DAVID HENDRIXSON

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint A phase-variable mechanism controlling the Campylobacter jejuni FlgR response regulator influences commensalism
    David R Hendrixson
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Microbiol 61:1646-59. 2006
  2. pmc A regulatory checkpoint during flagellar biogenesis in Campylobacter jejuni initiates signal transduction to activate transcription of flagellar genes
    Joseph M Boll
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    MBio 4:e00432-13. 2013
  3. pmc Polar flagellar biosynthesis and a regulator of flagellar number influence spatial parameters of cell division in Campylobacter jejuni
    Murat Balaban
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 7:e1002420. 2011
  4. pmc Restoration of flagellar biosynthesis by varied mutational events in Campylobacter jejuni
    David R Hendrixson
    Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Mol Microbiol 70:519-36. 2008
  5. pmc Analysis of the LIV system of Campylobacter jejuni reveals alternative roles for LivJ and LivK in commensalism beyond branched-chain amino acid transport
    Deborah A Ribardo
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Room NL 4 138A, Dallas, TX 75390 9048, USA
    J Bacteriol 193:6233-43. 2011
  6. pmc Characterization of two putative cytochrome c peroxidases of Campylobacter jejuni involved in promoting commensal colonization of poultry
    Lacey K Bingham-Ramos
    University of Texas Southwestern Medical Center, Department of Microbiology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
    Infect Immun 76:1105-14. 2008
  7. pmc Analysis of the roles of FlgP and FlgQ in flagellar motility of Campylobacter jejuni
    Shawn M Sommerlad
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
    J Bacteriol 189:179-86. 2007
  8. pmc Activation of the Campylobacter jejuni FlgSR two-component system is linked to the flagellar export apparatus
    Stephanie N Joslin
    University of Texas Southwestern Medical School, Department of Microbiology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
    J Bacteriol 191:2656-67. 2009
  9. pmc Functional analysis of the RdxA and RdxB nitroreductases of Campylobacter jejuni reveals that mutations in rdxA confer metronidazole resistance
    Deborah A Ribardo
    University of Texas Southwestern Medical School, Department of Microbiology, Dallas, TX 75390 9048, USA
    J Bacteriol 192:1890-901. 2010
  10. pmc FlhF and its GTPase activity are required for distinct processes in flagellar gene regulation and biosynthesis in Campylobacter jejuni
    Murat Balaban
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9048, USA
    J Bacteriol 191:6602-11. 2009

Research Grants

Collaborators

  • D Scott Merrell
  • Stephanie N Joslin
  • Deborah A Ribardo
  • Murat Balaban
  • Lacey K Bingham-Ramos
  • Joseph M Boll
  • Jeremy J Gilbreath
  • Shawn M Sommerlad
  • Rebecca S Wiesner
  • William L Cody
  • Victor J DiRita

Detail Information

Publications15

  1. ncbi request reprint A phase-variable mechanism controlling the Campylobacter jejuni FlgR response regulator influences commensalism
    David R Hendrixson
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Microbiol 61:1646-59. 2006
    ..jejuni that is absent in other Campylobacter species and contribute to reasons why C. jejuni is more frequently found as a commensal organism in poultry and as the cause of disease in humans...
  2. pmc A regulatory checkpoint during flagellar biogenesis in Campylobacter jejuni initiates signal transduction to activate transcription of flagellar genes
    Joseph M Boll
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    MBio 4:e00432-13. 2013
    ..jejuni, this regulatory checkpoint may exist in a broad range of bacteria to influence similar TCSs and flagellar gene transcription...
  3. pmc Polar flagellar biosynthesis and a regulator of flagellar number influence spatial parameters of cell division in Campylobacter jejuni
    Murat Balaban
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 7:e1002420. 2011
    ..Furthermore, we found that other polarly-flagellated bacteria produce FlhG proteins that influence cell division, suggesting that FlhG and polar flagella may function together in a broad range of bacteria to spatially regulate division...
  4. pmc Restoration of flagellar biosynthesis by varied mutational events in Campylobacter jejuni
    David R Hendrixson
    Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Mol Microbiol 70:519-36. 2008
    ..jejuni and suggests that the bacterium may possess a repertoire of mutational mechanisms to overcome genetic lesions that impair production of virulence and colonization determinants while lacking a normal mismatch repair system...
  5. pmc Analysis of the LIV system of Campylobacter jejuni reveals alternative roles for LivJ and LivK in commensalism beyond branched-chain amino acid transport
    Deborah A Ribardo
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Room NL 4 138A, Dallas, TX 75390 9048, USA
    J Bacteriol 193:6233-43. 2011
    ..In contrast to other studies indicating a requirement and utilization of other specific amino acids for colonization, acquisition of branched-chain amino acids does not appear to be a determinant for C. jejuni during commensalism...
  6. pmc Characterization of two putative cytochrome c peroxidases of Campylobacter jejuni involved in promoting commensal colonization of poultry
    Lacey K Bingham-Ramos
    University of Texas Southwestern Medical Center, Department of Microbiology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
    Infect Immun 76:1105-14. 2008
    ..Our data suggest that DocA and Cjj0382 have characteristics of CCPs but likely perform different physiological functions for the bacterium in colonization that are not related to resisting oxidative stress...
  7. pmc Analysis of the roles of FlgP and FlgQ in flagellar motility of Campylobacter jejuni
    Shawn M Sommerlad
    Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
    J Bacteriol 189:179-86. 2007
    ..This study provides insight into features of FlgP and FlgQ, two proteins with previously undefined functions that are required for the larger, multicomponent flagellar system of C. jejuni that is necessary for motility...
  8. pmc Activation of the Campylobacter jejuni FlgSR two-component system is linked to the flagellar export apparatus
    Stephanie N Joslin
    University of Texas Southwestern Medical School, Department of Microbiology, 5323 Harry Hines Boulevard, Dallas, TX 75390 9048, USA
    J Bacteriol 191:2656-67. 2009
    ..This study indicates that these apparatuses have broader functions beyond flagellar protein secretion, including activation of essential two-component regulatory systems required for expression of sigma(54)-dependent flagellar genes...
  9. pmc Functional analysis of the RdxA and RdxB nitroreductases of Campylobacter jejuni reveals that mutations in rdxA confer metronidazole resistance
    Deborah A Ribardo
    University of Texas Southwestern Medical School, Department of Microbiology, Dallas, TX 75390 9048, USA
    J Bacteriol 192:1890-901. 2010
    ....
  10. pmc FlhF and its GTPase activity are required for distinct processes in flagellar gene regulation and biosynthesis in Campylobacter jejuni
    Murat Balaban
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9048, USA
    J Bacteriol 191:6602-11. 2009
    ..jejuni FlhF GTPase are required for distinct steps in flagellar gene expression and biosynthesis. Our findings are likely applicable to many polarly flagellated bacteria that utilize FlhF in flagellar biosynthesis processes...
  11. pmc Analysis of the Campylobacter jejuni FlgR response regulator suggests integration of diverse mechanisms to activate an NtrC-like protein
    Stephanie N Joslin
    University of Texas Southwestern Medical School, Department of Microbiology, Dallas, TX 75390, USA
    J Bacteriol 190:2422-33. 2008
    ..Our results demonstrate that FlgR activation mechanisms are unusual among characterized NtrC-like proteins and emphasize that various means are utilized by the NtrC family of proteins to control the transcription of target genes...
  12. pmc Change is good: variations in common biological mechanisms in the epsilonproteobacterial genera Campylobacter and Helicobacter
    Jeremy J Gilbreath
    Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Microbiol Mol Biol Rev 75:84-132. 2011
    ....
  13. ncbi request reprint Identification of Campylobacter jejuni genes involved in commensal colonization of the chick gastrointestinal tract
    David R Hendrixson
    Unit for Laboratory Animal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0620, USA
    Mol Microbiol 52:471-84. 2004
    ..jejuni revealed one other required for wild-type levels of caecal colonization. This study represents one of the first genetic screens focusing on the bacterial requirements necessary for promoting commensalism in a vertebrate host...
  14. ncbi request reprint Transcription of sigma54-dependent but not sigma28-dependent flagellar genes in Campylobacter jejuni is associated with formation of the flagellar secretory apparatus
    David R Hendrixson
    Unit for Laboratory Animal Medicine, University of Michigan Medical School, 5641 Medical Science II, Box 0620, Ann Arbor, MI 48109 0620, USA
    Mol Microbiol 50:687-702. 2003
    ..jejuni...
  15. pmc Natural transformation of Campylobacter jejuni requires components of a type II secretion system
    Rebecca S Wiesner
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0620, USA
    J Bacteriol 185:5408-18. 2003
    ..Other genes identified in our screen encode proteins unique to C. jejuni or are homologous to proteins that have not been shown to play a role in the transformation in other bacteria...

Research Grants7

  1. Genetic Analysis of Campylobacter jejuni Colonization
    DAVID HENDRIXSON; Fiscal Year: 2003
    ..jejuni to identify genes required for chicken colonization. This last aim will allow us to begin to understand requirements of C. jejuni for colonization of a natural host. ..
  2. Campylobacter jejuni flagellar regulation and synthesis
    DAVID HENDRIXSON; Fiscal Year: 2006
    ..The proposed research activities will determine how certain proteins of C. jejuni function together to control production of flagellar proteins that make up the flagellar structure. ..
  3. Campylobacter jejuni flagellar regulation and synthesis
    DAVID HENDRIXSON; Fiscal Year: 2007
    ..The proposed research activities will determine how certain proteins of C. jejuni function together to control production of flagellar proteins that make up the flagellar structure. ..
  4. Campylobacter jejuni flagellar regulation and synthesis
    DAVID HENDRIXSON; Fiscal Year: 2009
    ..The proposed research activities will determine how certain proteins of C.jejunifunction together to control production of flagellar proteins that make up the flagellar structure. ..
  5. Campylobacter jejuni flagellar regulation and synthesis
    David R Hendrixson; Fiscal Year: 2010
    ..The proposed research activities will determine how certain proteins of C.jejunifunction together to control production of flagellar proteins that make up the flagellar structure. ..
  6. Campylobacter jejuni flagellar regulation and synthesis
    David R Hendrixson; Fiscal Year: 2010
    ..The proposed research activities will determine how certain proteins of C.jejunifunction together to control production of flagellar proteins that make up the flagellar structure. ..