P K Henke

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Renal artery aneurysms: diagnosis, management and outcomes
    P K Henke
    Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109 0329, USA
    Minerva Chir 58:305-11. 2003
  2. doi request reprint Procedure-specific venous thromboembolism prophylaxis: a paradigm from colectomy surgery
    Peter K Henke
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Surgery 152:528-34; discussion 534-6. 2012
  3. ncbi request reprint Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization
    Peter K Henke
    University of Michigan Health System, 1500 E Medical Center Drive, 2210 Taubman Health Care Center, Ann Arbor, MI 48109 0329 USA
    Thromb Haemost 95:272-81. 2006
  4. ncbi request reprint Clinical relevance of peripheral vascular occlusive disease in patients with rheumatoid arthritis and systemic lupus erythematosus
    Peter K Henke
    Section of Vascular Surgery and the Jobst Vascular Research Laboratory, Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA
    J Vasc Surg 38:111-5. 2003
  5. doi request reprint Contemporary management of acute limb ischemia: factors associated with amputation and in-hospital mortality
    Peter K Henke
    University of Michigan Health System, Cardiovascular Center, Ann Arbor, MI 48109 5867, USA
    Semin Vasc Surg 22:34-40. 2009
  6. doi request reprint Basic research by vascular surgeons: why it is important and how to keep it going
    Peter K Henke
    University of Michigan, Ann Arbor, MI, USA
    J Vasc Surg 47:882-5. 2008
  7. ncbi request reprint Plasmin and matrix metalloproteinase system in deep venous thrombosis resolution
    Peter K Henke
    Section of Vascular Surgery, Jobst Vascualr Research Laboratory, University of Michigan, Ann Arbor, MI 48109 0329, USA
    Vascular 15:366-71. 2007
  8. ncbi request reprint Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortality
    Peter K Henke
    Cardiovascular Division of Medicine, University of Michigan, Ann Arbor, MI, USA
    J Vasc Surg 39:357-65. 2004
  9. ncbi request reprint Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model
    Peter K Henke
    Section of Vascular Surgery, Jobst Vascular Research Laboratory, University of Michigan Medical School, Ann Arbor, Mich, USA
    Arterioscler Thromb Vasc Biol 24:1130-7. 2004
  10. ncbi request reprint The significant negative impact of in-hospital venous thromboembolism after cardiovascular procedures
    Peter Henke
    Section of Vascular Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Ann Vasc Surg 21:545-50. 2007

Collaborators

Detail Information

Publications88

  1. ncbi request reprint Renal artery aneurysms: diagnosis, management and outcomes
    P K Henke
    Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109 0329, USA
    Minerva Chir 58:305-11. 2003
    ..0 cm when hypertension present and RAA >1.5 to 2.0 cm when no hypertension present. Given the anatomic complexity of these lesions, little role for endovascular therapy is forecast...
  2. doi request reprint Procedure-specific venous thromboembolism prophylaxis: a paradigm from colectomy surgery
    Peter K Henke
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Surgery 152:528-34; discussion 534-6. 2012
    ..Colectomy patients are at high-risk for venous thromboembolism (VTE), but associated risk factors and best prophylaxis in this defined population are only generalized...
  3. ncbi request reprint Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularization
    Peter K Henke
    University of Michigan Health System, 1500 E Medical Center Drive, 2210 Taubman Health Care Center, Ann Arbor, MI 48109 0329 USA
    Thromb Haemost 95:272-81. 2006
    ..4-fold larger thrombi (P < .05). These data suggest a critical early role for PMN in post DVT vein wall remodeling...
  4. ncbi request reprint Clinical relevance of peripheral vascular occlusive disease in patients with rheumatoid arthritis and systemic lupus erythematosus
    Peter K Henke
    Section of Vascular Surgery and the Jobst Vascular Research Laboratory, Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA
    J Vasc Surg 38:111-5. 2003
    ..The present study was undertaken in an attempt to characterize patients with PVOD plus RD in terms of inflammatory serologic disorders, medications, and procedures, and their relation to limb salvage...
  5. doi request reprint Contemporary management of acute limb ischemia: factors associated with amputation and in-hospital mortality
    Peter K Henke
    University of Michigan Health System, Cardiovascular Center, Ann Arbor, MI 48109 5867, USA
    Semin Vasc Surg 22:34-40. 2009
    ..This article uses case reports to highlight critical issues that may arise during the course of diagnosis and treatment and describes clinical factors associated with morbidity and mortality in these patients...
  6. doi request reprint Basic research by vascular surgeons: why it is important and how to keep it going
    Peter K Henke
    University of Michigan, Ann Arbor, MI, USA
    J Vasc Surg 47:882-5. 2008
  7. ncbi request reprint Plasmin and matrix metalloproteinase system in deep venous thrombosis resolution
    Peter K Henke
    Section of Vascular Surgery, Jobst Vascualr Research Laboratory, University of Michigan, Ann Arbor, MI 48109 0329, USA
    Vascular 15:366-71. 2007
    ..Ultimately, better knowledge of these natural thrombolytic systems may allow local, directed, and specific acceleration of DVT resolution and decreased vein wall damage...
  8. ncbi request reprint Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortality
    Peter K Henke
    Cardiovascular Division of Medicine, University of Michigan, Ann Arbor, MI, USA
    J Vasc Surg 39:357-65. 2004
    ..Whether statin drugs and ACE inhibitors confer an improvement in graft patency, limb salvage, and operative mortality is unknown...
  9. ncbi request reprint Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model
    Peter K Henke
    Section of Vascular Surgery, Jobst Vascular Research Laboratory, University of Michigan Medical School, Ann Arbor, Mich, USA
    Arterioscler Thromb Vasc Biol 24:1130-7. 2004
    ..To determine the role of CXCR2, the receptor for cysteine-X-cysteine (CXC) chemokines, and its primary effector cell, the neutrophil (PMN), on deep venous thrombosis (DVT) resolution...
  10. ncbi request reprint The significant negative impact of in-hospital venous thromboembolism after cardiovascular procedures
    Peter Henke
    Section of Vascular Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA
    Ann Vasc Surg 21:545-50. 2007
    ..Process variables should be examined to identify practice patterns that might better prevent this complication...
  11. ncbi request reprint Proximate versus nonproximate risk factor associated primary deep venous thrombosis: clinical spectrum and outcomes
    Peter K Henke
    Section of Vascular Surgery, University of Michigan, School of Medicine, Ann Arbor, MI 48109, USA
    J Vasc Surg 45:998-1003; discussion 1003-4; quiz 1005-7. 2007
    ..This study compared clinical features and outcomes in patients who developed a primary DVT associated with a defined risk to those without any proximate risk factor...
  12. ncbi request reprint Popliteal artery aneurysms: tried, true, and new approaches to therapy
    Peter K Henke
    Department of Surgery, University of Michigan Health System, Ann Arbor, 48109 0329, USA
    Semin Vasc Surg 18:224-30. 2005
    ..This article delineates the current evaluation, preoperative planning, and surgical and endovascular approaches to this disease. With proper diagnosis and repair, excellent limb salvage and postoperative function has become the norm...
  13. ncbi request reprint Commentary on "The issue of spontaneous arteriovenous fistulae after superficial thrombophlebitis, endovenous ablations, and deep vein thrombosis: an unusual but predictable finding"
    Peter Henke
    Section of Vascular Surgery, University of Michigan, 2210D THCC, 1500 East Medical Center Drive, Ann Arbor, MI 48109 USA
    Perspect Vasc Surg Endovasc Ther 18:251-2. 2006
  14. pmc Osteomyelitis of the foot and toe in adults is a surgical disease: conservative management worsens lower extremity salvage
    Peter K Henke
    Section of Vascular Surgery, Department of Surgery, University of Michigan, School of Medicine, Ann Arbor, Michigan, USA
    Ann Surg 241:885-92; discussion 892-4. 2005
    ....
  15. ncbi request reprint Acute limb ischemia associated with type B aortic dissection: clinical relevance and therapy
    Peter K Henke
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich, USA
    Surgery 140:532-9; discussion 539-40. 2006
    ..The goal of the current study is to characterize the presentation, therapy, and outcomes of acute limb ischemia (ALI) associated with type B aortic dissection (AoD)...
  16. ncbi request reprint Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model
    Peter K Henke
    University of Michigan Health System, Ann Arbor, MI 48109, USA
    J Immunol 177:3388-97. 2006
    ..We conclude that an early CCR2-dependent Th1 lymphokine response predominates in normal DVT resolution, mediates this in part by MMP-9 activation, but is not solely dependent on IFN-gamma...
  17. ncbi request reprint Improving quality of care in vascular surgery: the tools are available now
    Peter K Henke
    University of Michigan Health System, 1500 E Medical Center Dr, 2210 Taubman Health Care Center, Ann Arbor, MI 48109 0329, USA
    Am J Surg 190:333-7. 2005
    ..It is this author's hope is that this overview will emphasize currently effective and underused therapies and stimulate further research into best practices for improving the quality of care for vascular surgery patients...
  18. ncbi request reprint Fibrotic injury after experimental deep vein thrombosis is determined by the mechanism of thrombogenesis
    Peter K Henke
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Thromb Haemost 98:1045-55. 2007
    ..Limited stasis, non-stasis thrombosis and non-thrombotic IVC occlusion showed a lesser inflammatory response. These data suggest both a static component and the thrombus directs vein wall injury via multiple mechanisms...
  19. pmc Renal artery aneurysms: a 35-year clinical experience with 252 aneurysms in 168 patients
    P K Henke
    Department of Surgery, Section of Vascular Surgery, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0329, USA
    Ann Surg 234:454-62; discussion 462-3. 2001
    ..To define the relevance of treating renal artery aneurysms (RAAs) surgically...
  20. doi request reprint What is the optimum perioperative drug therapy following lower-extremity vein bypass surgery?
    Peter Henke
    Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA
    Semin Vasc Surg 22:245-51. 2009
    ..We review the up to date use of medications with known vascular effects that may promote graft success, as well as decrease cardiovascular events in this high risk patient group...
  21. pmc Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution
    Peter K Henke
    CVC 5463, Ann Arbor, MI 48109, USA
    Arterioscler Thromb Vasc Biol 31:43-9. 2011
    ..Toll-like receptors (TLR) bridge innate immunity and host responses, including inflammation. Sterile inflammation such as a venous thrombus (Vt) may involve TLR signaling, including TLR9...
  22. ncbi request reprint Tissue loss, early primary graft occlusion, female gender, and a prohibitive failure rate of secondary infrainguinal arterial reconstruction
    Peter K Henke
    Department of Vascular Surgery, University of Michigan Medical School, 2210 Taubman Health Care Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 35:902-9. 2002
    ..This study tested the hypothesis that a subset of secondary infrainguinal arterial reconstructions show prohibitive failure rates...
  23. ncbi request reprint Relevance of basic laboratory and clinical research activities as part of the vascular surgery fellowship: an assessment by program directors and postfellowship surgeons
    Peter K Henke
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor 48109, USA
    J Vasc Surg 36:1083-91. 2002
    ....
  24. ncbi request reprint Interleukin-8 administration enhances venous thrombosis resolution in a rat model
    P K Henke
    Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Surg Res 99:84-91. 2001
    ....
  25. ncbi request reprint Approach to the patient with acute limb ischemia: diagnosis and therapeutic modalities
    Peter K Henke
    Section of Vascular Surgery, University of Michigan, 2210D THCC, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0329, USA
    Cardiol Clin 20:513-20. 2002
    ..g., GIIb/IIIa antagonists) and other anticoagulant agents must be better investigated before recommendations can be made. Save life over limb. Emergent guillotine amputation is sometimes required to save a patient's life...
  26. doi request reprint Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes
    Peter K Henke
    Department of Surgery, University of Michigan, USA
    Thromb Res 123:S72-8. 2009
    ..In this paper, we will review the evidence that venous thrombus resolution is an inflammatory process that is dependent on chemokines and leukocytes...
  27. doi request reprint A statewide consortium of surgical care: a longitudinal investigation of vascular operative procedures at 16 hospitals
    Peter K Henke
    Section of Vascular Surgery and Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Surgery 148:883-89; discussion 889-92. 2010
    ..Regional surgical quality improvement consortiums are becoming more common. Herein we have reported the effectiveness of a statewide consortium focusing on open vascular operative procedures...
  28. ncbi request reprint Impact of chronic obstructive pulmonary disease on elective and emergency abdominal aortic aneurysm repair
    D A Axelrod
    Robert Wood Johnson Clinical Scholars Program, University of Michigan, Ann Arbor, 48109 0329, USA
    J Vasc Surg 33:72-6. 2001
    ..This study was undertaken to determine if COPD increases operative death, morbidity, intensive care unit (ICU) length of stay (LOS), and hospital LOS, after AAA repair...
  29. ncbi request reprint The effect of secondary operations on mortality following abdominal aortic aneurysm repair in the United States: 1988-2001
    Jonathan L Eliason
    Surgical Outcomes Research Team SORT, Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
    Vasc Endovascular Surg 39:465-72. 2005
    ....
  30. doi request reprint A contemporary comparison of aortofemoral bypass and aortoiliac stenting in the treatment of aortoiliac occlusive disease
    Christopher R Burke
    Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA
    Ann Vasc Surg 24:4-13. 2010
    ..The objective of the current study was to determine the effect of these trends on treatment outcomes in a contemporary single-institution experience with AIOD...
  31. pmc Vein wall re-endothelialization after deep vein thrombosis is improved with low-molecular-weight heparin
    Daria K Moaveni
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor 48109, USA
    J Vasc Surg 47:616-24. 2008
    ..The purpose of this study was to quantify re-endothelialization after DVT and determine if low-molecular-weight heparin (LMWH) therapy affects this process...
  32. ncbi request reprint Efficacy and durability of autogenous saphenous vein conduits for lower extremity arterial reconstructions in preadolescent children
    J D Cardneau
    Department of Surgery, Sections of Vascular Surgery and Pediatric Surgery, University of Michigan Medical School, USA
    J Vasc Surg 34:34-40. 2001
    ..The reconstructions with 15 reversed and one in situ vein grafts included iliofemoral (11), femorofemoral (1), aortofemoral (1), femoropopliteal (1), popliteal-popliteal (1), and popliteal-posterior tibial (1) arterial bypass grafts...
  33. pmc A national and single institutional experience in the contemporary treatment of acute lower extremity ischemia
    Jonathan L Eliason
    Department of Surgery, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Ann Surg 238:382-9; discussion 389-90. 2003
    ..To determine the contemporary clinical relevance of acute lower extremity ischemia and the factors associated with amputation and in-hospital mortality...
  34. ncbi request reprint Outcome of surgical and endoluminal intervention for infrainguinal bypass anastomotic strictures
    Matthew J Eagleton
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, 48109, USA
    Vasc Endovascular Surg 40:11-22. 2006
    ..Open surgical repair, compared to PTA, provides improved graft function as evident by fewer subsequent interventions required to maintain graft patency...
  35. ncbi request reprint The treatment of acute embolic lower limb ischemia
    Peter K Henke
    Section of Vascular Surgery, Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
    Adv Surg 38:281-91. 2004
  36. ncbi request reprint P-selectin inhibition decreases post-thrombotic vein wall fibrosis in a rat model
    Porama Thanaporn
    Section of Vascular Surgery, Department of Surgery, Jobst Vascular Laboratory and Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Surgery 134:365-71. 2003
    ..This study tested the hypothesis that P-selectin inhibition would decrease post-thrombotic vein wall fibrosis and associated profibrotic mediators...
  37. ncbi request reprint Factors associated with recurrent venous thromboembolism in patients with malignant disease
    Jules Lin
    Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, USA
    J Vasc Surg 37:976-83. 2003
    ..This study was undertaken to assess factors associated with increased risk for recurrent VTE...
  38. ncbi request reprint Surgical treatment of intact thoracoabdominal aortic aneurysms in the United States: hospital and surgeon volume-related outcomes
    John A Cowan
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 37:1169-74. 2003
    ..The primary outcome measure was in-hospital postoperative mortality. Secondary outcome measures included length of stay, and cardiac, pulmonary, and renal complications. Adjusted and unadjusted analyses were conducted...
  39. ncbi request reprint Hospital volume-related differences in aorto-bifemoral bypass operative mortality in the United States
    Justin B Dimick
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, USA
    J Vasc Surg 37:970-5. 2003
    ..However, short-term outcome for complex surgical procedures is not uniform across medical centers. The objective of the current study was to define the relationship of hospital volume to operative mortality after AFB...
  40. ncbi request reprint Risk factors and clinical impact of postoperative symptomatic venous thromboembolism
    Chethan Gangireddy
    University of Michigan School of Medicine Section of Vascular Surgery, Ann Arbor, MI, USA
    J Vasc Surg 45:335-341; discussion 341-2. 2007
    ..This study evaluated prospective perioperative demographic and clinical variables associated with occurrence of postoperative symptomatic VTE...
  41. pmc Vein wall remodeling after deep vein thrombosis: differential effects of low molecular weight heparin and doxycycline
    Vikram Sood
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Ann Vasc Surg 24:233-41. 2010
    ..This study sought to determine the effect of exogenous MMP inhibition and its potential attenuation of early vein wall injury...
  42. ncbi request reprint Operative mortality rate for elective abdominal aortic aneurysm repair is not increased by the presence of a previous or concurrent thoracic or thoracoabdominal aortic dissection
    Rahul J Anand
    Section of Vascular Surgery, Department of Surgery, University of Michigan Hospital, Ann Arbor, MI 48109, USA
    J Vasc Surg 36:690-5. 2002
    ..The objective of this study was to determine the likelihood of mortality after abdominal aortic aneurysm (AAA) repair in patients with thoracic or thoracoabdominal aortic dissection...
  43. ncbi request reprint Common celiacomesenteric trunk: aneurysmal and occlusive disease
    Gorav Ailawadi
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Vasc Surg 40:1040-3. 2004
    ....
  44. pmc Plasmin inhibition increases MMP-9 activity and decreases vein wall stiffness during venous thrombosis resolution
    Nicholas A Dewyer
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    J Surg Res 142:357-63. 2007
    ..This study tested the hypothesis that pharmacological inhibition of the plasmin system would impair DVT resolution and worsen vein wall damage...
  45. ncbi request reprint Vein wall remodeling after deep vein thrombosis involves matrix metalloproteinases and late fibrosis in a mouse model
    Kristopher B Deatrick
    Jobst Vascular Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Vasc Surg 42:140-8. 2005
    ..This study investigated the expression of proteases and collagen involved in early vein wall remodeling...
  46. ncbi request reprint Southern Association for Vascular Surgery William J. von Leibig Award. Inflammation and intimal hyperplasia associated with experimental pulmonary embolism
    Matthew J Eagleton
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, University of Michigan Health System
    J Vasc Surg 36:581-8. 2002
    ....
  47. ncbi request reprint Computed tomographic venography is specific but not sensitive for diagnosis of acute lower-extremity deep venous thrombosis in patients with suspected pulmonary embolus
    D A Peterson
    Department of Surgery, University of Michigan Health System, Ann Arbor 48109-0329, USA
    J Vasc Surg 34:798-804. 2001
    ..Additionally, CTV is more costly than US scanning. Because of the lower sensitivity rate and positive predictive value and the increased cost of CTV, US remains the screening study of choice in cases of suspected acute LE-DVT...
  48. doi request reprint Urokinase plasminogen activator independent early experimental thrombus resolution: MMP2 as an alternative mechanism
    Vikram Sood
    Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Thromb Haemost 104:1174-83. 2010
    ..MMP2-dependent thrombolysis is an important compensatory mechanism of venous thrombus resolution, possibly by collagen type IV metabolism, and may represent an exploitable therapeutic avenue...
  49. ncbi request reprint Diffusion of new technology in health care: the case of aorto-iliac occlusive disease
    Gilbert R Upchurch
    Surgical Outcomes Research Team SORT, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 0329, USA
    Surgery 136:812-8. 2004
    ..The objective of the current study was to characterize temporal trends in the treatment of aorto-iliac occlusive disease (AIOD) and the impact of the introduction of less invasive therapy on overall intervention rates...
  50. doi request reprint Aging is associated with impaired thrombus resolution in a mouse model of stasis induced thrombosis
    April P McDonald
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 0654 USA
    Thromb Res 125:72-8. 2010
    ..To evaluate the effects of aging on venous thrombosis...
  51. ncbi request reprint Deep vein thrombosis resolution is not accelerated with increased neovascularization
    Manu R Varma
    Department of Surgery, University of Michigan Medical School, Ann Arbor, USA
    J Vasc Surg 40:536-42. 2004
    ..Deep venous thrombosis (DVT) resolution involves fibrinolysis, neovascularization, and fibrosis. We hypothesized that promoting neovascularization would accelerate DVT resolution...
  52. doi request reprint Routine stent implantation vs. percutaneous transluminal angioplasty in femoropopliteal artery disease: a meta-analysis of randomized controlled trials
    Christos Kasapis
    Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI 48109 5853, USA
    Eur Heart J 30:44-55. 2009
    ..We performed a meta-analysis of randomized controlled trials comparing routine stenting (ST) with percutaneous transluminal angioplasty (PTA) for symptomatic superficial femoral-popliteal artery (SFPA) disease...
  53. ncbi request reprint Diffusion of new technology for the treatment of renovascular hypertension in the United States: surgical revascularization versus catheter-based therapy, 1988-2001
    Brian S Knipp
    Section of Vascular Surgery, Departmetn of Surgery, University of Michigan Medical Center, Ann Arbor, USA
    J Vasc Surg 40:717-23. 2004
    ..Trends in the management of renovascular hypertension were evaluated by using a representative national database to determine whether a shift in treatment technology and outcomes has occurred...
  54. ncbi request reprint Neutropenia impairs venous thrombosis resolution in the rat
    Manu R Varma
    Department of Surgery, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Vasc Surg 38:1090-8. 2003
    ..This study tests the hypothesis that neutrophils (PMN) are active participants in DVT resolution...
  55. ncbi request reprint Cellular IL-10 is more effective than viral IL-10 in decreasing venous thrombosis
    Daniel D Myers
    Department of Surgery, Section of Vascular Surgery, Jobst Vascular Laboratory, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Surg Res 112:168-74. 2003
    ..Only cIL-10, despite sharing an 84% amino acid sequence homology with vIL-10, decreases thrombosis through mechanisms yet to be determined...
  56. pmc High-resolution ultrasound speckle tracking may detect vascular mechanical wall changes in peripheral artery bypass vein grafts
    William F Weitzel
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5725, USA
    Ann Vasc Surg 23:201-6. 2009
    ..These results suggest the possibility of noninvasive detection of neointimal hyperplasia preceding anastomotic stenosis...
  57. pmc Microparticle surface protein are associated with experimental venous thrombosis: a preliminary study
    Newaj M Abdullah
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Appl Thromb Hemost 15:201-8. 2009
    ..Further studies are needed to confirm the mechanistic role of these proteins in the pathogenesis of venous thrombosis...
  58. ncbi request reprint Predictors of severe morbidity and death after elective abdominal aortic aneurysmectomy in patients with chronic obstructive pulmonary disease
    Gilbert R Upchurch
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, 1500 E Medical Center Drive, Taubman Center 2210, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 37:594-9. 2003
    ..This study sought to identify risk factors associated with an unfavorable outcome after elective abdominal aortic aneurysm (AAA) repair in patients with chronic obstructive pulmonary disease (COPD)...
  59. pmc Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis
    Eduardo Ramacciotti
    Conrad Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical School Center, Ann Arbor, MI, USA
    Thromb Haemost 101:748-54. 2009
    ..Finally, TF bearing MPs showed a significant correlation to MP concentrations (R = 0.99). In conclusion, MPs appear to be an important element in venous thrombogenesis...
  60. doi request reprint A validation study of a retrospective venous thromboembolism risk scoring method
    Vinita Bahl
    Department of Clinical Information and Decision Support Services, Office of Clinical Affairs, University of Michigan, Ann Arbor, MI 48109 5485, USA
    Ann Surg 251:344-50. 2010
    ....
  61. doi request reprint The Michigan Surgical Quality Collaborative: a legacy of Shukri Khuri
    Darrell A Campbell
    Department of Surgery, University of Michigan, MI, USA
    Am J Surg 198:S49-55. 2009
    ..From the legacy of Shukri Khuri, we have successfully implemented a regional quality collaborative in Michigan, the Michigan Surgical Quality Collaborative (MSQC)...
  62. pmc P-selectin/ PSGL-1 inhibitors versus enoxaparin in the resolution of venous thrombosis: a meta-analysis
    Eduardo Ramacciotti
    Jobst Vascular Surgery Research Laboratory, Section of Vascular Surgery, Cardiovascular Center, University of Michigan, Ann Arbor, Michigan 48109, USA
    Thromb Res 125:e138-42. 2010
    ..P-selectin antagonism has been shown to decrease thrombogenesis and inflammation in animal models of deep venous thrombosis (DVT)...
  63. ncbi request reprint P-selectin inhibition enhances thrombus resolution and decreases vein wall fibrosis in a rat model
    Daniel D Myers
    Section of Vascular Surgery, Department of Surgery, Jobst Vascular Laboratory, Ann Arbor, MI 48109, USA
    J Vasc Surg 36:928-38. 2002
    ..The purpose of this study was to compare the efficacy of P-selectin inhibition with standard anticoagulant and thrombolytic therapy in a rodent model of established deep vein thrombosis (DVT)...
  64. ncbi request reprint Pediatric splanchnic arterial occlusive disease: clinical relevance and operative treatment
    Gilbert R Upchurch
    Section of Vascular Surgery, Department of Surgery, University of Michigan Hospital, 1500 E Medical Center Drive, 2210THCC, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 35:860-7. 2002
    ..Splanchnic arterial occlusive disease is rare in childhood. The purpose of this study was to review the clinical relevance and operative treatment of these lesions in a unique experience from a single institution...
  65. pmc Variation in death rate after abdominal aortic aneurysmectomy in the United States: impact of hospital volume, gender, and age
    Justin B Dimick
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, and Division of Vascular Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA
    Ann Surg 235:579-85. 2002
    ..To determine whether high-volume hospitals (HVHs) have lower in-hospital death rates after abdominal aortic aneurysm (AAA) repair compared with low-volume hospitals (LVHs)...
  66. doi request reprint Intravascular ultrasound-guided true lumen reentry device for recanalization of unilateral chronic total occlusion of iliac arteries: technique and follow-up
    Venkataramu N Krishnamurthy
    Section of Vascular and Interventional Radiology, Ann Arbor VA Health System, Ann Arbor, MI 48109 5030, USA
    Ann Vasc Surg 24:487-97. 2010
    ..This report describes the benefits of using true lumen reentry devices to improve the success and safety of conventional subintimal recanalization for revascularization of CTO of the iliac arteries...
  67. doi request reprint Mechanisms of venous thrombosis and resolution
    Thomas W Wakefield
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Arterioscler Thromb Vasc Biol 28:387-91. 2008
    ..Knowledge of molecular and immunologic mechanisms for venous thrombosis and its resolution should allow for the future development of targeted therapies...
  68. ncbi request reprint A negative carotid plaque area test is superior to other noninvasive atherosclerosis studies for reducing the likelihood of having underlying significant coronary artery disease
    Robert D Brook
    Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
    Arterioscler Thromb Vasc Biol 26:656-62. 2006
    ..Although each test may enhance risk stratification, their comparative abilities to screen for underlying coronary stenoses in individual patients is less established...
  69. ncbi request reprint Venous thromboembolism: regional differences in the nationwide inpatient sample, 1993 to 2000
    Mary C Proctor
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Vascular 12:374-80. 2004
    ..Regional diagnostic, treatment, and economic differences exist. The data are useful for the purposes of public health care planning and stimulating clinical trial questions...
  70. ncbi request reprint Uncomplicated carotid endarterectomy: factors contributing to blood pressure instability precluding safe early discharge
    Steven R Posner
    Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
    Vascular 12:278-84. 2004
    ..There were two strokes and no deaths. Patients undergoing CEA who are hemodynamically stable in the PACU appear to be reasonable candidates for same-day discharge and warrant further prospective study...
  71. ncbi request reprint Factors associated with outcome after interventional treatment of symptomatic iliac vein compression syndrome
    Brian S Knipp
    Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Vasc Surg 46:743-749. 2007
    ..Although therapy is often initially successful, factors associated with long-term outcome have been poorly defined. The purpose of this study was to identify factors associated with stent patency...
  72. ncbi request reprint Effect of increasing patient age on complication rates following intact abdominal aortic aneurysm repair in the United States
    Chandu Vemuri
    Surgical Outcomes Research Team, Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Surg Res 118:26-31. 2004
    ..This study was undertaken to determine the relation of patient age to complications following abdominal aortic aneurysm (AAA) repair in a population-based experience...
  73. ncbi request reprint D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis. A pilot study
    John E Rectenwald
    Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Thromb Haemost 94:1312-7. 2005
    ..However for clinical applicability, the sensitivity/specificity will need to be improved. These studies also suggest the importance of soluble P-selectin in assessing DVT in humans...
  74. ncbi request reprint The role of inflammation in early and late venous thrombosis: Are there clinical implications?
    Thomas W Wakefield
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
    Semin Vasc Surg 18:118-29. 2005
    ....
  75. pmc Proteomics of microparticles after deep venous thrombosis
    Eduardo Ramacciotti
    Jobst Vascular Research Laboratory, Section of Vascular Surgery, Cardiovascular Center, Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Thromb Res 125:e269-74. 2010
    ..MP present diverse biological expressions that may be linked to a unique subset of proteins derived from their origin cells...
  76. ncbi request reprint Experimental pulmonary embolism: effects of the thrombus and attenuation of pulmonary artery injury by low-molecular-weight heparin
    John E Rectenwald
    Department of Surgery, Jobst Vascular Research Laboratory, Section of Vascular Surgery, University of Michigan, Ann Arbor, USA
    J Vasc Surg 43:800-8. 2006
    ..This study evaluated the effect of the thrombus and tested the hypothesis that thrombolytic, antiplatelet, and anticoagulant agents would decrease pulmonary injury...
  77. ncbi request reprint Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis
    Daniel D Myers
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, 48109 0654, USA
    J Vasc Surg 44:625-32. 2006
    ....
  78. ncbi request reprint Cost of routine screening for carotid and lower extremity occlusive disease in patients with abdominal aortic aneurysms
    David A Axelrod
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, 48109 0604, USA
    J Vasc Surg 35:754-8. 2002
    ..Furthermore, the cost-effectiveness of routine versus selective preoperative noninvasive examination of the carotid and lower extremity arterial beds has not been established in patients who undergo elective AAA repair...
  79. ncbi request reprint Pediatric renovascular hypertension: 132 primary and 30 secondary operations in 97 children
    James C Stanley
    Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
    J Vasc Surg 44:1219-28; discussion 1228-9. 2006
    ..This study was undertaken to characterize the contemporary surgical treatment of pediatric renovascular hypertension...
  80. ncbi request reprint Increased MMP-9 expression and activity by aortic smooth muscle cells after nitric oxide synthase inhibition is associated with increased nuclear factor-kappaB and activator protein-1 activity
    Brian S Knipp
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Ann Arbor, Michigan 48109 0329, USA
    J Surg Res 116:70-80. 2004
    ..To determine the mechanism underlying increased expression and activity of matrix metalloproteinase 9 (MMP-9) by rat aortic smooth muscle cells (RA-SMC) after inhibition of inducible nitric oxide synthase (iNOS)...
  81. ncbi request reprint Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation
    Daniel D Myers
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, 2Unit for Laboratory Animal Medicine and 3Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0654, USA
    Thromb Haemost 97:400-7. 2007
    ..01). This study is the first to demonstrate the effectiveness of oral P-selectin inhibition to modify venous thrombogenesis, increase vein lumen opening, and decrease inflammation in a large animal model...
  82. ncbi request reprint Decreased venous thrombosis with an oral inhibitor of P selectin
    Daniel D Myers
    Section of Vascular Surgery, Jobst Vascular Research Laboratories, Ann Arbor, Mich, USA
    J Vasc Surg 42:329-36. 2005
    ..This study evaluated the effects on thrombosis and circulating microparticle populations in this murine venous thrombosis model...
  83. doi request reprint Role of selectins and fibrinolysis in VTE
    Thomas W Wakefield
    Department of Surgery, Ann Arbor, MI, USA
    Thromb Res 123:S35-40. 2009
    ..In this review, we will address the role of selectins and fibrinolysis in the process of venous thrombogenesis...
  84. doi request reprint The electrolytic inferior vena cava model (EIM) to study thrombogenesis and thrombus resolution with continuous blood flow in the mouse
    Jose A Diaz
    Department of Surgery, Section of Vascular Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, North Campus Research Complex NCRC, 2800 Plymouth Road, B26, R251N, Ann Arbor, MI 48105 0654, USA
    Thromb Haemost 109:1158-69. 2013
    ..Thrombus resolution was demonstrated by all modalities utilised in this study...
  85. ncbi request reprint Iliorenal bypass: indications and outcomes following 41 reconstructions
    Vladimir Grigoryants
    Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Ann Vasc Surg 21:1-9. 2007
    ..Iliorenal bypass is an effective means of renal revascularization in patients not amenable to more conventional open or transluminal procedures...
  86. ncbi request reprint Endovascular treatment of abdominal aortic aneurysm is associated with a low incidence of deep venous thrombosis
    Matthew J Eagleton
    Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor 48109, USA
    J Vasc Surg 36:912-6. 2002
    ..Because aortic endograft placement requires prolonged femoral vessel instrumentation, it may be hypothesized that these patients are at increased risk for development of an acute DVT...
  87. doi request reprint Acute venous disease: venous thrombosis and venous trauma
    Mark H Meissner
    Department of Surgery, University of Washington School of Medicine, Seattle 98195, USA
    J Vasc Surg 46:25S-53S. 2007
    ..Venous injuries are similarly under-reported and the true incidence is unknown. Current recommendations include repair of injuries to the major proximal veins. If repair not safe or possible, ligation should be performed...
  88. ncbi request reprint L-selectin-mediated neutrophil recruitment in experimental rodent aneurysm formation
    Kevin K Hannawa
    Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, Mich, USA
    Circulation 112:241-7. 2005
    ..This investigation tested the hypothesis that L-selectin is important in experimental abdominal aortic aneurysm (AAA) formation in rodents...

Research Grants7

  1. Thrombus resolution is CXC chemokine dependent
    Peter Henke; Fiscal Year: 2006
    ..abstract_text> ..
  2. Vein wall remodeling after DVT is matrix metalloproteinase dependent
    Peter Henke; Fiscal Year: 2007
    ..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
  3. Vein wall remodeling after DVT is matrix metalloproteinase dependent
    Peter Henke; Fiscal Year: 2009
    ..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
  4. Vein Wall Fibrotic Injury After DVT is SLC-CCR7 Dependent
    Peter Henke; Fiscal Year: 2009
    ..The long term goal is to define a therapy to decrease post thrombotic syndrome, a common and morbid complication of deep vein thrombosis. ..
  5. Vein Wall Fibrotic Injury After DVT is SLC-CCR7 Dependent
    Peter K Henke; Fiscal Year: 2010
    ..The long term goal is to define a therapy to decrease post thrombotic syndrome, a common and morbid complication of deep vein thrombosis. ..