Kim Heidenreich

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Molecular mechanisms of neuronal cell death
    Kim A Heidenreich
    Department of Pharmacology and Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Ann N Y Acad Sci 991:237-50. 2003
  2. ncbi request reprint Myocyte enhancer factor-2 transcription factors in neuronal differentiation and survival
    Kim A Heidenreich
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    Mol Neurobiol 29:155-66. 2004
  3. ncbi request reprint Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival
    Daniel A Linseman
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Biol Chem 278:41472-81. 2003
  4. pmc The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons
    Maria L Florez-McClure
    Department of Pharmacology, University of Colorado Health Sciences Center, and Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Neurosci 24:4498-509. 2004
  5. ncbi request reprint A myocyte enhancer factor 2D (MEF2D) kinase activated during neuronal apoptosis is a novel target inhibited by lithium
    Daniel A Linseman
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Neurochem 85:1488-99. 2003
  6. ncbi request reprint Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons
    Daniel A Linseman
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Neurosci 22:9287-97. 2002
  7. pmc Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons
    Shoshona S Le
    Research Service, Veterans Affairs Medical Center, Denver, Colorado 80220, USA
    J Neurochem 94:1025-39. 2005
  8. ncbi request reprint Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim
    Angela K Zimmermann
    Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Neurochem 94:22-36. 2005
  9. ncbi request reprint Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells
    Sheila M Nielsen-Preiss
    Department of Medicine, The University of Colorado at Denver, Denver, CO 80220, USA
    Endocrinology 148:2806-14. 2007
  10. pmc Novel mechanism for gonadotropin-releasing hormone neuronal migration involving Gas6/Ark signaling to p38 mitogen-activated protein kinase
    Melissa P Allen
    Department of Medicine, University of Colorado Health Sciences Center, Research Service, Veterans Affairs Medical Center, Denver, Colorado 80220, USA
    Mol Cell Biol 22:599-613. 2002

Research Grants

  1. IMPROVING SURVIVAL OF TRANSPLANTED DOPAMINE NEURONS
    Kim Heidenreich; Fiscal Year: 2004

Collaborators

  • Daniel A Linseman
  • Charleen T Chu
  • Curt Freed
  • Margaret Wierman
  • Melissa P Allen
  • Shoshona S Le
  • Ron J Bouchard
  • Maria L Florez-McClure
  • Mei Xu
  • Santiago E Farias
  • Sheila M Nielsen-Preiss
  • F Alexandra Loucks
  • Angela K Zimmermann
  • John E Pawlowski
  • Hiroshi Udo
  • Eric R Kandel
  • Ferogh A Ahmadi
  • Robert C Murphy
  • R J Bouchard
  • Brian C Varnum
  • Simona Zarini
  • Thomas Precht
  • Holger Barth
  • Kenneth L Tyler
  • Brent D Butts
  • Reid A Phelps
  • Klaus Aktories
  • Sarah Richardson-Burns
  • Phil A Barker
  • Tracey A Laessig
  • W Michael Zawada
  • Tom N Grammatopoulos
  • Susan M Jones
  • Jerome B Schaack
  • Gary M Bokoch
  • Brian Varnum

Detail Information

Publications15

  1. ncbi request reprint Molecular mechanisms of neuronal cell death
    Kim A Heidenreich
    Department of Pharmacology and Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Ann N Y Acad Sci 991:237-50. 2003
    ..Pinpointing molecular events that control neuronal cell death is critical for the development of new strategies to prevent and treat neurodegenerative disorders...
  2. ncbi request reprint Myocyte enhancer factor-2 transcription factors in neuronal differentiation and survival
    Kim A Heidenreich
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    Mol Neurobiol 29:155-66. 2004
    ..Here we focus our discussion on the role of MEF2 proteins in nervous tissue and the regulation of these transcription factors by calcium and phosphorylation signaling pathways...
  3. ncbi request reprint Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival
    Daniel A Linseman
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Biol Chem 278:41472-81. 2003
    ..These results indicate that depolarization-mediated calcium influx acts through CaMKII to inhibit HDAC5, thereby sustaining high MEF2 activity in CGNs maintained under depolarizing conditions...
  4. pmc The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons
    Maria L Florez-McClure
    Department of Pharmacology, University of Colorado Health Sciences Center, and Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Neurosci 24:4498-509. 2004
    ..The autophagic morphology resembles that found in neurodegenerative disorders, suggesting a potential role for this pathway in neurological disease...
  5. ncbi request reprint A myocyte enhancer factor 2D (MEF2D) kinase activated during neuronal apoptosis is a novel target inhibited by lithium
    Daniel A Linseman
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Neurochem 85:1488-99. 2003
    ..These results demonstrate that the kinase that phosphorylates and inhibits the pro-survival function of MEF2D in cerebellar granule neurons is a novel lithium target distinct from GSK-3 beta...
  6. ncbi request reprint Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons
    Daniel A Linseman
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Neurosci 22:9287-97. 2002
    ..These data suggest that IGF-I signaling via AKT promotes survival of cerebellar granule neurons by blocking the FKHRL1-dependent transcription of Bim, a principal effector of the intrinsic death-signaling cascade...
  7. pmc Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons
    Shoshona S Le
    Research Service, Veterans Affairs Medical Center, Denver, Colorado 80220, USA
    J Neurochem 94:1025-39. 2005
    ..These results indicate that Rac acts downstream of integrins and growth factors to promote neuronal survival by repressing c-Jun/Bim-mediated mitochondrial apoptosis...
  8. ncbi request reprint Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim
    Angela K Zimmermann
    Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Neurochem 94:22-36. 2005
    ..These results further indicate that, although Bcl-2/Bcl-x(L) antagonism is sufficient to induce neuronal apoptosis, Bim likely promotes neuronal death by interacting with additional proteins besides Bcl-2/Bcl-x(L)...
  9. ncbi request reprint Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells
    Sheila M Nielsen-Preiss
    Department of Medicine, The University of Colorado at Denver, Denver, CO 80220, USA
    Endocrinology 148:2806-14. 2007
    ..Together, these data show that the PI3K-Ras pathway is a major mediator of Axl actions upstream of Rac to induce GnRH neuronal cell migration...
  10. pmc Novel mechanism for gonadotropin-releasing hormone neuronal migration involving Gas6/Ark signaling to p38 mitogen-activated protein kinase
    Melissa P Allen
    Department of Medicine, University of Colorado Health Sciences Center, Research Service, Veterans Affairs Medical Center, Denver, Colorado 80220, USA
    Mol Cell Biol 22:599-613. 2002
    ..Furthermore, these studies support a potential role for Ark in the regulation of GnRH neuronal migration...
  11. ncbi request reprint Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis
    Daniel A Linseman
    Department of Pharmacology, University of Colorado Health Sciences Center, and Denver Veterans Affairs Medical Center, Denver, Colorado 80262, USA
    J Neurosci 24:9993-10002. 2004
    ..Our results indicate that GSK-3beta exerts some of its pro-apoptotic effects in neurons by regulating the mitochondrial localization of Bax, a key component of the intrinsic apoptotic cascade...
  12. ncbi request reprint The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons
    Ferogh A Ahmadi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurochem 87:914-21. 2003
    ..Understanding the mechanism of rotenone-induced apoptosis in dopamine neurons may contribute to the development of new neuroprotective strategies against Parkinson's disease...
  13. ncbi request reprint Adhesion-related kinase repression of gonadotropin-releasing hormone gene expression requires Rac activation of the extracellular signal-regulated kinase pathway
    Melissa P Allen
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:38133-40. 2002
    ..The data suggest that Ark suppresses GnRH gene expression via the coordinated activation of a Rac --> ERK signaling pathway and a distinct MEF2- dependent mechanism...
  14. ncbi request reprint Suppression of death receptor signaling in cerebellar Purkinje neurons protects neighboring granule neurons from apoptosis via an insulin-like growth factor I-dependent mechanism
    Daniel A Linseman
    Department of Pharmacology, University of Colorado Health Sciences Center and the Denver Veterans Affairs Medical Center, Denver, Colorado 80220, USA
    J Biol Chem 277:24546-53. 2002
    ..Thus, the extrinsic death pathway has a profound but indirect effect on the survival of cerebellar granule neurons...
  15. ncbi request reprint Transcellular biosynthesis of cysteinyl leukotrienes in rat neuronal and glial cells
    Santiago E Farias
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, and the Denver VA Medical Center, Denver, Colorado, USA
    J Neurochem 103:1310-8. 2007
    ..The formation of LTC(4) through this mechanism may be relevant in the genesis and progression of the inflammatory response as a result of brain injury...

Research Grants5

  1. IMPROVING SURVIVAL OF TRANSPLANTED DOPAMINE NEURONS
    Kim Heidenreich; Fiscal Year: 2004
    ....