To determine the effect of reading medication lists and providing medication pictures on recall of non-aspirin non-steroidal anti-inflammatory drugs (NANSAIDs) during telephone interviews in a case-control study...
  33. pmc Natural supplements for H1N1 influenza: retrospective observational infodemiology study of information and search activity on the Internet
    Shawndra Hill
    Operations and Information Management, The Wharton School, University of Pennsylvania, 3730 Walnut Street, Philadelphia, PA 19104, USA
    J Med Internet Res 13:e36. 2011
    ..As the incidence of H1N1 increases, the lay public may turn to the Internet for information about natural supplements for prevention and treatment...
  34. ncbi request reprint Chronic proton pump inhibitor therapy and the risk of colorectal cancer
    Yu Xiao Yang
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Gastroenterology 133:748-54. 2007
    ....
  35. ncbi request reprint Parenteral ketorolac and risk of myocardial infarction
    Stephen E Kimmel
    Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Pharmacoepidemiol Drug Saf 11:113-9. 2002
    ..To examine the effects of ketorolac, a non-aspirin non-steroidal anti-inflammatory drug (NANSAID) with antiplatelet properties, on the risk of in-hospital myocardial infarction (MI)...
  36. doi request reprint Adverse events associated with prolonged antibiotic use
    Sharon B Meropol
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:523-32. 2008
    ....
  37. pmc Effectiveness of an information technology intervention to improve prophylactic antibacterial use in the postoperative period
    Kevin Haynes
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Med Inform Assoc 18:164-8. 2011
    ..Electronic order sets have shown promise as a means of integrating guideline information with electronic order entry systems and facilitating safer, more effective care...
  38. ncbi request reprint The ineffectiveness of retrospective drug utilization review
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, Center for Education and Research on Therapeutics, University of Pennsylvania, USA
    LDI Issue Brief 9:1-4. 2003
    ..This Issue Brief summarizes a landmark study that suggests that retrospective DUR has had no measurable effects on outpatient drug use or clinical outcomes in the Medicaid program...
  39. ncbi request reprint Represcription of penicillin after allergic-like events
    Andrea J Apter
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 113:764-70. 2004
    ..We sought to determine the frequency of represcription of penicillin to individuals with penicillin allergy and the risk of a second reaction in those who had a previous reaction...
  40. ncbi request reprint Epidemiologic studies of adverse effects of anti-retroviral drugs: how well is statistical power reported
    Scott D Halpern
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 14:155-61. 2005
    ..To determine whether there is a difference in average statistical power between pharmacoepidemiologic studies of anti-retroviral adverse drug effects (ADEs) sponsored by for-profit versus non-profit organizations...
  41. ncbi request reprint Proton-pump inhibitor use and the risk for community-acquired pneumonia
    Monika Sarkar
    University of Pennsylvania, Philadelphia, Pennsylvania 19104 6021, USA
    Ann Intern Med 149:391-8. 2008
    ..Recent studies suggest that proton-pump inhibitors (PPIs) may increase the risk for community-acquired pneumonia (CAP)...
  42. ncbi request reprint On the estimation and use of propensity scores in case-control and case-cohort studies
    Roger Månsson
    Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Am J Epidemiol 166:332-9. 2007
    ..Researchers considering using propensity scores in case-control or case-cohort studies should consider the potential for artifactual effect modification and their reduced ability to control for potential confounding factors...
  43. ncbi request reprint PDUFA reauthorization--drug safety's golden moment of opportunity?
    Sean Hennessy
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 356:1703-4. 2007

Research Grants1

  1. RISK FACTORS FOR PHENYTOIN TOXICITY
    Sean Hennessy; Fiscal Year: 2005
    ..abstract_text> ..