MARK RICHARD HEMMILA

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Introduction to propensity scores: A case study on the comparative effectiveness of laparoscopic vs open appendectomy
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical School, Ann Arbor, 48109 5033, USA
    Arch Surg 145:939-45. 2010
  2. pmc Detecting the blind spot: complications in the trauma registry and trauma quality improvement
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 0033, USA
    Surgery 142:439-48; discussion 448-9. 2007
  3. ncbi request reprint Improved survival in mice given systemic gene therapy in a gram negative pneumonia model
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 0033, USA
    J Trauma 58:1110-8; discussion 1118. 2005
  4. pmc Real money: complications and hospital costs in trauma patients
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109 5033, USA
    Surgery 144:307-16. 2008
  5. pmc Intensive insulin therapy is associated with reduced infectious complications in burn patients
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 5033, USA
    Surgery 144:629-35; discussion 635-7. 2008
  6. pmc Burn-induced heart failure: lipopolysaccharide binding protein improves burn and endotoxin-induced cardiac contractility deficits
    Andreas D Niederbichler
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 5033, USA
    J Surg Res 165:128-35. 2011
  7. pmc Extracorporeal life support for severe acute respiratory distress syndrome in adults
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
    Ann Surg 240:595-605; discussion 605-7. 2004
  8. ncbi request reprint Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiology
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 0033, USA
    J Trauma 61:598-605; discussion 605-6. 2006
  9. doi request reprint The Trauma Quality Improvement Program: pilot study and initial demonstration of feasibility
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 5033, USA
    J Trauma 68:253-62. 2010
  10. ncbi request reprint Delayed repair for blunt thoracic aortic injury: is it really equivalent to early repair?
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, 48109 0033, USA
    J Trauma 56:13-23. 2004

Research Grants

Collaborators

Detail Information

Publications42

  1. doi request reprint Introduction to propensity scores: A case study on the comparative effectiveness of laparoscopic vs open appendectomy
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical School, Ann Arbor, 48109 5033, USA
    Arch Surg 145:939-45. 2010
    ..To demonstrate the use of propensity scores to evaluate the comparative effectiveness of laparoscopic and open appendectomy...
  2. pmc Detecting the blind spot: complications in the trauma registry and trauma quality improvement
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 0033, USA
    Surgery 142:439-48; discussion 448-9. 2007
    ..We sought to apply the NSQIP methodology to collect comorbidity and outcome data for trauma patients. Data were compared to the NTDB to determine the benefit and validity of using the NSQIP methodology for trauma...
  3. ncbi request reprint Improved survival in mice given systemic gene therapy in a gram negative pneumonia model
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 0033, USA
    J Trauma 58:1110-8; discussion 1118. 2005
    ..We postulate that systemic LBP gene therapy will reconstitute a protective innate immune response in LBP knockout mice and that overexpression of LBP in wild-type mice may offer a survival advantage...
  4. pmc Real money: complications and hospital costs in trauma patients
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109 5033, USA
    Surgery 144:307-16. 2008
    ..We used the National Surgical Quality Improvement Program (NSQIP) methodology to evaluate hospital costs, duration of stay, and payment associated with complications in trauma patients...
  5. pmc Intensive insulin therapy is associated with reduced infectious complications in burn patients
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI 48109 5033, USA
    Surgery 144:629-35; discussion 635-7. 2008
    ..We sought to evaluate our experience with intensive insulin therapy in burn-injured ICU patients with regard to mortality, morbidity, and use of hospital resources...
  6. pmc Burn-induced heart failure: lipopolysaccharide binding protein improves burn and endotoxin-induced cardiac contractility deficits
    Andreas D Niederbichler
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109 5033, USA
    J Surg Res 165:128-35. 2011
    ..In this study, we sought to determine the effect of recombinant rat LBP (rLBP) on cardiomyocyte sarcomere function after burn or sham injury in the presence or absence of bacterial endotoxin...
  7. pmc Extracorporeal life support for severe acute respiratory distress syndrome in adults
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
    Ann Surg 240:595-605; discussion 605-7. 2004
    ..The objective of this study was to evaluate our experience with ECLS in adult patients with severe ARDS with respect to mortality and morbidity...
  8. ncbi request reprint Gene therapy with lipopolysaccharide binding protein for gram-negative pneumonia: respiratory physiology
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 0033, USA
    J Trauma 61:598-605; discussion 605-6. 2006
    ..We postulate that LBP knockout mice will develop derangements in lung physiology from gram-negative pneumonia and that these changes can be reversed with systemic LBP gene therapy...
  9. doi request reprint The Trauma Quality Improvement Program: pilot study and initial demonstration of feasibility
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 5033, USA
    J Trauma 68:253-62. 2010
    ..This study details the feasibility and acceptance of TQIP among the participating centers...
  10. ncbi request reprint Delayed repair for blunt thoracic aortic injury: is it really equivalent to early repair?
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, 48109 0033, USA
    J Trauma 56:13-23. 2004
    ....
  11. pmc Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury
    Mark R Hemmila
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109 5033, USA
    Surgery 148:499-509. 2010
    ..In addition to reducing infection, nanoemulsion therapy may modulate dermal inflammatory signaling and thereby lessen inflammation following thermal injury...
  12. doi request reprint Angioembolization reduces operative intervention for blunt splenic injury
    Benjamin Wei
    Department of Surgery, Henry Ford Health System Detroit, Michigan, USA
    J Trauma 64:1472-7. 2008
    ..We postulated that splenic AE for BSI would have superior outcomes compared with operation and increase our splenic salvage rate...
  13. doi request reprint Injuries in nonurban areas are associated with increased disability at hospital discharge
    Kristen C Sihler
    Division of Acute Care Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 5033, USA
    J Trauma 67:903-9. 2009
    ..We hypothesized that disability at hospital discharge is worse for those injured in nonurban areas...
  14. pmc Topical p38 MAPK inhibition reduces bacterial growth in an in vivo burn wound model
    Kyros Ipaktchi
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Surgery 142:86-93. 2007
    ..We now question whether attenuating local inflammation would weaken bacterial wound resistance and compromise host defense...
  15. doi request reprint Centers for Medicare and Medicaid services quality indicators do not correlate with risk-adjusted mortality at trauma centers
    Shahid Shafi
    Department of Surgery, University of Texas Southwestern Medical School, Dallas, Texas, USA
    J Trauma 68:771-7. 2010
    ..We hypothesized that compliance with CMS quality indicators would correlate with risk-adjusted mortality rates in trauma patients...
  16. ncbi request reprint Attenuating burn wound inflammatory signaling reduces systemic inflammation and acute lung injury
    Kyros Ipaktchi
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 177:8065-71. 2006
    ..Attenuating local inflammatory signaling appears effective in reducing SIRS and subsequent systemic complications after burn injury...
  17. doi request reprint Mean glucose values predict trauma patient mortality
    Wendy L Wahl
    Trauma Burn Center, University of Michigan Health System, Ann Arbor, Michigan, USA
    J Trauma 65:42-7; discussion 47-8. 2008
    ..We postulated targeted therapy to achieve glucose levels <140 mg/dL would reduce infectious complications and mortality in trauma patients admitted to the intensive care unit (ICU)...
  18. doi request reprint Intensive care unit core measures improve infectious complications in burn patients
    Wendy L Wahl
    Department of Surgery, Trauma Burn Center, University of Michigan Health System, Ann Arbor, MI 481099, USA
    J Burn Care Res 31:190-5. 2010
    ....
  19. ncbi request reprint Attenuating burn wound inflammation improves pulmonary function and survival in a burn-pneumonia model
    Kyros Ipaktchi
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Crit Care Med 35:2139-44. 2007
    ..We hypothesized that this topical intervention would attenuate burn-induced lung injury, improve pulmonary function, protect lungs from bacterial invasion, and reduce mortality...
  20. pmc LPS-binding protein mediates LPS-induced liver injury and mortality in the setting of biliary obstruction
    Rebecca M Minter
    Univ of Michigan, Dept of Surgery, 1500 E Medical Center Dr, SPC 5343, Taubman Center TC2210D, Ann Arbor, MI 48109 5343, USA
    Am J Physiol Gastrointest Liver Physiol 296:G45-54. 2009
    ..Increased LBP production in the setting of cholestatic liver disease appears to be deleterious and may represent a potential therapeutic target for preventing overwhelming inflammatory responses to LPS in this setting...
  21. ncbi request reprint Lipopolysaccharide-binding protein modulates acetaminophen-induced liver injury in mice
    Grace L Su
    Medical Service, Department of Veterans Affairs Medical Center and the Department of Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    Hepatology 41:187-95. 2005
    ..This suggests a novel role for LBP in modulating acetaminophen-induced liver injury. Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/O270-9139/suppmat/index.html)...
  22. ncbi request reprint A comparison of prehospital and hospital data in trauma patients
    Saman Arbabi
    Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    J Trauma 56:1029-32. 2004
    ..We hypothesized that ED and Fd physiologic parameters are equally valid predictors of outcomes. In addition, we hypothesized that early field intubation will improve survival compared with later ED intubation...
  23. ncbi request reprint Altered Kupffer cell function in biliary obstruction
    Rebecca M Minter
    Veterans Administration Ann Arbor Healthcare Systems, Department of Surgery, University of Michigan Medical School, 48109 0331, USA
    Surgery 138:236-45. 2005
    ..Few studies, however, have directly examined KC function. We have sought to define the specific alterations in function and phenotype that occur in the KC after biliary obstruction...
  24. ncbi request reprint Beta-blocker use is associated with improved outcomes in adult burn patients
    Saman Arbabi
    Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109 0033, USA
    J Trauma 56:265-9; discussion 269-71. 2004
    ..However, beta-blockers decrease cardiac output and may decrease oxygen delivery, and theoretically may increase mortality. What is the effect of beta-blockers on healing time and mortality in burn patients?..
  25. ncbi request reprint Diagnosis and management of bile leaks after blunt liver injury
    Wendy L Wahl
    Trauma Burn Center, University of Michigan Health System, Ann Arbor 48109 0033, USA
    Surgery 138:742-7; discussion 747-8. 2005
    ..Furthermore, bile leaks are emerging as frequent complications of NOM. The goal of this study was to determine which BLI patients are at greatest risk for bile leaks and how to manage this complication...
  26. ncbi request reprint The cushion effect
    Saman Arbabi
    Department of Surgery, University of Michigan Health System, Ann Arbor, USA
    J Trauma 54:1090-3. 2003
    ..Human body characteristics such as height and weight may play an important role. We hypothesized that body mass index (BMI) will influence crash injury patterns...
  27. doi request reprint Restrictive red blood cell transfusion: not just for the stable intensive care unit patient
    Wendy L Wahl
    Trauma Burn Center, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48190 5539, USA
    Am J Surg 195:803-6. 2008
    ..We hypothesized that a RBC transfusion guideline would safely decrease our use of RBC transfusions in the ICU and lower the hematocrit at which our trauma and burn patients were transfused, both in the stable and symptomatic patient...
  28. ncbi request reprint Does bronchoalveolar lavage enhance our ability to treat ventilator-associated pneumonia in a trauma-burn intensive care unit?
    Wendy L Wahl
    Department of Surgery, University of Michigan Health System, Ann Arbor 48109 0033, USA
    J Trauma 54:633-8; discussion 638-9. 2003
    ..We hypothesized that BAL would decrease the number of cases of VAP diagnosed and impact our antibiotic use and ventilator days...
  29. ncbi request reprint Herb and vitamin supplementation use among a general ophthalmology practice population
    Adrienne L West
    Department of Ophthalmology, University of Michigan Health System, Ann Arbor, Michigan 48105, USA
    Am J Ophthalmol 139:522-9. 2005
    ..To survey comprehensive ophthalmology patients about their use of vitamins and herbal supplements...
  30. doi request reprint Late outcomes following open and endovascular repair of blunt thoracic aortic injury
    Himanshu J Patel
    Department of Surgery, University of Michigan Hospitals, Ann Arbor, Mich, USA
    J Vasc Surg 53:615-20; discussion 621. 2011
    ..Late results remain ill-defined and are the focus of this study...
  31. ncbi request reprint Bronchoalveolar lavage in diagnosis of ventilator-associated pneumonia in patients with burns
    Wendy L Wahl
    University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0033, USA
    J Burn Care Rehabil 26:57-61. 2005
    ..The use of BAL eliminated the unnecessary antibiotic treatment of 21% of patients in the BAL time period and was associated with a lower rate of VAP...
  32. ncbi request reprint Topical p38MAPK inhibition reduces dermal inflammation and epithelial apoptosis in burn wounds
    Kyros Ipaktchi
    Department of Surgery, Burn Center, University of Michigan Medical School, Ann Arbor, MI 48109 0033, USA
    Shock 26:201-9. 2006
    ..Blunting early excessive inflammatory signaling may be an efficient strategy to improve patient outcomes after burn injury...
  33. ncbi request reprint Cardiomyocyte function after burn injury and lipopolysaccharide exposure: single-cell contraction analysis and cytokine secretion profile
    Andreas D Niederbichler
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Shock 25:176-83. 2006
    ..These results demonstrate that LPS exposure and burn injury independently decrease peak cardiac shortening. These decreases did not directly correlate with the levels of cytokines released in response to each stressor...
  34. ncbi request reprint Blunt splenic injury: operation versus angiographic embolization
    Wendy L Wahl
    Trauma Burn Center, University of Michigan Health System, Ann Arbor 48109 0033, USA
    Surgery 136:891-9. 2004
    ..We hypothesized that splenic embolization would lead to equivalent, if not improved, outcomes in terms of mortality, total costs, complications, and duration of stay...
  35. ncbi request reprint Extracorporeal support for organ donation after cardiac death effectively expands the donor pool
    Joseph F Magliocca
    Department of Surgery, The University of Wisconsin School of Medicine, Madison WI, USA
    J Trauma 58:1095-101; discussion 1101-2. 2005
    ..Study parameters included increase in number of donors and organs, types of organs procured, and viability of kidneys transplanted...
  36. doi request reprint Duration of antibiotic therapy for ventilator-associated pneumonia in burn patients
    Wendy L Wahl
    University of Michigan Health System, Department of Surgery, Ann Arbor, MI 48109, USA
    J Burn Care Res 30:801-6. 2009
    ..In patients without virulent pathogens, a shorter antibiotic course was well-tolerated without recurrences...
  37. ncbi request reprint Survey of primary school educators regarding burn-risk behaviors and fire-safety education
    Joseph Dougherty
    The University of Michigan Health System Burn Center, Ann Arbor, MI, United States
    Burns 33:472-6. 2007
    ..To assess primary school educator knowledge and opinions regarding fire-setting behaviors and burn-injury prevention education...
  38. ncbi request reprint C5a-blockade improves burn-induced cardiac dysfunction
    Laszlo M Hoesel
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA
    J Immunol 178:7902-10. 2007
    ..These results suggest a linkage between C5a and burn-induced cardiac dysfunction and a possible contribution of LPS to these events...
  39. ncbi request reprint Perfusion induced hyperthermia for oncologic therapy with cardiac and cerebral protection
    Mark R Hemmila
    Department of Surgery, The University of Michigan Medical Center, Ann Arbor, USA
    ASAIO J 48:350-4. 2002
    ..Lower abdominal and pelvic hyperthermia at 42 degrees C can be safely produced and maintained for 4 hours using an extracorporeal perfusion circuit, while protecting the heart and brain from temperature elevation...
  40. ncbi request reprint Severe respiratory failure: advanced treatment options
    Mark R Hemmila
    Department of Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Crit Care Med 34:S278-90. 2006
    ..Severe respiratory failure (including acute lung injury and acute respiratory distress syndrome) continues to be associated with significant mortality and morbidity in patients of all ages...
  41. pmc Local wound p38 MAPK inhibition attenuates burn-induced cardiac dysfunction
    Laszlo M Hoesel
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI, USA
    Surgery 146:775-85; discussion 785-6. 2009
    ..Topical inhibition of activated p38 MAPK within burn wounds attenuates the local and systemic inflammatory response. In this study, we investigated the effects of local activated p38 MAPK inhibition on burn-induced cardiac dysfunction...
  42. pmc An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction
    Andreas D Niederbichler
    Department of Surgery, The University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Exp Med 203:53-61. 2006
    ..These data suggest that CLP induces C5aR on cardiomyocytes and that in vivo generation of C5a causes C5a-C5aR interaction, causing dysfunction of cardiomyocytes, resulting in compromise of cardiac performance...

Research Grants2

  1. Gram-Negative Pneumonia and Lipopolysaccharide Binding Protein
    Mark Hemmila; Fiscal Year: 2007
    ..The insights gained from the experiments proposed may lead to new therapeutic interventions for treatment and prevention of bacterial pneumonia. ..