Donald Henderson

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi request reprint Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration
    Eric C Bielefeld
    Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY, USA
    Acta Otolaryngol 127:914-9. 2007
  2. ncbi request reprint The role of oxidative stress in noise-induced hearing loss
    Donald Henderson
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Ear Hear 27:1-19. 2006
  3. doi request reprint The effects of acoustic environment after traumatic noise exposure on hearing and outer hair cells
    Chiemi Tanaka
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 250:10-8. 2009
  4. doi request reprint Aging outer hair cells (OHCs) in the Fischer 344 rat cochlea: function and morphology
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, NY 14214, USA
    Hear Res 248:39-47. 2009
  5. pmc Apoptotic outer hair cell death in the cochleae of aging Fischer 344/NHsd rats
    Bo Hua Hu
    Center for Hearing and Deafness, State University of New York at Buffalo, Department of Communicative Disorders and Sciences, Buffalo, NY 14214, USA
    Hear Res 245:48-57. 2008
  6. doi request reprint Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, NY, USA
    Hear Res 265:63-9. 2010
  7. ncbi request reprint Increased resistance to free radical damage induced by low-level sound conditioning
    Kelly Carney Harris
    Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA
    Hear Res 213:118-29. 2006
  8. pmc Age-related hearing loss: is it a preventable condition?
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 264:98-107. 2010
  9. ncbi request reprint A comparison of the protective effects of systemic administration of a pro-glutathione drug and a Src-PTK inhibitor against noise-induced hearing loss
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Noise Health 7:24-30. 2005
  10. ncbi request reprint Ameliorative effects of an augmented acoustic environment on age-related hearing loss in middle-aged Fischer 344/NHsd rats
    Chiemi Tanaka
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Laryngoscope 119:1374-9. 2009

Research Grants

  1. Prevention of Solvent and Noise-Induced Hearing Loss
    Donald Henderson; Fiscal Year: 2005
  2. Prevention and Treatment of Age-Related Hearing Loss
    Donald Henderson; Fiscal Year: 2005
  3. Prevention and Treatment of Age-Related Hearing Loss
    Donald Henderson; Fiscal Year: 2006
  4. Prevention and Treatment of Age-Related Hearing Loss
    Donald Henderson; Fiscal Year: 2007
  5. Prevention of Solvent and Noise-Induced Hearing Loss
    Donald Henderson; Fiscal Year: 2007

Detail Information

Publications33

  1. ncbi request reprint Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses, and routes of administration
    Eric C Bielefeld
    Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY, USA
    Acta Otolaryngol 127:914-9. 2007
    ..The studies further reveal the potential for the use of NAC in a clinical population exposed to noise...
  2. ncbi request reprint The role of oxidative stress in noise-induced hearing loss
    Donald Henderson
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Ear Hear 27:1-19. 2006
    ....
  3. doi request reprint The effects of acoustic environment after traumatic noise exposure on hearing and outer hair cells
    Chiemi Tanaka
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 250:10-8. 2009
    ..The results suggest that post-noise acoustic environment influenced the degree of hearing loss and OHC deterioration after traumatic noise exposure...
  4. doi request reprint Aging outer hair cells (OHCs) in the Fischer 344 rat cochlea: function and morphology
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, NY 14214, USA
    Hear Res 248:39-47. 2009
    ..Hu, B.H., Henderson, D., 2008. Age-related hearing loss in the Fischer 344/NHsd rat substrain. Hear. Res. 241, 26-33], the results suggest that disruption of prestin is the major cause of DPOAE loss and loss of cochlear sensitivity...
  5. pmc Apoptotic outer hair cell death in the cochleae of aging Fischer 344/NHsd rats
    Bo Hua Hu
    Center for Hearing and Deafness, State University of New York at Buffalo, Department of Communicative Disorders and Sciences, Buffalo, NY 14214, USA
    Hear Res 245:48-57. 2008
    ....
  6. doi request reprint Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, NY, USA
    Hear Res 265:63-9. 2010
    ..The mechanisms underlying these unexpected, permanent salicylate-induced reductions in neural activity are discussed...
  7. ncbi request reprint Increased resistance to free radical damage induced by low-level sound conditioning
    Kelly Carney Harris
    Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA
    Hear Res 213:118-29. 2006
    ..The conditioned animals showed reductions in permanent threshold shift and reduced inner hair cell loss relative to controls. These results reinforce the hypothesis that antioxidants are primary mediators of the conditioning effect...
  8. pmc Age-related hearing loss: is it a preventable condition?
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 264:98-107. 2010
    ..Using the animal models, different techniques for prevention of ARHL have been developed and tested. The current review discusses ARHL patterns in humans and animal models, followed by discussions of the different prevention techniques...
  9. ncbi request reprint A comparison of the protective effects of systemic administration of a pro-glutathione drug and a Src-PTK inhibitor against noise-induced hearing loss
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Noise Health 7:24-30. 2005
    ..There were no significant side effects (i.e.: appetite loss, weight loss, lethargy, etc.) related to either of the drug treatments. KX1-004 produced at least as much protection as L-NAC, but at a significantly lower concentration...
  10. ncbi request reprint Ameliorative effects of an augmented acoustic environment on age-related hearing loss in middle-aged Fischer 344/NHsd rats
    Chiemi Tanaka
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Laryngoscope 119:1374-9. 2009
    ..To investigate the effects of an augmented acoustic environment (AAE) on age-related hearing loss (ARHL) and outer hair cell (OHC) pathology in middle-aged Fischer 344/NHsd (F344/NHsd) rats...
  11. pmc Expression pattern of oxidative stress and antioxidant defense-related genes in the aging Fischer 344/NHsd rat cochlea
    Chiemi Tanaka
    Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, NY, USA
    Neurobiol Aging 33:1842.e1-14. 2012
    ..Our results identified specific subsets of oxidative stress genes that appear to play an important role in ARHL in the Fischer 344/NHsd rat...
  12. doi request reprint Cochlear injuries induced by the combined exposure to noise and styrene
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 254:25-33. 2009
    ....
  13. doi request reprint Protective effect of N-acetyl-L-cysteine (L-NAC) against styrene-induced cochlear injuries
    Wei Ping Yang
    Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, New York 14214, USA
    Acta Otolaryngol 129:1036-43. 2009
    ..Styrene exposure causes hair cell death through both apoptotic and necrotic pathways and treatment with N-acetyl-L-cysteine (L-NAC) reduces styrene ototoxicity...
  14. pmc Age-related hearing loss in the Fischer 344/NHsd rat substrain
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, United States
    Hear Res 241:26-33. 2008
    ..Collectively, these findings suggest damage to the outer hair cells, but anatomical examination of the outer hair cells revealed a relative lack of cell loss compared to the magnitude of the hearing and DPOAE loss...
  15. ncbi request reprint F-actin cleavage in apoptotic outer hair cells in chinchilla cochleas exposed to intense noise
    Bo Hua Hu
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 215 Parker Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 172:1-9. 2002
    ..The results of this study indicate that F-actin cleavage is an important early cellular event in apoptotic development in OHCs following exposure to traumatic noise...
  16. ncbi request reprint Quantitative analysis of apoptotic and necrotic outer hair cells after exposure to different levels of continuous noise
    Wei Ping Yang
    Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 196:69-76. 2004
    ..The results of the study indicate that the early expansion of cochlear lesion is attributed primarily to apoptosis, whereas the later stage of lesion expansion is likely the result of an equal contribution from apoptosis and necrosis...
  17. ncbi request reprint Extremely rapid induction of outer hair cell apoptosis in the chinchilla cochlea following exposure to impulse noise
    Bo Hua Hu
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 211:16-25. 2006
    ..The results of the study demonstrate that induction of OHC apoptosis after the noise exposure is an extremely rapid process...
  18. pmc Damage and threshold shift resulting from cochlear exposure to paraquat-generated superoxide
    Eric C Bielefeld
    Department of Communicative Disorders and Sciences, Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 207:35-42. 2005
    ..Outer and inner hair cell losses were consistent with PTS. The similarities between PQ ototoxicity and noise-induced hearing loss suggest the possibility of similar biochemical pathways involving superoxide...
  19. pmc Multiple dosing strategies with acetyl L-carnitine (ALCAR) fail to alter age-related hearing loss in the Fischer 344/NHsd rat
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    J Negat Results Biomed 7:4. 2008
    ..Acetyl L-carnitine (ALCAR) is known to enhance mitochondrial bioenergetics and membrane efficiency. Therefore, ALCAR was targeted as a possible pharmacologic intervention to prevent, or even restore, hearing loss from aging...
  20. pmc The caspase pathway in noise-induced apoptosis of the chinchilla cochlea
    Thomas M Nicotera
    Molecular and Cellular Biophysics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    J Assoc Res Otolaryngol 4:466-77. 2003
    ..Lastly, use of the TUNEL assay in combination with PI labeling provides a more accurate discrimination between apoptosis and necrosis...
  21. pmc The impact of mitochondrial energetic dysfunction on apoptosis in outer hair cells of the cochlea following exposure to intense noise
    Bo Hua Hu
    Center for Hearing and Deafness, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo NY 14214, USA
    Hear Res 236:11-21. 2008
    ....
  22. ncbi request reprint Relation between outer hair cell loss and hearing loss in rats exposed to styrene
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, NY 14214, USA
    Hear Res 243:28-34. 2008
    ....
  23. ncbi request reprint Influence of sympathetic fibers on noise-induced hearing loss in the chinchilla
    Eric C Bielefeld
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, United States
    Hear Res 223:11-9. 2007
    ..Effects of SCGectomy on OHC loss were small. Results of the study suggest that sympathetic fibers do exert some influence on susceptibility to noise, but the influence may not be a major one...
  24. ncbi request reprint Noise-induced hearing loss in chinchillas pre-treated with glutathione monoethylester and R-PIA
    Nancy G Hight
    Center for Hearing and Deafness, State University at Buffalo, 215 Parker Hall, Buffalo, NY 14226, USA
    Hear Res 179:21-32. 2003
    ..All the drug treatments elevated GSH levels. The results are discussed in terms of antioxidant treatments as a prophylactic measure against noise-induced hearing loss...
  25. ncbi request reprint Styrene induced alterations in biomarkers of exposure and effects in the cochlea: mechanisms of hearing loss
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, New York, USA
    Toxicol Sci 98:167-77. 2007
    ..In the styrene-induced apoptotic OHCs, histochemical staining detected activated caspases-9 and 8, indicating that both mitochondrial-dependent pathway and death receptor-dependent pathway were involved in the styrene-induced cell death...
  26. doi request reprint An Src-protein tyrosine kinase inhibitor to reduce cisplatin ototoxicity while preserving its antitumor effect
    Eric C Bielefeld
    Department of Speech and Hearing Science, The Ohio State University, Columbus, Ohio 43220, USA
    Anticancer Drugs 24:43-51. 2013
    ..The findings suggest that the Src inhibitor may provide an effective cotreatment with cisplatin to reduce cisplatin's ototoxicity, without compromising its antitumor capability...
  27. ncbi request reprint Prevention of noise-induced hearing loss with Src-PTK inhibitors
    Kelly Carney Harris
    Center for Hearing and Deafness, University at Buffalo, Buffalo, NY 14214, USA
    Hear Res 208:14-25. 2005
    ..For all conditions, the results suggest a role for Src-PTK activation in noise-induced hearing loss (NIHL), and that therapeutic intervention with a Src-PTK inhibitor may offer a novel approach in the treatment of NIHL...
  28. pmc Age-related changes in antioxidant enzymes related to hydrogen peroxide metabolism in rat inner ear
    Donald Coling
    Center for Hearing and Deafness, University at Buffalo, UB South Campus, Buffalo, NY 14214, United States
    Neurosci Lett 464:22-5. 2009
    ..These findings suggest that increased Gpx activity in vascular cochlear tissue may be an age-related compensation for a decrease in glutathione and a decline in the redox state measured by the ratio of reduced to oxidized glutathione...
  29. ncbi request reprint Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise
    Bo Hua Hu
    Center for Hearing and Deafness, Department of Communicative Disorders and Sciences, State University of New York at Buffalo, 215 Parker Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 166:62-71. 2002
    ..These results clearly implicate the apoptotic pathway in the post-exposure progression of OHC demise...
  30. pmc Functional anatomy of the masking level difference, an fMRI study
    David S Wack
    Buffalo Neuroimaging Analysis Center, Dept of Neurology, University at Buffalo, Buffalo, New York, United States of America
    PLoS ONE 7:e41263. 2012
    ..Signal detection level for the noise/signal combinations N0Sπ and NπS0 is typically 10-20 dB better than for N0S0. All combinations have the same spectrum, level, and duration of both the signal and the noise...
  31. ncbi request reprint Ototoxicity of organic solvents - from scientific evidence to health policy
    Mariola Sliwinska-Kowalska
    Department of Physical Hazards and Department of Audiology and Phoniatrics, Nofer Institute of Occupational Medicine, Łódź, Poland
    Int J Occup Med Environ Health 20:215-22. 2007
    ..Its main purpose was to review the key scientific evidence to gather the necessary knowledge for developing adequate occupational health policies. This paper summarizes the workshop sessions and subsequent discussions...
  32. ncbi request reprint Prevention of impulse noise-induced hearing loss with antioxidants
    Richard Kopke
    Hough Ear Institute, Oklahoma City, Oklahoma 73112, USA
    Acta Otolaryngol 125:235-43. 2005
    ..These findings indicate a strong protective effect of ALCAR and NAC on impulse noise-induced cochlear damage, and suggest the feasibility of using clinically available antioxidant compounds to protect the ear from acute acoustic injury...
  33. ncbi request reprint Susceptibility to the ototoxic properties of toluene is species specific
    Rickie R Davis
    Hearing Loss Prevention Section, Engineering and Physical Hazards Branch, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    Hear Res 166:24-32. 2002
    ..However, chinchillas may provide a valuable model for investigating how ototoxic agents can be detoxified to less damaging compounds...

Research Grants7

  1. Prevention of Solvent and Noise-Induced Hearing Loss
    Donald Henderson; Fiscal Year: 2005
    ....
  2. Prevention and Treatment of Age-Related Hearing Loss
    Donald Henderson; Fiscal Year: 2005
    ..The biochemical, morphological and histological measures will be correlated with hearing threshold. ..
  3. Prevention and Treatment of Age-Related Hearing Loss
    Donald Henderson; Fiscal Year: 2006
    ..The biochemical, morphological and histological measures will be correlated with hearing threshold. ..
  4. Prevention and Treatment of Age-Related Hearing Loss
    Donald Henderson; Fiscal Year: 2007
    ..The biochemical, morphological and histological measures will be correlated with hearing threshold. ..
  5. Prevention of Solvent and Noise-Induced Hearing Loss
    Donald Henderson; Fiscal Year: 2007
    ..abstract_text> ..