SUSAN HECKBERT

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
  2. ncbi request reprint Risk of recurrent coronary events in relation to use and recent initiation of postmenopausal hormone therapy
    S R Heckbert
    Cardiovascular Health Research Unit, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, WA 98101 1448, USA
    Arch Intern Med 161:1709-13. 2001
  3. pmc Depression in relation to long-term control of glycemia, blood pressure, and lipids in patients with diabetes
    Susan R Heckbert
    Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
    J Gen Intern Med 25:524-9. 2010
  4. ncbi request reprint Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly
    Susan R Heckbert
    Department of Epidemiology, University of Washington, Seattle, USA
    Circulation 107:2021-4. 2003
  5. pmc Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis
    Susan R Heckbert
    Department of Epidemiology, University of Washington, Seattle, Washington 98101 1448, USA
    J Am Coll Cardiol 48:2285-92. 2006
  6. doi request reprint Use of alendronate and risk of incident atrial fibrillation in women
    Susan R Heckbert
    Cardiovascular Health Research Unit, University of Washington, 1730 Minor Ave, Ste 1360, Seattle, WA 98101 1448, USA
    Arch Intern Med 168:826-31. 2008
  7. ncbi request reprint Comparison of self-report, hospital discharge codes, and adjudication of cardiovascular events in the Women's Health Initiative
    Susan R Heckbert
    Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Seattle, WA 98101 1448, USA
    Am J Epidemiol 160:1152-8. 2004
  8. pmc Antihypertensive treatment with ACE inhibitors or beta-blockers and risk of incident atrial fibrillation in a general hypertensive population
    Susan R Heckbert
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Am J Hypertens 22:538-44. 2009
  9. pmc Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke
    Daniel A Enquobahrie
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Am J Cardiol 101:1683-8. 2008
  10. ncbi request reprint Risk factors for hospitalized upper or lower gastrointestinal tract bleeding in treated hypertensives
    Robert C Kaplan
    Cardiovascular Health Research Unit, University of Washington, USA
    Prev Med 34:455-62. 2002

Detail Information

Publications89

  1. pmc Genetics of coronary artery calcification among African Americans, a meta-analysis
    Mary K Wojczynski
    Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA
    BMC Med Genet 14:75. 2013
    ..African Americans (AA) have higher rates of CHD but are less well-studied in genomic studies. We assembled the largest AA data resource currently available with measured CAC to identify associated genetic variants...
  2. ncbi request reprint Risk of recurrent coronary events in relation to use and recent initiation of postmenopausal hormone therapy
    S R Heckbert
    Cardiovascular Health Research Unit, University of Washington, 1730 Minor Ave, Suite 1360, Seattle, WA 98101 1448, USA
    Arch Intern Med 161:1709-13. 2001
    ..We assessed the risk of recurrent myocardial infarction or coronary heart disease death associated with the use and recent initiation of hormone therapy in women who survived a first myocardial infarction...
  3. pmc Depression in relation to long-term control of glycemia, blood pressure, and lipids in patients with diabetes
    Susan R Heckbert
    Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
    J Gen Intern Med 25:524-9. 2010
    ..Little information is available about the association of depression with long-term control of glycemia, blood pressure, or lipid levels in patients with diabetes...
  4. ncbi request reprint Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly
    Susan R Heckbert
    Department of Epidemiology, University of Washington, Seattle, USA
    Circulation 107:2021-4. 2003
    ..We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study...
  5. pmc Traditional cardiovascular risk factors in relation to left ventricular mass, volume, and systolic function by cardiac magnetic resonance imaging: the Multiethnic Study of Atherosclerosis
    Susan R Heckbert
    Department of Epidemiology, University of Washington, Seattle, Washington 98101 1448, USA
    J Am Coll Cardiol 48:2285-92. 2006
    ....
  6. doi request reprint Use of alendronate and risk of incident atrial fibrillation in women
    Susan R Heckbert
    Cardiovascular Health Research Unit, University of Washington, 1730 Minor Ave, Ste 1360, Seattle, WA 98101 1448, USA
    Arch Intern Med 168:826-31. 2008
    ..This adverse effect was unexpected and had not been recognized previously...
  7. ncbi request reprint Comparison of self-report, hospital discharge codes, and adjudication of cardiovascular events in the Women's Health Initiative
    Susan R Heckbert
    Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Seattle, WA 98101 1448, USA
    Am J Epidemiol 160:1152-8. 2004
    ....
  8. pmc Antihypertensive treatment with ACE inhibitors or beta-blockers and risk of incident atrial fibrillation in a general hypertensive population
    Susan R Heckbert
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Am J Hypertens 22:538-44. 2009
    ..Information is scant about the association of beta-blocker use with AF risk in hypertensive patients without heart failure...
  9. pmc Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke
    Daniel A Enquobahrie
    Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
    Am J Cardiol 101:1683-8. 2008
    ..77 to 0.99). No within-gene or gene-gene interaction was associated with MI or ischemic stroke risk. In conclusion, potential SNP-disease associations identified in the present study are novel and need further investigation...
  10. ncbi request reprint Risk factors for hospitalized upper or lower gastrointestinal tract bleeding in treated hypertensives
    Robert C Kaplan
    Cardiovascular Health Research Unit, University of Washington, USA
    Prev Med 34:455-62. 2002
    ..We examined risk factors for hospitalized gastrointestinal bleeding among health maintenance organization (HMO) members with hypertension...
  11. ncbi request reprint Conjugated equine estrogens and coronary heart disease: the Women's Health Initiative
    Judith Hsia
    Department of Medicine, George Washington University, Washington, DC, USA
    Arch Intern Med 166:357-65. 2006
    ..These trials did not address the role of unopposed estrogen for coronary protection...
  12. ncbi request reprint Logic regression for analysis of the association between genetic variation in the renin-angiotensin system and myocardial infarction or stroke
    Charles Kooperberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Epidemiol 165:334-43. 2007
    ....
  13. pmc Relationship styles and mortality in patients with diabetes
    Paul Ciechanowski
    Department of Psychiatry, University of Washington, Seattle, Washington, USA
    Diabetes Care 33:539-44. 2010
    ..Further research is needed to examine possible mechanisms for this relationship and to develop appropriate interventions...
  14. ncbi request reprint Acute lung injury in patients with subarachnoid hemorrhage: incidence, risk factors, and outcome
    Jeremy M Kahn
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA
    Crit Care Med 34:196-202. 2006
    ..Ventilator management was analyzed to determine the proportion of patients with subarachnoid hemorrhage and acute lung injury who a received a low-tidal volume ventilation strategy...
  15. pmc Depression and advanced complications of diabetes: a prospective cohort study
    Elizabeth H B Lin
    Group Health Research Institute, Group Health, Seattle, Washington, USA
    Diabetes Care 33:264-9. 2010
    ..To prospectively examine the association of depression with risks for advanced macrovascular and microvascular complications among patients with type 2 diabetes...
  16. ncbi request reprint Antibiotic use in relation to the risk of breast cancer
    Christine M Velicer
    Department of Epidemiology, University of Washington, Seattle, USA
    JAMA 291:827-35. 2004
    ....
  17. pmc Myocardial infarction and stroke associated with diuretic based two drug antihypertensive regimens: population based case-control study
    Inbal Boger-Megiddo
    Cardiovascular Health Research Unit, University of Washington, Seattle, WA 98101, USA
    BMJ 340:c103. 2010
    ..Design Population based case-control study. Setting Group Health Cooperative, Seattle, WA, USA...
  18. pmc Depression and increased mortality in diabetes: unexpected causes of death
    Elizabeth H B Lin
    Group Health Research Institute, Seattle, Washington 98101, USA
    Ann Fam Med 7:414-21. 2009
    ..Recent evidence suggests that depression is linked to increased mortality among patients with diabetes. This study examines the association of depression with all-cause and cause-specific mortality in diabetes...
  19. ncbi request reprint Risk of new-onset atrial fibrillation in relation to body mass index
    Sascha Dublin
    Veterans Affairs Puget Sound Health Care System, Seattle, WA 98101, USA
    Arch Intern Med 166:2322-8. 2006
    ..It is also unknown to what extent cardiovascular risk factors may mediate this association...
  20. ncbi request reprint Serum lipid levels and the risk of venous thrombosis
    Carine J M Doggen
    Department of Epidemiology, University of Washington, Seattle, USA
    Arterioscler Thromb Vasc Biol 24:1970-5. 2004
    ..Lipids, through effects on the coagulation and fibrinolytic systems, may contribute to the development of venous thrombosis. This association has been investigated in a few studies, with conflicting results...
  21. pmc Common genetic variation in six lipid-related and statin-related genes, statin use and risk of incident nonfatal myocardial infarction and stroke
    Lucia A Hindorff
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
    Pharmacogenet Genomics 18:677-82. 2008
    ....
  22. ncbi request reprint Risk of epithelial ovarian cancer in relation to use of antidepressants, benzodiazepines, and other centrally acting medications
    Sascha Dublin
    Department of Epidemiology, University of Washington, Seattle 98195, USA
    Cancer Causes Control 13:35-45. 2002
    ..An increased risk of ovarian cancer among users of antidepressants and benzodiazepines has been observed in some but not all prior studies. We examined these associations in a population-based case-control study...
  23. ncbi request reprint Conjugated equine estrogens and peripheral arterial disease risk: the Women's Health Initiative
    Judith Hsia
    Department of Medicine, George Washington University, Washington, DC, USA
    Am Heart J 152:170-6. 2006
    ..Estradiol reduced progression of ultrasonographic carotid disease in a randomized trial. No trials of unopposed estrogen for prevention of lower extremity arterial disease or aortic aneurysm have been conducted...
  24. ncbi request reprint A validation study of patient interview data and pharmacy records for antihypertensive, statin, and antidepressant medication use among older women
    Denise M Boudreau
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Am J Epidemiol 159:308-17. 2004
    ..Trivial changes in estimates were observed when health maintenance organization records alone were used as the gold standard. Self-reported use of antihypertensives and statins appears to be relatively accurate among older women...
  25. pmc Multiple imputation for missing with cardiac magnetic resonance imaging data: results from the Multi-Ethnic Study of Atherosclerosis (MESA)
    Joseph A Chris Delaney
    Department of Biostatistics, University of Washington, Seattle, Washington 98115, USA
    Can J Cardiol 25:e232-5. 2009
    ..However, some subjects either refuse or are unable to complete testing, and the impact of excluding these missing data from predictive models is unknown...
  26. ncbi request reprint Estrogen therapy and risk of cardiovascular events among women with type 2 diabetes
    Katherine M Newton
    Center for Health Studies, Group Health Cooperative, Seattle, Washington, USA
    Diabetes Care 26:2810-6. 2003
    ..To evaluate the association between estrogen therapy and cardiovascular disease risk among women with type 2 diabetes...
  27. pmc Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study
    Cara L Carty
    Department of Epidemiology, University of Washington, WA, USA
    J Atheroscler Thromb 16:419-30. 2009
    ..Interaction of the SAA genes with genetic variants of their regulators, IL-1, IL-6 and TNF-alpha in influencing CVD was also explored...
  28. pmc Statin use and breast cancer risk in a large population-based setting
    Denise M Boudreau
    Group Health, Center for Health Studies, Suite 1600, 1730 Minor Avenue, Seattle, WA 98101, USA
    Cancer Epidemiol Biomarkers Prev 16:416-21. 2007
    ..Mechanistic studies suggest that 3-hydroxy-3-methylglutaryl CoA inhibitors (statins) reduce the risk of breast cancer. Observational studies offer mixed results...
  29. pmc Short-term and long-term risk of incident ischemic stroke after transient ischemic attack
    Evan L Thacker
    Department of Epidemiology, University of Washington, Seattle, Wash, USA
    Stroke 41:239-43. 2010
    ..We sought to estimate short-term and long-term relative risks of ischemic stroke associated with clinically diagnosed TIA...
  30. doi request reprint Erectile dysfunction is not independently associated with cardiovascular death: data from the vitamins and lifestyle (VITAL) study
    James M Hotaling
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    J Sex Med 9:2104-10. 2012
    ..Erectile dysfunction (ED) is a significant problem among aging men. ED is independently associated with cardiovascular (CV) events (angina, myocardial infarction, and stroke)...
  31. doi request reprint beta1- and beta2-adrenergic receptor gene variation, beta-blocker use and risk of myocardial infarction and stroke
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Hypertens 21:290-6. 2008
    ..The benefits of beta-blocker therapy may depend on underlying genetic susceptibility...
  32. ncbi request reprint Newly detected atrial fibrillation and compliance with antithrombotic guidelines
    Nicole L Glazer
    Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, 1730 Minor Avenue, Seattle, WA 98101, USA
    Arch Intern Med 167:246-52. 2007
    ..Our objective was to assess compliance with antithrombotic guidelines and to identify patient characteristics associated with warfarin use...
  33. ncbi request reprint Association of genetic variations with nonfatal venous thrombosis in postmenopausal women
    Nicholas L Smith
    Department of Epidemiology, University of Washington, Seattle, WA 98101, USA
    JAMA 297:489-98. 2007
    ....
  34. doi request reprint Predictors of hospital mortality in a population-based cohort of patients with acute lung injury
    Colin R Cooke
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, University of Washington, Seattle, WA 98104, USA
    Crit Care Med 36:1412-20. 2008
    ..We sought to determine the predictors of mortality in a population-based cohort of patients with acute lung injury and to characterize the performance of current severity of illness scores in this population...
  35. doi request reprint Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke
    Kristin D Marciante
    Cardiovascular Health Research Unit, Seattle, Washington 98101, USA
    Pharmacogenet Genomics 18:535-43. 2008
    ..We conducted a population-based, case-control study at Group Health to determine whether common genetic variation in the CYP2J2, CYP2C8, and CYP2C9 genes was associated with the risk of myocardial infarction and ischemic stroke...
  36. pmc Variation in inflammation-related genes and risk of incident nonfatal myocardial infarction or ischemic stroke
    Joshua C Bis
    Department of Medicine, University of Washington, Seattle, WA 981041, USA
    Atherosclerosis 198:166-73. 2008
    ....
  37. pmc Variation in eicosanoid genes, non-fatal myocardial infarction and ischemic stroke
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA
    Atherosclerosis 204:e58-63. 2009
    ..A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC)...
  38. pmc Ascertainment of warfarin and aspirin use by medical record review compared with automated pharmacy data
    Renu K Garg
    Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
    Pharmacoepidemiol Drug Saf 20:313-6. 2011
    ..This study aimed to measure agreement on warfarin and aspirin use between medical records and automated pharmacy data among patients with newly detected atrial fibrillation (AF)...
  39. doi request reprint Association of combinations of lipid parameters with carotid intima-media thickness and coronary artery calcium in the MESA (Multi-Ethnic Study of Atherosclerosis)
    Pathmaja Paramsothy
    Division of Cardiology, Department of Internal Medicine, University of Washington, Seattle, Washington 98104, USA
    J Am Coll Cardiol 56:1034-41. 2010
    ..The purpose of this study was to determine the association of combinations of lipid parameters with subclinical atherosclerosis...
  40. pmc Prediction of critical illness during out-of-hospital emergency care
    Christopher W Seymour
    Division of Pulmonary and Critical Care Medicine, University of Washington, Harborview Medical Center, PO Box 359762, Seattle, WA 98104, USA
    JAMA 304:747-54. 2010
    ..Early identification of nontrauma patients in need of critical care services in the emergency setting may improve triage decisions and facilitate regionalization of critical care...
  41. pmc Depression and incident diabetic foot ulcers: a prospective cohort study
    LISA H WILLIAMS
    Department of Medicine, Division of Dermatology, University of Washington, Seattle, Wash, USA
    Am J Med 123:748-754.e3. 2010
    ..To test whether depression is associated with an increased risk of incident diabetic foot ulcers...
  42. pmc The association of restrained eating with weight change over time in a community-based sample of twins
    Ellen A Schur
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Obesity (Silver Spring) 18:1146-52. 2010
    ..These data demonstrate that observed relationships between BMI, weight gain, and restrained eating, as assessed by the Restraint Scale, have a strong environmental influence and are not solely due to shared genetic factors...
  43. pmc Comorbid depression is associated with an increased risk of dementia diagnosis in patients with diabetes: a prospective cohort study
    Wayne J Katon
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1959 NE Pacific Street, Box 356560, Seattle, WA 98195 6560, USA
    J Gen Intern Med 25:423-9. 2010
    ..Both depression and diabetes have been found to be risk factors for dementia. This study examined whether comorbid depression in patients with diabetes increases the risk for dementia compared to those with diabetes alone...
  44. pmc Body size adjustments for left ventricular mass by cardiovascular magnetic resonance and their impact on left ventricular hypertrophy classification
    Lyndia C Brumback
    Department of Biostatistics, University of Washington, Box 357232, Seattle, WA 98195 7232, USA
    Int J Cardiovasc Imaging 26:459-68. 2010
    ..The predictive value of hypertrophy is significantly better with the new allometric height-weight index than with non-indexed LV mass and may be better than indices without weight...
  45. pmc How does change in depressive symptomatology influence weight change in patients with diabetes? Observational results from the Pathways longitudinal cohort
    Evette J Ludman
    Group Health Research Institute, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101, USA
    J Gerontol A Biol Sci Med Sci 65:93-8. 2010
    ..Little is known about how change in depressive symptoms over time is associated with change in weight...
  46. pmc Diabetes and poor disease control: is comorbid depression associated with poor medication adherence or lack of treatment intensification?
    Wayne Katon
    Department of Psychiatry and Behavioral Sciences, Box 356560, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    Psychosom Med 71:965-72. 2009
    ..Depression is a common comorbidity and may affect disease control through adverse effects on adherence and physician intensification of treatment...
  47. pmc Discovering novel risk factors for venous thrombosis: a candidate-gene approach
    Nicholas L Smith
    Department of Epidemiology, University of Washington, Seattle, USA
    Thromb Res 123:S25-9. 2009
    ..As an example, we present a candidate-gene approach to identify novel associations between variation in 24 clotting genes and the risk of incident venous thrombosis...
  48. pmc Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study
    Cara L Carty
    Department of Epidemiology, University of Washington, Seattle, USA
    Ann Hum Genet 74:1-10. 2010
    ..Although IL-6 responsive binding sites are present in fibrinogen gene promoter regions, we did not find strong evidence of interaction between fibrinogen SNPs and IL6 SNPs or levels influencing CVD...
  49. ncbi request reprint Conjugated equine estrogen, esterified estrogen, prothrombotic variants, and the risk of venous thrombosis in postmenopausal women
    Nicholas L Smith
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    Arterioscler Thromb Vasc Biol 26:2807-12. 2006
    ..Esterified estrogen (EE), an alternative estrogenic compound, appears not to be associated with increased risk and nothing is known about the joint risk with prothrombotic genetic variants...
  50. ncbi request reprint Survival associated with two sets of diagnostic criteria for congestive heart failure
    Gina D Schellenbaum
    Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
    Am J Epidemiol 160:628-35. 2004
    ..Compared with Cardiovascular Health Study central adjudication, Framingham criteria for CHF identified a larger group of participants with incident CHF, but all-cause mortality rates were similar across these diagnostic classifications...
  51. ncbi request reprint Angiotensinogen Met235Thr polymorphism, angiotensin-converting enzyme inhibitor therapy, and the risk of nonfatal stroke or myocardial infarction in hypertensive patients
    Joshua C Bis
    Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, Washington 98101, USA
    Am J Hypertens 16:1011-7. 2003
    ....
  52. ncbi request reprint Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis
    Nicholas L Smith
    Department of Epidemiology, University of Washington, Seattle, USA
    JAMA 292:1581-7. 2004
    ..The findings from these trials, which used oral conjugated equine estrogens, may not be generalizable to other estrogen compounds...
  53. ncbi request reprint Risk of myocardial infarction attributable to elevated levels of total cholesterol among hypertensives
    Nicole L Glazer
    Department of Epidemiology, University of Washington, Seattle, Washington 98101, USA
    Am J Hypertens 18:759-66. 2005
    ....
  54. ncbi request reprint Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Am J Hypertens 15:1050-6. 2002
    ..We examined the association between this polymorphism and new-onset hypertension, blood pressure (BP) control, and incident cardiovascular events in a large population-based cohort of older adults...
  55. ncbi request reprint Association of beta-blocker use with mortality among patients with congestive heart failure in the Cardiovascular Health Study (CHS)
    Jeannie D Chan
    Department of Pharmacy, University of Washington, Seattle, Washington, USA
    Am Heart J 150:464-70. 2005
    ..This study assessed the association between beta-blocker therapy and mortality among community-dwelling older adults with CHF...
  56. ncbi request reprint Weight loss, muscle strength, and angiotensin-converting enzyme inhibitors in older adults with congestive heart failure or hypertension
    Gina D Schellenbaum
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 53:1996-2000. 2005
    ..To determine whether angiotensin-converting enzyme (ACE) inhibitor use may be associated with weight maintenance and sustained muscle strength (measured by grip strength) in older adults...
  57. ncbi request reprint Influenza vaccination is not associated with a reduction in the risk of recurrent coronary events
    Lisa A Jackson
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101 1448, USA
    Am J Epidemiol 156:634-40. 2002
    ..06, 95% CI: 0.63, 1.78) or inactivity (May through October) (HR = 1.34, 95% CI: 0.76, 2.36). These results suggest that the benefit of influenza vaccine for older adults does not extend to protection against recurrent coronary events...
  58. ncbi request reprint Hormone replacement therapy and associated risk of stroke in postmenopausal women
    Rozenn N Lemaitre
    Department of Medicine, Cardiovascular Health Research Unit, University of Washington, Seattle 98101, USA
    Arch Intern Med 162:1954-60. 2002
    ..There is little information about the risk of stroke in relation to time since initiation of hormone therapy and in relation to estrogen dose...
  59. ncbi request reprint Association between antibiotic use prior to breast cancer diagnosis and breast tumour characteristics (United States)
    Christine M Velicer
    Department of Epidemiology, University of Washington, Seattle, 98195, USA
    Cancer Causes Control 17:307-13. 2006
    ..To determine if breast tumour characteristics varied by antibiotic use prior to diagnosis in 2,266 women with primary, invasive breast cancer...
  60. ncbi request reprint Smoking status and risk for recurrent coronary events after myocardial infarction
    Thomas D Rea
    University of Washington, Cardiovascular Health Research Unit, Metropolitan Park, East Tower, 1730 Minor Avenue, Suite 1360, Seattle, WA 98101, USA
    Ann Intern Med 137:494-500. 2002
    ..Questions remain about the importance of smoking and smoking cessation after incident myocardial infarction...
  61. ncbi request reprint Therapy with hydroxymethylglutaryl coenzyme a reductase inhibitors (statins) and associated risk of incident cardiovascular events in older adults: evidence from the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
    Arch Intern Med 162:1395-400. 2002
    ....
  62. ncbi request reprint Fasting and 2-hour postchallenge serum glucose measures and risk of incident cardiovascular events in the elderly: the Cardiovascular Health Study
    Nicholas L Smith
    Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
    Arch Intern Med 162:209-16. 2002
    ..This study examined the relative predictive power of fasting and 2-hour glucose level on cardiovascular event risk...
  63. ncbi request reprint Diuretic therapy, the alpha-adducin gene variant, and the risk of myocardial infarction or stroke in persons with treated hypertension
    Bruce M Psaty
    Cardiovascular Health Research Unit, 1730 Minor Ave, Suite 1360, Seattle, WA 98101, USA
    JAMA 287:1680-9. 2002
    ..Whether this genetic variant modifies the effect of diuretic therapy on the incidence of myocardial infarction (MI) and stroke is unknown...
  64. ncbi request reprint Nonsteroidal anti-inflammatory drugs and risk of Parkinson's disease
    Thanh G Ton
    Department of Epidemiology, University of Washington, Seattle, Washington 98195, USA
    Mov Disord 21:964-9. 2006
    ..Our results provide only limited support for the hypothesis that use of aspirin may reduce the risk of this disease, and no indication of protection from other NSAIDs...
  65. ncbi request reprint Renin-angiotensin system haplotypes and the risk of myocardial infarction and stroke in pharmacologically treated hypertensive patients
    Kristin D Marciante
    Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
    Am J Epidemiol 166:19-27. 2007
    ..17). In this case-control study, RAS gene haplotypes were not significantly associated with increased risks of myocardial infarction or stroke...
  66. ncbi request reprint Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes
    Darcy B Carr
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195 6460, USA
    Diabetes Care 29:2078-83. 2006
    ..We sought to determine whether a history of gestational diabetes mellitus (GDM) further increases the risk of cardiovascular disease (CVD) in parous women with first-degree relatives with type 2 diabetes...
  67. pmc Low-fat, increased fruit, vegetable, and grain dietary pattern, fractures, and bone mineral density: the Women's Health Initiative Dietary Modification Trial
    Anne McTiernan
    Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA 98019, USA
    Am J Clin Nutr 89:1864-76. 2009
    ..The effects of dietary changes on osteoporosis, low bone density, and frequent falls are unestablished...
  68. doi request reprint Low-fat dietary pattern and risk of treated diabetes mellitus in postmenopausal women: the Women's Health Initiative randomized controlled dietary modification trial
    Lesley F Tinker
    Women s Health Initiative, Fred Hutchinson Cancer Research Center, PO Box 19024, Mail Stop M3 A410, Seattle, WA 98109, USA
    Arch Intern Med 168:1500-11. 2008
    ..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women...
  69. ncbi request reprint Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiology
    Mary Cushman
    Department of Medicine, University of Vermont, Burlington, USA
    Am J Med 117:19-25. 2004
    ..To determine the incidence of deep vein thrombosis and pulmonary embolism in two cohorts representing regions of the United States...
  70. ncbi request reprint beta(2)-Adrenergic receptor polymorphisms and determinants of cardiovascular risk: the Cardiovascular Health Study
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Am J Hypertens 18:392-7. 2005
    ....
  71. ncbi request reprint Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review
    Lawrence S Engel
    Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Am J Epidemiol 156:95-109. 2002
    ..45, 95% CI: -0.03, 0.93). These results indicate that, among populations studied to date, GSTM1 null status is associated with a modest increase in the risk of bladder cancer...
  72. pmc The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE study
    Laura J Rasmussen-Torvik
    Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St Suite 300, Minneapolis, MN 55454, USA
    Thromb Res 121:1-7. 2007
    ..However, the effect of this common variant on risk of venous thromboembolism (VTE) is unclear. This paper reports the association between the Thr312Ala variant and VTE in the LITE study...
  73. ncbi request reprint Esterified estrogen and conjugated equine estrogen and the risk of incident myocardial infarction and stroke
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, and Center for Health Studies, Group Health Cooperative, Seattle 98101 1448, USA
    Arch Intern Med 166:399-404. 2006
    ..The association of these end points with the use of esterified estrogen (EE) is unknown...
  74. ncbi request reprint Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology
    Albert W Tsai
    Division of Epidemiology, School of Public Health, University of Minnesota, 1300 S Second St, Suite 300, Minneapolis, MN 55454, USA
    Arch Intern Med 162:1182-9. 2002
    ..The association between traditional cardiovascular risk factors and risk of venous thromboembolism (VTE) has not been extensively examined in prospective studies...
  75. ncbi request reprint Lipid-lowering drug use and cardiovascular events after myocardial infarction
    Olaf H Klungel
    Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
    Ann Pharmacother 36:751-7. 2002
    ....
  76. ncbi request reprint A prospective study of venous thromboembolism in relation to factor V Leiden and related factors
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Blood 99:2720-5. 2002
    ....
  77. ncbi request reprint Prospective study of polymorphisms of the protein Z-dependent protease inhibitor and risk of venous thromboembolism
    Aaron R Folsom
    Thromb Haemost 97:493-4. 2007
  78. ncbi request reprint Common genetic variation in the prothrombin gene, hormone therapy, and incident nonfatal myocardial infarction in postmenopausal women
    Lucia A Hindorff
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98101, USA
    Am J Epidemiol 163:600-7. 2006
    ..These preliminary results suggest that common genetic variants in the prothrombin gene or other variants in linkage disequilibrium are associated with myocardial infarction in postmenopausal women...
  79. doi request reprint Modestly elevated glucose levels during pregnancy are associated with a higher risk of future diabetes among women without gestational diabetes mellitus
    Darcy B Carr
    Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington 98195 6460, USA
    Diabetes Care 31:1037-9. 2008
    ..To determine whether 1-h oral glucose challenge test (OGCT) or 3-h oral glucose tolerance test (OGTT) results below gestational diabetes mellitus (GDM) criteria are associated with developing diabetes...
  80. ncbi request reprint Predictors of subsequent coronary events, stroke, and death among survivors of first hospitalized myocardial infarction
    Robert C Kaplan
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Belfer Building, Room 1308C, Bronx, NY 10461, USA
    J Clin Epidemiol 55:654-64. 2002
    ..Finally, high creatinine was a strong, independent predictor of a variety of adverse outcomes after first MI...
  81. ncbi request reprint The relationship of cardiovascular risk factors to microalbuminuria in older adults with or without diabetes mellitus or hypertension: the cardiovascular health study
    Joshua I Barzilay
    Kaiser Permanente of Georgia, Tucker, GA 30084, USA
    Am J Kidney Dis 44:25-34. 2004
    ..Microalbuminuria is a risk factor for coronary heart disease (CHD). It occurs most commonly in the settings of diabetes and hypertension. The mechanisms by which it increases CHD risk are uncertain...
  82. ncbi request reprint Estrogen plus progestin and the risk of coronary heart disease
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02215, USA
    N Engl J Med 349:523-34. 2003
    ..In this report, we provide the final results with regard to estrogen plus progestin and CHD from the Women's Health Initiative (WHI)...
  83. ncbi request reprint Hormone replacement therapy and the risk of incident congestive heart failure: the Cardiovascular Health Study
    Thomas D Rea
    Cardiovascular Health Research Unit, University of Washington, Metropolitan Park, East Tower, 1730 Minor Avenue, Seattle, WA 98101, USA
    J Womens Health (Larchmt) 12:341-50. 2003
    ..Hormone replacement therapy (HRT) affects several of the pathways that may be important in the development of CHF. We hypothesized that HRT would be associated with a decreased risk of incident CHF...
  84. ncbi request reprint Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE)
    Albert W Tsai
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
    Am J Hematol 72:192-200. 2003
    ..74, 95% CI = 0.56-0.98). Our prospective data showed, at most, a weak relationship between homocysteine and VTE risk, with associations larger among younger participants. MTHFR C677T was not a risk factor for VTE...
  85. ncbi request reprint Coagulation factors, inflammation markers, and venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE)
    Albert W Tsai
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Med 113:636-42. 2002
    ..We sought to assess prospectively whether higher levels of blood coagulation factors and inflammation markers are risk factors for venous thromboembolism...
  86. ncbi request reprint Congestive heart failure incidence and prognosis: case identification using central adjudication versus hospital discharge diagnoses
    Gina D Schellenbaum
    Department of Epidemiology, University of Washington, Seattle, WA 98101, and Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN, USA
    Ann Epidemiol 16:115-22. 2006
    ..We compared hospitalized congestive heart failure (CHF) incidence and prognosis estimates using hospital discharge diagnoses or central adjudication...
  87. ncbi request reprint Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolism
    Aaron R Folsom
    Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454 1015, USA
    Am J Hematol 71:285-90. 2002
    ..38). There was no association between venous thromboembolism and plasma prothrombin antigen level. We estimated that the G20210A polymorphism may account for approximately 2.5% of venous thromboembolism events in United States whites...
  88. ncbi request reprint Fibrin fragment D-dimer and the risk of future venous thrombosis
    Mary Cushman
    Laboratory for Clinical Biochemistry Research and Department of Medicine, University of Vermont, Colchester, VT 05446, USA
    Blood 101:1243-8. 2003
    ..D-dimer is strongly and positively related to the occurrence of future venous thrombosis...
  89. ncbi request reprint Hormone replacement therapy, prothrombotic mutations, and the risk of incident nonfatal ischemic stroke in postmenopausal women
    Rozenn N Lemaitre
    Arterioscler Thromb Vasc Biol 22:1051-2. 2002

Research Grants6

  1. Atrial Fibrillation Incidence, Risk Factors and Genetics
    SUSAN HECKBERT; Fiscal Year: 2002
    ..abstract_text> ..
  2. Atrial Fibrillation Incidence, Risk Factors and Genetics
    SUSAN HECKBERT; Fiscal Year: 2003
    ..abstract_text> ..
  3. Atrial Fibrillation Incidence, Risk Factors and Genetics
    SUSAN HECKBERT; Fiscal Year: 2004
    ..abstract_text> ..
  4. Atrial Fibrillation Incidence, Risk Factors and Genetics
    SUSAN HECKBERT; Fiscal Year: 2005
    ..abstract_text> ..
  5. Atrial Fibrillation: Incidence, Risk Factors, and Genetics
    SUSAN HECKBERT; Fiscal Year: 2009
    ..The ultimate goal of this research is to increase knowledge about AF risk factors and prognosis and to enhance prevention efforts and improve care for patients with AF. ..
  6. Atrial Fibrillation: Incidence, Risk Factors, and Genetics
    SUSAN HECKBERT; Fiscal Year: 2010
    ..The ultimate goal of this research is to increase knowledge about AF risk factors and prognosis and to enhance prevention efforts and improve care for patients with AF. ..