Zdenek Hel

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infection
    Zdenek Hel
    Department of Pathology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, Alabama 35294 2170, USA
    Endocr Rev 31:79-97. 2010
  2. ncbi request reprint HIV infection: first battle decides the war
    Zdenek Hel
    Department of Pathology, University of Alabama at Birmingham, 619 19th Street South, Room SW W286, Birmingham, AL 35249 7331, USA
    Trends Immunol 27:274-81. 2006
  3. pmc Hormonal contraception and HIV-1 infection: medroxyprogesterone acetate suppresses innate and adaptive immune mechanisms
    Richard P H Huijbregts
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Endocrinology 154:1282-95. 2013
  4. pmc Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infection
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Reprod Immunol 83:196-200. 2009
  5. doi request reprint Effect of hormonal contraception on the function of plasmacytoid dendritic cells and distribution of immune cell populations in the female reproductive tract
    Katherine G Michel
    Departments of Pathology Obstetrics and Gynecology Microbiology, University of Alabama at Birmingham, Birmingham, AL and Center for AIDS Research, University of Alabama at Birmingham, Birmingham, AL
    J Acquir Immune Defic Syndr 68:511-8. 2015
  6. pmc A model for testing the immunogenicity of simian immunodeficiency virus and simian-human immunodeficiency virus vaccine candidates in mice
    Jun Xu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    J Virol Methods 158:70-6. 2009
  7. pmc Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway
    Nathan L Bowers
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Pathog 10:e1003993. 2014
  8. pmc Optimization of the transductional efficiency of lentiviral vectors: effect of sera and polycations
    Warren Denning
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Mol Biotechnol 53:308-14. 2013
  9. pmc Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses
    Milan Raska
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Vaccine 26:1541-51. 2008
  10. doi request reprint Altered serum cytokine signature in common variable immunodeficiency
    Zdenek Hel
    Department of Pathology and Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Clin Immunol 34:971-8. 2014

Collaborators

Detail Information

Publications20

  1. pmc Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infection
    Zdenek Hel
    Department of Pathology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, Alabama 35294 2170, USA
    Endocr Rev 31:79-97. 2010
    ..This review summarizes current knowledge of the effects of various types of sex steroid hormones on immune processes involved in the biology of HIV-1 infection...
  2. ncbi request reprint HIV infection: first battle decides the war
    Zdenek Hel
    Department of Pathology, University of Alabama at Birmingham, 619 19th Street South, Room SW W286, Birmingham, AL 35249 7331, USA
    Trends Immunol 27:274-81. 2006
    ....
  3. pmc Hormonal contraception and HIV-1 infection: medroxyprogesterone acetate suppresses innate and adaptive immune mechanisms
    Richard P H Huijbregts
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Endocrinology 154:1282-95. 2013
    ..The presented results suggest that MPA suppresses both innate and adaptive arms of the immune system resulting in a reduction of host resistance to invading pathogens...
  4. pmc Mucosal immunology of the genital and gastrointestinal tracts and HIV-1 infection
    Jiri Mestecky
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Reprod Immunol 83:196-200. 2009
    ..Whether humoral responses to previously or newly encountered antigens are compromised in HIV-1-infected persons is under current investigation...
  5. doi request reprint Effect of hormonal contraception on the function of plasmacytoid dendritic cells and distribution of immune cell populations in the female reproductive tract
    Katherine G Michel
    Departments of Pathology Obstetrics and Gynecology Microbiology, University of Alabama at Birmingham, Birmingham, AL and Center for AIDS Research, University of Alabama at Birmingham, Birmingham, AL
    J Acquir Immune Defic Syndr 68:511-8. 2015
    ..We sought to elucidate the biological mechanisms underlying the effect of hormonal contraception on the immune system...
  6. pmc A model for testing the immunogenicity of simian immunodeficiency virus and simian-human immunodeficiency virus vaccine candidates in mice
    Jun Xu
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    J Virol Methods 158:70-6. 2009
    ..In addition, using the newly defined epitopes, the relationship is described between the amount of plasmid DNA, volume of inoculate, and the extent of ensuing immune responses following intramuscular DNA immunization...
  7. pmc Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway
    Nathan L Bowers
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Pathog 10:e1003993. 2014
    ..Collectively, the accumulated data suggest that chronic HIV-1 infection results in an induction of immunosuppressive activity of neutrophils characterized by high expression of PD-L1 and an inhibitory effect on T cell function. ..
  8. pmc Optimization of the transductional efficiency of lentiviral vectors: effect of sera and polycations
    Warren Denning
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 2182, USA
    Mol Biotechnol 53:308-14. 2013
    ..In conclusion, various polycations and types of sera should be tested when optimizing lentiviral transduction of target cell populations...
  9. pmc Delivery of DNA HIV-1 vaccine to the liver induces high and long-lasting humoral immune responses
    Milan Raska
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Vaccine 26:1541-51. 2008
    ..7% of CD8(+) splenocytes after in vitro stimulation with HIV-1 envelope peptides. These results demonstrate that DNA vaccines targeted to tissues with high proteosynthetic activity, such as the liver, results in enhanced immune responses...
  10. doi request reprint Altered serum cytokine signature in common variable immunodeficiency
    Zdenek Hel
    Department of Pathology and Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Clin Immunol 34:971-8. 2014
    ..We and others have recently shown that CVID is associated with increased concentration of soluble CD14 (sCD14) and other factors indicating limited microbial translocation...
  11. doi request reprint Effect of progestins on immunity: medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs
    Richard P H Huijbregts
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA
    Contraception 90:123-9. 2014
    ..The study presented here addresses the immunomodulatory properties of several common progestins with a potential to replace DMPA...
  12. pmc Menstrual blood as a potential source of endometrial derived CD3+ T cells
    Steffanie Sabbaj
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e28894. 2011
    ..These data may open new avenues of investigation for cell mediated immune studies involving the female reproductive tract without the need for biopsies...
  13. pmc Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responses
    Warren L Denning
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 6:e16897. 2011
    ....
  14. ncbi request reprint A novel chimeric Rev, Tat, and Nef (Retanef) antigen as a component of an SIV/HIV vaccine
    Zdenek Hel
    Basic Research Laboratory, National Cancer Institute, 41 D804, Bethesda, MD 20892, USA
    Vaccine 20:3171-86. 2002
    ..No adverse effects were observed in either naive or SIV-infected rhesus macaques. Thus, an analogous HIV-1-based chimeric vaccine may represent useful component of an HIV-1 vaccine...
  15. pmc Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels
    Ranajit Pal
    Advanced BioScience Laboratories, Inc, Kensington, Maryland 20895, USA
    J Virol 80:3732-42. 2006
    ..Thus, systemic immunization with ALVAC-HIV-1 vaccine candidates elicits anti-HIV-1 immune responses able to contain virus replication also at mucosal sites in macaques...
  16. ncbi request reprint Containment of simian immunodeficiency virus infection in vaccinated macaques: correlation with the magnitude of virus-specific pre- and postchallenge CD4+ and CD8+ T cell responses
    Zdenek Hel
    Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 169:4778-87. 2002
    ..The results presented in this work also further demonstrate the potential of a DNA-prime/attenuated poxvirus-boost vaccine regimen in an animal model that well mirrors human AIDS...
  17. ncbi request reprint Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy
    Elzbieta Tryniszewska
    Basic Research Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 169:5347-57. 2002
    ..These data provide the proof of concept that therapeutic vaccination before cessation of ART may be a feasible approach in the clinical management of HIV-1 infection...
  18. ncbi request reprint Immune intervention strategies for HIV-1 infection of humans in the SIV macaque model
    Genoveffa Franchini
    National Cancer Institute, Basic Research Laboratory, 41 D804, Bethesda, MD 20892 5055, USA
    Vaccine 20:A52-60. 2002
    ..Here, we will review the relative effect of ART and vaccination during primary SIVmac infection of macaques...
  19. ncbi request reprint Equivalent immunogenicity of the highly attenuated poxvirus-based ALVAC-SIV and NYVAC-SIV vaccine candidates in SIVmac251-infected macaques
    Zdenek Hel
    Aventis Pasteur, Ltd 1755 Steeles Avenue West, Toronto, Ontario, M2R 3T4, Canada
    Virology 304:125-34. 2002
    ..Thus, both these vaccine modalities alone or in combination may be suitable candidate vaccines for immune therapy of HIV-1-infected individuals...
  20. pmc Cervicovaginal lamina propria lymphocytes: phenotypic characterization and their importance in cytotoxic T-lymphocyte responses to simian immunodeficiency virus SIVmac251
    Liljana Stevceva
    Animal Models and Retroviral Vaccines Section, Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Virol 76:9-18. 2002
    ..Information on the quality and quantity of local immune responses may help in the design of vaccine strategies aimed at containing viral replication at the site of viral encounter...