Research Topics | DAVID HENDRIXSONSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Publications
A phase-variable mechanism controlling the Campylobacter jejuni FlgR response regulator influences commensalismDavid R Hendrixson
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Mol Microbiol 61:1646-59. 2006..jejuni that is absent in other Campylobacter species and contribute to reasons why C. jejuni is more frequently found as a commensal organism in poultry and as the cause of disease in humans...
Restoration of flagellar biosynthesis by varied mutational events in Campylobacter jejuniDavid R Hendrixson
Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Mol Microbiol 70:519-36. 2008..jejuni and suggests that the bacterium may possess a repertoire of mutational mechanisms to overcome genetic lesions that impair production of virulence and colonization determinants while lacking a normal mismatch repair system...- Analysis of the LIV system of Campylobacter jejuni reveals alternative roles for LivJ and LivK in commensalism beyond branched-chain amino acid transportDeborah A Ribardo
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Room NL 4 138A, Dallas, TX 75390 9048, USA
J Bacteriol 193:6233-43. 2011..In contrast to other studies indicating a requirement and utilization of other specific amino acids for colonization, acquisition of branched-chain amino acids does not appear to be a determinant for C. jejuni during commensalism... - Characterization of two putative cytochrome c peroxidases of Campylobacter jejuni involved in promoting commensal colonization of poultryLacey K Bingham-Ramos
University of Texas Southwestern Medical Center, Department of Microbiology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
Infect Immun 76:1105-14. 2008..Our data suggest that DocA and Cjj0382 have characteristics of CCPs but likely perform different physiological functions for the bacterium in colonization that are not related to resisting oxidative stress... - Analysis of the roles of FlgP and FlgQ in flagellar motility of Campylobacter jejuniShawn M Sommerlad
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
J Bacteriol 189:179-86. 2007..This study provides insight into features of FlgP and FlgQ, two proteins with previously undefined functions that are required for the larger, multicomponent flagellar system of C. jejuni that is necessary for motility... - Activation of the Campylobacter jejuni FlgSR two-component system is linked to the flagellar export apparatusStephanie N Joslin
University of Texas Southwestern Medical School, Department of Microbiology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
J Bacteriol 191:2656-67. 2009..This study indicates that these apparatuses have broader functions beyond flagellar protein secretion, including activation of essential two-component regulatory systems required for expression of sigma(54)-dependent flagellar genes... - Functional analysis of the RdxA and RdxB nitroreductases of Campylobacter jejuni reveals that mutations in rdxA confer metronidazole resistanceDeborah A Ribardo
University of Texas Southwestern Medical School, Department of Microbiology, Dallas, TX 75390 9048, USA
J Bacteriol 192:1890-901. 2010.... - FlhF and its GTPase activity are required for distinct processes in flagellar gene regulation and biosynthesis in Campylobacter jejuniMurat Balaban
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9048, USA
J Bacteriol 191:6602-11. 2009..jejuni FlhF GTPase are required for distinct steps in flagellar gene expression and biosynthesis. Our findings are likely applicable to many polarly flagellated bacteria that utilize FlhF in flagellar biosynthesis processes... - Analysis of the Campylobacter jejuni FlgR response regulator suggests integration of diverse mechanisms to activate an NtrC-like proteinStephanie N Joslin
University of Texas Southwestern Medical School, Department of Microbiology, Dallas, TX 75390, USA
J Bacteriol 190:2422-33. 2008..Our results demonstrate that FlgR activation mechanisms are unusual among characterized NtrC-like proteins and emphasize that various means are utilized by the NtrC family of proteins to control the transcription of target genes... - Change is good: variations in common biological mechanisms in the epsilonproteobacterial genera Campylobacter and HelicobacterJeremy J Gilbreath
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
Microbiol Mol Biol Rev 75:84-132. 2011.... - Identification of Campylobacter jejuni genes involved in commensal colonization of the chick gastrointestinal tractDavid R Hendrixson
Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-0620, USA
Mol Microbiol 52:471-84. 2004..jejuni revealed one other required for wild-type levels of caecal colonization. This study represents one of the first genetic screens focusing on the bacterial requirements necessary for promoting commensalism in a vertebrate host... - Transcription of sigma54-dependent but not sigma28-dependent flagellar genes in Campylobacter jejuni is associated with formation of the flagellar secretory apparatusDavid R Hendrixson
Unit for Laboratory Animal Medicine, University of Michigan Medical School, 5641 Medical Science II, Box 0620, Ann Arbor, MI 48109-0620, USA
Mol Microbiol 50:687-702. 2003..jejuni... - Natural transformation of Campylobacter jejuni requires components of a type II secretion systemRebecca S Wiesner
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
J Bacteriol 185:5408-18. 2003..Other genes identified in our screen encode proteins unique to C. jejuni or are homologous to proteins that have not been shown to play a role in the transformation in other bacteria...
Research Grants
- Genetic Analysis of Campylobacter jejuni ColonizationDAVID HENDRIXSON; Fiscal Year: 2003..jejuni to identify genes required for chicken colonization. This last aim will allow us to begin to understand requirements of C. jejuni for colonization of a natural host. ..
- Campylobacter jejuni flagellar regulation and synthesisDAVID HENDRIXSON; Fiscal Year: 2007..The proposed research activities will determine how certain proteins of C. jejuni function together to control production of flagellar proteins that make up the flagellar structure. ..
- Campylobacter jejuni flagellar regulation and synthesisDAVID HENDRIXSON; Fiscal Year: 2009..The proposed research activities will determine how certain proteins of C.jejunifunction together to control production of flagellar proteins that make up the flagellar structure. ..
- Campylobacter jejuni flagellar regulation and synthesisDavid R Hendrixson; Fiscal Year: 2010..The proposed research activities will determine how certain proteins of C.jejunifunction together to control production of flagellar proteins that make up the flagellar structure. ..