MARC KOPEL HELLERSTEIN

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Measurement of protein turnover rates by heavy water labeling of nonessential amino acids
    Robert Busch
    KineMed, Inc, Emeryville, CA 94608, USA
    Biochim Biophys Acta 1760:730-44. 2006
  2. ncbi request reprint Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo
    Carine Beysen
    KineMed, Inc, Emeryville, California, USA
    Diabetes Care 30:1143-9. 2007
  3. pmc Measurement of reverse cholesterol transport pathways in humans: in vivo rates of free cholesterol efflux, esterification, and excretion
    Scott Turner
    KineMed, Inc, Emeryville, CA S T, J V, A G, S K, J D, H M, E M, J L, M A
    J Am Heart Assoc 1:e001826. 2012
  4. ncbi request reprint Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations
    M K Hellerstein
    Department of Nutritional Sciences, University of California at Berkeley, Berkeley, CA 94720, USA
    Am J Physiol 276:E1146-70. 1999
  5. ncbi request reprint Stable isotope-mass spectrometric measurements of molecular fluxes in vivo: emerging applications in drug development
    Marc K Hellerstein
    University of California at Berkeley, Department of Nutritional Sciences and Toxicology, Berkeley, CA 94720 3104, USA
    Curr Opin Mol Ther 6:249-64. 2004
  6. pmc Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection
    Marc K Hellerstein
    University of California, Berkeley, 119 Morgan Hall, Berkeley, California 94720 3104, USA
    J Clin Invest 112:956-66. 2003
  7. ncbi request reprint Turnover of adipose components and mitochondrial DNA in humans: kinetic biomarkers for human immunodeficiency virus-associated lipodystrophy and mitochondrial toxicity?
    Marc K Hellerstein
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, 94720 3104, USA
    Clin Infect Dis 37:S52-61. 2003
  8. ncbi request reprint In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research
    Marc K Hellerstein
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, California 94720 3104, USA
    Annu Rev Nutr 23:379-402. 2003
  9. ncbi request reprint Measurement of mitochondrial DNA synthesis in vivo using a stable isotope-mass spectrometric technique
    Michelle L Collins
    Graduate Group in Molecular and Biochemical Nutrition, University of California at Berkeley, Berkeley, CA 94720, USA
    J Appl Physiol (1985) 94:2203-11. 2003
  10. ncbi request reprint A critique of the molecular target-based drug discovery paradigm based on principles of metabolic control: advantages of pathway-based discovery
    Marc K Hellerstein
    Department of Nutritional Sciences, 309 Morgan Hall, University of California at Berkeley, CA 94720, USA
    Metab Eng 10:1-9. 2008

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Measurement of protein turnover rates by heavy water labeling of nonessential amino acids
    Robert Busch
    KineMed, Inc, Emeryville, CA 94608, USA
    Biochim Biophys Acta 1760:730-44. 2006
    ..In conclusion, 2H2O labeling permits sensitive, quantitative, operationally simple measurements of protein turnover in vivo by the rise-to-plateau approach, especially for proteins with slow constitutive turnover...
  2. ncbi request reprint Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo
    Carine Beysen
    KineMed, Inc, Emeryville, California, USA
    Diabetes Care 30:1143-9. 2007
    ....
  3. pmc Measurement of reverse cholesterol transport pathways in humans: in vivo rates of free cholesterol efflux, esterification, and excretion
    Scott Turner
    KineMed, Inc, Emeryville, CA S T, J V, A G, S K, J D, H M, E M, J L, M A
    J Am Heart Assoc 1:e001826. 2012
    ....
  4. ncbi request reprint Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations
    M K Hellerstein
    Department of Nutritional Sciences, University of California at Berkeley, Berkeley, CA 94720, USA
    Am J Physiol 276:E1146-70. 1999
    ..In conclusion, MIDA remains the "equation for biosynthesis," but attention to potentially confounding factors and analytic performance is required for optimal application...
  5. ncbi request reprint Stable isotope-mass spectrometric measurements of molecular fluxes in vivo: emerging applications in drug development
    Marc K Hellerstein
    University of California at Berkeley, Department of Nutritional Sciences and Toxicology, Berkeley, CA 94720 3104, USA
    Curr Opin Mol Ther 6:249-64. 2004
    ..Several fundamental advantages of kinetic measurements are demonstrated. Measurement of molecular fluxes represents a powerful addition to drug development technology...
  6. pmc Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection
    Marc K Hellerstein
    University of California, Berkeley, 119 Morgan Hall, Berkeley, California 94720 3104, USA
    J Clin Invest 112:956-66. 2003
    ..The greatest impact of advanced HIV-1 infection is to reduce the generation of long-lived, potential progenitor T cells...
  7. ncbi request reprint Turnover of adipose components and mitochondrial DNA in humans: kinetic biomarkers for human immunodeficiency virus-associated lipodystrophy and mitochondrial toxicity?
    Marc K Hellerstein
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, 94720 3104, USA
    Clin Infect Dis 37:S52-61. 2003
    ..The results suggest that the kinetics of adipose-tissue components and mitochondrial DNA are measurable in vivo and that these measurements may prove useful as clinical biomarkers in patients with HIV/AIDS...
  8. ncbi request reprint In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research
    Marc K Hellerstein
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, California 94720 3104, USA
    Annu Rev Nutr 23:379-402. 2003
    ..Several examples demonstrate that pathway flux results are often unexpected and not predicted by classic biochemistry or the expression of genes and proteins...
  9. ncbi request reprint Measurement of mitochondrial DNA synthesis in vivo using a stable isotope-mass spectrometric technique
    Michelle L Collins
    Graduate Group in Molecular and Biochemical Nutrition, University of California at Berkeley, Berkeley, CA 94720, USA
    J Appl Physiol (1985) 94:2203-11. 2003
    ..Use of this technique may allow improved understanding of the regulation of mitochondrial biogenesis in health and disease...
  10. ncbi request reprint A critique of the molecular target-based drug discovery paradigm based on principles of metabolic control: advantages of pathway-based discovery
    Marc K Hellerstein
    Department of Nutritional Sciences, 309 Morgan Hall, University of California at Berkeley, CA 94720, USA
    Metab Eng 10:1-9. 2008
    ..New approaches that take account of and are built on principles described by metabolic engineers are needed for the next generation of DDD...
  11. ncbi request reprint Carbohydrate-induced hypertriglyceridemia: modifying factors and implications for cardiovascular risk
    Marc K Hellerstein
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, California 94720 3104, USA
    Curr Opin Lipidol 13:33-40. 2002
    ..Although some progress has been made in this field, the central public health issue - the net effect on cardiovascular risk - remains unresolved...
  12. doi request reprint Exploiting complexity and the robustness of network architecture for drug discovery
    Marc K Hellerstein
    Department of Nutritional Sciences and Toxicology, 309 Morgan Hall, University of California, Berkeley, CA 94720
    J Pharmacol Exp Ther 325:1-9. 2008
    ..Pathway-based screening in vivo represents an alternative to the high attrition of the molecular target-based discovery paradigm...
  13. ncbi request reprint Effect of nucleoside reverse transcriptase inhibitors on mitochondrial DNA synthesis in rats and humans
    Michelle L Collins
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, CA 94720 3104, USA
    J Acquir Immune Defic Syndr 37:1132-9. 2004
    ....
  14. ncbi request reprint Isolation of nuclei from label-retaining cells and measurement of their turnover rates in rat colon
    Sylvia Jeewon Kim
    Graduate Group in Molecular and Biochemical Nutrition, University of California, Berkeley, 94720, USA
    Am J Physiol Cell Physiol 286:C1464-73. 2004
    ..Use of this approach may allow better understanding of mechanisms by which agents induce or protect against colon carcinogenesis...
  15. pmc AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency
    Kathy Jaworski
    Department of Nutritional Science and Toxicology, 220 Morgan Hall, University of California, Berkeley, California 94720, USA
    Nat Med 15:159-68. 2009
    ..AdPLA is a major regulator of adipocyte lipolysis and is crucial for the development of obesity...
  16. pmc Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression
    Kristin Ladell
    Division of Experimental Medicine and Department of Medicine, University of California, San Francisco, CA 94110, USA
    J Immunol 180:7907-18. 2008
    ....
  17. ncbi request reprint Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions
    James L Gardner
    Dept of Nutritional Sciences and Toxicology, Univ of California, Berkeley, CA 94720, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1695-705. 2007
    ....
  18. pmc Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity
    Maryam Ahmadian
    Department of Nutritional Science and Toxicology, University of California, Berkeley, California, USA
    Diabetes 58:855-66. 2009
    ..To investigate the role of desnutrin in adipose tissue triacylglycerol (TAG) and fatty acid metabolism...
  19. ncbi request reprint Measurement of mouse vascular smooth muscle and atheroma cell proliferation by 2H2O incorporation into DNA
    Alice Chu
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720 7360, USA
    Am J Physiol Cell Physiol 291:C1014-21. 2006
    ..In summary, proliferation of VSMC and atheroma cells can be quantified reliably and sensitively without radioactivity and may be an informative biomarker in vascular hyperplastic diseases, including atherosclerosis...
  20. ncbi request reprint Physiologic and pharmacologic factors influencing glyceroneogenic contribution to triacylglyceride glycerol measured by mass isotopomer distribution analysis
    Jerry L Chen
    Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, California 94720, USA
    J Biol Chem 280:25396-402. 2005
    ..low carbohydrate diet) or down-regulated in liver (e.g. fructose infusion). Additionally, stimulation of glyceroneogenesis by rosiglitazone in adipose tissue may be an important factor in the antilipolytic actions of thiazolidinediones...
  21. ncbi request reprint Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding
    Elaine A Hsieh
    Department of Nutritional Sciences and Toxicology, Morgan Hall, Rm 309, University of California, Berkeley, CA 94720, USA
    Am J Physiol Endocrinol Metab 288:E965-72. 2005
    ..In summary, the CR effect on cell proliferation is potent, rapid, and reversible in several tissues, and an intermittent feeding pattern reproduces much of the effect in the absence of substantial CR...
  22. ncbi request reprint Dynamics of keratinocytes in vivo using HO labeling: a sensitive marker of epidermal proliferation state
    Elaine A Hsieh
    Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley, CA 94720, USA
    J Invest Dermatol 123:530-6. 2004
    ..Potential applications of this inherently safe method in humans might include studies of psoriasis, wound healing, chemopreventive agents, and caloric intake...
  23. ncbi request reprint Alternate-day fasting reduces global cell proliferation rates independently of dietary fat content in mice
    Krista A Varady
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, California, USA
    Nutrition 25:486-91. 2009
    ..Accordingly, we examined the effects of 85% restriction on the fast day (ADF-85%) with an LF or HF background diet on proliferation rates of various tissues...
  24. ncbi request reprint Dose effects of modified alternate-day fasting regimens on in vivo cell proliferation and plasma insulin-like growth factor-1 in mice
    Krista A Varady
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, California 94720 3104, USA
    J Appl Physiol (1985) 103:547-51. 2007
    ..These findings confirm the beneficial effects of ADF-100% on cancer risk by decreasing cell proliferation and IGF-1 levels and suggest that modified ADF regimens comprising 25-50% CR on the fast day do not replicate these effects...
  25. ncbi request reprint Alternate-day fasting and chronic disease prevention: a review of human and animal trials
    Krista A Varady
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA 94720 3104, USA
    Am J Clin Nutr 86:7-13. 2007
    ..More research is required to establish definitively the consequences of ADF...
  26. doi request reprint Do calorie restriction or alternate-day fasting regimens modulate adipose tissue physiology in a way that reduces chronic disease risk?
    Krista A Varady
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, California 94720 3104, USA
    Nutr Rev 66:333-42. 2008
    ..e., adipose tissue morphology, triglyceride metabolism, and adipokine release, and attempts to link these changes to indicators of chronic disease risk...
  27. doi request reprint Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction
    Krista A Varady
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA 94720, USA
    J Nutr Biochem 21:188-95. 2010
    ..These findings indicate that ADF (both modified and true) produces similar beneficial modulations in body fat distribution and adiponectin levels as daily CR...
  28. pmc Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates
    Matthew D Bruss
    Dept of Nutritional Sciences and Toxicology, Univ of California at Berkeley, Morgan Hall, Rm 309, Berkeley, CA 94720 3104, USA
    Am J Physiol Endocrinol Metab 298:E108-16. 2010
    ..This pattern may have implications for oxidative damage and disease risk...
  29. doi request reprint Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared with prednisolone
    Donald J Roohk
    Department of Nutritional Sciences and Toxicology, 309 Morgan Hall, University of California, Berkeley, CA 94720 3104, USA
    J Pharmacol Exp Ther 333:281-9. 2010
    ..Because multiple actions can be measured concurrently in a single animal, this method is a powerful systems approach for characterizing and differentiating the effects of ligands that bind nuclear receptors...
  30. pmc The effects of physiological adaptations to calorie restriction on global cell proliferation rates
    Matthew D Bruss
    Department of Nutritional Science and Toxicology, University of California at Berkeley, 94720 3104, USA
    Am J Physiol Endocrinol Metab 300:E735-45. 2011
    ..In addition, these data are consistent with the hypothesis that reduced cell proliferation rates could be useful as a biomarker of interventions that increase longevity...
  31. ncbi request reprint In vivo measurement of DNA synthesis rates of colon epithelial cells in carcinogenesis
    Sylvia Jeewon Kim
    Graduate Group in Molecular and Biochemical Nutrition, 309 Morgan Hall, University of California at Berkeley, CA 94720, USA
    Biochem Biophys Res Commun 331:203-9. 2005
    ..In conclusion, DNA synthesis rates of colon epithelial cells can be measured directly in vivo using stable-isotope labeling. Potential applications in humans include use as a biomarker for cancer chemoprevention studies...
  32. ncbi request reprint Heavy water labeling of keratin as a non-invasive biomarker of skin turnover in vivo in rodents and humans
    Glen Lindwall
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    J Invest Dermatol 126:841-8. 2006
    ..In summary, 2H2O labeling of skin keratin represents a non-invasive approach for assessing skin turnover dynamics in pre-clinical models and in human subjects...
  33. ncbi request reprint New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into functional genomics and biochemical phenotyping
    Marc K Hellerstein
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, 309 Morgon Hall, Berkeley, CA 94720 3104, USA
    Metab Eng 6:85-100. 2004
    ....
  34. ncbi request reprint Pharmacological doses of dietary curcumin increase colon epithelial cell proliferation in vivo in rats
    Sylvia Jeewon Kim
    Graduate Group in Molecular and Biochemical Nutrition, 309 Morgan Hall, University of California at Berkeley, CA 94720, USA
    Phytother Res 21:995-8. 2007
    ..05). Thus, pharmacological doses of curcumin increase CEC proliferation rate and pool size in normal rats. Reduction of CEC proliferation therefore cannot explain the proposed chemopreventive actions of curcumin in colon cancer...
  35. ncbi request reprint Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans
    Aruna Vedala
    Department of Nutritional Sciences and Toxicology, University of California at Berkeley, Berkeley, CA 94720, USA
    J Lipid Res 47:2562-74. 2006
    ..The turnover time and sources of this pool differ in diabetic HPTG and nondiabetic HPTG, with potential therapeutic implications...
  36. ncbi request reprint Heavy water labeling of DNA for measurement of cell proliferation and recruitment during primary murine lymph node responses against model antigens
    Robert Busch
    KineMed Inc, 5980 Horton Street, Emeryville, CA 94608, USA
    J Immunol Methods 337:24-34. 2008
    ....
  37. pmc Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis
    Jeewon Kim
    Department of Chemical and Systems Biology, Stanford University, School of Medicine, Stanford, California 94305 5174, USA
    Cancer Res 68:6831-9. 2008
    ..Our results suggest that a PKCbetaII inhibitor such as betaIIV5-3 may be used to reduce prostate cancer growth by targeting both angiogenesis and tumor cell growth...
  38. ncbi request reprint CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy
    Steven G Deeks
    Department of Medicine, University of California at San Francisco and San Francisco General Hospital, San Francisco, CA 94110, USA
    J Infect Dis 185:315-23. 2002
    ..These data indicate that partial virus suppression reduces CD4(+) cell turnover and activation, thereby resulting in sustained CD4(+) cell gains, and that measurements of T cell dynamics may provide an in vivo marker of viral virulence...
  39. ncbi request reprint Isolation of peripheral blood CD4(+) T cells using RosetteSep and MACS for studies of DNA turnover by deuterium labeling
    Robert Busch
    KineMed, Inc, 5980 Horton St, Emeryville, CA 94608, USA
    J Immunol Methods 286:97-109. 2004
    ..Thus, both FACS and the new method isolate a similar mixture of long- and short-lived CD4(+) T cells. In practice, the RosetteSep/MACS method is simple, rapid, robust and capable of high throughput...
  40. ncbi request reprint Measurement of very low rates of cell proliferation by heavy water labeling of DNA and gas chromatography/pyrolysis/isotope ratio-mass spectrometric analysis
    Jason N Voogt
    KineMed Inc, 5980 Horton Street, Emeryville, California 94608, USA
    Nat Protoc 2:3058-62. 2007
    ..Indolent hematologic malignancies, such as chronic lymphocytic leukemia, and other relatively quiescent cells represent promising areas of application...
  41. ncbi request reprint Measurement of cell proliferation by heavy water labeling
    Robert Busch
    KineMed Inc, 5980 Horton Street, Emeryville, California 94608, USA
    Nat Protoc 2:3045-57. 2007
    ..The protocols enable definitive in vivo studies of the fraction or absolute number of newly divided cells and their subsequent survival kinetics in animals and humans...
  42. pmc In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
    Bradley T Messmer
    Institute for Medical Research, North Shore LIJ Research Institute, Manhasset, New York 11030, USA
    J Clin Invest 115:755-64. 2005
    ..A correlation between birth rates and disease activity and progression appears to exist, which may help identify patients at risk for worsening disease in advance of clinical deterioration...
  43. ncbi request reprint Emerging applications of kinetic biomarkers in preclinical and clinical drug development
    Scott M Turner
    KineMed Inc, Emeryville, CA 94608, USA
    Curr Opin Drug Discov Devel 8:115-26. 2005
    ..Stable isotope mass spectrometric technologies may provide a parallel efficiency for converting molecules into approved drugs with sufficient throughput and reproducibility to maintain pace with the modern engine for generating leads...
  44. pmc A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
    Mark P Keller
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53076, USA
    Genome Res 18:706-16. 2008
    ....
  45. ncbi request reprint Measurement of brain microglial proliferation rates in vivo in response to neuroinflammatory stimuli: application to drug discovery
    Mahalakshmi Shankaran
    KineMed Inc, Emeryville, California, USA
    J Neurosci Res 85:2374-84. 2007
    ..In conclusion, 2H2O labeling represents a relatively high-throughput, quantitative, and highly reproducible technique for measuring microglial proliferation, and is useful for screening and discovering novel anti-neuroinflammatory drugs...
  46. ncbi request reprint Discovery of novel hippocampal neurogenic agents by using an in vivo stable isotope labeling technique
    Mahalakshmi Shankaran
    KineMed, Inc, 5980 Horton Street, Suite 400, Emeryville, CA 94608, USA
    J Pharmacol Exp Ther 319:1172-81. 2006
    ..In conclusion, stable isotope labeling is an efficient, high-throughput in vivo method for measuring hippocampal progenitor cell proliferation that can be used to screen for novel neurogenic drugs...
  47. pmc The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects
    Lisa C Hudgins
    The Rogosin Institute, New York, NY 10021, USA
    J Nutr Biochem 19:237-45. 2008
    ..However, the dietary responsiveness of the key enzyme controlling DNL in human adipose tissue, fatty acid synthase (FAS), is uncertain...
  48. ncbi request reprint Development of a novel method for measuring in vivo breast epithelial cell proliferation in humans
    Lisa M Misell
    KineMed, Inc, 5980 Horton St, Suite 470, Emeryville, CA 94608, USA
    Breast Cancer Res Treat 89:257-64. 2005
    ..In summary, this novel method of measuring BEC proliferation in vivo holds promise for assessing the effects of anti-proliferative chemopreventive and chemotherapeutic agents...
  49. ncbi request reprint Increased lipogenesis and resistance of lipoproteins to oxidative modification in two patients with glycogen storage disease type 1a
    Robert H J Bandsma
    Groningen University Institute for Drug Exploration, Center for Liver, The Netherlands
    J Pediatr 140:256-60. 2002
    ..These findings are potentially relevant for antihyperlipidemic treatment in patients with glycogen storage disease type 1a...
  50. ncbi request reprint Thematic review series: patient-oriented research. Recent advances in liver triacylglycerol and fatty acid metabolism using stable isotope labeling techniques
    Elizabeth J Parks
    Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, USA
    J Lipid Res 47:1651-60. 2006
    ..Patient-oriented research in conditions such as dyslipidemia and hepatic steatosis is made feasible by these scientific advances...
  51. ncbi request reprint Measurement of pancreatic islet cell proliferation by heavy water labeling
    Songyuan Chen
    KineMed Inc, Emeryville, CA 94608, USA
    Am J Physiol Endocrinol Metab 293:E1459-64. 2007
    ..In summary, heavy water labeling is a quantitative approach for measuring islet cell proliferation and testing therapeutic agents...
  52. ncbi request reprint In vivo measurement of microtubule dynamics using stable isotope labeling with heavy water. Effect of taxanes
    Patrizia Fanara
    KineMed, Inc, Emeryville, California 94608, USA
    J Biol Chem 279:49940-7. 2004
    ..This sensitive and quantitative in vivo assay of microtubule dynamics may prove useful for pre-clinical and clinical development of the next generation of MTPAs as anticancer drugs...

Research Grants21

  1. DIRECTLY MEASURED T CELL DYNAMICS IN HIV PATHOGENESIS
    Marc Hellerstein; Fiscal Year: 2000
    ....
  2. DIRECTLY MEASURED T CELL DYNAMICS IN HIV PATHOGENESIS
    Marc Hellerstein; Fiscal Year: 2004
    ..Results have potential relevance to HIV-1 pathogenesis and therapy and to vaccination strategies. ..
  3. Response to and signals of caloric restriction and intermittent feeding regimens
    Marc Hellerstein; Fiscal Year: 2009
    ....
  4. T-Cell Kinetics and Sources--Effects of HIV and Therapy
    Marc Hellerstein; Fiscal Year: 2007
    ..J.M McCune. In summary, advances in technology now make it possible to directly address hypotheses concerning the role of thymic function in HIV-1 pathogenesis and the kinetic consequences of HIV-1 infection and therapies. ..
  5. DIRECTLY MEASURED T CELL DYNAMICS IN HIV PATHOGENESIS
    Marc Hellerstein; Fiscal Year: 2003
    ..Results have potential relevance to HIV-1 pathogenesis and therapy and to vaccination strategies. ..
  6. ADIPOCYTE TURNOVER AND METABOLISM IN HIV-1 LIPOATROPHY
    Marc Hellerstein; Fiscal Year: 2002
    ....
  7. DIRECTLY MEASURED T CELL DYNAMICS IN HIV PATHOGENESIS
    Marc Hellerstein; Fiscal Year: 2002
    ..Results have potential relevance to HIV-1 pathogenesis and therapy and to vaccination strategies. ..
  8. T CELL KINETICS AND SOURCES--EFFECTS OF HIV AND THERAPY
    Marc Hellerstein; Fiscal Year: 2002
    ....
  9. DIRECTLY MEASURED T CELL DYNAMICS IN HIV PATHOGENESIS
    Marc Hellerstein; Fiscal Year: 2001
    ..Results have potential relevance to HIV-1 pathogenesis and therapy and to vaccination strategies. ..
  10. T CELL KINETICS AND SOURCES--EFFECTS OF HIV AND THERAPY
    Marc Hellerstein; Fiscal Year: 2001
    ....
  11. ADIPOCYTE TURNOVER AND METABOLISM IN HIV-1 LIPOATROPHY
    Marc Hellerstein; Fiscal Year: 2000
    ....
  12. T CELL KINETICS AND SOURCES--EFFECTS OF HIV AND THERAPY
    Marc Hellerstein; Fiscal Year: 1999
    ....
  13. DIRECTLY MEASURED T CELL DYNAMICS IN HIV PATHOGENESIS
    Marc Hellerstein; Fiscal Year: 1999
    ....
  14. ADIPOCYTE TURNOVER AND METABOLISM IN HIV-1 LIPOATROPHY
    Marc Hellerstein; Fiscal Year: 2001
    ....
  15. T-Cell Kinetics and Sources--Effects of HIV and Therapy
    Marc Hellerstein; Fiscal Year: 2007
    ..J.M McCune. In summary, advances in technology now make it possible to directly address hypotheses concerning the role of thymic function in HIV-1 pathogenesis and the kinetic consequences of HIV-1 infection and therapies. ..
  16. T CELL KINETICS AND SOURCES--EFFECTS OF HIV AND THERAPY
    Marc Hellerstein; Fiscal Year: 2000
    ....
  17. ADIPOCYTE TURNOVER AND METABOLISM IN HIV-1 LIPOATROPHY
    Marc Hellerstein; Fiscal Year: 2003
    ....
  18. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ....