SUSAN HECKBERT

..We assessed the risk of recurrent myocardial infarction or coronary heart disease death associated with the use and recent initiation of hormone therapy in women who survived a first myocardial infarction...

..We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study...

....

..This adverse effect was unexpected and had not been recognized previously...

..Information is scant about the association of beta-blocker use with AF risk in hypertensive patients without heart failure...

..Little information is available about the association of depression with long-term control of glycemia, blood pressure, or lipid levels in patients with diabetes...

....

..77 to 0.99). No within-gene or gene-gene interaction was associated with MI or ischemic stroke risk. In conclusion, potential SNP-disease associations identified in the present study are novel and need further investigation...

..We examined risk factors for hospitalized gastrointestinal bleeding among health maintenance organization (HMO) members with hypertension...

..These trials did not address the role of unopposed estrogen for coronary protection...

....

..Further research is needed to examine possible mechanisms for this relationship and to develop appropriate interventions...

..To prospectively examine the association of depression with risks for advanced macrovascular and microvascular complications among patients with type 2 diabetes...

..Research is needed to determine the causes of acute lung injury in this population and whether these patients are candidates for evidence-based ventilator strategies to reduce mortality...

..Design Population based case-control study. Setting Group Health Cooperative, Seattle, WA, USA...

..Recent evidence suggests that depression is linked to increased mortality among patients with diabetes. This study examines the association of depression with all-cause and cause-specific mortality in diabetes...

..Although further studies are needed, these findings reinforce the need for prudent long-term use of antibiotics...

..Trivial changes in estimates were observed when health maintenance organization records alone were used as the gold standard. Self-reported use of antihypertensives and statins appears to be relatively accurate among older women...

....

..Lipids, through effects on the coagulation and fibrinolytic systems, may contribute to the development of venous thrombosis. This association has been investigated in a few studies, with conflicting results...

..However, some subjects either refuse or are unable to complete testing, and the impact of excluding these missing data from predictive models is unknown...

..Mechanistic studies suggest that 3-hydroxy-3-methylglutaryl CoA inhibitors (statins) reduce the risk of breast cancer. Observational studies offer mixed results...

..Interaction of the SAA genes with genetic variants of their regulators, IL-1, IL-6 and TNF-alpha in influencing CVD was also explored...

..To evaluate the association between estrogen therapy and cardiovascular disease risk among women with type 2 diabetes...

..We sought to estimate short-term and long-term relative risks of ischemic stroke associated with clinically diagnosed TIA...

..It is also unknown to what extent cardiovascular risk factors may mediate this association...

..An increased risk of ovarian cancer among users of antidepressants and benzodiazepines has been observed in some but not all prior studies. We examined these associations in a population-based case-control study...

..Estradiol reduced progression of ultrasonographic carotid disease in a randomized trial. No trials of unopposed estrogen for prevention of lower extremity arterial disease or aortic aneurysm have been conducted...

..The effects of dietary changes on osteoporosis, low bone density, and frequent falls are unestablished...

..The benefits of beta-blocker therapy may depend on underlying genetic susceptibility...

..Whether this genetic variant modifies the effect of diuretic therapy on the incidence of myocardial infarction (MI) and stroke is unknown...

..We sought to determine the predictors of mortality in a population-based cohort of patients with acute lung injury and to characterize the performance of current severity of illness scores in this population...

..17). In this case-control study, RAS gene haplotypes were not significantly associated with increased risks of myocardial infarction or stroke...

..Our objective was to assess compliance with antithrombotic guidelines and to identify patient characteristics associated with warfarin use...

..We conducted a population-based, case-control study at Group Health to determine whether common genetic variation in the CYP2J2, CYP2C8, and CYP2C9 genes was associated with the risk of myocardial infarction and ischemic stroke...

..A secondary aim was to replicate the interaction of PTGS2 rs20417 (-765G to C) with aspirin use on coronary heart disease risk observed in the Atherosclerosis Risk in Communities Study (ARIC)...

....

..As an example, we present a candidate-gene approach to identify novel associations between variation in 24 clotting genes and the risk of incident venous thrombosis...

..The purpose of this study was to determine the association of combinations of lipid parameters with subclinical atherosclerosis...

..Early identification of nontrauma patients in need of critical care services in the emergency setting may improve triage decisions and facilitate regionalization of critical care...

..To test whether depression is associated with an increased risk of incident diabetic foot ulcers...

..This study examined the relative predictive power of fasting and 2-hour glucose level on cardiovascular event risk...

..These data demonstrate that observed relationships between BMI, weight gain, and restrained eating, as assessed by the Restraint Scale, have a strong environmental influence and are not solely due to shared genetic factors...

..Both depression and diabetes have been found to be risk factors for dementia. This study examined whether comorbid depression in patients with diabetes increases the risk for dementia compared to those with diabetes alone...

..The predictive value of hypertrophy is significantly better with the new allometric height-weight index than with non-indexed LV mass and may be better than indices without weight...

..Our results provide only limited support for the hypothesis that use of aspirin may reduce the risk of this disease, and no indication of protection from other NSAIDs...

..Depression is a common comorbidity and may affect disease control through adverse effects on adherence and physician intensification of treatment...

..Little is known about how change in depressive symptoms over time is associated with change in weight...

..This study aimed to measure agreement on warfarin and aspirin use between medical records and automated pharmacy data among patients with newly detected atrial fibrillation (AF)...

....

..Although IL-6 responsive binding sites are present in fibrinogen gene promoter regions, we did not find strong evidence of interaction between fibrinogen SNPs and IL6 SNPs or levels influencing CVD...

..To determine whether angiotensin-converting enzyme (ACE) inhibitor use may be associated with weight maintenance and sustained muscle strength (measured by grip strength) in older adults...

..This study assessed the association between beta-blocker therapy and mortality among community-dwelling older adults with CHF...

....

..The findings from these trials, which used oral conjugated equine estrogens, may not be generalizable to other estrogen compounds...

....

..Compared with Cardiovascular Health Study central adjudication, Framingham criteria for CHF identified a larger group of participants with incident CHF, but all-cause mortality rates were similar across these diagnostic classifications...

..We examined the association between this polymorphism and new-onset hypertension, blood pressure (BP) control, and incident cardiovascular events in a large population-based cohort of older adults...

..06, 95% CI: 0.63, 1.78) or inactivity (May through October) (HR = 1.34, 95% CI: 0.76, 2.36). These results suggest that the benefit of influenza vaccine for older adults does not extend to protection against recurrent coronary events...

..There is little information about the risk of stroke in relation to time since initiation of hormone therapy and in relation to estrogen dose...

....

..To determine if breast tumour characteristics varied by antibiotic use prior to diagnosis in 2,266 women with primary, invasive breast cancer...

..Questions remain about the importance of smoking and smoking cessation after incident myocardial infarction...

..Esterified estrogen (EE), an alternative estrogenic compound, appears not to be associated with increased risk and nothing is known about the joint risk with prothrombotic genetic variants...

..We sought to determine whether a history of gestational diabetes mellitus (GDM) further increases the risk of cardiovascular disease (CVD) in parous women with first-degree relatives with type 2 diabetes...

..This study was undertaken to assess the effects of a low-fat dietary pattern on incidence of treated diabetes among generally healthy postmenopausal women...

..45, 95% CI: -0.03, 0.93). These results indicate that, among populations studied to date, GSTM1 null status is associated with a modest increase in the risk of bladder cancer...

..74, 95% CI = 0.56-0.98). Our prospective data showed, at most, a weak relationship between homocysteine and VTE risk, with associations larger among younger participants. MTHFR C677T was not a risk factor for VTE...

..Venous thromboembolism, unlike arterial disease, was not related to inflammatory markers...

....

..The association of these end points with the use of esterified estrogen (EE) is unknown...

..38). There was no association between venous thromboembolism and plasma prothrombin antigen level. We estimated that the G20210A polymorphism may account for approximately 2.5% of venous thromboembolism events in United States whites...

..D-dimer is strongly and positively related to the occurrence of future venous thrombosis...

..In addition, the findings suggest a hypothesis that avoidance of obesity and diabetes or vigilance in prophylaxis in patients with those conditions may prevent some venous thromboses...

....

..However, the effect of this common variant on risk of venous thromboembolism (VTE) is unclear. This paper reports the association between the Thr312Ala variant and VTE in the LITE study...

..In this report, we provide the final results with regard to estrogen plus progestin and CHD from the Women's Health Initiative (WHI)...

..To determine whether 1-h oral glucose challenge test (OGCT) or 3-h oral glucose tolerance test (OGTT) results below gestational diabetes mellitus (GDM) criteria are associated with developing diabetes...

..We compared hospitalized congestive heart failure (CHF) incidence and prognosis estimates using hospital discharge diagnoses or central adjudication...

..Finally, high creatinine was a strong, independent predictor of a variety of adverse outcomes after first MI...

..Hormone replacement therapy (HRT) affects several of the pathways that may be important in the development of CHF. We hypothesized that HRT would be associated with a decreased risk of incident CHF...

..Microalbuminuria is a risk factor for coronary heart disease (CHD). It occurs most commonly in the settings of diabetes and hypertension. The mechanisms by which it increases CHD risk are uncertain...

..To determine the incidence of deep vein thrombosis and pulmonary embolism in two cohorts representing regions of the United States...

..These preliminary results suggest that common genetic variants in the prothrombin gene or other variants in linkage disequilibrium are associated with myocardial infarction in postmenopausal women...

....

..abstract_text> ..

..The ultimate goal of this research is to increase knowledge about AF risk factors and prognosis and to enhance prevention efforts and improve care for patients with AF. ..