Ricki M Helm
Affiliation: University of Arkansas for Medical Sciences
- Food biotechnology: is this good or bad? Implications to allergic diseasesRicki M Helm
Arkansas Children s Hospital Research Institute, Little Rock, Arkansas 72202 3591, USA
Ann Allergy Asthma Immunol 90:90-8. 2003..With respect to safety, foods developed through biotechnology techniques represent one of the most extensively reviewed agricultural advancements in history...
- Sensitization and allergic response and intervention therapy in animal modelsRicki M Helm
University of Arkansas for Medical Sciences ACHRI ACNC, Department of Microbiology Immunology, Little Rock, AR 72202 3591, USA
J AOAC Int 87:1441-7. 2004..In summary, murine and swine animal models are being used to address immunotherapeutic avenues and investigation into the mechanisms of food-allergic sensitization...
- Animal models of food allergyRicki M Helm
ACHRI UAMS, Department of Pediatrics, Little Rock, Arkansas 72202, USA
Curr Opin Allergy Clin Immunol 2:541-6. 2002..The focus of this review will be on recent animal models of food allergy. Animal models are being used to investigate underlying mechanisms of IgE-mediated disease and for prophylactic/intervention therapies to treat allergic disease...
- Nonmurine animal models of food allergyRicki M Helm
Department of Pediatrics, Division of Allergy Immunology, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, Arkansas, USA
Environ Health Perspect 111:239-44. 2003....
- Diet regulates the development of gut-associated lymphoid tissue in neonatal pigletsRicki M Helm
Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
Neonatology 91:248-55. 2007..Furthermore, studies on dietary effects on the development of the neonatal immune system, especially gut-associated lymphoid tissue (GALT), are lacking...
- Cockroach and other inhalant insect allergensRicki M Helm
University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Clin Allergy Immunol 18:271-96. 2004
- Intralesional immunotherapy of warts with mumps, Candida, and Trichophyton skin test antigens: a single-blinded, randomized, and controlled trialThomas D Horn
Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Arch Dermatol 141:589-94. 2005..Other treatment options include immunotherapy. Intralesional immunotherapy using mumps, Candida, or Trichophyton skin test antigens has proved efficacy in the treatment of warts...
- Biotechnology and food allergyRicki M Helm
University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 1120 Marshall Street, Little Rock, AR 72202 3591, USA
Curr Allergy Asthma Rep 2:55-62. 2002....
- Modification of peanut allergen Ara h 3: effects on IgE binding and T cell stimulationPat Rabjohn
Department of Biochemistry and Molecular Biology, Arkansas Children's Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
Int Arch Allergy Immunol 128:15-23. 2002....
- Diet and the development of atopic diseaseRicki M Helm
Department of Microbiology/Immunology, Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Curr Opin Allergy Clin Immunol 4:125-9. 2004..Increasing data on the genetic, humoral and cellular forms associated with these diseases will provide more clear-cut diagnostic criteria, treatment regimens and a more strict definition of the disease variants...
- Food allergy animal models: an overviewRicki M Helm
Allergy and Immunology, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock 72202, USA
Ann N Y Acad Sci 964:139-50. 2002....
- Comparison of physiological and in vitro porcine gastric fluid digestionRandall A Kopper
Department of Chemistry, Hendrix College, Conway, Ark, USA
Int Arch Allergy Immunol 141:217-22. 2006..GI digestion of food allergens can play a prominent role when assessing allergens within the context of a food matrix or meal and during the sensitization phase of IgE-mediated allergy...
- Peanut protein allergens: the effect of roasting on solubility and allergenicityRandall A Kopper
Chemistry Department, Hendrix College, Conway, Ark 72202, USA
Int Arch Allergy Immunol 136:16-22. 2005..CONCLUSION: The presence of these insolubilized peanut proteins provides a continuous source of major allergens to the gastrointestinal mucosal immune system...
- Soy immunotherapy for peanut-allergic mice: modulation of the peanut-allergic responseLaurent Pons
Department of Pediatrics, Division of Pediatric Allergy and Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Allergy Clin Immunol 114:915-21. 2004..CONCLUSIONS: Soy IT can be used to desensitize/downregulate peanut-specific response in peanut-allergic mice and could provide a new therapeutic intervention for peanut allergy...
- Peanut protein allergens: gastric digestion is carried out exclusively by pepsinRandall A Kopper
Chemistry Department, Hendrix College, Conway, Arkansas, USA
J Allergy Clin Immunol 114:614-8. 2004..Additional experimentation using crude food extracts, both in the presence and absence of a complete meal, is needed to elucidate the complete physiologic nature of food allergen digestion...
- A neonatal swine model for peanut allergyRicki M Helm
Division of Allergy/Immunology, Department of Pediatrics, Arkansas Children's Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock 72201, USA
J Allergy Clin Immunol 109:136-42. 2002..The model will be useful for determining IgE-mediated mechanisms and conducting endoscopic histologic assessment of tissues and immunotherapeutic intervention strategies with repeated allergen challenges...
- Assessment of protein allergenicity on the basis of immune reactivity: animal modelsIan Kimber
Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, United Kingdom
Environ Health Perspect 111:1125-30. 2003..Progress made in the design and evaluation of models in the rat, the mouse, the dog and in swine is reviewed and discussed...
- Genetic modification removes an immunodominant allergen from soybeanEliot M Herman
Plant Genetics Research Unit, United States Department of Agriculture/Agricultural Research Service, Donald Danforth Plant Science Center, 975 North Warson Street, St. Louis, Missouri 63132, USA
Plant Physiol 132:36-43. 2003..These data provide evidence for substantial equivalence of composition of transgenic and non-transgenic seed eliminating one of the dominant allergens of soybean seeds...
- Workshop overview: approaches to the assessment of the allergenic potential of food from genetically modified cropsGregory S Ladics
The DuPont Co, Haskell Laboratory, Newark, Delaware 19714, USA
Toxicol Sci 73:8-16. 2003..However, further efforts are needed to evaluate and validate the sensitivity, specificity, and reproducibility of many of these assays for determining the allergenicity potential of GM foods...
- Monitoring peanut allergen in food products by measuring Ara h 1Anna Pomes
INDOOR Biotechnologies, Inc, Charlottesville, VA 22903, USA
J Allergy Clin Immunol 111:640-5. 2003..Peanut allergy is an important health problem in the United States, affecting approximately 0.6% of children. Inadvertent exposure to peanut is a risk factor for life-threatening food-induced anaphylaxis...
- IgE reactivity of tandem repeats derived from cockroach allergen, Bla g 1Anna Pomes
Asthma and Allergic Diseases Center, Department of Medicine, University of Virginia, Charlottesville, VA, USA
Eur J Biochem 269:3086-92. 2002..The rBla g 1 is suitable for structural studies and a candidate for clinical use in diagnosis of cockroach allergy and development of new forms of immunotherapy...