Research Topics
| J C HemphillSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Influence of data resolution and interpolation method on assessment of secondary brain insults in neurocritical careJ Claude Hemphill
Department of Neurology, University of California, San Francisco, CA, USA San Francisco Injury Center, San Francisco, CA, USA
Physiol Meas 26:373-86. 2005..High frequency data acquisition may be necessary for more precise evaluation of secondary brain injury in neurocritical care...- The ICH score: a simple, reliable grading scale for intracerebral hemorrhageJ C Hemphill
Department of Neurology, University of California, San Francisco, USA
Stroke 32:891-7. 2001..Despite several existing outcome prediction models for ICH, there is no standard clinical grading scale for ICH analogous to those for traumatic brain injury, subarachnoid hemorrhage, or ischemic stroke... - Report from the Indian Third National Workshop on Critical Care NeurologyJ Claude Hemphill
Department of Neurology, San Francisco General Hospital, San Francisco, CA 94110, USA
Neurocrit Care 3:282-3. 2005 - Brain tissue oxygen monitoring in intracerebral hemorrhageJ Claude Hemphill
Department of Neurology, University of California, San Francisco, CA, 94110, USA
Neurocrit Care 3:260-70. 2005..We report complementary preliminary studies in a large animal model and in patients that demonstrate the feasibility of PbrO2 monitoring after ICH... - Hospital usage of early do-not-resuscitate orders and outcome after intracerebral hemorrhageJ Claude Hemphill
Department of Neurology, University of California, San Francisco, Calif, USA
Stroke 35:1130-4. 2004..Do-not-resuscitate (DNR) orders are commonly used after severe stroke. We hypothesized that there is significant variability in how these orders are applied after intracerebral hemorrhage and that this influences outcome... - Contrast extravasation on CT predicts mortality in primary intracerebral hemorrhageJ Kim
Department of Radiology, Neuroradiology Section, University of California, San Francisco, San Francisco, CA 94143 0628, USA
AJNR Am J Neuroradiol 29:520-5. 2008.... - The spontaneous breathing pattern and work of breathing of patients with acute respiratory distress syndrome and acute lung injuryRichard H Kallet
Critical Care Division, Department of Anesthesia, University of California, San Francisco General Hospital, NH GA 2, 1001 Potrero Avenue, San Francisco CA 94110, USA
Respir Care 52:989-95. 2007..We examined the relationship between f/VT, WOB, and respiratory system mechanics in patients with ARDS/ALI... 
Do-not-resuscitate orders, unintended consequences, and the ripple effectJ Claude Hemphill
Department of Neurology, Room 4M62, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Crit Care 11:121. 2007..As illustrated by the example of intracerebral hemorrhage, this may unexpectedly influence outcome even in patients without DNR orders in place...- Cumulative dose of hypertension predicts outcome in intracranial hemorrhage better than American Heart Association guidelinesChristopher W Barton
Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
Acad Emerg Med 14:695-701. 2007..The American Heart Association recommends that blood pressure be maintained at a mean arterial pressure (MAP) less than 130 mm Hg to prevent secondary brain injury... - International neurocritical care: report from the Costa Rica Neurointensive and Neuromonitoring CourseJ Claude Hemphill
Department of Neurology, San Francisco General Hospital, Room 4M62, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Neurocrit Care 8:308-9. 2008 
Hypertonic saline versus mannitol for the treatment of elevated intracranial pressure: a meta-analysis of randomized clinical trialsHooman Kamel
Department of Neurology, University of California, San Francisco, CA, USA
Crit Care Med 39:554-9. 2011..We therefore combined their findings in a meta-analysis...- A novel method of evaluating the impact of secondary brain insults on functional outcomes in traumatic brain-injured patientsChristopher W Barton
Department of Medicine, University of California, San Francisco, CA 94110, USA
Acad Emerg Med 12:1-6. 2005..The authors hypothesized that a new method that accounts for the cumulative depth and duration of SBIs would provide a more informative measure that better correlates with outcome... - Diagnosis of posttraumatic transverse sinus thrombosis with magnetic resonance imaging/magnetic resonance venography: report of two casesAlfredo Quinones-Hinojosa
Department of Neurosurgery, San Francisco General Hospital, University of California, 94143 0112, USA
J Trauma 56:201-4. 2004 - Post-operative expansion of hemorrhagic contusions after unilateral decompressive hemicraniectomy in severe traumatic brain injuryAlexander C Flint
Department of Neurology, Neurovascular and Neurocritical Care Service, University of California San Francisco, San Francisco General Hospital, San Francisco, California 94110, USA
J Neurotrauma 25:503-12. 2008..Severity of initial CT findings may predict the risk of contusion expansion following hemicraniectomy, thereby identifying a subgroup of patients who might benefit from therapies aimed at augmenting the coagulation system... - Clinical nihilism in neuroemergenciesJ Claude Hemphill
Department of Neurology, San Francisco General Hospital, University of California, San Francisco, CA 94110, USA
Emerg Med Clin North Am 27:27-37, vii-viii. 2009.... - Prospective validation of the ICH Score for 12-month functional outcomeJ Claude Hemphill
Department of Neurology, University of California, San Francisco, USA
Neurology 73:1088-94. 2009..The goals of this study were to assess whether the ICH Score accurately stratifies patients with regard to 12-month functional outcome and to further delineate the pace of recovery of patients during the first year post-ICH... - Prognostic significance of angiographically confirmed large vessel intracranial occlusion in patients presenting with acute brain ischemiaWade S Smith
Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
Neurocrit Care 4:14-7. 2006..Because large-vessel occlusion and stroke severity are likely correlated, it is unclear if largevessel occlusion independently predicts outcome or is simply a marker for stroke severity... - Carbon dioxide reactivity and pressure autoregulation of brain tissue oxygenJ C Hemphill
Department of Neurology, University of California San Francisco, 94143-0112, USA
Neurosurgery 48:377-83; discussion 383-4. 2001..The relationship of PbrO2 with ET-CO2 and MAP appears to be similar to those historically established for CBF with ET-CO2 and MAP. This suggests that, under normal conditions, PbrO2 is strongly influenced by factors that regulate CBF... - Continuous monitoring of the microcirculation in neurocritical care: an update on brain tissue oxygenationJack C Rose
Neurovascular Service, University of California, San Francisco, California 94110, USA
Curr Opin Crit Care 12:97-102. 2006..Prospective trials of PbrO2 guided treatment protocols are now needed to demonstrate impact on clinical outcomes... - Brain tissue oxygen tension is more indicative of oxygen diffusion than oxygen delivery and metabolism in patients with traumatic brain injuryGuy Rosenthal
Department of Neurosurgery, University of California, San Francisco, USA
Crit Care Med 36:1917-24. 2008..The objective of this study was to evaluate whether P(bt)O2 more closely reflects variables related to cerebral oxygen diffusion or reflects cerebral oxygen delivery and metabolism... - External validation of the ICH scoreJennifer L Clarke
Department of Neurology, University of California, San Francisco, and San Francisco General Hospital, CA 94110, USA
Neurocrit Care 1:53-60. 2004..Thus, the ICH score is a validated clinical grading scale that can be easily and rapidly applied at ICH presentation. Ascale such as the ICH score could be used to standardize clinical treatment protocols or clinical studies... - New approaches to physiological informatics in neurocritical careMARCO D SORANI
Program in Biological and Medical Informatics, University of California, San Francisco, USA
Neurocrit Care 7:45-52. 2007..We propose that advances in monitoring must be accompanied by advances in methods of high-frequency, multivariate data analysis that integrate the multiple processes occurring in critically ill patients... - Critical care of acute ischemic strokeR A Bernstein
Department of Neurology, San Francisco General Hospital, 1001 Potrero Avenue, Room 4M62, San Francisco, CA 94110, USA
Curr Neurol Neurosci Rep 1:587-92. 2001..In addition, there is concern that some of these interventions may preserve life at the cost of quality of life. This article reviews the evidence behind these approaches to the critical care of ischemic stroke... - Intracerebral hemorrhageLucas Elijovich
Department of Neurology, University of California San Francisco, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Semin Neurol 28:657-67. 2008..Ongoing clinical trials are investigating surgical evacuation of lobar hemorrhage, minimally invasive surgical hematoma evacuation, and aggressive blood pressure lowering... - Advanced cerebral monitoring in neurocritical careNobl Barazangi
Department of Neurology, University of California, San Francisco and Neurocritical Care Program, San Francisco General Hospital, California 94110, USA
Neurol India 56:405-14. 2008.... - The new Licox combined brain tissue oxygen and brain temperature monitor: assessment of in vitro accuracy and clinical experience in severe traumatic brain injuryCampbell Stewart
Department of Surgery, San Francisco General Hospital, University of California, San Francisco, San Francisco, California 94110, USA
Neurosurgery 63:1159-64; discussion 1164-5. 2008..We also describe our clinical experience with the Licox PMO probe... - Small-volume resuscitation with HBOC-201: effects on cardiovascular parameters and brain tissue oxygen tension in an out-of-hospital model of hemorrhage in swineSeong K Lee
San Francisco Injury Center, University of California, San Francisco, School of Medicine, San Francisco, CA, USA
Acad Emerg Med 9:969-76. 2002..The results of this preliminary study demonstrate that HBOC-201 could potentially improve current resuscitation measures and that further investigations with HBOC-201 are warranted... - The role of lung function in brain tissue oxygenation following traumatic brain injuryGuy Rosenthal
Department of Neurosurgery, University of California, San Francisco, California, USA
J Neurosurg 108:59-65. 2008..The purpose of this study was to investigate the influence of lung function on PbtO2 with an oxygen challenge (increase in fraction of inspired oxygen [FiO2] concentration to 1.0)... - Initial Glasgow Coma Scale score predicts outcome following thrombolysis for posterior circulation strokeJack W Tsao
Department of Neurology, San Francisco General Hospital, San Francisco, Calif, USA
Arch Neurol 62:1126-9. 2005..Consequently, there is less published information on thrombolytic therapy for posterior circulation stroke... - Prior antiplatelet therapy and outcome following intracerebral hemorrhage: a systematic reviewB B Thompson
Department of Neurology, Brown University, Providence, RI, USA
Neurology 75:1333-42. 2010..We performed a systematic review and meta-analysis to address the hypothesis that pre-ICH APT use is associated with mortality and poor functional outcome following ICH... - Transcranial Doppler ultrasonography in the neurologic intensive care unitV Singh
Neurovascular Service, Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, California 94143, USA
Neurol India 49:S81-9. 2001..TCD is likely to play a larger role in evaluation of the patient in the future because of its safety, portability and ability to define moment-to-moment changes in cerebral blood flow velocities and cerebral blood flow... - Relationship between brain tissue oxygen tension and CT perfusion: feasibility and initial resultsJ Claude Hemphill
Department of Neurology, University of California, San Francisco, CA 94110, USA
AJNR Am J Neuroradiol 26:1095-100. 2005.... - Prevalence and prognosis of coexistent asymptomatic intracranial stenosisFadi Nahab
Stroke 39:1039-41. 2008..5%, 95% CI: 0.8% to 9.0%). CONCLUSIONS: Whereas the prevalence of coexisting AIS (50% to 99%) in patients with symptomatic stenosis is high, the risk of stroke from these asymptomatic stenoses is low... - Stroke thrombolysis in the elderly: risk or benefit?J Claude Hemphill
Neurology 65:1690-1. 2005 - Small-volume resuscitation with the hemoglobin substitute HBOC-201: effect on brain tissue oxygenationGeoffrey T Manley
School of Medicine, University of California San Francisco, San Francisco Injury Center, Department of Neurological Surgery, USA
Adv Exp Med Biol 530:311-7. 2003..These results suggest that a small-volume bolus of HBOC-201 may provide adequate oxygen and pressure support during the initial management of hemorrhage... - Program requirements for fellowship training in neurological intensive care: United Council for Neurologic Subspecialties guidelinesStephan A Mayer
United Council for Neuroloic Subspecialties, St Paul, MN 55116, USA
Neurocrit Care 5:166-71. 2006 - Treating warfarin-related intracerebral hemorrhage: is fresh frozen plasma enough?J Claude Hemphill
Stroke 37:6-7. 2006 - The need for a registry renaissance in neurocritical careJ Claude Hemphill
Crit Care Med 35:2208-9. 2007 - Core curriculum and competencies for advanced training in neurological intensive care: United Council for Neurologic Subspecialties guidelinesStephan A Mayer
United Council for Neurologic Subspecialties, St Paul, MN 55116, USA
Neurocrit Care 5:159-65. 2006