Dale J Hedges

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Comparison of three targeted enrichment strategies on the SOLiD sequencing platform
    Dale J Hedges
    John T MacDonald Department of Human Genetics, Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 6:e18595. 2011
  2. pmc Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci
    Dale J Hedges
    Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10 Ave, M 860, Miami, FL 33136, USA
    Mol Autism 3:2. 2012
  3. pmc Evaluating mitochondrial DNA variation in autism spectrum disorders
    Athena Hadjixenofontos
    John P Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Ann Hum Genet 77:9-21. 2013
  4. pmc Exome sequencing of a multigenerational human pedigree
    Dale J Hedges
    John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 4:e8232. 2009
  5. pmc An X chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males
    Ren Hua Chung
    Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, PO Box 019132 M 860, Miami, FL 33101, USA
    Mol Autism 2:18. 2011
  6. doi request reprint Sample degradation leads to false-positive copy number variation calls in multiplex real-time polymerase chain reaction assays
    HOLLY N CUKIER
    Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Anal Biochem 386:288-90. 2009
  7. pmc A genome-wide association study of autism reveals a common novel risk locus at 5p14.1
    Deqiong Ma
    Miami Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, USA
    Ann Hum Genet 73:263-73. 2009
  8. pmc Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy
    Nadine Norton
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Circ Cardiovasc Genet 6:144-53. 2013

Collaborators

Detail Information

Publications8

  1. pmc Comparison of three targeted enrichment strategies on the SOLiD sequencing platform
    Dale J Hedges
    John T MacDonald Department of Human Genetics, Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 6:e18595. 2011
    ..Both Raindance and Nimblegen SeqCap exhibited tighter distributions of read depth around the mean, but both suffered from lower on-target efficiency in our experiments. Raindance demonstrated the highest versatility in assay design...
  2. pmc Evidence of novel fine-scale structural variation at autism spectrum disorder candidate loci
    Dale J Hedges
    Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, 1501 NW 10 Ave, M 860, Miami, FL 33136, USA
    Mol Autism 3:2. 2012
    ..abstract:..
  3. pmc Evaluating mitochondrial DNA variation in autism spectrum disorders
    Athena Hadjixenofontos
    John P Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Ann Hum Genet 77:9-21. 2013
    ..Accordingly, while there may be attractive biological hints suggesting the role of mitochondria in ASD our data indicate that mtDNA variation is not a major contributing factor to the development of ASD...
  4. pmc Exome sequencing of a multigenerational human pedigree
    Dale J Hedges
    John P Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 4:e8232. 2009
    ....
  5. pmc An X chromosome-wide association study in autism families identifies TBL1X as a novel autism spectrum disorder candidate gene in males
    Ren Hua Chung
    Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, PO Box 019132 M 860, Miami, FL 33101, USA
    Mol Autism 2:18. 2011
    ..abstract:..
  6. doi request reprint Sample degradation leads to false-positive copy number variation calls in multiplex real-time polymerase chain reaction assays
    HOLLY N CUKIER
    Miami Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Anal Biochem 386:288-90. 2009
    ..Results suggest the possibility of biased degradation among genomic regions and emphasize the need to assess sample integrity immediately prior to real-time qPCR experiments...
  7. pmc A genome-wide association study of autism reveals a common novel risk locus at 5p14.1
    Deqiong Ma
    Miami Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, USA
    Ann Hum Genet 73:263-73. 2009
    ..24E-04 to 3.40E-06) than in either dataset alone. Our findings demonstrate that in addition to multiple rare variations, part of the complex genetic architecture of autism involves common variation...
  8. pmc Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy
    Nadine Norton
    Cardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA
    Circ Cardiovasc Genet 6:144-53. 2013
    ..However, the lack of segregation of all identified TTN truncating variants illustrates the challenge of determining variant pathogenicity even with full exome sequencing...