Peiman Hematti

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. doi Potential role of mesenchymal stromal cells in pancreatic islet transplantation
    Peiman Hematti
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI, USA
    Transplant Rev (Orlando) 27:21-9. 2013
  2. doi Mesenchymal stromal cells and fibroblasts: a case of mistaken identity?
    Peiman Hematti
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, and University of Wisconsin Carbone Cancer Center, Madison, WI, USA
    Cytotherapy 14:516-21. 2012
  3. pmc Human embryonic stem cell-derived mesenchymal stromal cells
    Peiman Hematti
    Department of Medicine, Division of Hematology Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, Wisconsin 53705 2275, USA
    Transfusion 51:138S-144S. 2011
  4. pmc Role of mesenchymal stromal cells in solid organ transplantation
    Peiman Hematti
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI 53792, USA
    Transplant Rev (Orlando) 22:262-73. 2008
  5. pmc Macrophages in multiple myeloma: emerging concepts and therapeutic implications
    Fotis Asimakopoulos
    Division of Hematology Oncology, Department of Medicine, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA and University of Wisconsin Carbone Cancer Center, Madison, WI, USA
    Leuk Lymphoma 54:2112-21. 2013
  6. pmc Thiol-ene Michael-type formation of gelatin/poly(ethylene glycol) biomatrices for three-dimensional mesenchymal stromal/stem cell administration to cutaneous wounds
    Kedi Xu
    School of Pharmacy, Division of Pharmaceutical Sciences, University of Wisconsin Madison, 777 Highland Avenue, Madison, WI 53705, USA Quishi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, People s Republic of China
    Acta Biomater 9:8802-14. 2013
  7. pmc Biologic and immunomodulatory properties of mesenchymal stromal cells derived from human pancreatic islets
    Jaehyup Kim
    University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin, USA
    Cytotherapy 14:925-35. 2012
  8. doi Comparative analysis of adipose-derived mesenchymal stem cells isolated from abdominal and breast tissue
    Summer E Hanson
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Aesthet Surg J 33:888-98. 2013
  9. ncbi Comparison of breast and abdominal adipose tissue mesenchymal stromal/stem cells in support of proliferation of breast cancer cells
    Jaehyup Kim
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin, USA, 1
    Cancer Invest 31:550-4. 2013
  10. pmc Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells
    Jaehyup Kim
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, USA
    Br J Haematol 158:336-46. 2012

Research Grants

Collaborators

Detail Information

Publications29

  1. doi Potential role of mesenchymal stromal cells in pancreatic islet transplantation
    Peiman Hematti
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI, USA
    Transplant Rev (Orlando) 27:21-9. 2013
    ..Further, tissue specific pancreatic islet derived MSCs may open new opportunities for its use in islet transplantation as those cells might be more physiological to pancreatic islets...
  2. doi Mesenchymal stromal cells and fibroblasts: a case of mistaken identity?
    Peiman Hematti
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, and University of Wisconsin Carbone Cancer Center, Madison, WI, USA
    Cytotherapy 14:516-21. 2012
    ....
  3. pmc Human embryonic stem cell-derived mesenchymal stromal cells
    Peiman Hematti
    Department of Medicine, Division of Hematology Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, Wisconsin 53705 2275, USA
    Transfusion 51:138S-144S. 2011
    ....
  4. pmc Role of mesenchymal stromal cells in solid organ transplantation
    Peiman Hematti
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI 53792, USA
    Transplant Rev (Orlando) 22:262-73. 2008
    ..In the future, MSCs might potentially provide novel therapeutic options for treatment/prevention of rejection and/or repair of organ allografts through their multifaceted properties...
  5. pmc Macrophages in multiple myeloma: emerging concepts and therapeutic implications
    Fotis Asimakopoulos
    Division of Hematology Oncology, Department of Medicine, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA and University of Wisconsin Carbone Cancer Center, Madison, WI, USA
    Leuk Lymphoma 54:2112-21. 2013
    ..Targeted reprogramming of these interactions harbors significant untapped therapeutic potential, particularly in the setting of minimal residual disease, the main obstacle toward a cure...
  6. pmc Thiol-ene Michael-type formation of gelatin/poly(ethylene glycol) biomatrices for three-dimensional mesenchymal stromal/stem cell administration to cutaneous wounds
    Kedi Xu
    School of Pharmacy, Division of Pharmaceutical Sciences, University of Wisconsin Madison, 777 Highland Avenue, Madison, WI 53705, USA Quishi Academy for Advanced Studies, Zhejiang University, Hangzhou 310027, People s Republic of China
    Acta Biomater 9:8802-14. 2013
    ....
  7. pmc Biologic and immunomodulatory properties of mesenchymal stromal cells derived from human pancreatic islets
    Jaehyup Kim
    University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin, USA
    Cytotherapy 14:925-35. 2012
    ..In this study, we investigated the biologic and immunomodulatory properties of human pancreatic islet-derived MSC...
  8. doi Comparative analysis of adipose-derived mesenchymal stem cells isolated from abdominal and breast tissue
    Summer E Hanson
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Aesthet Surg J 33:888-98. 2013
    ..Due to these properties, there is increasing interest in their potential use in autologous fat grafting, particularly to the breast...
  9. ncbi Comparison of breast and abdominal adipose tissue mesenchymal stromal/stem cells in support of proliferation of breast cancer cells
    Jaehyup Kim
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin, USA, 1
    Cancer Invest 31:550-4. 2013
    ....
  10. pmc Macrophages and mesenchymal stromal cells support survival and proliferation of multiple myeloma cells
    Jaehyup Kim
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, USA
    Br J Haematol 158:336-46. 2012
    ..Our in vitro studies provide evidence that highlights the role of macrophages as a key component of the BM microenvironment facilitating the growth of malignant plasma cells in MM...
  11. pmc Cell encapsulating biomaterial regulates mesenchymal stromal/stem cell differentiation and macrophage immunophenotype
    David Antonio Cantu
    Division of Pharmaceutical Sciences, School of Pharmacy, University of Wisconsin Madison, Wisconsin 53705, USA
    Stem Cells Transl Med 1:740-9. 2012
    ..A better understanding of the effect of cell encapsulation on differentiation potency and immunomodulation of MSCs is essential for MSC-based, biomaterial-enabled therapies...
  12. pmc The effect of mesenchymal stromal cell-hyaluronic acid hydrogel constructs on immunophenotype of macrophages
    Summer E Hanson
    Division of Plastic and Reconstructive Surgery, University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Tissue Eng Part A 17:2463-71. 2011
    ..Development of macrophages, with this immunophenotype, upon interaction with the MSC-hydrogel constructs may play a potentially significant role in tissue repair when using a cellular-biomaterial therapeutic approach...
  13. pmc TPL2 kinase regulates the inflammatory milieu of the myeloma niche
    Chelsea Hope
    Department of Medicine, Division of Hematology Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI University of Wisconsin Carbone Cancer Center, Madison, WI
    Blood 123:3305-15. 2014
    ..Our results highlight a TLR2/6-dependent TPL2 pathway as novel therapeutic target acting nonautonomously through macrophages to control myeloma progression. ..
  14. pmc Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages
    Jaehyup Kim
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI 53705 2275, USA
    Exp Hematol 37:1445-53. 2009
    ..This study investigates the hypothesis that interaction of MSCs with macrophages could play a significant role in their antiinflammatory/immune modulatory effects...
  15. pmc In vitro characterization of macrophage interaction with mesenchymal stromal cell-hyaluronan hydrogel constructs
    Suzanne N King
    Division of Otolaryngology Head and Neck Surgery, University of Wisconsin Madison, Madison, Wisconsin
    J Biomed Mater Res A 102:890-902. 2014
    ..Our results indicate an alteration of expression of ECM proteins important to tissue regeneration and cytokines critical to the inflammatory cascade when 3D constructs were cultured with differentiating macrophages...
  16. pmc Characterization of mesenchymal stem cells from human vocal fold fibroblasts
    Summer E Hanson
    Division of Plastic and Reconstructive Surgery, School of Medicine and Public Health, University of Wisconsin Madison, Madison, Wisconsin, USA
    Laryngoscope 120:546-51. 2010
    ..We hypothesized that human vocal fold fibroblasts (hVFF) isolated from the lamina propria meet the criteria established to define MSCs and are functionally similar to MSCs derived from BM and adipose tissue...
  17. pmc Clinical applications of mesenchymal stem cells in soft tissue augmentation
    Summer E Hanson
    Division of Plastic and Reconstructive Surgery, University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin, USA
    Aesthet Surg J 30:838-42. 2010
    ..In this article, the authors review the clinical advances in cell-based therapies relevant to aesthetic surgery, including tissue augmentation, rejuvenation, and regeneration...
  18. pmc Derivation and immunological characterization of mesenchymal stromal cells from human embryonic stem cells
    Parul Trivedi
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI 53792 5156, USA
    Exp Hematol 36:350-9. 2008
    ..We investigated whether MSCs can be derived from human ESCs without coculturing with OP9 cells, and if such cells exhibit immunological properties similar to MSCs derived from adult human bone marrow (BM)...
  19. doi Mesenchymal stromal cells are present in the heart and promote growth of adult stem cells in vitro
    Entela B Lushaj
    Division of Cardiothoracic Surgery Department of Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53792 3236, USA
    Cytotherapy 13:400-6. 2011
    ..The impact of MSC on growth and differentiation of adult cardiac stem cells (CSC) was also analyzed...
  20. pmc Mice engrafted with human fetal thymic tissue and hematopoietic stem cells develop pathology resembling chronic graft-versus-host disease
    Jennifer L Lockridge
    Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    Biol Blood Marrow Transplant 19:1310-22. 2013
    ..This model thus provides a new system to investigate disease pathophysiology relating to human thymic events and to evaluate treatment strategies to combat multiorgan fibrotic pathology produced by human immune cells...
  21. pmc MAP3K8 kinase regulates myeloma growth by cell-autonomous and non-autonomous mechanisms involving myeloma-associated monocytes/macrophages
    Ellen Hebron
    Department of Medicine, Division of Hematology Oncology, University of Wisconsin Madison School of Medicine and Public Health, Madison, WI, USA
    Br J Haematol 160:779-84. 2013
    ..Pharmacological MAP3K8 inhibition results in dose-dependent, tumour cell-autonomous apoptosis despite contact with primary stroma. MAP3K8 blockade may disrupt crucial macrophage-tumour cell interactions within myeloma niches...
  22. pmc Mesenchymal stem cells in hematopoietic stem cell transplantation
    Minoo Battiwalla
    Department of Medicine, Roswell Park Cancer Institute, New York, New York, USA
    Cytotherapy 11:503-15. 2009
    ....
  23. pmc Mesenchymal stem cell therapy for nonhealing cutaneous wounds
    Summer E Hanson
    Division of Plastic and Reconstructive Surgery, Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, and the University of Wisconsin Carbone Cancer Center, Madison, Wis, USA
    Plast Reconstr Surg 125:510-6. 2010
    ....
  24. pmc Generation of mesenchymal stromal cells from HOXB4-expressing human embryonic stem cells
    Yi Ping Liu
    University of Wisconsin Madison, School of Medicine and Public Health, Madison, Wisconsin, USA
    Cytotherapy 11:716-25. 2009
    ..Overexpression of HOXB4 in murine and human embryonic stem cells (ESC) has been used to generate hematopoietic stem cells (HSC) via the embryoid body formation method...
  25. pmc Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-kappaB activity in myeloma cells
    Stephanie Markovina
    Program in Cellular and Molecular Biology and Medical Science Training Program, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53705, USA
    Mol Cancer 9:176. 2010
    ..The mediating factor(s) of this bortezomib-resistant NF-kappaB activity is induced by BMSCs is not currently understood...
  26. pmc Clinical applications of mesenchymal stem cells in laryngotracheal reconstruction
    Summer Hanson
    Division of Plastic and Reconstructive Surgery, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI 53792, USA
    Curr Stem Cell Res Ther 5:268-72. 2010
    ..The clinical role of tissue-derived MSCs, though not well understood, holds promise for many therapeutic applications in regenerative medicine and reconstruction...
  27. pmc Generation of CD34+ cells from human embryonic stem cells using a clinically applicable methodology and engraftment in the fetal sheep model
    Jaehyup Kim
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI 53705, USA
    Exp Hematol 41:749-758.e5. 2013
    ....
  28. ncbi Simultaneous generation of CD34+ primitive hematopoietic cells and CD73+ mesenchymal stem cells from human embryonic stem cells cocultured with murine OP9 stromal cells
    Parul Trivedi
    Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI, USA
    Exp Hematol 35:146-54. 2007
    ....
  29. doi Human embryonic stem cell-derived mesenchymal progenitors: an overview
    Peiman Hematti
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, USA
    Methods Mol Biol 690:163-74. 2011
    ..Finally, immunomodulatory properties of hESC-derived MSCs are likely to prove valuable for inducing immune tolerance toward other cells or tissues derived from the same hESC lines...

Research Grants2

  1. Embryonic Stem Cell Derived HSC Transplantation in Rhesus Macaque Model
    Peiman Hematti; Fiscal Year: 2007
    ..End of Abstract) ..