Volkmar Heinrich

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Differential effects of serum heat treatment on chemotaxis and phagocytosis by human neutrophils
    Alexander R Mankovich
    Department of Biomedical Engineering, University of California Davis, Davis, California, USA
    PLoS ONE 8:e54735. 2013
  2. pmc Protrusive push versus enveloping embrace: computational model of phagocytosis predicts key regulatory role of cytoskeletal membrane anchors
    Marc Herant
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
    PLoS Comput Biol 7:e1001068. 2011
  3. doi request reprint Imaging biomolecular interactions by fast three-dimensional tracking of laser-confined carrier particles
    Volkmar Heinrich
    Department of Biomedical Engineering and Biomedical Engineering Graduate Group, University of California at Davis, 451 East Health Sciences Drive, Davis, CA 95616, USA
    Langmuir 24:1194-203. 2008
  4. pmc Force versus axial deflection of pipette-aspirated closed membranes
    Volkmar Heinrich
    Department of Biomedical Engineering and Biomedical Engineering Graduate Group, University of California, Davis, California 95616, USA
    Biophys J 93:363-72. 2007
  5. pmc Blurred line between chemotactic chase and phagocytic consumption: an immunophysical single-cell perspective
    Volkmar Heinrich
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    J Cell Sci 124:3041-51. 2011
  6. ncbi request reprint Nano-to-microscale mechanical switches and fuses mediate adhesive contacts between leukocytes and the endothelium
    Volkmar Heinrich
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    J Chem Inf Model 45:1482-90. 2005
  7. pmc Nano- to microscale dynamics of P-selectin detachment from leukocyte interfaces. II. Tether flow terminated by P-selectin dissociation from PSGL-1
    Volkmar Heinrich
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215 USA
    Biophys J 88:2299-308. 2005
  8. ncbi request reprint Mechanics of neutrophil phagocytosis: experiments and quantitative models
    Marc Herant
    Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    J Cell Sci 119:1903-13. 2006
  9. pmc Nano- to microscale dynamics of P-selectin detachment from leukocyte interfaces. I. Membrane separation from the cytoskeleton
    Evan Evans
    Biomedical Engineering, Boston University, Boston, Massachusetts 02215 USA
    Biophys J 88:2288-98. 2005
  10. pmc Nano-to-micro scale dynamics of P-selectin detachment from leukocyte interfaces. III. Numerical simulation of tethering under flow
    Michael R King
    Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA
    Biophys J 88:1676-83. 2005

Collaborators

Detail Information

Publications19

  1. pmc Differential effects of serum heat treatment on chemotaxis and phagocytosis by human neutrophils
    Alexander R Mankovich
    Department of Biomedical Engineering, University of California Davis, Davis, California, USA
    PLoS ONE 8:e54735. 2013
    ..These results not only refine our understanding of a widely used laboratory method, they also establish a basis for new applications of this method...
  2. pmc Protrusive push versus enveloping embrace: computational model of phagocytosis predicts key regulatory role of cytoskeletal membrane anchors
    Marc Herant
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
    PLoS Comput Biol 7:e1001068. 2011
    ..These linkages are presumably actin-binding protein complexes associating with the cytoplasmic domains of cell-surface receptors that are engaged in adhesion to zymosan and Fc-domains...
  3. doi request reprint Imaging biomolecular interactions by fast three-dimensional tracking of laser-confined carrier particles
    Volkmar Heinrich
    Department of Biomedical Engineering and Biomedical Engineering Graduate Group, University of California at Davis, 451 East Health Sciences Drive, Davis, CA 95616, USA
    Langmuir 24:1194-203. 2008
    ....
  4. pmc Force versus axial deflection of pipette-aspirated closed membranes
    Volkmar Heinrich
    Department of Biomedical Engineering and Biomedical Engineering Graduate Group, University of California, Davis, California 95616, USA
    Biophys J 93:363-72. 2007
    ..In this linear regime the pressurized membrane bag behaves like a Hookean spring, with a spring constant that is significantly larger than previously published for the biomembrane force probe...
  5. pmc Blurred line between chemotactic chase and phagocytic consumption: an immunophysical single-cell perspective
    Volkmar Heinrich
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    J Cell Sci 124:3041-51. 2011
    ....
  6. ncbi request reprint Nano-to-microscale mechanical switches and fuses mediate adhesive contacts between leukocytes and the endothelium
    Volkmar Heinrich
    Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    J Chem Inf Model 45:1482-90. 2005
  7. pmc Nano- to microscale dynamics of P-selectin detachment from leukocyte interfaces. II. Tether flow terminated by P-selectin dissociation from PSGL-1
    Volkmar Heinrich
    Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215 USA
    Biophys J 88:2299-308. 2005
    ..07 pN/nm provides good agreement with the time course of the tether force approach to the plateau under constant pulling speed...
  8. ncbi request reprint Mechanics of neutrophil phagocytosis: experiments and quantitative models
    Marc Herant
    Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    J Cell Sci 119:1903-13. 2006
    ..5 microm), and that the flattening force can plausibly be generated by the known concentrations of unconventional myosins at the leading edge...
  9. pmc Nano- to microscale dynamics of P-selectin detachment from leukocyte interfaces. I. Membrane separation from the cytoskeleton
    Evan Evans
    Biomedical Engineering, Boston University, Boston, Massachusetts 02215 USA
    Biophys J 88:2288-98. 2005
    ..The rheological properties of tether growth subsequent to the membrane unbinding events are presented in a companion article II...
  10. pmc Nano-to-micro scale dynamics of P-selectin detachment from leukocyte interfaces. III. Numerical simulation of tethering under flow
    Michael R King
    Department of Biomedical Engineering, University of Rochester, Rochester, New York 14642, USA
    Biophys J 88:1676-83. 2005
    ..Surprisingly, a mixture of 10% single bonds and 90% dimeric bonds is sufficient to fully match the data of the P-selectin:PSGL-1 experiments, with the calculated decay in fraction of attached cells still appearing exponential...
  11. pmc Baseline mechanical characterization of J774 macrophages
    Jonathan Lam
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Biophys J 96:248-54. 2009
    ..Scanning electron micrographs show how microscopic membrane wrinkles are smoothed out and recruited into the apparent surface area during phagocytosis of large targets...
  12. pmc Target-specific mechanics of phagocytosis: protrusive neutrophil response to zymosan differs from the uptake of antibody-tagged pathogens
    Cheng Yuk Lee
    Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
    J Cell Sci 124:1106-14. 2011
    ..Remarkably, an intact actin cytoskeleton is required to suppress, in antibody-mediated phagocytosis, the initially protrusive deformation that distinguishes the neutrophil response to zymosan...
  13. ncbi request reprint Mechanics of neutrophil phagocytosis: behavior of the cortical tension
    Marc Herant
    Biomedical Engineering Department, Boston University, 44 Cummington Street, Boston, MA 02215, USA
    J Cell Sci 118:1789-97. 2005
    ..We propose that this is the result of phagocytosis-triggered enzymatic activity that releases spare plasma membrane normally sequestered by velcro-like bonds in a reservoir of surface folds and villi...
  14. pmc Versatile horizontal force probe for mechanical tests on pipette-held cells, particles, and membrane capsules
    Chawin Ounkomol
    Department of Biomedical Engineering, University of California, Davis, Davis, California 95616, USA
    Biophys J 96:1218-31. 2009
    ....
  15. pmc Single-cell adhesion tests against functionalized microspheres arrayed on AFM cantilevers confirm heterophilic E- and N-cadherin binding
    Chawin Ounkomol
    Department of Biomedical Engineering, University of California at Davis, Davis, California, USA
    Biophys J 99:L100-2. 2010
    ..We support this assessment with a rough estimate of the ratio of on-rate constants of E/N-cadherin binding...
  16. ncbi request reprint Automated, high-resolution micropipet aspiration reveals new insight into the physical properties of fluid membranes
    Volkmar Heinrich
    Boston University, Department of Biomedical Engineering, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Langmuir 21:1962-71. 2005
    ....
  17. pmc Mechanical switching and coupling between two dissociation pathways in a P-selectin adhesion bond
    Evan Evans
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:11281-6. 2004
    ..The two-pathway switch seems to provide a mechanism for the "catch bond" response observed recently with PSGL-1-P-selectin bonds subjected to small-constant forces...
  18. pmc Dynamic tension spectroscopy and strength of biomembranes
    Evan Evans
    Department of Physics, Department of Pathology, University of British Columbia, Vancouver, Canada
    Biophys J 85:2342-50. 2003
    ..As key predictors of membrane strength, the results for spontaneous frequencies of defect formation and hole edge energies were found to correlate with membrane thicknesses and elastic bending moduli, respectively...
  19. ncbi request reprint Modulation of cell adhesion and motility in the immune system by Myo1f
    Sangwon V Kim
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 314:136-9. 2006
    ..In vivo, Myo1f-deficient mice showed increased susceptibility to infection by Listeria monocytogenes and an impaired neutrophil response. Thus, Myo1f directs immune cell motility and innate host defense against infection...

Research Grants5

  1. Integrative Experimental and Theoretical Studies of the Mechanics of Phagocytosis
    Volkmar Heinrich; Fiscal Year: 2007
    ..This is a determining element for the recovery from infectious challenges in human health. ..
  2. Integrative Experimental and Theoretical Studies of the Mechanics of Phagocytosis
    Volkmar Heinrich; Fiscal Year: 2009
    ..This is a determining element for the recovery from infectious challenges in human health. ..
  3. Integrative Experimental and Theoretical Studies of the Mechanics of Phagocytosis
    Volkmar Heinrich; Fiscal Year: 2010
    ..This is a determining element for the recovery from infectious challenges in human health. ..
  4. Integrative Experimental and Theoretical Studies of the Mechanics of Phagocytosis
    Volkmar Heinrich; Fiscal Year: 2010
    ..This is a determining element for the recovery from infectious challenges in human health. ..