William Helferich

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. doi request reprint Phytoestrogens and breast cancer: a complex story
    W G Helferich
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Bevier Hall, Room 580, 905 S Goodwin Ave, Urbana, IL 61801, USA
    Inflammopharmacology 16:219-26. 2008
  2. ncbi request reprint A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin, Room 580 Bevier Hall, Urbana, IL 61801, United States
    Food Chem Toxicol 46:310-20. 2008
  3. ncbi request reprint Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin, Room 580 Bevier Hall, Urbana, IL, USA
    Carcinogenesis 27:1292-9. 2006
  4. ncbi request reprint Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats
    Clinton D Allred
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Carcinogenesis 25:211-8. 2004
  5. pmc Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin Avenue, Room 580 Bevier Hall, Urbana, IL 61801, USA
    Carcinogenesis 29:2162-8. 2008
  6. doi request reprint Effects of chronic estradiol treatment on delayed spatial alternation and differential reinforcement of low rates of responding
    Victor C Wang
    Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Behav Neurosci 122:794-804. 2008
  7. pmc Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding
    Edmund C Chang
    Department of Molecular, University of Illinois, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 22:1032-43. 2008
  8. ncbi request reprint Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Cancer Res 62:2474-7. 2002
  9. ncbi request reprint beta-Sitosterol, beta-Sitosterol Glucoside, and a Mixture of beta-Sitosterol and beta-Sitosterol Glucoside Modulate the Growth of Estrogen-Responsive Breast Cancer Cells In Vitro and in Ovariectomized Athymic Mice
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 134:1145-51. 2004
  10. ncbi request reprint Soy processing influences growth of estrogen-dependent breast cancer tumors
    Clinton D Allred
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Carcinogenesis 25:1649-57. 2004

Research Grants

  1. PHYTOESTROGENS AND AGING: DOSE, TIMING & TISSUE
    William Helferich; Fiscal Year: 2007
  2. Dietary Isoflavones, Tamoxifen, and Tumor Growth
    William Helferich; Fiscal Year: 2005
  3. STIMULATION OF TUMOR GROWTH BY DIETARY GENISTEIN
    William Helferich; Fiscal Year: 2000

Collaborators

Detail Information

Publications20

  1. doi request reprint Phytoestrogens and breast cancer: a complex story
    W G Helferich
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Bevier Hall, Room 580, 905 S Goodwin Ave, Urbana, IL 61801, USA
    Inflammopharmacology 16:219-26. 2008
    ..Additionally, dietary genistein can negate the inhibitory effects of TAM on E-stimulated growth of MCF-7 cell tumours implanted into ovariectomized athymic mice...
  2. ncbi request reprint A dietary supplement for female sexual dysfunction, Avlimil, stimulates the growth of estrogen-dependent breast tumors (MCF-7) implanted in ovariectomized athymic nude mice
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin, Room 580 Bevier Hall, Urbana, IL 61801, United States
    Food Chem Toxicol 46:310-20. 2008
    ....
  3. ncbi request reprint Genistein stimulates growth of human breast cancer cells in a novel, postmenopausal animal model, with low plasma estradiol concentrations
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin, Room 580 Bevier Hall, Urbana, IL, USA
    Carcinogenesis 27:1292-9. 2006
    ..Results from this study suggest that consumption of products containing GEN may not be safe for postmenopausal women with estrogen-dependent breast cancer...
  4. ncbi request reprint Dietary genistein results in larger MNU-induced, estrogen-dependent mammary tumors following ovariectomy of Sprague-Dawley rats
    Clinton D Allred
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Carcinogenesis 25:211-8. 2004
    ..The data suggest that in an endogenous estrogen environment similar to that of a postmenopausal woman, dietary genistein can stimulate the growth of a mammary carcinogen MNU-induced estrogen-dependent mammary tumors...
  5. pmc Dietary genistein negates the inhibitory effect of letrozole on the growth of aromatase-expressing estrogen-dependent human breast cancer cells (MCF-7Ca) in vivo
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin Avenue, Room 580 Bevier Hall, Urbana, IL 61801, USA
    Carcinogenesis 29:2162-8. 2008
    ..Caution is warranted for consumption of dietary GEN by postmenopausal women with estrogen-dependent breast cancer taking LET treatment...
  6. doi request reprint Effects of chronic estradiol treatment on delayed spatial alternation and differential reinforcement of low rates of responding
    Victor C Wang
    Neuroscience Program, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Behav Neurosci 122:794-804. 2008
    ..These data suggest that chronic estrogen exposure may impair rats' abilities on measures of executive function including working memory and response inhibition...
  7. pmc Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding
    Edmund C Chang
    Department of Molecular, University of Illinois, Urbana, Illinois 61801 3704, USA
    Mol Endocrinol 22:1032-43. 2008
    ....
  8. ncbi request reprint Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Cancer Res 62:2474-7. 2002
    ..g., pS2, PR, and cyclin D1). Therefore, caution is warranted for postmenopausal women consuming dietary genistein while on TAM therapy for E-responsive breast cancer...
  9. ncbi request reprint beta-Sitosterol, beta-Sitosterol Glucoside, and a Mixture of beta-Sitosterol and beta-Sitosterol Glucoside Modulate the Growth of Estrogen-Responsive Breast Cancer Cells In Vitro and in Ovariectomized Athymic Mice
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 134:1145-51. 2004
    ..Although BSSG comprises only 1% of MC, BSSG made MC less estrogenic than BSS alone in vitro. However, dietary BSS and MC protected against E(2)-stimulated MCF-7 tumor growth and lowered circulating E(2) levels...
  10. ncbi request reprint Soy processing influences growth of estrogen-dependent breast cancer tumors
    Clinton D Allred
    Department of Food Science and Human Nutrition, University of Illinois, Urbana, IL 61801, USA
    Carcinogenesis 25:1649-57. 2004
    ..Collectively, these findings suggest that for postmenopausal women with estrogen-dependent breast cancer, the consumption of foods containing soy flour is more advisable than consuming isoflavones in more purified forms...
  11. ncbi request reprint Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice
    Young H Ju
    Department of Food Science and Human Nutrition, University of Illinois, 905 S Goodwin, Room 580 Bevier Hall, Urbana, IL 61801, USA
    Carcinogenesis 27:856-63. 2006
    ..These results suggest that pharmacokinetic and/or metabolic factors attenuate the estrogenic effects of daidzein and equol in vivo...
  12. ncbi request reprint The soy isoflavone genistein decreases adipose deposition in mice
    Afia Naaz
    Department of Veterinary Biosciences, University of Illinois, Urbana, Illinois 61802, USA
    Endocrinology 144:3315-20. 2003
    ..79 +/- 0.32 microM, 2.55 +/- 0.18 microM, and 3.81 +/- 0.39 microM, respectively. These results indicate dietary genistein at 500-1500 ppm produces antilipogenic effects in mice at serum levels that humans are realistically exposed to...
  13. pmc Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells
    Xinguo Jiang
    Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USA
    Endocrinology 149:5366-73. 2008
    ..A significant population consumes levels of genistein in soy products that may be high enough to induce PI-9, perhaps potentiating the survival of some preexisting breast cancers by enabling them to evade immunosurveillance...
  14. pmc Impact of dietary genistein and aging on executive function in rats
    Steven L Neese
    Department of Veterinary Sciences, University of Illinois at Urbana Champaign, 2001 S Lincoln Avenue, Urbana, IL 61802, USA
    Neurotoxicol Teratol 32:200-11. 2010
    ....
  15. ncbi request reprint Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta
    Rajeev S Muthyala
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA
    Bioorg Med Chem 12:1559-67. 2004
    ..The availability and the in vitro characterization of the equol enantiomers should enable their biological effects to be studied in detail...
  16. ncbi request reprint Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
    Karson S Putt
    Department of Biochemistry, University of Illinois, Urbana, Illinois 61801, USA
    Nat Chem Biol 2:543-50. 2006
    ..The direct activation of executioner caspases is an anticancer strategy that may prove beneficial in treating the many cancers in which procaspase-3 concentrations are elevated...
  17. ncbi request reprint Estrogenicity of the isoflavone metabolite equol on reproductive and non-reproductive organs in mice
    Vimal Selvaraj
    Department of Veterinary Biosciences, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Biol Reprod 71:966-72. 2004
    ....
  18. pmc The phytoestrogen genistein induces thymic and immune changes: a human health concern?
    Srikanth Yellayi
    Department of Veterinary Biosciences, University of Illinois, Urbana, IL 61802, USA
    Proc Natl Acad Sci U S A 99:7616-21. 2002
    ....
  19. ncbi request reprint Soy processing affects metabolism and disposition of dietary isoflavones in ovariectomized BALB/c mice
    Clinton D Allred
    Department of Food Science and Human Nutrition, University of Illinois, Urbana Champaign, IL 61801, USA
    J Agric Food Chem 53:8542-50. 2005
    ....
  20. pmc Acute and chronic effects of oral genistein administration in neonatal mice
    Melissa A Cimafranca
    Department of Veterinary Biosciences, Division of Nutritional Sciences, University of Illinois, 2001 S Lincoln Ave, Urbana, IL 61802, USA
    Biol Reprod 83:114-21. 2010
    ..The immediate and long-term effects in this neonatal animal model raise concerns that high serum concentrations of genistein are estrogenic and could potentially impact the development of human infants fed soy formula...

Research Grants10

  1. PHYTOESTROGENS AND AGING: DOSE, TIMING & TISSUE
    William Helferich; Fiscal Year: 2007
    ..abstract_text> ..
  2. Dietary Isoflavones, Tamoxifen, and Tumor Growth
    William Helferich; Fiscal Year: 2005
    ..abstract_text> ..
  3. STIMULATION OF TUMOR GROWTH BY DIETARY GENISTEIN
    William Helferich; Fiscal Year: 2000
    ..Results of the proposed studies will elucidate the role of genistein from soy on growth of estrogen-dependent tumors in vivo. ..