S L Helfand

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint Calorie restriction delays lipid oxidative damage in Drosophila melanogaster
    Jianyu Zheng
    University of Connecticut Health Center, Department of Genetics and Developmental Biology, Farmington, CT 06030, USA
    Aging Cell 4:209-16. 2005
  2. ncbi request reprint The humble fly: what a model system can reveal about the human biology of aging
    Johannes H Bauer
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02903, USA
    Med Health R I 89:314-5. 2006
  3. ncbi request reprint Neurobiology. Chaperones take flight
    Stephen L Helfand
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 295:809-10. 2002
  4. ncbi request reprint From genes to aging in Drosophila
    Stephen L Helfand
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Adv Genet 49:67-109. 2003
  5. ncbi request reprint Rejuvenating views of the ageing process
    Stephen L Helfand
    School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA
    Nat Rev Genet 3:149-53. 2002
  6. ncbi request reprint Genetics of aging in the fruit fly, Drosophila melanogaster
    Stephen L Helfand
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3301, USA
    Annu Rev Genet 37:329-48. 2003
  7. ncbi request reprint Molecular genetics of aging in the fly: is this the end of the beginning?
    Stephen L Helfand
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030 3301, USA
    Bioessays 25:134-41. 2003
  8. ncbi request reprint Functional characterization of a Drosophila mitochondrial uncoupling protein
    Yih Woei C Fridell
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Bioenerg Biomembr 36:219-28. 2004
  9. ncbi request reprint The expression of a reporter protein, beta-galactosidase, is preserved during maturation and aging in some cells of the adult Drosophila melanogaster
    S L Helfand
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Mech Dev 55:45-51. 1996
  10. ncbi request reprint Cu, Zn superoxide dismutase deficiency accelerates the time course of an age-related marker in Drosophila melanogaster
    B Rogina
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Biogerontology 1:163-9. 2000

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Calorie restriction delays lipid oxidative damage in Drosophila melanogaster
    Jianyu Zheng
    University of Connecticut Health Center, Department of Genetics and Developmental Biology, Farmington, CT 06030, USA
    Aging Cell 4:209-16. 2005
    ..These studies associate damage from lipid peroxidation with aging and lifespan in Drosophila and show that calorie restriction in flies, as in mammals, slows the accumulation of lipid related oxidative damage...
  2. ncbi request reprint The humble fly: what a model system can reveal about the human biology of aging
    Johannes H Bauer
    Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02903, USA
    Med Health R I 89:314-5. 2006
  3. ncbi request reprint Neurobiology. Chaperones take flight
    Stephen L Helfand
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 295:809-10. 2002
  4. ncbi request reprint From genes to aging in Drosophila
    Stephen L Helfand
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Adv Genet 49:67-109. 2003
    ..Invertebrate model systems such as Drosophila and Caenorhabditis elegans that permit extensive genetic analysis are at the forefront of this renaissance...
  5. ncbi request reprint Rejuvenating views of the ageing process
    Stephen L Helfand
    School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA
    Nat Rev Genet 3:149-53. 2002
    ..So, the time is ripe to re-examine these assumptions about the ageing process and to rethink the scientific foundations of the field...
  6. ncbi request reprint Genetics of aging in the fruit fly, Drosophila melanogaster
    Stephen L Helfand
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut 06030 3301, USA
    Annu Rev Genet 37:329-48. 2003
    ....
  7. ncbi request reprint Molecular genetics of aging in the fly: is this the end of the beginning?
    Stephen L Helfand
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030 3301, USA
    Bioessays 25:134-41. 2003
    ....
  8. ncbi request reprint Functional characterization of a Drosophila mitochondrial uncoupling protein
    Yih Woei C Fridell
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Bioenerg Biomembr 36:219-28. 2004
    ..The conserved regulation of the expression of this gene from mammals to fruit flies suggests a role for UCP5 in the brain...
  9. ncbi request reprint The expression of a reporter protein, beta-galactosidase, is preserved during maturation and aging in some cells of the adult Drosophila melanogaster
    S L Helfand
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Mech Dev 55:45-51. 1996
    ..These studies suggest that the ability to express a reporter protein, beta-galactosidase, is preserved in at least a subset of cells in the aging fly...
  10. ncbi request reprint Cu, Zn superoxide dismutase deficiency accelerates the time course of an age-related marker in Drosophila melanogaster
    B Rogina
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Biogerontology 1:163-9. 2000
    ....
  11. ncbi request reprint Regulation of gene expression is preserved in aging Drosophila melanogaster
    B Rogina
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Curr Biol 8:475-8. 1998
    ..Although regulation of gene expression is a central feature of life, a global decline in the control of gene expression does not appear to be either a cause or a consequence of the process of aging...
  12. ncbi request reprint Extended life-span conferred by cotransporter gene mutations in Drosophila
    B Rogina
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington CT 06030, USA
    Science 290:2137-40. 2000
    ..Excision of the P element resulted in a reversion to normal life-span. These mutations may create a metabolic state that mimics caloric restriction, which has been shown to extend life-span...
  13. ncbi request reprint Spatial and temporal pattern of expression of the wingless and engrailed genes in the adult antenna is regulated by age-dependent mechanisms
    B Rogina
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Mech Dev 63:89-97. 1997
    ..These studies suggest that the expression of wg and en in the adult antenna is controlled by age-dependent mechanisms...
  14. pmc Timing of expression of a gene in the adult Drosophila is regulated by mechanisms independent of temperature and metabolic rate
    B Rogina
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Genetics 143:1643-51. 1996
    ..Type II expression is restricted in the antenna to a small (< 20-30) set of cells whose level of expression changes in a periodic manner with time. The regulation of this periodicity appears to be linked to ambient temperature...
  15. ncbi request reprint Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly
    Yih Woei C Fridell
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA
    Cell Metab 1:145-52. 2005
    ..Our results demonstrate that neuronal-specific expression of hUCP2 in adult flies decreases cellular oxidative damage and is sufficient to extend life span...
  16. pmc Involvement of Drosophila uncoupling protein 5 in metabolism and aging
    Adolfo Sánchez-Blanco
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Genetics 172:1699-710. 2006
    ..Taken together, these data indicate that UCP5 is important to maintain metabolic homeostasis in the fly. We hypothesize that UCP5 influences hormonal control of metabolism...
  17. pmc Sir2 mediates longevity in the fly through a pathway related to calorie restriction
    Blanka Rogina
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 101:15998-6003. 2004
    ..These data lead us to propose a genetic pathway by which calorie restriction extends life span and provides a framework for genetic and pharmacological studies of life span extension in metazoans...
  18. pmc An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster
    Johannes H Bauer
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 101:12980-5. 2004
    ..We propose that this assay can be used to screen pharmacological as well as genetic interventions more rapidly for positive effects on lifespan...
  19. pmc Drosophila drop-dead mutations accelerate the time course of age-related markers
    B Rogina
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 94:6303-6. 1997
    ..In the drop-dead mutant, there is an acceleration in the temporal pattern of expression of these age-related markers...
  20. pmc Regulation of gene expression is linked to life span in adult Drosophila
    B Rogina
    Department of BioStructure and Function, School of Dental Medicine, University of Connecticut Health Center, Farmington 06030, USA
    Genetics 141:1043-8. 1995
    ..Results provide direct evidence for linkage between the regulation of gene expression and life span and establish a model system for the genetic analysis of aging...
  21. ncbi request reprint Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span
    Johannes H Bauer
    University of Connecticut Health Center, Department of Genetics and Developmental Biology, 263 Farmington Avenue, Farmington, Connecticut 06073, USA
    Curr Biol 15:2063-8. 2005
    ....
  22. ncbi request reprint Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction
    Blanka Rogina
    Department of Genetics and Developmental Biology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Science 298:1745. 2002
  23. ncbi request reprint Temperature compensation and temporal expression mediated by an enhancer element in Drosophila
    Barry Hoopengardner
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, CT 06030, USA
    Mech Dev 110:27-37. 2002
    ..A 120 bp region can reproduce the general features of the larger EAE fragment. The Deformed binding site is essential for temporal and spatial expression of beta-galactosidase during embryogenesis but is not required in the adult...
  24. ncbi request reprint Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction
    Tyson G Bross
    University of Connecticut Health Center, Department of Genetics and Developmental Biology, Farmington, CT 06030, USA
    Aging Cell 4:309-17. 2005
    ..Fertility and activity levels demonstrate that the diets surveyed are comparable, and that increasing the calorie content of laboratory food up to twice the normal concentration is not pathologic for experimental fly populations...
  25. ncbi request reprint Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    Jason G Wood
    Department of Pathology, Harvard Medical School, 77 Ave Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 430:686-9. 2004
    ..Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction...
  26. pmc Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies
    James H Marden
    Department of Biology, 208 Mueller Lab, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 100:3369-73. 2003
    ..These results provide evidence that there do exist mechanisms, albeit conditional, that can extend life span without significant reduction in fecundity, metabolic rate, or locomotion...
  27. pmc Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy
    Felix Knauf
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 99:14315-9. 2002
    ..The life-extending effect of mutations in Indy is likely caused by an alteration in energy balance caused by a decrease in INDY transport function...
  28. pmc Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling
    Johannes H Bauer
    Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02903, USA
    Proc Natl Acad Sci U S A 104:13355-60. 2007
    ....
  29. pmc New tricks of an old molecule: lifespan regulation by p53
    Johannes H Bauer
    Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Laboratories for Molecular Medicine, Providence, Rhode Island 02903, USA
    Aging Cell 5:437-40. 2006
    ..Although the mechanism by which p53 regulates lifespan remains to be determined, these findings highlight the possibility that careful manipulation of p53 activity during adult life may result in beneficial effects on healthy lifespan...