P K Henke

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. Gallagher K, Obi A, Elfline M, Hogikyan E, Luke C, Henke S, et al. Alterations in macrophage phenotypes in experimental venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2016;4:463-71 pubmed publisher
    ..Altering the M1/M2 macrophage balance may accelerate thrombus resolution and allow the development of translatable novel therapies to treat VT and to prevent post-thrombotic syndrome. ..
  2. Obi A, Andraska E, Kanthi Y, Kessinger C, Elfline M, Luke C, et al. Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. Thromb Haemost. 2017;117:339-348 pubmed publisher
    ..Endotoxaemia enhanced early VT occurs in a TLR-4 and ICAM-1 dependent fashion, and is potentiated by neutropenia. ICAM-1 and/or TLR-4 inhibition may be a unique strategy to prevent sepsis-associated VT. ..
  3. request reprint
    Henke P, Varga A, De S, Deatrick C, Eliason J, Arenberg D, et al. Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model. Arterioscler Thromb Vasc Biol. 2004;24:1130-7 pubmed
    ..Normal DVT resolution involves CXCR2-mediated neovascularization, collagen turnover, and fibrinolysis, and it is probably primarily monocyte-dependent. ..
  4. request reprint
    Henke P. Approach to the patient with acute limb ischemia: diagnosis and therapeutic modalities. Cardiol Clin. 2002;20:513-20 pubmed
    ..g., GIIb/IIIa antagonists) and other anticoagulant agents must be better investigated before recommendations can be made. Save life over limb. Emergent guillotine amputation is sometimes required to save a patient's life...
  5. request reprint
    Henke P, Pearce C, Moaveni D, Moore A, Lynch E, Longo C, et al. Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. J Immunol. 2006;177:3388-97 pubmed
    ..We conclude that an early CCR2-dependent Th1 lymphokine response predominates in normal DVT resolution, mediates this in part by MMP-9 activation, but is not solely dependent on IFN-gamma. ..
  6. Henke P, Mitsuya M, Luke C, Elfline M, Baldwin J, Deatrick K, et al. Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution. Arterioscler Thromb Vasc Biol. 2011;31:43-9 pubmed publisher
    ..TLR9 signaling is integral for early and mid-Vt resolution through modulation of sterile inflammation, maintaining a TH1 milieu, and effects on the thrombosis pathway. ..

Locale

Detail Information

Publications6

  1. Gallagher K, Obi A, Elfline M, Hogikyan E, Luke C, Henke S, et al. Alterations in macrophage phenotypes in experimental venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2016;4:463-71 pubmed publisher
    ..Altering the M1/M2 macrophage balance may accelerate thrombus resolution and allow the development of translatable novel therapies to treat VT and to prevent post-thrombotic syndrome. ..
  2. Obi A, Andraska E, Kanthi Y, Kessinger C, Elfline M, Luke C, et al. Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. Thromb Haemost. 2017;117:339-348 pubmed publisher
    ..Endotoxaemia enhanced early VT occurs in a TLR-4 and ICAM-1 dependent fashion, and is potentiated by neutropenia. ICAM-1 and/or TLR-4 inhibition may be a unique strategy to prevent sepsis-associated VT. ..
  3. request reprint
    Henke P, Varga A, De S, Deatrick C, Eliason J, Arenberg D, et al. Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse model. Arterioscler Thromb Vasc Biol. 2004;24:1130-7 pubmed
    ..Normal DVT resolution involves CXCR2-mediated neovascularization, collagen turnover, and fibrinolysis, and it is probably primarily monocyte-dependent. ..
  4. request reprint
    Henke P. Approach to the patient with acute limb ischemia: diagnosis and therapeutic modalities. Cardiol Clin. 2002;20:513-20 pubmed
    ..g., GIIb/IIIa antagonists) and other anticoagulant agents must be better investigated before recommendations can be made. Save life over limb. Emergent guillotine amputation is sometimes required to save a patient's life...
  5. request reprint
    Henke P, Pearce C, Moaveni D, Moore A, Lynch E, Longo C, et al. Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse model. J Immunol. 2006;177:3388-97 pubmed
    ..We conclude that an early CCR2-dependent Th1 lymphokine response predominates in normal DVT resolution, mediates this in part by MMP-9 activation, but is not solely dependent on IFN-gamma. ..
  6. Henke P, Mitsuya M, Luke C, Elfline M, Baldwin J, Deatrick K, et al. Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution. Arterioscler Thromb Vasc Biol. 2011;31:43-9 pubmed publisher
    ..TLR9 signaling is integral for early and mid-Vt resolution through modulation of sterile inflammation, maintaining a TH1 milieu, and effects on the thrombosis pathway. ..