P K Henke


Affiliation: University of Michigan
Country: USA


  1. Henke P, Zamora Berridi G, Englesbe M, Cai S, Brooks L, McKeown E, et al. A case-cohort study of postoperative myocardial infarction: impact of anemia and cardioprotective medications. Surgery. 2014;156:1018-26, 1029 pubmed publisher
    ..This risk is decreased with preoperative use of acetylsalicylic acid and post MI β-blockade. Further study is warranted to explore the role of anemia and cardiac interventions after poMI. ..
  2. Krishnamurthy V, Munir K, Rectenwald J, Mansour A, Hans S, Eliason J, et al. Contemporary outcomes with percutaneous vascular interventions for peripheral critical limb ischemia in those with and without poly-vascular disease. Vasc Med. 2014;19:491-9 pubmed publisher
    ..This study also underscores that PAD patients still lag in cardioprotective medication use as compared with polyvascular patients. ..
  3. Obi A, Park Y, Bove P, Cuff R, Kazmers A, Gurm H, et al. The association of perioperative transfusion with 30-day morbidity and mortality in patients undergoing major vascular surgery. J Vasc Surg. 2015;61:1000-9.e1 pubmed publisher
    ..Given indeterminate causation, these data suggest the need for a prospective transfusion threshold study in vascular surgical patients. ..
  4. Ten Cate Hoek A, Henke P, Wakefield T. The post thrombotic syndrome: Ignore it and it will come back to bite you. Blood Rev. 2016;30:131-7 pubmed publisher
    ..The problem of PTS prevention is therefore clearly relevant to patients, doctors as well as policy makers. ..
  5. Jacobs B, Henke P. Evidence-Based Therapies for Pharmacologic Prevention and Treatment of Acute Deep Vein Thrombosis and Pulmonary Embolism. Surg Clin North Am. 2018;98:239-253 pubmed publisher
    ..Selected cases of iliofemoral deep vein thrombosis may be treated by pharmacomechanical thrombolysis, but more data are needed before this is standard of care. ..
  6. Obi A, Alvarez R, Reames B, Moote M, Thompson M, Wakefield T, et al. A prospective evaluation of standard versus battery-powered sequential compression devices in postsurgical patients. Am J Surg. 2015;209:675-81 pubmed publisher
    ..005). The dual venous thromboembolism prevention strategies of early mobilization and SCD utilization can be met with the appropriate equipment. ..
  7. Dewyer N, El Sayed O, Luke C, Elfline M, Kittan N, Allen R, et al. Divergent effects of Tlr9 deletion in experimental late venous thrombosis resolution and vein wall injury. Thromb Haemost. 2015;114:1028-37 pubmed publisher
    ..These findings provide insight into the Tlr9 MØ mechanisms of sterile inflammation in this disease process. ..
  8. Zarinsefat A, Henke P. Update in preoperative risk assessment in vascular surgery patients. J Vasc Surg. 2015;62:499-509 pubmed publisher
    ..We also review the most recent American Heart Association guideline changes, and suggest a pathway for risk stratification. ..
  9. El Sayed O, Dewyer N, Luke C, Elfline M, Laser A, Hogaboam C, et al. Intact Toll-like receptor 9 signaling in neutrophils modulates normal thrombogenesis in mice. J Vasc Surg. 2016;64:1450-1458.e1 pubmed publisher
    ..These data suggest that the thrombogenic model affects Tlr9 thrombogenic mechanisms and that functional Tlr9 signaling in PMNs, but not in platelets or NETs, is an important mechanism in early stasis experimental venous thrombogenesis. ..

More Information


  1. Gallagher K, Obi A, Elfline M, Hogikyan E, Luke C, Henke S, et al. Alterations in macrophage phenotypes in experimental venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2016;4:463-71 pubmed publisher
    ..Altering the M1/M2 macrophage balance may accelerate thrombus resolution and allow the development of translatable novel therapies to treat VT and to prevent post-thrombotic syndrome. ..
  2. Obi A, Andraska E, Kanthi Y, Kessinger C, Elfline M, Luke C, et al. Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. Thromb Haemost. 2017;117:339-348 pubmed publisher
    ..Endotoxaemia enhanced early VT occurs in a TLR-4 and ICAM-1 dependent fashion, and is potentiated by neutropenia. ICAM-1 and/or TLR-4 inhibition may be a unique strategy to prevent sepsis-associated VT. ..
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    Henke P, Varga A, De S, Deatrick C, Eliason J, Arenberg D, et al. Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model. Arterioscler Thromb Vasc Biol. 2004;24:1130-7 pubmed
    ..Normal DVT resolution involves CXCR2-mediated neovascularization, collagen turnover, and fibrinolysis, and it is probably primarily monocyte-dependent. ..
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    Henke P. Approach to the patient with acute limb ischemia: diagnosis and therapeutic modalities. Cardiol Clin. 2002;20:513-20 pubmed
    ..g., GIIb/IIIa antagonists) and other anticoagulant agents must be better investigated before recommendations can be made. Save life over limb. Emergent guillotine amputation is sometimes required to save a patient's life...
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    Henke P, Pearce C, Moaveni D, Moore A, Lynch E, Longo C, et al. Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. J Immunol. 2006;177:3388-97 pubmed
    ..We conclude that an early CCR2-dependent Th1 lymphokine response predominates in normal DVT resolution, mediates this in part by MMP-9 activation, but is not solely dependent on IFN-gamma. ..
  6. Henke P, Mitsuya M, Luke C, Elfline M, Baldwin J, Deatrick K, et al. Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution. Arterioscler Thromb Vasc Biol. 2011;31:43-9 pubmed publisher
    ..TLR9 signaling is integral for early and mid-Vt resolution through modulation of sterile inflammation, maintaining a TH1 milieu, and effects on the thrombosis pathway. ..