Affiliation: University of Minnesota
Li Y, Park A, Mou H, Colpan C, Bizhanova A, Akama Garren E, et al
. A versatile reporter system for CRISPR-mediated chromosomal rearrangements. Genome Biol. 2015;16:111 pubmed publisher
..Moreover, we detect Cas9 cleavage at the fourth nucleotide on the non-complementary strand, leading to staggered instead of blunt DNA breaks. These reporters allow mechanisms of chromosomal rearrangements to be investigated. ..
Baird D, Hendrickson E. Telomeres and Chromosomal Translocations : There's a Ligase at the End of the Translocation. Adv Exp Med Biol. 2018;1044:89-112 pubmed publisher
..A better understanding of the relationship between DNA repair pathways and chromosomal translocations is guaranteed to lead to improved therapeutic treatments for cancer. ..
Fattah F, Kweon J, Wang Y, Lee E, Kan Y, Lichter N, et al
. A role for XLF in DNA repair and recombination in human somatic cells. DNA Repair (Amst). 2014;15:39-53 pubmed publisher
..We conclude that human XLF is a non-essential, but critical, C-NHEJ-repair factor. ..
Oh S, Harvey A, Zimbric J, Wang Y, Nguyen T, Jackson P, et al
. DNA ligase III and DNA ligase IV carry out genetically distinct forms of end joining in human somatic cells. DNA Repair (Amst). 2014;21:97-110 pubmed publisher
..Moreover, we describe that a robust Ku-independent, LIGIV-dependent repair pathway exists in human somatic cells. ..
Kan Y, Batada N, Hendrickson E. Human somatic cells deficient for RAD52 are impaired for viral integration and compromised for most aspects of homology-directed repair. DNA Repair (Amst). 2017;55:64-75 pubmed publisher
..In toto, our work demonstrates that RAD52 contributes to the maintenance of genome stability and tumor suppression in human cells. ..