J A Helms

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint A molecular analysis of matrix remodeling and angiogenesis during long bone development
    C I Colnot
    Department of Orthopedic Surgery, University of California at San Francisco, CA 94143 0514, USA
    Mech Dev 100:245-50. 2001
  2. ncbi request reprint Sonic hedgehog participates in craniofacial morphogenesis and is down-regulated by teratogenic doses of retinoic acid
    J A Helms
    Department of Orthopaedic Surgery, University of California at San Francisco, 94143, USA
    Dev Biol 187:25-35. 1997
  3. ncbi request reprint The role of sonic hedgehog in normal and abnormal craniofacial morphogenesis
    D Hu
    Department of Orthopaedic Surgery, School of Medicine, U 453, University of California at San Francisco, San Francisco, CA 94143 0514, USA
    Development 126:4873-84. 1999
  4. ncbi request reprint Molecular aspects of healing in stabilized and non-stabilized fractures
    A X Le
    Department of Orthopaedic Surgery, University of California at San Francisco, 94143-0514, USA
    J Orthop Res 19:78-84. 2001
  5. ncbi request reprint Does adult fracture repair recapitulate embryonic skeletal formation?
    C Ferguson
    Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Ave, San Francisco, USA
    Mech Dev 87:57-66. 1999
  6. ncbi request reprint Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH
    R A Schneider
    Department of Orthopaedic Surgery, 533 Parnassus Avenue, Suite U-453, University of California at San Francisco, San Francisco, CA 94143-0514, USA
    Development 128:2755-67. 2001
  7. ncbi request reprint Cranial skeletal biology
    J A Helms
    University of California at San Francisco, Room U 453, 533 Parnassus Avenue, San Francisco, California 94143 0514, USA
    Nature 423:326-31. 2003
  8. ncbi request reprint The cellular and molecular origins of beak morphology
    R A Schneider
    Department of Orthopaedic Surgery, 533 Parnassus Avenue, Suite U 453, University of California, San Francisco, CA 94143, USA
    Science 299:565-8. 2003
  9. ncbi request reprint Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis
    M Iwasaki
    Department of Orthopaedic Surgery, University of California, San Francisco 94143 0514, USA
    Mech Dev 69:197-202. 1997
  10. pmc Primary cilia act as mechanosensors during bone healing around an implant
    P Leucht
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Med Eng Phys 35:392-402. 2013

Collaborators

Detail Information

Publications17

  1. ncbi request reprint A molecular analysis of matrix remodeling and angiogenesis during long bone development
    C I Colnot
    Department of Orthopedic Surgery, University of California at San Francisco, CA 94143 0514, USA
    Mech Dev 100:245-50. 2001
    ..Here, we have produced a 'molecular map' of the initial vascularization of the developing skeleton that provides a framework in which to interpret a wide range of fetal skeletal malformations, disruptions, and dysplasias...
  2. ncbi request reprint Sonic hedgehog participates in craniofacial morphogenesis and is down-regulated by teratogenic doses of retinoic acid
    J A Helms
    Department of Orthopaedic Surgery, University of California at San Francisco, 94143, USA
    Dev Biol 187:25-35. 1997
    ..In addition, we discuss a novel mechanism whereby retinoids can exert a teratogenic effect on craniofacial morphogenesis independent of its effects on Hox gene expression or neural crest cell migration...
  3. ncbi request reprint The role of sonic hedgehog in normal and abnormal craniofacial morphogenesis
    D Hu
    Department of Orthopaedic Surgery, School of Medicine, U 453, University of California at San Francisco, San Francisco, CA 94143 0514, USA
    Development 126:4873-84. 1999
    ....
  4. ncbi request reprint Molecular aspects of healing in stabilized and non-stabilized fractures
    A X Le
    Department of Orthopaedic Surgery, University of California at San Francisco, 94143-0514, USA
    J Orthop Res 19:78-84. 2001
    ..These data support the hypothesis that mechanical influences affect mesenchymal cell differentiation to bone...
  5. ncbi request reprint Does adult fracture repair recapitulate embryonic skeletal formation?
    C Ferguson
    Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Ave, San Francisco, USA
    Mech Dev 87:57-66. 1999
    ..Taken together, these data suggest the genetic mechanisms regulating fetal skeletogenesis also regulate adult skeletal regeneration, and point to important regulators of angiogenesis and ossification in bone regeneration...
  6. ncbi request reprint Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH
    R A Schneider
    Department of Orthopaedic Surgery, 533 Parnassus Avenue, Suite U-453, University of California at San Francisco, San Francisco, CA 94143-0514, USA
    Development 128:2755-67. 2001
    ..We propose that the local source of retinoic acid in the rostral head initiates a regulatory cascade that coordinates forebrain and frontonasal process morphogenesis...
  7. ncbi request reprint Cranial skeletal biology
    J A Helms
    University of California at San Francisco, Room U 453, 533 Parnassus Avenue, San Francisco, California 94143 0514, USA
    Nature 423:326-31. 2003
    ....
  8. ncbi request reprint The cellular and molecular origins of beak morphology
    R A Schneider
    Department of Orthopaedic Surgery, 533 Parnassus Avenue, Suite U 453, University of California, San Francisco, CA 94143, USA
    Science 299:565-8. 2003
    ..Thus, neural crest cells are a source of molecular information that generates interspecific variation in beak morphology...
  9. ncbi request reprint Expression of indian hedgehog, bone morphogenetic protein 6 and gli during skeletal morphogenesis
    M Iwasaki
    Department of Orthopaedic Surgery, University of California, San Francisco 94143 0514, USA
    Mech Dev 69:197-202. 1997
    ..Collectively our findings suggest that ihh participates in, but is not required for chondrocyte hypertrophy...
  10. pmc Primary cilia act as mechanosensors during bone healing around an implant
    P Leucht
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Med Eng Phys 35:392-402. 2013
    ..The ability to manipulate the genetic background of peri-implant cells within the context of a whole, living tissue provides a rare opportunity to explore mechanotransduction from a multi-scale perspective...
  11. ncbi request reprint LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation
    S D Boden
    Emory University School of Medicine, Department of Orthopaedic Surgery, and Atlanta Veterans Affairs Medical Center, Decatur, Georgia 30033, USA
    Endocrinology 139:5125-34. 1998
    ..These data demonstrate that LMP-1 is an essential positive regulator of the osteoblast differentiation program as well as an important intermediate step in the BMP-6 signaling pathway...
  12. ncbi request reprint Molecular analysis of healing at a bone-implant interface
    C Colnot
    Department of Orthopaedic Surgery, University of California, San Francisco, CA 94110 1342, USA
    J Dent Res 86:862-7. 2007
    ..The general stages of healing in this mouse model resembled those in larger animal models, and supported the use of this new model as a test bed for studying cellular and molecular responses to biomaterial and biomechanical conditions...
  13. ncbi request reprint Cellular and molecular characterization of a murine non-union model
    P Choi
    Department of Orthopaedic Surgery, University of California at San Francisco, 533 Parnassus Avenue, San Francisco, CA 94143 0514, USA
    J Orthop Res 22:1100-7. 2004
    ..We have developed a method to study the molecular and cellular events underlying delayed skeletal repair in a model that utilizes distraction osteogenesis...
  14. pmc MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
    T H Vu
    Department of Anatomy, University of California, San Francisco 94143, USA
    Cell 93:411-22. 1998
    ..Growth plates from gelatinase B-null mice in culture show a delayed release of an angiogenic activator, establishing a role for this proteinase in controlling angiogenesis...
  15. ncbi request reprint Looking different: understanding diversity in facial form
    S A Brugmann
    Department of Plastic and Reconstructive Surgery, Stanford University, Stanford, California 94305, USA
    Am J Med Genet A 140:2521-9. 2006
    ..Taken together, these data facilitate our fledgling understanding of the process by which facial morphogenesis is regulated...
  16. pmc Craniofacial tissue engineering by stem cells
    J J Mao
    Columbia University College of Dental Medicine and Biomedical Engineering, 630 W 168 St PH7 CDM, New York, NY 10032, USA
    J Dent Res 85:966-79. 2006
    ..Craniofacial tissue engineering is likely to be realized in the foreseeable future, and represents an opportunity that dentistry cannot afford to miss...
  17. ncbi request reprint Cloning and analysis of a new developmentally regulated member of the basic helix-loop-helix family
    J A Helms
    Neuroscience Program, University of Connecticut Health Center, Farmington 06032
    Mech Dev 48:93-108. 1994
    ..Strikingly, GbHLH1.4 expression in chick embryos exhibits significant overlap with that reported for the murine negative HLH regulator, Id...