Christian Heiss

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week
    Christian Heiss
    Institute for Biochemistry and Molecular Biology I, Aachen, Germany
    J Cardiovasc Pharmacol 49:74-80. 2007
  2. ncbi request reprint Endothelial function, nitric oxide, and cocoa flavanols
    Christian Heiss
    Department of Medicine, Division of Cardiology, University of California, San Francisco, CA 94143 0214, USA
    J Cardiovasc Pharmacol 47:S128-35; discussion S172-6. 2006
  3. doi request reprint Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease
    Christian Heiss
    Division of Cardiology, University of California San Francisco, San Francisco, California, USA
    J Am Coll Cardiol 56:218-24. 2010
  4. doi request reprint Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise
    Thomas Lauer
    Dept of Medicine, Pulmonology and Vascular Medicine, University Hospital Aachen, Aachen, Germany
    Basic Res Cardiol 103:291-7. 2008
  5. doi request reprint Dietary nitrate supplementation improves revascularization in chronic ischemia
    Ulrike B Hendgen-Cotta
    Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Hospital Dusseldorf, Dusseldorf, Germany
    Circulation 126:1983-92. 2012
  6. ncbi request reprint Flavanols and cardiovascular health: effects on the circulating NO pool in humans
    Jan Balzer
    Medical Clinic I, Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital RWTH Aachen, Germany
    J Cardiovasc Pharmacol 47:S122-7; discussion S172-6. 2006
  7. ncbi request reprint Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients
    Patrick Horn
    Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Moorenstrasse 5, Düsseldorf D 40235, Germany
    Br J Nutr 111:1245-52. 2014
  8. ncbi request reprint Plasma nitroso compounds are decreased in patients with endothelial dysfunction
    Christian Heiss
    Department of Cardiology, Pneumology, and Vascular Medicine, RWTH Aachen, Aachen, Germany
    J Am Coll Cardiol 47:573-9. 2006
  9. doi request reprint Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial
    Jan Balzer
    Department for Cardiology, Pulmonology, and Vascular Medicine, University Hospital RWTH Aachen, Aachen, Germany
    J Am Coll Cardiol 51:2141-9. 2008
  10. ncbi request reprint Resting microvascular resistance and conduit artery tone: relevance to endothelium-dependent flow-mediated dilation
    Thomas Lauer
    Department of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Aachen, Aachen, Germany
    Eur J Cardiovasc Prev Rehabil 15:677-82. 2008

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 week
    Christian Heiss
    Institute for Biochemistry and Molecular Biology I, Aachen, Germany
    J Cardiovasc Pharmacol 49:74-80. 2007
    ..The daily consumption of flavanol-rich cocoa has the potential to reverse endothelial dysfunction in a sustained and dose-dependent manner...
  2. ncbi request reprint Endothelial function, nitric oxide, and cocoa flavanols
    Christian Heiss
    Department of Medicine, Division of Cardiology, University of California, San Francisco, CA 94143 0214, USA
    J Cardiovasc Pharmacol 47:S128-35; discussion S172-6. 2006
    ....
  3. doi request reprint Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease
    Christian Heiss
    Division of Cardiology, University of California San Francisco, San Francisco, California, USA
    J Am Coll Cardiol 56:218-24. 2010
    ....
  4. doi request reprint Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exercise
    Thomas Lauer
    Dept of Medicine, Pulmonology and Vascular Medicine, University Hospital Aachen, Aachen, Germany
    Basic Res Cardiol 103:291-7. 2008
    ..The fact that aging is associated with an impaired capacity of the vasculature to adequately increase nitrite to physiological stimuli may contribute to attenuated maintenance and further deterioration of vascular homeostasis with aging...
  5. doi request reprint Dietary nitrate supplementation improves revascularization in chronic ischemia
    Ulrike B Hendgen-Cotta
    Division of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, University Hospital Dusseldorf, Dusseldorf, Germany
    Circulation 126:1983-92. 2012
    ..Whether dietary nitrate, serially reduced to nitrite by commensal bacteria in the oral cavity and subsequently to nitric oxide and other nitrogen oxides, enhances ischemia-induced remodeling of the vascular network is not known...
  6. ncbi request reprint Flavanols and cardiovascular health: effects on the circulating NO pool in humans
    Jan Balzer
    Medical Clinic I, Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital RWTH Aachen, Germany
    J Cardiovasc Pharmacol 47:S122-7; discussion S172-6. 2006
    ..This review is aimed at evaluating the suitability of quantifying this NO pool as a biomarker for cardiovascular function in humans, in particular during dietary interventions with flavonoid-rich foods...
  7. ncbi request reprint Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients
    Patrick Horn
    Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Moorenstrasse 5, Düsseldorf D 40235, Germany
    Br J Nutr 111:1245-52. 2014
    ..Our data show that flavanols lower the levels of EMP along with higher endothelial function, lending evidence to the novel concept that flavanols may improve endothelial integrity...
  8. ncbi request reprint Plasma nitroso compounds are decreased in patients with endothelial dysfunction
    Christian Heiss
    Department of Cardiology, Pneumology, and Vascular Medicine, RWTH Aachen, Aachen, Germany
    J Am Coll Cardiol 47:573-9. 2006
    ..We investigated whether plasma nitros(yl)ated species (RXNOs) that mediate systemic nitric oxide (NO) bioactivity are depleted in individuals with cardiovascular risk factors and endothelial dysfunction...
  9. doi request reprint Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial
    Jan Balzer
    Department for Cardiology, Pulmonology, and Vascular Medicine, University Hospital RWTH Aachen, Aachen, Germany
    J Am Coll Cardiol 51:2141-9. 2008
    ..Our goal was to test feasibility and efficacy of a dietary intervention based on daily intake of flavanol-containing cocoa for improving vascular function of medicated diabetic patients...
  10. ncbi request reprint Resting microvascular resistance and conduit artery tone: relevance to endothelium-dependent flow-mediated dilation
    Thomas Lauer
    Department of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Aachen, Aachen, Germany
    Eur J Cardiovasc Prev Rehabil 15:677-82. 2008
    ..The significance of the interaction between microcirculation and macrocirculation in the flow-mediated dilation (FMD) is poorly understood...
  11. pmc Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli
    Christian Heiss
    Division of Cardiology, University of California, San Francisco, San Francisco, CA 94143 0124, USA
    Arterioscler Thromb Vasc Biol 30:2212-8. 2010
    ..The role of nitric oxide (NO) in CAC function is poorly understood. We hypothesized that CAC migration toward angiogenic signals is modulated by both NO synthase (NOS) expression and functional response to NO...
  12. doi request reprint Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickening
    Stefanie Keymel
    Medical Clinic I, Dept of Medicine, Division of Cardiology, Pulmonology, and Vascular Medicine, RWTH University Hospital Aachen, Pauwelstrasse 30, 52074, Aachen, Germany
    Basic Res Cardiol 103:582-6. 2008
    ..We investigated whether qualitative or quantitative alterations of the endothelial progenitor cell (EPC) pool predict age-related structural vessel wall changes...
  13. doi request reprint Characterization of the non-invasive assessment of the cutaneous microcirculation by laser Doppler perfusion scanner
    Stefanie Keymel
    Department of Medicine, Division of Cardiology, Pneumology, and Vascular Diseases, University Hospital, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
    Microcirculation 17:358-66. 2010
    ..Here, we aimed at establishing a sensitive and valid method to measure microvascular reactivity during post-occlusive reactive hyperemia (PORH) using scanning laser Doppler perfusion imaging (LDPI) of the forearm...
  14. doi request reprint Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production
    Christian Heiss
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0103, USA
    J Am Coll Cardiol 51:1760-71. 2008
    ..This study sought to analyze the effects of acute secondhand smoke (SHS) exposure on the number and function of endothelial progenitor cells (EPCs) over 24 h...
  15. ncbi request reprint Plasma nitrite reserve and endothelial function in the human forearm circulation
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, University Hospital Aachen, 52074 Aachen, Germany
    Free Radic Biol Med 41:295-301. 2006
    ..001). This observation suggests that nitrite changes reflect endothelial function. Assessment of local plasma nitrite during reactive hyperemia may open new avenues in the diagnosis of vascular function...
  16. doi request reprint Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients
    Nicolas Amabile
    Department of Medicine, Division of Cardiology, University of California at San Francisco, San Francisco, California, USA
    J Heart Lung Transplant 28:1081-6. 2009
    ..We hypothesized that the levels of circulating EMPs and LMPs could predict outcome in these patients...
  17. pmc Nitric oxide synthase-derived plasma nitrite predicts exercise capacity
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    Br J Sports Med 41:669-73; discussion 673. 2007
    ..As NO is necessary to maintain an adequate vascular response to the increased demands of blood flow, it is believed to be important for vasodilation induced by exercise...
  18. doi request reprint Hemodialysis-induced release of hemoglobin limits nitric oxide bioavailability and impairs vascular function
    Christian Meyer
    Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital, Duesseldorf, Germany
    J Am Coll Cardiol 55:454-9. 2010
    ..This study sought to characterize the impact of hemodialysis (HD)-induced release of hemoglobin on the bioavailability of nitric oxide (NO) and endothelial function...
  19. pmc Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunction
    Patrick Horn
    Division of Cardiology, Pulmonology, and Vascular Medicine, University Duesseldorf, Duesseldorf, Germany
    J Am Heart Assoc 2:e003764. 2013
    ..As a significant proportion of MPs originate from platelets and endothelial cells, we hypothesized that MPs may harbor functional enzymes including an endothelial NO synthase (eNOS)...
  20. pmc (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans
    Hagen Schroeter
    Department of Nutrition, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 103:1024-9. 2006
    ..Collectively, our data demonstrate that the human ingestion of the flavanol (-)-epicatechin is, at least in part, causally linked to the reported vascular effects observed after the consumption of flavanol-rich cocoa...
  21. ncbi request reprint Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers
    Christian Heiss
    Institute for Biochemistry and Molecular Biology I, Heinrich Heine University, Duesseldorf, Germany
    J Am Coll Cardiol 46:1276-83. 2005
    ..This study was designed to assess the effect of flavanol-rich food on the circulating pool of bioactive nitric oxide (NO) and endothelial dysfunction in smokers...
  22. ncbi request reprint Reduction of peripheral flow reserve impairs endothelial function in conduit arteries of patients with essential hypertension
    Thomas Lauer
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine University, Duesseldorf, Germany
    J Hypertens 23:563-9. 2005
    ..Hypertension is associated with structural alterations in the microcirculation and a reduced endothelium-dependent dilation in conduit arteries. Both have been demonstrated to predict future cardiovascular events...
  23. ncbi request reprint TNF-α, myocardial perfusion and function in patients with ST-segment elevation myocardial infarction and primary percutaneous coronary intervention
    Eva S Kehmeier
    Division of Cardiology, Pulmonary Diseases and Vascular Medicine, Department of Medicine, University Hospital Aachen, 52074 Aachen, Germany
    Clin Res Cardiol 101:815-27. 2012
    ....
  24. ncbi request reprint In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound
    Christian Heiss
    Division of Cardiology, Department of Medicine, University of California, San Francisco 94143 0124, USA
    Am J Physiol Heart Circ Physiol 294:H1086-93. 2008
    ..To our knowledge, this is the first integrative physiological model to reproducibly study FMD of conduit arteries in living rats...
  25. doi request reprint Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension
    Nicolas Amabile
    Division of Cardiology, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0103, USA
    Am J Respir Crit Care Med 177:1268-75. 2008
    ..Endothelial MPs are a biological marker of dysfunctional endothelium. Vascular remodeling and endothelial dysfunction are involved in pulmonary hypertension (PH)...
  26. ncbi request reprint Cocoa polyphenols and inflammatory mediators
    Helmut Sies
    Institute for Biochemistry and Molecular Biology I and the Department of Medicine, Division of Cardiology, Pulmonary Diseases, and Angiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Am J Clin Nutr 81:304S-312S. 2005
    ..Adverse effects of NO metabolites, such as nitrite and peroxynitrite, were thus attenuated...
  27. doi request reprint The potential of flavanol and procyanidin intake to influence age-related vascular disease
    Roberta R Holt
    Department of Nutrition, University of California, Davis, California 95616, USA
    J Nutr Gerontol Geriatr 31:290-323. 2012
    ..In the current article we review a selection of these studies, and comment on some of the potential mechanisms that have been postulated to underlie the health effects of flavanol and procyanidin-rich foods...
  28. doi request reprint Dietary inorganic nitrate mobilizes circulating angiogenic cells
    Christian Heiss
    University Düsseldorf, Medical Faculty, Division of Cardiology, Pulmonology, and Vascular Medicine, Duesseldorf, Germany
    Free Radic Biol Med 52:1767-72. 2012
    ..Dietary inorganic nitrate acutely mobilizes CACs via serial reduction to nitrite and NO. The nitrate-nitrite-NO pathway could offer a novel nutritional approach for regulation of vascular regenerative processes...
  29. doi request reprint Predicting neurally mediated syncope based on pulse arrival time: algorithm development and preliminary results
    Christian Meyer
    Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Dusseldorf, Germany
    J Cardiovasc Electrophysiol 22:1042-8. 2011
    ..The circulatory adjustments to orthostatic stress occur just prior to a sudden loss of consciousness. NMS prediction would protect patients from falls or accidents...
  30. ncbi request reprint Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia
    Shobha Natarajan
    Division of Pediatric Cardiology, University of California San Francisco, San Francisco, CA, USA
    Am J Cardiol 103:862-6. 2009
    ....
  31. doi request reprint Chronic kidney disease aggravates arteriovenous fistula damage in rats
    Stephan Langer
    European Vascular Center Aachen Maastricht, Department of Vascular Surgery, University Hospital RWTH Aachen, Aachen, Germany
    Kidney Int 78:1312-21. 2010
    ..Thus, CKD triggers adverse effects on vascular remodeling in AVFs, all of which contribute to anatomical and/or functional stenosis...
  32. pmc Evidence for in vivo transport of bioactive nitric oxide in human plasma
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine Universitat, Dusseldorf, Germany
    J Clin Invest 109:1241-8. 2002
    ..Our results suggest that NO can be transported in bioactive form for significant distances along the vascular bed. Both free NO and plasma nitroso species contribute to the dilation of the downstream vasculature...
  33. ncbi request reprint Is there a role for antioxidants in the treatment of stable angina?
    Dominik Schuler
    University Duesseldorf, Medical Faculty, Division of Cardiology, Pulmonology, and Vascular Medicine, Duesseldorf, Germany
    Curr Pharm Des 19:1601-15. 2013
    ..Taken together, there is currently not enough evidence that treatment with antioxidants per se will play a role in cardiovascular medicine...
  34. pmc Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells
    Christian Heiss
    Department of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, California 94143 0124, USA
    J Cell Physiol 215:366-73. 2008
    ..These data suggest that PTN may mediate its pro-angiogenic effects by increasing the local number of not only endothelial cells but also early EPCs at angiogenic sites...
  35. pmc Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function
    Kranthi Pinnamaneni
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA
    Nicotine Tob Res 16:584-90. 2014
    ..In humans, SHS exposure for 30min impairs FMD. It is important to gain a better understanding of the acute effects of exposure to SHS at low concentrations and for brief periods of time...
  36. doi request reprint Pre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophoblasts and maternal blood
    Andrea Schanz
    Department of Cell and Tissue Biology, University of California, San Francisco, CA, United States
    Eur J Obstet Gynecol Reprod Biol 157:32-7. 2011
    ..Placental derived vasculogenic/angiogenic substances in maternal blood are dysregulated in pre-eclampsia. We hypothesized that CXCL12, a chemokine with vasculogenic actions, is amongst such molecules...
  37. ncbi request reprint Vascular effects of cocoa rich in flavan-3-ols
    Christian Heiss
    JAMA 290:1030-1. 2003
  38. ncbi request reprint New blood vessel formation and expression of VEGF receptors after implantation of platelet growth factor-enriched biodegradable nanocrystalline hydroxyapatite
    Olaf Kilian
    Department of Trauma Surgery, University of Giessen, Giessen, Germany
    Growth Factors 23:125-33. 2005
    ..These observation are most likely attributable to a stimulating effect of TGF-ss from the platelet factor on VEGF expression in osteoblasts...
  39. ncbi request reprint Impaired progenitor cell activity in age-related endothelial dysfunction
    Christian Heiss
    Department of Cardiology, Pneumology, and Vascular Medicine, Heinrich Heine University, Dusseldorf, Germany
    J Am Coll Cardiol 45:1441-8. 2005
    ..We investigated whether human age-related endothelial dysfunction is accompanied by quantitative and qualitative alterations of the endothelial progenitor cell (EPC) pool...