Genomes and Genes
J A Helms
Affiliation: University of California
- A molecular analysis of matrix remodeling and angiogenesis during long bone developmentC I Colnot
Department of Orthopedic Surgery, University of California at San Francisco, CA 94143 0514, USA
Mech Dev 100:245-50. 2001..Here, we have produced a 'molecular map' of the initial vascularization of the developing skeleton that provides a framework in which to interpret a wide range of fetal skeletal malformations, disruptions, and dysplasias...
- Sonic hedgehog participates in craniofacial morphogenesis and is down-regulated by teratogenic doses of retinoic acidJ A Helms
Department of Orthopaedic Surgery, University of California at San Francisco, 94143, USA
Dev Biol 187:25-35. 1997..In addition, we discuss a novel mechanism whereby retinoids can exert a teratogenic effect on craniofacial morphogenesis independent of its effects on Hox gene expression or neural crest cell migration...
- The role of sonic hedgehog in normal and abnormal craniofacial morphogenesisD Hu
Department of Orthopaedic Surgery, School of Medicine, U 453, University of California at San Francisco, San Francisco, CA 94143 0514, USA
Development 126:4873-84. 1999....
- Molecular aspects of healing in stabilized and non-stabilized fracturesA X Le
Department of Orthopaedic Surgery, University of California at San Francisco, 94143-0514, USA
J Orthop Res 19:78-84. 2001..These data support the hypothesis that mechanical influences affect mesenchymal cell differentiation to bone...
- Does adult fracture repair recapitulate embryonic skeletal formation?C Ferguson
Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Ave, San Francisco, USA
Mech Dev 87:57-66. 1999..Taken together, these data suggest the genetic mechanisms regulating fetal skeletogenesis also regulate adult skeletal regeneration, and point to important regulators of angiogenesis and ossification in bone regeneration...
- Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHHR A Schneider
Department of Orthopaedic Surgery, 533 Parnassus Avenue, Suite U-453, University of California at San Francisco, San Francisco, CA 94143-0514, USA
Development 128:2755-67. 2001..We propose that the local source of retinoic acid in the rostral head initiates a regulatory cascade that coordinates forebrain and frontonasal process morphogenesis...
- Cranial skeletal biologyJ A Helms
University of California at San Francisco, Room U 453, 533 Parnassus Avenue, San Francisco, California 94143 0514, USA
Nature 423:326-31. 2003....
- The cellular and molecular origins of beak morphologyR A Schneider
Department of Orthopaedic Surgery, 533 Parnassus Avenue, Suite U 453, University of California, San Francisco, CA 94143, USA
Science 299:565-8. 2003..Thus, neural crest cells are a source of molecular information that generates interspecific variation in beak morphology...
- Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesisM Iwasaki
Department of Orthopaedic Surgery, University of California, San Francisco 94143 0514, USA
Mech Dev 69:197-202. 1997..Collectively our findings suggest that ihh participates in, but is not required for chondrocyte hypertrophy...
- Primary cilia act as mechanosensors during bone healing around an implantP Leucht
Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Med Eng Phys 35:392-402. 2013..The ability to manipulate the genetic background of peri-implant cells within the context of a whole, living tissue provides a rare opportunity to explore mechanotransduction from a multi-scale perspective...
- LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formationS D Boden
Emory University School of Medicine, Department of Orthopaedic Surgery, and Atlanta Veterans Affairs Medical Center, Decatur, Georgia 30033, USA
Endocrinology 139:5125-34. 1998..These data demonstrate that LMP-1 is an essential positive regulator of the osteoblast differentiation program as well as an important intermediate step in the BMP-6 signaling pathway...
- Molecular analysis of healing at a bone-implant interfaceC Colnot
Department of Orthopaedic Surgery, University of California, San Francisco, CA 94110 1342, USA
J Dent Res 86:862-7. 2007..The general stages of healing in this mouse model resembled those in larger animal models, and supported the use of this new model as a test bed for studying cellular and molecular responses to biomaterial and biomechanical conditions...
- Cellular and molecular characterization of a murine non-union modelP Choi
Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143 0514, USA
J Orthop Res 22:1100-7. 2004..We have developed a method to study the molecular and cellular events underlying delayed skeletal repair in a model that utilizes distraction osteogenesis...
- MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytesT H Vu
Department of Anatomy, University of California, San Francisco 94143, USA
Cell 93:411-22. 1998..Growth plates from gelatinase B-null mice in culture show a delayed release of an angiogenic activator, establishing a role for this proteinase in controlling angiogenesis...
- Looking different: understanding diversity in facial formS A Brugmann
Department of Plastic and Reconstructive Surgery, Stanford University, Stanford, California 94305, USA
Am J Med Genet A 140:2521-9. 2006..Taken together, these data facilitate our fledgling understanding of the process by which facial morphogenesis is regulated...
- Craniofacial tissue engineering by stem cellsJ J Mao
Columbia University College of Dental Medicine and Biomedical Engineering, 630 W 168 St PH7 CDM, New York, NY 10032, USA
J Dent Res 85:966-79. 2006..Craniofacial tissue engineering is likely to be realized in the foreseeable future, and represents an opportunity that dentistry cannot afford to miss...
- Cloning and analysis of a new developmentally regulated member of the basic helix-loop-helix familyJ A Helms
Neuroscience Program, University of Connecticut Health Center, Farmington 06032
Mech Dev 48:93-108. 1994..Strikingly, GbHLH1.4 expression in chick embryos exhibits significant overlap with that reported for the murine negative HLH regulator, Id...