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Genomes and Genes | P K HenkeSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Renal artery aneurysms: diagnosis, management and outcomesP K Henke
Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109 0329, USA
Minerva Chir 58:305-11. 2003..0 cm when hypertension present and RAA >1.5 to 2.0 cm when no hypertension present. Given the anatomic complexity of these lesions, little role for endovascular therapy is forecast...
Procedure-specific venous thromboembolism prophylaxis: a paradigm from colectomy surgeryPeter K Henke
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Surgery 152:528-34; discussion 534-6. 2012..Colectomy patients are at high-risk for venous thromboembolism (VTE), but associated risk factors and best prophylaxis in this defined population are only generalized...- Neutrophils modulate post-thrombotic vein wall remodeling but not thrombus neovascularizationPeter K Henke
University of Michigan Health System, 1500 E Medical Center Drive, 2210 Taubman Health Care Center, Ann Arbor, MI 48109 0329 USA
Thromb Haemost 95:272-81. 2006..4-fold larger thrombi (P < .05). These data suggest a critical early role for PMN in post DVT vein wall remodeling... - Popliteal artery aneurysms: tried, true, and new approaches to therapyPeter K Henke
Department of Surgery, University of Michigan Health System, Ann Arbor, 48109 0329, USA
Semin Vasc Surg 18:224-30. 2005..This article delineates the current evaluation, preoperative planning, and surgical and endovascular approaches to this disease. With proper diagnosis and repair, excellent limb salvage and postoperative function has become the norm... - Improving quality of care in vascular surgery: the tools are available nowPeter K Henke
University of Michigan Health System, 1500 E Medical Center Dr, 2210 Taubman Health Care Center, Ann Arbor, MI 48109 0329, USA
Am J Surg 190:333-7. 2005..It is this author's hope is that this overview will emphasize currently effective and underused therapies and stimulate further research into best practices for improving the quality of care for vascular surgery patients... 
Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolutionPeter K Henke
CVC 5463, Ann Arbor, MI 48109, USA
Arterioscler Thromb Vasc Biol 31:43-9. 2011..Toll-like receptors (TLR) bridge innate immunity and host responses, including inflammation. Sterile inflammation such as a venous thrombus (Vt) may involve TLR signaling, including TLR9...- Osteomyelitis of the foot and toe in adults is a surgical disease: conservative management worsens lower extremity salvagePeter K Henke
Section of Vascular Surgery, Department of Surgery, University of Michigan, School of Medicine, Ann Arbor, Michigan, USA
Ann Surg 241:885-92; discussion 892-4. 2005.... - Commentary on "The issue of spontaneous arteriovenous fistulae after superficial thrombophlebitis, endovenous ablations, and deep vein thrombosis: an unusual but predictable finding"Peter Henke
Section of Vascular Surgery, University of Michigan, 2210D THCC, 1500 East Medical Center Drive, Ann Arbor, MI 48109 USA
Perspect Vasc Surg Endovasc Ther 18:251-2. 2006 - Deep vein thrombosis resolution is modulated by monocyte CXCR2-mediated activity in a mouse modelPeter K Henke
Section of Vascular Surgery, Jobst Vascular Research Laboratory, University of Michigan Medical School, Ann Arbor, Mich, USA
Arterioscler Thromb Vasc Biol 24:1130-7. 2004..To determine the role of CXCR2, the receptor for cysteine-X-cysteine (CXC) chemokines, and its primary effector cell, the neutrophil (PMN), on deep venous thrombosis (DVT) resolution... - Patients undergoing infrainguinal bypass to treat atherosclerotic vascular disease are underprescribed cardioprotective medications: effect on graft patency, limb salvage, and mortalityPeter K Henke
Cardiovascular Division of Medicine, University of Michigan, Ann Arbor, MI, USA
J Vasc Surg 39:357-65. 2004..Whether statin drugs and ACE inhibitors confer an improvement in graft patency, limb salvage, and operative mortality is unknown... - Targeted deletion of CCR2 impairs deep vein thombosis resolution in a mouse modelPeter K Henke
University of Michigan Health System, Ann Arbor, MI 48109, USA
J Immunol 177:3388-97. 2006..We conclude that an early CCR2-dependent Th1 lymphokine response predominates in normal DVT resolution, mediates this in part by MMP-9 activation, but is not solely dependent on IFN-gamma... - Acute limb ischemia associated with type B aortic dissection: clinical relevance and therapyPeter K Henke
Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, Mich, USA
Surgery 140:532-9; discussion 539-40. 2006..The goal of the current study is to characterize the presentation, therapy, and outcomes of acute limb ischemia (ALI) associated with type B aortic dissection (AoD)... - Proximate versus nonproximate risk factor associated primary deep venous thrombosis: clinical spectrum and outcomesPeter K Henke
Section of Vascular Surgery, University of Michigan, School of Medicine, Ann Arbor, MI 48109, USA
J Vasc Surg 45:998-1003; discussion 1003-4; quiz 1005-7. 2007..This study compared clinical features and outcomes in patients who developed a primary DVT associated with a defined risk to those without any proximate risk factor... - The significant negative impact of in-hospital venous thromboembolism after cardiovascular proceduresPeter Henke
Section of Vascular Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA
Ann Vasc Surg 21:545-50. 2007..Process variables should be examined to identify practice patterns that might better prevent this complication... - Fibrotic injury after experimental deep vein thrombosis is determined by the mechanism of thrombogenesisPeter K Henke
Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
Thromb Haemost 98:1045-55. 2007..Limited stasis, non-stasis thrombosis and non-thrombotic IVC occlusion showed a lesser inflammatory response. These data suggest both a static component and the thrombus directs vein wall injury via multiple mechanisms... - Plasmin and matrix metalloproteinase system in deep venous thrombosis resolutionPeter K Henke
Section of Vascular Surgery, Jobst Vascualr Research Laboratory, University of Michigan, Ann Arbor, MI 48109 0329, USA
Vascular 15:366-71. 2007..Ultimately, better knowledge of these natural thrombolytic systems may allow local, directed, and specific acceleration of DVT resolution and decreased vein wall damage... - Contemporary management of acute limb ischemia: factors associated with amputation and in-hospital mortalityPeter K Henke
University of Michigan Health System, Cardiovascular Center, Ann Arbor, MI 48109 5867, USA
Semin Vasc Surg 22:34-40. 2009..This article uses case reports to highlight critical issues that may arise during the course of diagnosis and treatment and describes clinical factors associated with morbidity and mortality in these patients... - Thrombus resolution and vein wall injury: dependence on chemokines and leukocytesPeter K Henke
Department of Surgery, University of Michigan, USA
Thromb Res 123:S72-8. 2009..In this paper, we will review the evidence that venous thrombus resolution is an inflammatory process that is dependent on chemokines and leukocytes... - What is the optimum perioperative drug therapy following lower-extremity vein bypass surgery?Peter Henke
Section of Vascular Surgery, University of Michigan, Ann Arbor, MI, USA
Semin Vasc Surg 22:245-51. 2009..We review the up to date use of medications with known vascular effects that may promote graft success, as well as decrease cardiovascular events in this high risk patient group... - A statewide consortium of surgical care: a longitudinal investigation of vascular operative procedures at 16 hospitalsPeter K Henke
Section of Vascular Surgery and Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Surgery 148:883-89; discussion 889-92. 2010..Regional surgical quality improvement consortiums are becoming more common. Herein we have reported the effectiveness of a statewide consortium focusing on open vascular operative procedures... - Approach to the patient with acute limb ischemia: diagnosis and therapeutic modalitiesPeter K Henke
Section of Vascular Surgery, University of Michigan, 2210D THCC, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0329, USA
Cardiol Clin 20:513-20. 2002..g., GIIb/IIIa antagonists) and other anticoagulant agents must be better investigated before recommendations can be made. Save life over limb. Emergent guillotine amputation is sometimes required to save a patient's life... - Interleukin-8 administration enhances venous thrombosis resolution in a rat modelP K Henke
Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Surg Res 99:84-91. 2001.... - Relevance of basic laboratory and clinical research activities as part of the vascular surgery fellowship: an assessment by program directors and postfellowship surgeonsPeter K Henke
Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor 48109, USA
J Vasc Surg 36:1083-91. 2002.... - Basic research by vascular surgeons: why it is important and how to keep it goingPeter K Henke
University of Michigan, Ann Arbor, MI, USA
J Vasc Surg 47:882-5. 2008 - Renal artery aneurysms: a 35-year clinical experience with 252 aneurysms in 168 patientsP K Henke
Department of Surgery, Section of Vascular Surgery, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109 0329, USA
Ann Surg 234:454-62; discussion 462-3. 2001..To define the relevance of treating renal artery aneurysms (RAAs) surgically... - Tissue loss, early primary graft occlusion, female gender, and a prohibitive failure rate of secondary infrainguinal arterial reconstructionPeter K Henke
Department of Vascular Surgery, University of Michigan Medical School, 2210 Taubman Health Care Center, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0329, USA
J Vasc Surg 35:902-9. 2002..This study tested the hypothesis that a subset of secondary infrainguinal arterial reconstructions show prohibitive failure rates... - Clinical relevance of peripheral vascular occlusive disease in patients with rheumatoid arthritis and systemic lupus erythematosusPeter K Henke
Section of Vascular Surgery and the Jobst Vascular Research Laboratory, Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI, USA
J Vasc Surg 38:111-5. 2003..The present study was undertaken in an attempt to characterize patients with PVOD plus RD in terms of inflammatory serologic disorders, medications, and procedures, and their relation to limb salvage... - Impact of chronic obstructive pulmonary disease on elective and emergency abdominal aortic aneurysm repairD A Axelrod
Robert Wood Johnson Clinical Scholars Program, University of Michigan, Ann Arbor, 48109 0329, USA
J Vasc Surg 33:72-6. 2001..This study was undertaken to determine if COPD increases operative death, morbidity, intensive care unit (ICU) length of stay (LOS), and hospital LOS, after AAA repair... - A contemporary comparison of aortofemoral bypass and aortoiliac stenting in the treatment of aortoiliac occlusive diseaseChristopher R Burke
Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA
Ann Vasc Surg 24:4-13. 2010..The objective of the current study was to determine the effect of these trends on treatment outcomes in a contemporary single-institution experience with AIOD... - The effect of secondary operations on mortality following abdominal aortic aneurysm repair in the United States: 1988-2001Jonathan L Eliason
Surgical Outcomes Research Team (SORT, Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI 48109-0329, USA
Vasc Endovascular Surg 39:465-72. 2005.... - Vein wall re-endothelialization after deep vein thrombosis is improved with low-molecular-weight heparinDaria K Moaveni
Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor 48109, USA
J Vasc Surg 47:616-24. 2008..The purpose of this study was to quantify re-endothelialization after DVT and determine if low-molecular-weight heparin (LMWH) therapy affects this process... - Efficacy and durability of autogenous saphenous vein conduits for lower extremity arterial reconstructions in preadolescent childrenJ D Cardneau
Department of Surgery, Sections of Vascular Surgery and Pediatric Surgery, University of Michigan Medical School, USA
J Vasc Surg 34:34-40. 2001..The reconstructions with 15 reversed and one in situ vein grafts included iliofemoral (11), femorofemoral (1), aortofemoral (1), femoropopliteal (1), popliteal-popliteal (1), and popliteal-posterior tibial (1) arterial bypass grafts... - A national and single institutional experience in the contemporary treatment of acute lower extremity ischemiaJonathan L Eliason
Department of Surgery, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
Ann Surg 238:382-9; discussion 389-90. 2003..07, 0.01-0.57). CONCLUSIONS: In patients with acute limb ischemia, the more widespread use of heparin anticoagulation and, in select patients, performance of embolectomy rather than pursuing thrombolysis may improve patient outcomes... - Outcome of surgical and endoluminal intervention for infrainguinal bypass anastomotic stricturesMatthew J Eagleton
Section of Vascular Surgery, Department of Surgery, University of Michigan Medical School, Ann Arbor, 48109, USA
Vasc Endovascular Surg 40:11-22. 2006..Open surgical repair, compared to PTA, provides improved graft function as evident by fewer subsequent interventions required to maintain graft patency... - Factors associated with recurrent venous thromboembolism in patients with malignant diseaseJules Lin
Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, USA
J Vasc Surg 37:976-83. 2003..VCF may be a reasonable alternative to long-term anticoagulation therapy in this subgroup of patients at high risk patients, provided their quality of life is reasonable... - P-selectin inhibition decreases post-thrombotic vein wall fibrosis in a rat modelPorama Thanaporn
Section of Vascular Surgery, Department of Surgery, Jobst Vascular Laboratory and Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
Surgery 134:365-71. 2003..05). CONCLUSIONS: P-selectin inhibition with rPSGL-Ig or LMWH decreases post-DVT vein wall fibrosis, and is associated with decreased vein wall profibrotic mediators. This effect is independent of thrombus mass and vein wall leukocytes... - The treatment of acute embolic lower limb ischemiaPeter K Henke
Section of Vascular Surgery, Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan, USA
Adv Surg 38:281-91. 2004 - Operative mortality rate for elective abdominal aortic aneurysm repair is not increased by the presence of a previous or concurrent thoracic or thoracoabdominal aortic dissectionRahul J Anand
Section of Vascular Surgery, Department of Surgery, University of Michigan Hospital, Ann Arbor, MI 48109, USA
J Vasc Surg 36:690-5. 2002..Nevertheless, the conduct of the operation is usually complex, especially in the setting of an acute aortic dissection... - Risk factors and clinical impact of postoperative symptomatic venous thromboembolismChethan Gangireddy
University of Michigan School of Medicine Section of Vascular Surgery, Ann Arbor, MI, USA
J Vasc Surg 45:335-341; discussion 341-2. 2007..This study evaluated prospective perioperative demographic and clinical variables associated with occurrence of postoperative symptomatic VTE... - Vein wall remodeling after deep vein thrombosis: differential effects of low molecular weight heparin and doxycyclineVikram Sood
Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
Ann Vasc Surg 24:233-41. 2010..This study sought to determine the effect of exogenous MMP inhibition and its potential attenuation of early vein wall injury... - Surgical treatment of intact thoracoabdominal aortic aneurysms in the United States: hospital and surgeon volume-related outcomesJohn A Cowan
Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109-0329, USA
J Vasc Surg 37:1169-74. 2003.... - Hospital volume-related differences in aorto-bifemoral bypass operative mortality in the United StatesJustin B Dimick
Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, USA
J Vasc Surg 37:970-5. 2003..The effect of hospital volume of AFB procedures on outcome should be of importance to patients, providers, and health policy makers... - Vein wall remodeling after deep vein thrombosis involves matrix metalloproteinases and late fibrosis in a mouse modelKristopher B Deatrick
Jobst Vascular Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, 48109, USA
J Vasc Surg 42:140-8. 2005..Additionally, the corresponding collagen upregulation and proximate plasmin system mediators are determined. With this knowledge, potential therapies to reduce vein wall injury directly might be possible... - Southern Association for Vascular Surgery William J. von Leibig Award. Inflammation and intimal hyperplasia associated with experimental pulmonary embolismMatthew J Eagleton
Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, University of Michigan Health System
J Vasc Surg 36:581-8. 2002..These factors may mediate these two processes after PE. This offers targets for further study with the hopes of minimizing the pathophysiologic response to PE... - Common celiacomesenteric trunk: aneurysmal and occlusive diseaseGorav Ailawadi
Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
J Vasc Surg 40:1040-3. 2004.... - Plasmin inhibition increases MMP-9 activity and decreases vein wall stiffness during venous thrombosis resolutionNicholas A Dewyer
Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
J Surg Res 142:357-63. 2007..This study tested the hypothesis that pharmacological inhibition of the plasmin system would impair DVT resolution and worsen vein wall damage... - Computed tomographic venography is specific but not sensitive for diagnosis of acute lower-extremity deep venous thrombosis in patients with suspected pulmonary embolusD A Peterson
Department of Surgery, University of Michigan Health System, Ann Arbor 48109-0329, USA
J Vasc Surg 34:798-804. 2001..Additionally, CTV is more costly than US scanning. Because of the lower sensitivity rate and positive predictive value and the increased cost of CTV, US remains the screening study of choice in cases of suspected acute LE-DVT... - Urokinase plasminogen activator independent early experimental thrombus resolution: MMP2 as an alternative mechanismVikram Sood
Jobst Vascular Surgery Laboratory, Section of Vascular Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
Thromb Haemost 104:1174-83. 2010..MMP2-dependent thrombolysis is an important compensatory mechanism of venous thrombus resolution, possibly by collagen type IV metabolism, and may represent an exploitable therapeutic avenue... - Diffusion of new technology in health care: the case of aorto-iliac occlusive diseaseGilbert R Upchurch
Surgical Outcomes Research Team (SORT, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109-0329, USA
Surgery 136:812-8. 2004..Acceptable clinical outcomes have likely lowered the threshold for treatment and contributed to the rapid diffusion of this technology for the treatment of AIOD... - Routine stent implantation vs. percutaneous transluminal angioplasty in femoropopliteal artery disease: a meta-analysis of randomized controlled trialsChristos Kasapis
Division of Cardiovascular Medicine, University of Michigan Health System, Ann Arbor, MI 48109 5853, USA
Eur Heart J 30:44-55. 2009..We performed a meta-analysis of randomized controlled trials comparing routine stenting (ST) with percutaneous transluminal angioplasty (PTA) for symptomatic superficial femoral-popliteal artery (SFPA) disease... - Deep vein thrombosis resolution is not accelerated with increased neovascularizationManu R Varma
Department of Surgery, University of Michigan Medical School, Ann Arbor, USA
J Vasc Surg 40:536-42. 2004..Solely promoting thrombus neovascularization will not likely speed resolution... - Neutropenia impairs venous thrombosis resolution in the ratManu R Varma
Department of Surgery, University of Michigan Medical School, Ann Arbor, 48109, USA
J Vasc Surg 38:1090-8. 2003..CONCLUSION: Neutropenia impairs DVT resolution by several measures, most likely by altering normal fibrinolytic activity and thrombus collagen turnover... - Aging is associated with impaired thrombus resolution in a mouse model of stasis induced thrombosisApril P McDonald
Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 0654 USA
Thromb Res 125:72-8. 2010..To evaluate the effects of aging on venous thrombosis... - Diffusion of new technology for the treatment of renovascular hypertension in the United States: surgical revascularization versus catheter-based therapy, 1988-2001Brian S Knipp
Section of Vascular Surgery, Departmetn of Surgery, University of Michigan Medical Center, Ann Arbor, USA
J Vasc Surg 40:717-23. 2004..A better understanding of the diffusion of this technology in the treatment of individuals with renovascular hypertension will influence the training and distribution of future vascular specialists responsible for these patients... - Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosisEduardo Ramacciotti
Conrad Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical School Center, Ann Arbor, MI, USA
Thromb Haemost 101:748-54. 2009..Finally, TF bearing MPs showed a significant correlation to MP concentrations (R = 0.99). In conclusion, MPs appear to be an important element in venous thrombogenesis... - Mechanisms of venous thrombosis and resolutionThomas W Wakefield
Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Arterioscler Thromb Vasc Biol 28:387-91. 2008..Knowledge of molecular and immunologic mechanisms for venous thrombosis and its resolution should allow for the future development of targeted therapies... - Variation in death rate after abdominal aortic aneurysmectomy in the United States: impact of hospital volume, gender, and ageJustin B Dimick
Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, and Division of Vascular Surgery, Wayne State University School of Medicine, Detroit, Michigan, USA
Ann Surg 235:579-85. 2002..These data support the regionalization of patients to HVHs for AAA repair... - High-resolution ultrasound speckle tracking may detect vascular mechanical wall changes in peripheral artery bypass vein graftsWilliam F Weitzel
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 5725, USA
Ann Vasc Surg 23:201-6. 2009..These results suggest the possibility of noninvasive detection of neointimal hyperplasia preceding anastomotic stenosis... - Cellular IL-10 is more effective than viral IL-10 in decreasing venous thrombosisDaniel D Myers
Department of Surgery, Section of Vascular Surgery, Jobst Vascular Laboratory, University of Michigan, Ann Arbor, Michigan 48109, USA
J Surg Res 112:168-74. 2003..Only cIL-10, despite sharing an 84% amino acid sequence homology with vIL-10, decreases thrombosis through mechanisms yet to be determined... - Intravascular ultrasound-guided true lumen reentry device for recanalization of unilateral chronic total occlusion of iliac arteries: technique and follow-upVenkataramu N Krishnamurthy
Section of Vascular and Interventional Radiology, Ann Arbor VA Health System, Ann Arbor, MI 48109 5030, USA
Ann Vasc Surg 24:487-97. 2010..This report describes the benefits of using true lumen reentry devices to improve the success and safety of conventional subintimal recanalization for revascularization of CTO of the iliac arteries... - Microparticle surface protein are associated with experimental venous thrombosis: a preliminary studyNewaj M Abdullah
Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
Clin Appl Thromb Hemost 15:201-8. 2009..Further studies are needed to confirm the mechanistic role of these proteins in the pathogenesis of venous thrombosis... - P-selectin/ PSGL-1 inhibitors versus enoxaparin in the resolution of venous thrombosis: a meta-analysisEduardo Ramacciotti
Jobst Vascular Surgery Research Laboratory, Section of Vascular Surgery, Cardiovascular Center, University of Michigan, Ann Arbor, Michigan 48109, USA
Thromb Res 125:e138-42. 2010..P-selectin antagonism has been shown to decrease thrombogenesis and inflammation in animal models of deep venous thrombosis (DVT)... - A validation study of a retrospective venous thromboembolism risk scoring methodVinita Bahl
Department of Clinical Information and Decision Support Services, Office of Clinical Affairs, University of Michigan, Ann Arbor, MI 48109 5485, USA
Ann Surg 251:344-50. 2010.... - The Michigan Surgical Quality Collaborative: a legacy of Shukri KhuriDarrell A Campbell
Department of Surgery, University of Michigan, MI, USA
Am J Surg 198:S49-55. 2009..From the legacy of Shukri Khuri, we have successfully implemented a regional quality collaborative in Michigan, the Michigan Surgical Quality Collaborative (MSQC)... - P-selectin inhibition enhances thrombus resolution and decreases vein wall fibrosis in a rat modelDaniel D Myers
Section of Vascular Surgery, Department of Surgery, Jobst Vascular Laboratory, Ann Arbor, MI 48109, USA
J Vasc Surg 36:928-38. 2002..The purpose of this study was to compare the efficacy of P-selectin inhibition with standard anticoagulant and thrombolytic therapy in a rodent model of established deep vein thrombosis (DVT)... - A negative carotid plaque area test is superior to other noninvasive atherosclerosis studies for reducing the likelihood of having underlying significant coronary artery diseaseRobert D Brook
Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
Arterioscler Thromb Vasc Biol 26:656-62. 2006..Although each test may enhance risk stratification, their comparative abilities to screen for underlying coronary stenoses in individual patients is less established... - Predictors of severe morbidity and death after elective abdominal aortic aneurysmectomy in patients with chronic obstructive pulmonary diseaseGilbert R Upchurch
Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, 1500 E Medical Center Drive, Taubman Center 2210, Ann Arbor, MI 48109 0329, USA
J Vasc Surg 37:594-9. 2003..This study sought to identify risk factors associated with an unfavorable outcome after elective abdominal aortic aneurysm (AAA) repair in patients with chronic obstructive pulmonary disease (COPD)... - D-dimer, P-selectin, and microparticles: novel markers to predict deep venous thrombosis. A pilot studyJohn E Rectenwald
Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, Michigan, USA
Thromb Haemost 94:1312-7. 2005..However for clinical applicability, the sensitivity/specificity will need to be improved. These studies also suggest the importance of soluble P-selectin in assessing DVT in humans... - Venous thromboembolism: regional differences in the nationwide inpatient sample, 1993 to 2000Mary C Proctor
Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Vascular 12:374-80. 2004..Regional diagnostic, treatment, and economic differences exist. The data are useful for the purposes of public health care planning and stimulating clinical trial questions... - Uncomplicated carotid endarterectomy: factors contributing to blood pressure instability precluding safe early dischargeSteven R Posner
Section of Vascular Surgery, Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
Vascular 12:278-84. 2004..There were two strokes and no deaths. Patients undergoing CEA who are hemodynamically stable in the PACU appear to be reasonable candidates for same-day discharge and warrant further prospective study... - Factors associated with outcome after interventional treatment of symptomatic iliac vein compression syndromeBrian S Knipp
Department of Surgery, Section of Vascular Surgery, University of Michigan, Ann Arbor, MI 48109, USA
J Vasc Surg 46:743-749. 2007..Although therapy is often initially successful, factors associated with long-term outcome have been poorly defined. The purpose of this study was to identify factors associated with stent patency... - Pediatric splanchnic arterial occlusive disease: clinical relevance and operative treatmentGilbert R Upchurch
Section of Vascular Surgery, Department of Surgery, University of Michigan Hospital, 1500 E Medical Center Drive, 2210THCC, Ann Arbor, MI 48109 0329, USA
J Vasc Surg 35:860-7. 2002..Splanchnic arterial occlusive disease is rare in childhood. The purpose of this study was to review the clinical relevance and operative treatment of these lesions in a unique experience from a single institution... - Effect of increasing patient age on complication rates following intact abdominal aortic aneurysm repair in the United StatesChandu Vemuri
Surgical Outcomes Research Team, Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
J Surg Res 118:26-31. 2004..Quality improvement efforts must focus on minimizing complication rates in elderly patients undergoing common vascular surgical procedures including AAA repair... - Proteomics of microparticles after deep venous thrombosisEduardo Ramacciotti
Jobst Vascular Research Laboratory, Section of Vascular Surgery, Cardiovascular Center, Department of Surgery, University of Michigan, Ann Arbor, MI, USA
Thromb Res 125:e269-74. 2010..MP present diverse biological expressions that may be linked to a unique subset of proteins derived from their origin cells... - Decreased venous thrombosis with an oral inhibitor of P selectinDaniel D Myers
Section of Vascular Surgery, Jobst Vascular Research Laboratories, Ann Arbor, Mich, USA
J Vasc Surg 42:329-36. 2005..This study evaluated the effects on thrombosis and circulating microparticle populations in this murine venous thrombosis model... - The role of inflammation in early and late venous thrombosis: Are there clinical implications?Thomas W Wakefield
Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
Semin Vasc Surg 18:118-29. 2005.... - Increased MMP-9 expression and activity by aortic smooth muscle cells after nitric oxide synthase inhibition is associated with increased nuclear factor-kappaB and activator protein-1 activityBrian S Knipp
Jobst Vascular Research Laboratories, Section of Vascular Surgery, Ann Arbor, Michigan 48109 0329, USA
J Surg Res 116:70-80. 2004..To determine the mechanism underlying increased expression and activity of matrix metalloproteinase 9 (MMP-9) by rat aortic smooth muscle cells (RA-SMC) after inhibition of inducible nitric oxide synthase (iNOS)... - Experimental pulmonary embolism: effects of the thrombus and attenuation of pulmonary artery injury by low-molecular-weight heparinJohn E Rectenwald
Department of Surgery, Jobst Vascular Research Laboratory, Section of Vascular Surgery, University of Michigan, Ann Arbor, USA
J Vasc Surg 43:800-8. 2006..This study evaluated the effect of the thrombus and tested the hypothesis that thrombolytic, antiplatelet, and anticoagulant agents would decrease pulmonary injury... - Cost of routine screening for carotid and lower extremity occlusive disease in patients with abdominal aortic aneurysmsDavid A Axelrod
Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, 48109 0604, USA
J Vasc Surg 35:754-8. 2002..Furthermore, the cost-effectiveness of routine versus selective preoperative noninvasive examination of the carotid and lower extremity arterial beds has not been established in patients who undergo elective AAA repair... - Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulationDaniel D Myers
Jobst Vascular Research Laboratories, Section of Vascular Surgery, 2Unit for Laboratory Animal Medicine and 3Department of Radiology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0654, USA
Thromb Haemost 97:400-7. 2007..01). This study is the first to demonstrate the effectiveness of oral P-selectin inhibition to modify venous thrombogenesis, increase vein lumen opening, and decrease inflammation in a large animal model... - Role of selectins and fibrinolysis in VTEThomas W Wakefield
Department of Surgery, Ann Arbor, MI, USA
Thromb Res 123:S35-40. 2009..In this review, we will address the role of selectins and fibrinolysis in the process of venous thrombogenesis... - Pediatric renovascular hypertension: 132 primary and 30 secondary operations in 97 childrenJames C Stanley
Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0329, USA
J Vasc Surg 44:1219-28; discussion 1228-9. 2006..This study was undertaken to characterize the contemporary surgical treatment of pediatric renovascular hypertension... - Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosisDaniel D Myers
Jobst Vascular Research Laboratories, Section of Vascular Surgery, University of Michigan Medical Center, Ann Arbor, 48109 0654, USA
J Vasc Surg 44:625-32. 2006.... - L-selectin-mediated neutrophil recruitment in experimental rodent aneurysm formationKevin K Hannawa
Jobst Vascular Research Laboratories, Section of Vascular Surgery, Department of Surgery, University of Michigan, Ann Arbor, Mich, USA
Circulation 112:241-7. 2005..This investigation tested the hypothesis that L-selectin is important in experimental abdominal aortic aneurysm (AAA) formation in rodents... - Iliorenal bypass: indications and outcomes following 41 reconstructionsVladimir Grigoryants
Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
Ann Vasc Surg 21:1-9. 2007..Iliorenal bypass is an effective means of renal revascularization in patients not amenable to more conventional open or transluminal procedures... - Endovascular treatment of abdominal aortic aneurysm is associated with a low incidence of deep venous thrombosisMatthew J Eagleton
Section of Vascular Surgery, Department of Surgery, University of Michigan Health System, Ann Arbor 48109, USA
J Vasc Surg 36:912-6. 2002..These patients had a number of risk factors for the development of a DVT; however, no specific factor was identified that predisposed to DVT... - Acute venous disease: venous thrombosis and venous traumaMark H Meissner
Department of Surgery, University of Washington School of Medicine, Seattle 98195, USA
J Vasc Surg 46:25S-53S. 2007..Venous injuries are similarly under-reported and the true incidence is unknown. Current recommendations include repair of injuries to the major proximal veins. If repair not safe or possible, ligation should be performed...
Research Grants
- Thrombus resolution is CXC chemokine dependentPeter Henke; Fiscal Year: 2006..abstract_text> ..
- Vein wall remodeling after DVT is matrix metalloproteinase dependentPeter Henke; Fiscal Year: 2007..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
- Vein wall remodeling after DVT is matrix metalloproteinase dependentPeter Henke; Fiscal Year: 2009..This proposal will provide important mechanistic insight into the pathophysiology of post-phelbitic syndrome with real potential translation to decreasing the morbidity from this under-acknowledged disease. ..
- Vein Wall Fibrotic Injury After DVT is SLC-CCR7 DependentPeter Henke; Fiscal Year: 2009..The long term goal is to define a therapy to decrease post thrombotic syndrome, a common and morbid complication of deep vein thrombosis. ..
- Vein Wall Fibrotic Injury After DVT is SLC-CCR7 DependentPeter K Henke; Fiscal Year: 2010..The long term goal is to define a therapy to decrease post thrombotic syndrome, a common and morbid complication of deep vein thrombosis. ..