Affiliation: University of California
- Sustained increase in flow-mediated dilation after daily intake of high-flavanol cocoa drink over 1 weekChristian Heiss
Institute for Biochemistry and Molecular Biology I, Aachen, Germany
J Cardiovasc Pharmacol 49:74-80. 2007..The daily consumption of flavanol-rich cocoa has the potential to reverse endothelial dysfunction in a sustained and dose-dependent manner...
- Endothelial function, nitric oxide, and cocoa flavanolsChristian Heiss
Department of Medicine, Division of Cardiology, University of California, San Francisco, CA 94143 0214, USA
J Cardiovasc Pharmacol 47:S128-35; discussion S172-6. 2006....
- Age-dependent endothelial dysfunction is associated with failure to increase plasma nitrite in response to exerciseThomas Lauer
Dept of Medicine, Pulmonology and Vascular Medicine, University Hospital Aachen, Aachen, Germany
Basic Res Cardiol 103:291-7. 2008..The fact that aging is associated with an impaired capacity of the vasculature to adequately increase nitrite to physiological stimuli may contribute to attenuated maintenance and further deterioration of vascular homeostasis with aging...
- Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery diseaseChristian Heiss
Division of Cardiology, University of California San Francisco, San Francisco, California, USA
J Am Coll Cardiol 56:218-24. 2010....
- Dietary nitrate supplementation improves revascularization in chronic ischemiaUlrike B Hendgen-Cotta
University Hospital Dusseldorf, Medical Faculty, Division of Cardiology, Pulmonology and Vascular Medicine, Moorenstrasse 5, D 40225 Dusseldorf, Germany
Circulation 126:1983-92. 2012..Whether dietary nitrate, serially reduced to nitrite by commensal bacteria in the oral cavity and subsequently to nitric oxide and other nitrogen oxides, enhances ischemia-induced remodeling of the vascular network is not known...
- Flavanols and cardiovascular health: effects on the circulating NO pool in humansJan Balzer
Medical Clinic I, Division of Cardiology, Pulmonary Disease and Vascular Medicine, University Hospital RWTH Aachen, Germany
J Cardiovasc Pharmacol 47:S122-7; discussion S172-6. 2006..This review is aimed at evaluating the suitability of quantifying this NO pool as a biomarker for cardiovascular function in humans, in particular during dietary interventions with flavonoid-rich foods...
- Resting microvascular resistance and conduit artery tone: relevance to endothelium-dependent flow-mediated dilationThomas Lauer
Department of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Aachen, Aachen, Germany
Eur J Cardiovasc Prev Rehabil 15:677-82. 2008..The significance of the interaction between microcirculation and macrocirculation in the flow-mediated dilation (FMD) is poorly understood...
- Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trialJan Balzer
Department for Cardiology, Pulmonology, and Vascular Medicine, University Hospital RWTH Aachen, Aachen, Germany
J Am Coll Cardiol 51:2141-9. 2008..Our goal was to test feasibility and efficacy of a dietary intervention based on daily intake of flavanol-containing cocoa for improving vascular function of medicated diabetic patients...
- Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuliChristian Heiss
Division of Cardiology, University of California, San Francisco, San Francisco, CA 94143 0124, USA
Arterioscler Thromb Vasc Biol 30:2212-8. 2010..The role of nitric oxide (NO) in CAC function is poorly understood. We hypothesized that CAC migration toward angiogenic signals is modulated by both NO synthase (NOS) expression and functional response to NO...
- Plasma nitroso compounds are decreased in patients with endothelial dysfunctionChristian Heiss
Department of Cardiology, Pneumology, and Vascular Medicine, RWTH Aachen, Aachen, Germany
J Am Coll Cardiol 47:573-9. 2006..We investigated whether plasma nitros(yl)ated species (RXNOs) that mediate systemic nitric oxide (NO) bioactivity are depleted in individuals with cardiovascular risk factors and endothelial dysfunction...
- Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickeningStefanie Keymel
Medical Clinic I, Dept of Medicine, Division of Cardiology, Pulmonology, and Vascular Medicine, RWTH University Hospital Aachen, Pauwelstrasse 30, 52074, Aachen, Germany
Basic Res Cardiol 103:582-6. 2008..We investigated whether qualitative or quantitative alterations of the endothelial progenitor cell (EPC) pool predict age-related structural vessel wall changes...
- Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patientsNicolas Amabile
Department of Medicine, Division of Cardiology, University of California at San Francisco, San Francisco, California, USA
J Heart Lung Transplant 28:1081-6. 2009..We hypothesized that the levels of circulating EMPs and LMPs could predict outcome in these patients...
- Plasma nitrite reserve and endothelial function in the human forearm circulationTienush Rassaf
Department of Medicine, Division of Cardiology, University Hospital Aachen, 52074 Aachen, Germany
Free Radic Biol Med 41:295-301. 2006..001). This observation suggests that nitrite changes reflect endothelial function. Assessment of local plasma nitrite during reactive hyperemia may open new avenues in the diagnosis of vascular function...
- Characterization of the non-invasive assessment of the cutaneous microcirculation by laser Doppler perfusion scannerStefanie Keymel
Department of Medicine, Division of Cardiology, Pneumology, and Vascular Diseases, University Hospital, Heinrich Heine University Duesseldorf, Duesseldorf, Germany
Microcirculation 17:358-66. 2010..Here, we aimed at establishing a sensitive and valid method to measure microvascular reactivity during post-occlusive reactive hyperemia (PORH) using scanning laser Doppler perfusion imaging (LDPI) of the forearm...
- Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide productionChristian Heiss
Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143 0103, USA
J Am Coll Cardiol 51:1760-71. 2008..This study sought to analyze the effects of acute secondhand smoke (SHS) exposure on the number and function of endothelial progenitor cells (EPCs) over 24 h...
- Nitric oxide synthase-derived plasma nitrite predicts exercise capacityTienush Rassaf
Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, University Hospital Aachen, Pauwelsstr 30, 52074 Aachen, Germany
Br J Sports Med 41:669-73; discussion 673. 2007..As NO is necessary to maintain an adequate vascular response to the increased demands of blood flow, it is believed to be important for vasodilation induced by exercise...
- Hemodialysis-induced release of hemoglobin limits nitric oxide bioavailability and impairs vascular functionChristian Meyer
Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital, Duesseldorf, Germany
J Am Coll Cardiol 55:454-9. 2010..This study sought to characterize the impact of hemodialysis (HD)-induced release of hemoglobin on the bioavailability of nitric oxide (NO) and endothelial function...
- Circulating microparticles carry a functional endothelial nitric oxide synthase that is decreased in patients with endothelial dysfunctionPatrick Horn
Division of Cardiology, Pulmonology, and Vascular Medicine, University Duesseldorf, Duesseldorf, Germany
J Am Heart Assoc 2:e003764. 2013..As a significant proportion of MPs originate from platelets and endothelial cells, we hypothesized that MPs may harbor functional enzymes including an endothelial NO synthase (eNOS)...
- (-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humansHagen Schroeter
Department of Nutrition, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 103:1024-9. 2006..Collectively, our data demonstrate that the human ingestion of the flavanol (-)-epicatechin is, at least in part, causally linked to the reported vascular effects observed after the consumption of flavanol-rich cocoa...
- Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokersChristian Heiss
Institute for Biochemistry and Molecular Biology I, Heinrich Heine University, Duesseldorf, Germany
J Am Coll Cardiol 46:1276-83. 2005..This study was designed to assess the effect of flavanol-rich food on the circulating pool of bioactive nitric oxide (NO) and endothelial dysfunction in smokers...
- Reduction of peripheral flow reserve impairs endothelial function in conduit arteries of patients with essential hypertensionThomas Lauer
Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine University, Duesseldorf, Germany
J Hypertens 23:563-9. 2005..Hypertension is associated with structural alterations in the microcirculation and a reduced endothelium-dependent dilation in conduit arteries. Both have been demonstrated to predict future cardiovascular events...
- TNF-α, myocardial perfusion and function in patients with ST-segment elevation myocardial infarction and primary percutaneous coronary interventionEva S Kehmeier
Division of Cardiology, Pulmonary Diseases and Vascular Medicine, Department of Medicine, University Hospital Aachen, 52074 Aachen, Germany
Clin Res Cardiol 101:815-27. 2012....
- In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasoundChristian Heiss
Division of Cardiology, Department of Medicine, University of California, San Francisco 94143 0124, USA
Am J Physiol Heart Circ Physiol 294:H1086-93. 2008..To our knowledge, this is the first integrative physiological model to reproducibly study FMD of conduit arteries in living rats...
- Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertensionNicolas Amabile
Division of Cardiology, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0103, USA
Am J Respir Crit Care Med 177:1268-75. 2008..Endothelial MPs are a biological marker of dysfunctional endothelium. Vascular remodeling and endothelial dysfunction are involved in pulmonary hypertension (PH)...
- Cocoa polyphenols and inflammatory mediatorsHelmut Sies
Institute for Biochemistry and Molecular Biology I and the Department of Medicine, Division of Cardiology, Pulmonary Diseases, and Angiology, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
Am J Clin Nutr 81:304S-312S. 2005..Adverse effects of NO metabolites, such as nitrite and peroxynitrite, were thus attenuated...
- Dietary inorganic nitrate mobilizes circulating angiogenic cellsChristian Heiss
University Düsseldorf, Medical Faculty, Division of Cardiology, Pulmonology, and Vascular Medicine, Duesseldorf, Germany
Free Radic Biol Med 52:1767-72. 2012..Dietary inorganic nitrate acutely mobilizes CACs via serial reduction to nitrite and NO. The nitrate-nitrite-NO pathway could offer a novel nutritional approach for regulation of vascular regenerative processes...
- The potential of flavanol and procyanidin intake to influence age-related vascular diseaseRoberta R Holt
Department of Nutrition, University of California, Davis, California 95616, USA
J Nutr Gerontol Geriatr 31:290-323. 2012..In the current article we review a selection of these studies, and comment on some of the potential mechanisms that have been postulated to underlie the health effects of flavanol and procyanidin-rich foods...
- Predicting neurally mediated syncope based on pulse arrival time: algorithm development and preliminary resultsChristian Meyer
Division of Cardiology, Pulmonology and Vascular Medicine, Heinrich Heine University, Dusseldorf, Germany
J Cardiovasc Electrophysiol 22:1042-8. 2011..The circulatory adjustments to orthostatic stress occur just prior to a sudden loss of consciousness. NMS prediction would protect patients from falls or accidents...
- Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemiaShobha Natarajan
Division of Pediatric Cardiology, University of California San Francisco, San Francisco, CA, USA
Am J Cardiol 103:862-6. 2009....
- Evidence for in vivo transport of bioactive nitric oxide in human plasmaTienush Rassaf
Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine Universitat, Dusseldorf, Germany
J Clin Invest 109:1241-8. 2002..Our results suggest that NO can be transported in bioactive form for significant distances along the vascular bed. Both free NO and plasma nitroso species contribute to the dilation of the downstream vasculature...
- Chronic kidney disease aggravates arteriovenous fistula damage in ratsStephan Langer
European Vascular Center Aachen Maastricht, Department of Vascular Surgery, University Hospital RWTH Aachen, Aachen, Germany
Kidney Int 78:1312-21. 2010..Thus, CKD triggers adverse effects on vascular remodeling in AVFs, all of which contribute to anatomical and/or functional stenosis...
- Is there a role for antioxidants in the treatment of stable angina?Dominik Schuler
University Duesseldorf, Medical Faculty, Division of Cardiology, Pulmonology, and Vascular Medicine, Duesseldorf, Germany
Curr Pharm Des 19:1601-15. 2013..Taken together, there is currently not enough evidence that treatment with antioxidants per se will play a role in cardiovascular medicine...
- Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cellsChristian Heiss
Department of Medicine, Division of Cardiology, University of California, San Francisco, San Francisco, California 94143 0124, USA
J Cell Physiol 215:366-73. 2008..These data suggest that PTN may mediate its pro-angiogenic effects by increasing the local number of not only endothelial cells but also early EPCs at angiogenic sites...
- Pre-eclampsia is associated with elevated CXCL12 levels in placental syncytiotrophoblasts and maternal bloodAndrea Schanz
Department of Cell and Tissue Biology, University of California, San Francisco, CA, United States
Eur J Obstet Gynecol Reprod Biol 157:32-7. 2011..Placental derived vasculogenic/angiogenic substances in maternal blood are dysregulated in pre-eclampsia. We hypothesized that CXCL12, a chemokine with vasculogenic actions, is amongst such molecules...
- Vascular effects of cocoa rich in flavan-3-olsChristian Heiss
JAMA 290:1030-1. 2003
- New blood vessel formation and expression of VEGF receptors after implantation of platelet growth factor-enriched biodegradable nanocrystalline hydroxyapatiteOlaf Kilian
Department of Trauma Surgery, University of Giessen, Giessen, Germany
Growth Factors 23:125-33. 2005..These observation are most likely attributable to a stimulating effect of TGF-ss from the platelet factor on VEGF expression in osteoblasts...
- Impaired progenitor cell activity in age-related endothelial dysfunctionChristian Heiss
Department of Cardiology, Pneumology, and Vascular Medicine, Heinrich Heine University, Dusseldorf, Germany
J Am Coll Cardiol 45:1441-8. 2005..We investigated whether human age-related endothelial dysfunction is accompanied by quantitative and qualitative alterations of the endothelial progenitor cell (EPC) pool...