Stephen Hecht

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco
    Stephen S Hecht
    Author s Affiliation Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
    Cancer Prev Res (Phila) 7:639-47. 2014
  2. doi request reprint Fifty years of tobacco carcinogenesis research: from mechanisms to early detection and prevention of lung cancer
    Stephen S Hecht
    University of Minnesota, 2231 6th Street Southeast, Room 2 148 CCRB, Minneapolis, MN 55455 Phone 612 624 7604 Fax 612 624 3869 and Eva Szabo, Lung and Upper Aerodigestive Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, HHS, 9609 Medical Center Drive, Room 5E 102, Bethesda, MD 20892
    Cancer Prev Res (Phila) 7:1-8. 2014
  3. pmc Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Biomarkers 18:144-50. 2013
  4. pmc Lung carcinogenesis by tobacco smoke
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 131:2724-32. 2012
  5. ncbi request reprint Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers
    Stephen S Hecht
    Transdisciplinary Tabacco Use Research Center and The Cancer Center, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 15:1805-11. 2006
  6. pmc Analysis of phenanthrene diol epoxide mercapturic acid detoxification products in human urine: relevance to molecular epidemiology studies of glutathione S-transferase polymorphisms
    Stephen S Hecht
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Carcinogenesis 29:937-43. 2008
  7. ncbi request reprint Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes
    Stephen S Hecht
    Transdiciplinary Tobacco Use Research and Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 14:693-8. 2005
  8. pmc Smoking and lung cancer--a new role for an old toxicant?
    Stephen S Hecht
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 103:15725-6. 2006
  9. ncbi request reprint Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese
    Stephen S Hecht
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 13:997-1004. 2004
  10. pmc Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of phenanthrene in human hepatocytes: relevance to molecular epidemiology studies of glutathione-s-transferase polymorphisms and cancer
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:426-32. 2009

Research Grants

  1. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen Hecht; Fiscal Year: 2007
  2. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen S Hecht; Fiscal Year: 2010
  3. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2005
  4. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2006
  5. DETECTION OF DNA ADDUCTS OF PULMONARY CARCINOGENS BY AMS
    Stephen Hecht; Fiscal Year: 2004
  6. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
  7. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2006
  8. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2007
  9. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2007
  10. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2009

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. pmc It is time to regulate carcinogenic tobacco-specific nitrosamines in cigarette tobacco
    Stephen S Hecht
    Author s Affiliation Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
    Cancer Prev Res (Phila) 7:639-47. 2014
    ....
  2. doi request reprint Fifty years of tobacco carcinogenesis research: from mechanisms to early detection and prevention of lung cancer
    Stephen S Hecht
    University of Minnesota, 2231 6th Street Southeast, Room 2 148 CCRB, Minneapolis, MN 55455 Phone 612 624 7604 Fax 612 624 3869 and Eva Szabo, Lung and Upper Aerodigestive Cancer Research Group, Division of Cancer Prevention, National Cancer Institute, NIH, HHS, 9609 Medical Center Drive, Room 5E 102, Bethesda, MD 20892
    Cancer Prev Res (Phila) 7:1-8. 2014
    ..Collectively, research performed since the 1964 Report demonstrates unequivocally that the majority of deaths from lung cancer are preventable...
  3. pmc Longitudinal study of [D10]phenanthrene metabolism by the diol epoxide pathway in smokers
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Biomarkers 18:144-50. 2013
    ..The overall coefficient of variation for 24 subjects was (mean ± S.D.) 27.4% ± 8.83%. Thus, a single administration of [D10]phenanthrene is likely sufficient to determine a smoker's ability to metabolize it to [D10]PheT...
  4. pmc Lung carcinogenesis by tobacco smoke
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Int J Cancer 131:2724-32. 2012
    ..37 million deaths per year...
  5. ncbi request reprint Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers
    Stephen S Hecht
    Transdisciplinary Tabacco Use Research Center and The Cancer Center, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 15:1805-11. 2006
    ..However, the results of this study indicate that genotyping is not an effective way to predict PAH metabolism at least as represented by PheT/HOPhe ratios...
  6. pmc Analysis of phenanthrene diol epoxide mercapturic acid detoxification products in human urine: relevance to molecular epidemiology studies of glutathione S-transferase polymorphisms
    Stephen S Hecht
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Carcinogenesis 29:937-43. 2008
    ..These results demonstrate the need for integration of genotyping and phenotyping information in molecular epidemiology studies...
  7. ncbi request reprint Similar uptake of lung carcinogens by smokers of regular, light, and ultralight cigarettes
    Stephen S Hecht
    Transdiciplinary Tobacco Use Research and Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 14:693-8. 2005
    ..The results are consistent with epidemiologic studies that show no difference in lung cancer risk in smokers of these cigarettes...
  8. pmc Smoking and lung cancer--a new role for an old toxicant?
    Stephen S Hecht
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 103:15725-6. 2006
  9. ncbi request reprint Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese
    Stephen S Hecht
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 13:997-1004. 2004
    ..The results of this study demonstrate the complexities in assessing effects of cruciferous vegetables on carcinogen metabolism...
  10. pmc Preferential glutathione conjugation of a reverse diol epoxide compared to a bay region diol epoxide of phenanthrene in human hepatocytes: relevance to molecular epidemiology studies of glutathione-s-transferase polymorphisms and cancer
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:426-32. 2009
    ....
  11. ncbi request reprint Effects of reduced cigarette smoking on levels of 1-hydroxypyrene in urine
    Stephen S Hecht
    Transdisciplinary Tobacco Use Research Center and Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 13:834-42. 2004
    ....
  12. ncbi request reprint Carcinogenicity studies of inhaled cigarette smoke in laboratory animals: old and new
    Stephen S Hecht
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street, SE, Minneapolis, MN 55455, USA
    Carcinogenesis 26:1488-92. 2005
    ..This commentary attempts to put the new results in perspective with the existing literature on cigarette smoke inhalation studies in animals and discusses strengths, limitations and possible applications of available models...
  13. doi request reprint Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users
    Stephen S Hecht
    The Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 17:732-5. 2008
    ..The results of this study also indicate that metabolic activation of NNK to intermediates that can react with DNA is its major pathway of metabolism in smokeless tobacco users...
  14. ncbi request reprint Similar exposure to a tobacco-specific carcinogen in smokeless tobacco users and cigarette smokers
    Stephen S Hecht
    Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota Cancer Center, 420 Delaware Street Southeast, MMC 806, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 16:1567-72. 2007
    ..001). These results show similar exposures to the potent tobacco-specific carcinogen NNK in smokeless tobacco users and smokers. These findings do not support the use of smokeless tobacco as a safe substitute for smoking...
  15. ncbi request reprint Longitudinal study of urinary phenanthrene metabolite ratios: effect of smoking on the diol epoxide pathway
    Stephen S Hecht
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 14:2969-74. 2005
    ..This finding is consistent with previous studies indicating that inducibility of PAH metabolism contributes to cancer risk in smokers...
  16. pmc Progress and challenges in selected areas of tobacco carcinogenesis
    Stephen S Hecht
    University of Minnesota Cancer Center, MMC 806, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:160-71. 2008
    ..It is hoped that a better understanding of mechanisms of tobacco-induced cancer will lead to new and useful approaches for the prevention of lung cancer and other cancers caused by tobacco use...
  17. pmc Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity
    Stephen S Hecht
    The Cancer Center, University of Minnesota Minneapolis, MN 55455, USA
    Carcinogenesis 27:1617-26. 2006
    ..The results of this study demonstrate that cyanidin glycosides of freeze-dried black raspberries are bioactive compounds which could account for at least some of the chemopreventive activity observed in animal models...
  18. ncbi request reprint 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides in the urine of infants exposed to environmental tobacco smoke
    Stephen S Hecht
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 15:988-92. 2006
    ..The results of this study show substantial uptake of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in infants exposed to ETS and support the concept that persistent ETS exposure in childhood could be related to cancer later in life...
  19. pmc Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats
    Stephen S Hecht
    The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:543-9. 2007
    ..The results of this study do not support the hypothesis that exposure to dietary myosmine could lead to HPB-releasing DNA or Hb adducts in humans...
  20. ncbi request reprint A biomarker of exposure to environmental tobacco smoke (ETS) and Ernst Wynder's opinion about ETS and lung cancer
    Stephen S Hecht
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, Minneapolis, MN 55455, USA
    Prev Med 43:256-60. 2006
    ..These studies strongly support the epidemiologic data demonstrating that ETS exposure causes lung cancer in non-smokers and have likely had an impact on tobacco control...
  21. ncbi request reprint Cigarette smoking: cancer risks, carcinogens, and mechanisms
    Stephen S Hecht
    The Cancer Center, University of Minnesota, Box 806 Mayo, 420 Delaware Street SE, Minneapolis, MN, USA
    Langenbecks Arch Surg 391:603-13. 2006
    ..Cigarette smoking causes about 30% of all cancer mortality in developed countries. Although smoking is decreasing in developed countries, it is increasing in some developing countries...
  22. ncbi request reprint Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 17:588-97. 2004
    ..Furthermore, 26 was identified as a major 4-HPB releasing adduct of NNKCH(2)OAc. These results suggest that pyrimidine adducts of tobacco specific nitrosamines may be important contributors to their mutagenic and carcinogenic activity...
  23. pmc Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco
    S S Hecht
    Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Tob Control 17:128-31. 2008
    ..Smokeless tobacco is an efficient delivery vehicle for nicotine and can contain significant amounts of carcinogens. However, few studies have examined factors that might moderate levels of nicotine or carcinogen exposure...
  24. ncbi request reprint Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung
    Stephen S Hecht
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Cancer Lett 187:87-94. 2002
    ..These results firmly establish gavaged BITC as a strong inhibitor of lung tumorigenesis induced in A/J mice by PAH, and support its further development for chemoprevention of smoking-induced lung cancer...
  25. pmc Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Nicotine Tob Res 14:18-28. 2012
    ..S. Food and Drug Administration to regulate tobacco products. Potential research related to tobacco product ingredients, nicotine, and harmful or potentially harmful constituents of tobacco products is discussed...
  26. ncbi request reprint Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Carcinogenesis 23:1455-61. 2002
    ..These results provide a basis for further development of mixtures of PEITC-NAC and MI for chemoprevention of lung cancer...
  27. pmc Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:1001-8. 2010
    ....
  28. pmc Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States
    Chem Res Toxicol 24:781-90. 2011
    ....
  29. pmc Elevated levels of volatile organic carcinogen and toxicant biomarkers in Chinese women who regularly cook at home
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, School of Public Health, MMC 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 19:1185-92. 2010
    ..Our goal was to quantify carcinogen and toxicant biomarkers in Chinese women who reported regularly doing home cooking compared with women randomly selected from the Singapore Chinese Health Study as controls...
  30. pmc Analysis of phenanthrene and benzo[a]pyrene tetraol enantiomers in human urine: relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 23:900-8. 2010
    ....
  31. ncbi request reprint Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Lancet Oncol 3:461-9. 2002
    ..These new approaches are necessary as adjuncts to education and cessation efforts, which despite some success have not eliminated tobacco smoking...
  32. pmc Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers
    Stephen S Hecht
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street South East, Minneapolis, Minnesota 55455, USA
    Nat Rev Cancer 9:476-88. 2009
    ..It seems likely that logically constructed mixtures of these agents, developed from the ground up, will be necessary for the prevention of lung carcinogenesis...
  33. ncbi request reprint Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen
    Stephen S Hecht
    Transdisciplinary Tobacco Use Research Center and College of Pharmacy, University of Minnesota, Minneapolis, USA
    J Natl Cancer Inst 96:107-15. 2004
    ....
  34. ncbi request reprint Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Res 62:129-34. 2002
    ..These data may have considerable implications for understanding mechanisms of tumor induction by NNK...
  35. ncbi request reprint Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children
    S S Hecht
    University of Minnesota Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Epidemiol Biomarkers Prev 10:1109-16. 2001
    ..Our data indicate that objective biomarkers of carcinogen uptake are important in studies of childhood exposure to ETS and cancer later in life...
  36. ncbi request reprint Tobacco carcinogens, their biomarkers and tobacco-induced cancer
    Stephen S Hecht
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Nat Rev Cancer 3:733-44. 2003
    ..What are the mechanisms by which this deadly combination leads to 30% of cancer-related deaths in developed countries, and how can carcinogen biomarkers help to reveal these mechanisms?..
  37. pmc Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke
    S S Hecht
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Tob Control 13:i48-56. 2004
    ..These biomarkers are specifically related to known carcinogens in tobacco smoke and include urinary metabolites, DNA adducts, and blood protein adducts...
  38. ncbi request reprint r-1,t-2,3,c-4-Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene in human urine: a potential biomarker for assessing polycyclic aromatic hydrocarbon metabolic activation
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Epidemiol Biomarkers Prev 12:1501-8. 2003
    ..We propose that measurement of this metabolite of phenanthrene may be important as part of a carcinogen metabolite-phenotyping approach to determine individual response to PAH exposure...
  39. pmc Effects of high dose transdermal nicotine replacement in cigarette smokers
    Dorothy Hatsukami
    Transdisciplinary Tobacco Use Research Center, University of Minnesota, Department of Psychiatry, Minneapolis, MN 55414, United States
    Pharmacol Biochem Behav 86:132-9. 2007
    ..In most of these studies, only conventional doses of NRT have been tested and higher doses may be required to result in significant reductions in smoking and in biomarkers of exposure...
  40. pmc Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Pramod Upadhyaya
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:1468-76. 2008
    ....
  41. ncbi request reprint Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers
    Ozlem E Tulunay
    Tobacco Use Research Center, University of Minnesota, 2701 University Avenue Southeast, 201, Minneapolis, MN 55414, USA
    Cancer Epidemiol Biomarkers Prev 14:1283-6. 2005
    ..The results of this study show that smoke exposure in bars and restaurants may have important health effects on nonsmoking employees, elicited by the increase in carcinogen levels...
  42. ncbi request reprint Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
    John R Jalas
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 16:794-806. 2003
    ....
  43. pmc Analysis of pyridyloxobutyl DNA adducts in F344 rats chronically treated with (R)- and (S)-N'-nitrosonornicotine
    Yanbin Lao
    Department of Medicinal Chemistry, and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:246-56. 2007
    ....
  44. ncbi request reprint Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice
    C Clifford Conaway
    American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, New York, USA
    Cancer Res 65:8548-57. 2005
    ..The results of the study provide a basis for future evaluation of the potential of phenethyl isothiocyanate and sulforaphane and their conjugates as chemopreventive agents in smokers and ex-smokers with early lung lesions...
  45. doi request reprint Chemopreventive effect of kava on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumorigenesis in A/J mice
    Thomas E Johnson
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Prev Res (Phila) 1:430-8. 2008
    ..Although not rigorously evaluated in this study, our preliminary data were not suggestive of hepatotoxicity. Based on these results, further studies are warranted to explore the chemopreventive potential and safety of kava...
  46. pmc Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry
    Yanbin Lao
    Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:674-82. 2006
    ....
  47. pmc Comparative levels of O6-methylguanine, pyridyloxobutyl-, and pyridylhydroxybutyl-DNA adducts in lung and liver of rats treated chronically with the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Pramod Upadhyaya
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Drug Metab Dispos 37:1147-51. 2009
    ..The results of this study demonstrate that substantial amounts of O(6)-methyl-G are formed at various time points in lung and liver DNA of rats treated chronically with NNK, supporting its role in carcinogenesis...
  48. ncbi request reprint Pilot study on lower nitrosamine smokeless tobacco products compared with medicinal nicotine
    M Irene Mendoza-Baumgart
    Transdisciplinary Tobacco Use Research Center, Cancer Center, University of Minnesota, Minneapolis, MN 55414, USA
    Nicotine Tob Res 9:1309-23. 2007
    ..However, the population effect of marketing of such products as reduced exposure/reduced risk is unknown. The need for further research in this area and regulation of tobacco products is evident...
  49. ncbi request reprint Ethylation and methylation of hemoglobin in smokers and non-smokers
    Steven G Carmella
    University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Carcinogenesis 23:1903-10. 2002
    ..As levels of hemoglobin and DNA adducts often correlate, the results of this study support the proposal that cigarette smoke contains an as yet unidentified ethylating agent, which might be involved in DNA damage and tumor initiation...
  50. ncbi request reprint Relationships between cigarette consumption and biomarkers of tobacco toxin exposure
    Anne M Joseph
    Section of General Internal Medicine 111 0, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    Cancer Epidemiol Biomarkers Prev 14:2963-8. 2005
    ....
  51. ncbi request reprint Uptake of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by Moldovan children
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 15:7-11. 2006
    ..These results should be useful in heightening the awareness of the dangers of smoking and ETS exposure in this eastern European country...
  52. pmc Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Yanbin Lao
    Department of Medicinal Chemistry, and the Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 20:235-45. 2007
    ....
  53. pmc Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Siyi Zhang
    Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:926-36. 2009
    ....
  54. pmc Identification of adducts formed in the reaction of 5'-acetoxy-N'-nitrosonornicotine with deoxyguanosine and DNA
    Pramod Upadhyaya
    The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:426-35. 2006
    ..These results provide the first structural characterization of DNA adducts that can be formed by 5'-hydroxylation of NNN...
  55. ncbi request reprint Combined analysis of r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in smokers' plasma
    Steven G Carmella
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 15:1490-4. 2006
    ..This method should be useful in molecular epidemiology studies of carcinogen uptake and lung cancer in smokers...
  56. ncbi request reprint Urinary biomarkers to assess exposure of cats to environmental tobacco smoke
    Elizabeth A McNiel
    University of Minnesota Cancer Center, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA
    Am J Vet Res 68:349-53. 2007
    ..To evaluate the use of urinary biomarkers to assess exposure of cats to environmental tobacco smoke (ETS)...
  57. ncbi request reprint Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens
    Stephen S Hecht
    J Natl Cancer Inst 97:1634-5. 2005
  58. ncbi request reprint Exposure to a tobacco-specific lung carcinogen in adolescent versus adult smokers
    Louise A Hertsgaard
    University of Minnesota Transdisciplinary Tobacco Use Research Center, 2701 University Avenue Southeast, 201, Minneapolis, MN 55414, USA
    Cancer Epidemiol Biomarkers Prev 17:3337-43. 2008
    ..This study compared carcinogen and nicotine exposure in adolescent and adult smokers across categories of CPD...
  59. pmc Quantitation of pyridyloxobutyl DNA adducts in nasal and oral mucosa of rats treated chronically with enantiomers of N'-nitrosonornicotine
    Siyi Zhang
    Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:949-56. 2009
    ..Our results also support the potential importance of NNN as an oral carcinogen in people who use smokeless tobacco products...
  60. ncbi request reprint Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5
    John R Jalas
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 16:782-93. 2003
    ..The implications of these differences in metabolism for the tumorigenic mechanism of NNAL are discussed...
  61. ncbi request reprint Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 14:885-91. 2005
    ....
  62. ncbi request reprint Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA
    Pramod Upadhyaya
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 16:180-90. 2003
    ..Thus, DNA that had been allowed to react with NNALCH(2)OAc contained adducts 17, 19, and 21. The results of this study provide markers for investigating the role of specific NNAL-DNA adducts in carcinogenesis by NNAL and NNK...
  63. ncbi request reprint Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen
    John R Jalas
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 18:95-110. 2005
  64. ncbi request reprint Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung
    Kristina R K Sticha
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Carcinogenesis 23:1433-9. 2002
    ..However, the observed inhibition was modest, suggesting that other effects of isothiocyanates are also involved in chemoprevention in this model...
  65. ncbi request reprint Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine
    Steven G Carmella
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Epidemiol Biomarkers Prev 12:1257-61. 2003
    ..042 +/- 0.020 (n = 18) in nonsmokers exposed to environmental tobacco smoke. The new method is faster and more sensitive than the traditional method and should greatly facilitate studies on human uptake of NNK...
  66. ncbi request reprint Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tissue distribution
    Zheng Wu
    College of Pharmacy and Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Carcinogenesis 23:171-9. 2002
    ..The present studies suggest a need to look beyond metabolic activation as the sole mechanism for lung carcinogenesis...
  67. ncbi request reprint The association of a tobacco-specific biomarker and cigarette consumption and its dependence on host characteristics
    Jay H Lubin
    Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20852, USA
    Cancer Epidemiol Biomarkers Prev 16:1852-7. 2007
    ..Variations in the ratio with host characteristics were generally similar to a recent epidemiologic analysis of effect modification of the association between lung cancer and cigarette smoking...
  68. ncbi request reprint Reducing harm caused by tobacco. Research findings from the University of Minnesota
    Stephen Hecht
    University of Minnesota Cancer Center, USA
    Minn Med 88:40-3. 2005
    ..Researchers found little, if any, benefit to products that promise less exposure to cancer-causing tobacco toxins...
  69. ncbi request reprint Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
    Shana J Sturla
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Chem Res Toxicol 18:1048-55. 2005
    ....
  70. pmc Formation and distribution of NNK metabolites in an isolated perfused rat lung
    Laura A Maertens
    College of Pharmacy, Department of Pharmaceutics, University of Minnesota, 308 Harvard Street SE, 9 149B Weaver Densford Hall, Minneapolis, MN 55455, USA
    Drug Metab Dispos 38:752-60. 2010
    ..Pyridylhydroxybutyl-DNA adducts were not detected in any of the treatment groups. Thus, the IPRL system is useful in determining pulmonary metabolism and DNA adduct formation separate from other metabolizing organs...
  71. pmc Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in human urine: comparison with glutathione-S-transferase genotypes in smokers
    Pramod Upadhyaya
    The Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 19:1234-40. 2006
    ..The results of this study provide the first evidence for a PAH-derived mercapturic acid in human urine and should be useful in the development of a phenotyping approach to assess individual differences in PAH metabolism...
  72. ncbi request reprint Analysis of phenanthrols in human urine by gas chromatography-mass spectrometry: potential use in carcinogen metabolite phenotyping
    Steven G Carmella
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 13:2167-74. 2004
    ..There was a 7.5-fold spread of ratios in smokers, and a 12.3-fold spread in nonsmokers, suggesting that this may be a useful parameter for distinguishing individual metabolic responses to PAH exposure...
  73. ncbi request reprint Improved method for determination of 1-hydroxypyrene in human urine
    Steven G Carmella
    The Cancer Center, University of Minnesota, Minneapolis, 55455, USA
    Cancer Epidemiol Biomarkers Prev 13:1261-4. 2004
    ..1 %) and week-to-week (mean RSD, 38.2 %) intra-individual variation, indicating the necessity for multiple sampling in studies concerned with relatively small differences in polycyclic aromatic hydrocarbon exposure...
  74. pmc Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers
    Steven G Carmella
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:734-41. 2009
    ....
  75. ncbi request reprint Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens
    Mingyao Wang
    University of Minnesota Cancer Center, 420 Delaware Street SE, Mayo Mail Code 806, Minneapolis 55455, USA
    Chem Res Toxicol 16:616-26. 2003
    ..Adducts 23, 25, and 10 did not release HPB upon neutral thermal hydrolysis. The results of this study provide the first structural identification of an HPB-releasing DNA adduct of the tobacco specific nitrosamines NNK and NNN...
  76. ncbi request reprint Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in smokers' blood
    Steven G Carmella
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 14:2669-72. 2005
    ..Levels of total NNAL averaged 42 +/- 22 (SD) and ranged 1.7 to 88 fmol/mL plasma in 16 smokers; NNAL was not detected in the plasma of five nonsmokers. These results show that total NNAL can readily be quantified in 1-mL plasma samples...
  77. ncbi request reprint Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels
    Fekadu Kassie
    Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 67:6502-11. 2007
    ....
  78. pmc Children's exposure to environmental tobacco smoke: using diverse exposure metrics to document ethnic/racial differences
    Ken Sexton
    School of Public Health, University of Texas, Brownsville Regional Campus, 80 Fort Brown, RAHC Building, Brownsville, TX 78520, USA
    Environ Health Perspect 112:392-7. 2004
    ..73). The results suggest that when children are exposed to ETS primarily in their homes, questionnaires and T-A logs might be effective screening tools for identifying those likely to experience higher uptake of nicotine...
  79. ncbi request reprint Tobacco-specific nitrosamines in new tobacco products
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 8:309-13. 2006
    ..These results demonstrate that TSNA levels in new tobacco products range from relatively low to comparable with those found in some conventional brands...
  80. ncbi request reprint Endogenous formation of N'-nitrosonornicotine in F344 rats in the presence of some antioxidants and grape seed extract
    Diana Porubin
    Department of Industrial and Ecological Chemistry, Moldova State University, 60 A Mateevici Street, Chisinau, Moldova
    J Agric Food Chem 55:7199-204. 2007
    ..This is the first study that demonstrates endogenous NNN formation in rats treated with nornicotine and sodium nitrite and effective inhibition of this process by ascorbic acid, dixydroxyfumaric acid, and catechin...
  81. ncbi request reprint Effects of benzyl isothiocyanate and 2-phenethyl isothiocyanate on benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolism in F-344 rats
    Gunnar Boysen
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Carcinogenesis 24:517-25. 2003
    ..These results demonstrate that dietary PEITC, or a mixture of BITC plus PEITC, inhibit the formation of HPB releasing adducts of NNK in the rodent lung, leading to inhibition of tumorigenesis...
  82. pmc Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers
    Jian Min Yuan
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 69:2990-5. 2009
    ..Findings of the present study directly link NNK exposure to lung cancer development in humans...
  83. pmc Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:406-14. 2009
    ..The results support the hypothesis that preferential binding of tobacco carcinogens to mtDNA of the lung might be functionally important in the development of smoking-induced lung cancer...
  84. pmc Dose-dependent inhibition of tobacco smoke carcinogen-induced lung tumorigenesis in A/J mice by indole-3-carbinol
    Fekadu Kassie
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Prev Res (Phila) 1:568-76. 2008
    ....
  85. ncbi request reprint Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons
    Kristin E Anderson
    Division of Epidemiology, Comprehensive Cancer Center, University of Minnesota, Minneapolis, Minnesota 55454, USA
    Cancer Epidemiol Biomarkers Prev 12:1544-6. 2003
    ..044 nmol/mg creatinine, P < 0.0001) and total NNAL (0.018 pmol/mg creatinine, P < 0.001). These findings demonstrate that exposure of nonsmokers to ETS in a commercial setting results in uptake of a tobacco-specific lung carcinogen...
  86. ncbi request reprint Preliminary study on reducing oral moist snuff use
    Dorothy K Hatsukami
    University of Minnesota, Tobacco Use Research Center, 2701 University Ave SE, 210, Minneapolis 55414, USA
    Drug Alcohol Depend 70:215-20. 2003
    ..This pilot study examined whether reducing ST use using various methods can be achieved and whether this reduction results in lower exposure to carcinogens...
  87. ncbi request reprint Tobacco smoke carcinogens and breast cancer
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Environ Mol Mutagen 39:119-26. 2002
    ..Collectively, the link between smoking and breast cancer is plausible but has been difficult to establish, probably because of the low carcinogen dose...
  88. pmc Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products
    Irina Stepanov
    Masonic Cancer Center and Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 69:8236-40. 2009
    ..Given the carcinogenicity of NNN and the frequent use of nicotine gum as a smoking cessation aid, further studies are needed so that preventive measures can be developed...
  89. ncbi request reprint Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation
    Dorothy K Hatsukami
    University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA
    Addiction 105:343-55. 2010
    ..To examine the effects of reduced nicotine cigarettes on smoking behavior, toxicant exposure, dependence and abstinence...
  90. ncbi request reprint Null association between frequency of cured meat consumption and methylvaline and ethylvaline hemoglobin adduct levels: the N-nitroso brain cancer hypothesis
    James G Gurney
    Division of Pediatric Epidemiology, Department of Pediatrics, University of Minnesota and University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Epidemiol Biomarkers Prev 11:421-2. 2002
  91. doi request reprint Abstinence and relapse rates following a college campus-based quit & win contest
    Janet L Thomas
    Department of Medicine, Division of General Internal Medicine, University of Minnesota, Minneapolis 55414, USA
    J Am Coll Health 58:365-72. 2010
    ..To conduct and evaluate Quit & Win contests at 2 2-year college and 2 4-year university campuses...
  92. pmc Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination
    Fekadu Kassie
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Carcinogenesis 31:1634-41. 2010
    ..In conclusion, our studies demonstrated the promise of combinations of PEITC-NAC, I3C/DIM and MI for the chemoprevention of lung carcinogenesis in current and former smokers...
  93. pmc Evidence for endogenous formation of N'-nitrosonornicotine in some long-term nicotine patch users
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, 420 Delaware Street SE Mayo Mail Code 806, Minneapolis, MN 55455, USA
    Nicotine Tob Res 11:99-105. 2009
    ..Nitrosation of nicotine or its metabolites in the human body could lead to formation of the 2 carcinogenic tobacco-specific nitrosamines-N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)...
  94. ncbi request reprint Biomarkers to assess the utility of potential reduced exposure tobacco products
    Dorothy K Hatsukami
    University of Minnesota Cancer Center, Minneapolis, MN, USA
    Nicotine Tob Res 8:600-22. 2006
    ..Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area...
  95. ncbi request reprint Biomarkers to assess the utility of potential reduced exposure tobacco products
    Dorothy K Hatsukami
    Tobacco Use Research Center, University of Minnesota Cancer Center, Minneapolis, MN 55414, USA
    Nicotine Tob Res 8:169-91. 2006
    ..Other promising biomarkers were discussed. No existing biomarkers have been demonstrated to be predictive of tobacco-related disease, which highlights the importance and urgency of conducting research in this area...
  96. ncbi request reprint Changing smokeless tobacco products new tobacco-delivery systems
    Dorothy K Hatsukami
    Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55414, USA
    Am J Prev Med 33:S368-78. 2007
    ....
  97. ncbi request reprint Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 15:2378-83. 2006
    ..These sensitive and quantitative methods should be useful in epidemiologic studies of the role of chronic tobacco smoke exposure, including environmental tobacco smoke exposure, in human cancer...
  98. ncbi request reprint Developing the science base for reducing tobacco harm
    Dorothy K Hatsukami
    University of Minnesota Transdisciplinary Tobacco Use Research Center, Minneapolis, MN 55414, USA
    Nicotine Tob Res 9:S537-53. 2007
    ..A description of the ongoing activities and challenges in these areas is provided, along with projected directions for the future...
  99. doi request reprint Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice
    Fekadu Kassie
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware Street SE, MN 55455, USA
    Carcinogenesis 29:610-9. 2008
    ..These proteins may have utility for development of candidate lung cancer biomarkers and as targets of chemopreventive/chemotherapeutic agents...
  100. pmc Detection and quantitation of N'-nitrosonornicotine in human toenails by liquid chromatography-electrospray ionization-tandem mass spectrometry
    Irina Stepanov
    The Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 17:945-8. 2008
    ..58; P = 0.05). The results of this study show the feasibility of quantifying NNN in human toenails, providing a potentially useful new biomarker of tobacco carcinogen exposure...
  101. pmc New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels
    Irina Stepanov
    Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Nicotine Tob Res 10:1773-82. 2008
    ..The large variation in the levels of some toxicants and carcinogens analyzed here indicates that more effort is required from the U.S. tobacco industry to further reduce their amounts in new and traditional smokeless tobacco products...

Research Grants42

  1. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen Hecht; Fiscal Year: 2007
    ..The results of this study will greatly improve our understanding of PAH metabolism in humans and could ultimately lead to a predictive algorithm for lung cancer risk in smokers. Such information is vital for lung cancer prevention. ..
  2. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen S Hecht; Fiscal Year: 2010
    ..The results of this study will greatly improve our understanding of PAH metabolism in humans and could ultimately lead to a predictive algorithm for lung cancer risk in smokers. Such information is vital for lung cancer prevention. ..
  3. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2005
    ..abstract_text> ..
  4. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2006
    ..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
  5. DETECTION OF DNA ADDUCTS OF PULMONARY CARCINOGENS BY AMS
    Stephen Hecht; Fiscal Year: 2004
    ..abstract not provided ..
  6. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
  7. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2006
    ..abstract_text> ..
  8. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2007
    ..abstract_text> ..
  9. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2007
    ..These studies will provide critical data on the occurrence and biological significance of acetaldehyde DNA adducts and their possible role in human cancer. ..
  10. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2009
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  11. Benzo[a]pyrene metabolism: phenotyping and genotyping
    Stephen Hecht; Fiscal Year: 2009
    ..The results of this study will greatly improve our understanding of PAH metabolism in humans and could ultimately lead to a predictive algorithm for lung cancer risk in smokers. Such information is vital for lung cancer prevention. ..
  12. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen S Hecht; Fiscal Year: 2010
    ..These studies will provide critical data on the occurrence and biological significance of acetaldehyde DNA adducts and their possible role in human cancer. ..
  13. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  14. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2005
    ..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
  15. Benzo(a) pyrene Metabolism: Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2004
    ....
  16. Metabolism of Carcinogenic Tobacco-Specific Nitrosamines
    Stephen Hecht; Fiscal Year: 2007
    ....
  17. Benzo(a) pyrene Metabolism: Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2002
    ....
  18. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2002
    ..This grant proposal will replace the corresponding portion of the Principal Investigator's Outstanding Investigator Grant, as the latter program is being phased out by the National Cancer Institute. ..
  19. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2002
    ..abstract_text> ..
  20. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2009
    ..These studies will provide critical data on the occurrence and biological significance of acetaldehyde DNA adducts and their possible role in human cancer. ..
  21. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2001
    ..This grant proposal will replace the corresponding portion of the Principal Investigator's Outstanding Investigator Grant, as the latter program is being phased out by the National Cancer Institute. ..
  22. Benzo(a) pyrene Metabolism--Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2001
    ....
  23. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2001
    ..abstract_text> ..
  24. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2000
    ..abstract_text> ..
  25. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 1999
    ..abstract_text> ..
  26. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2003
    ..This grant proposal will replace the corresponding portion of the Principal Investigator's Outstanding Investigator Grant, as the latter program is being phased out by the National Cancer Institute. ..
  27. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2004
    ..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
  28. Benzo(a) pyrene Metabolism: Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2005
    ....
  29. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2007
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  30. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  31. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2004
    ..abstract_text> ..
  32. Benzo(a) pyrene Metabolism: Phenotyping and Genotyping
    Stephen Hecht; Fiscal Year: 2003
    ....
  33. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2006
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  34. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2002
    ..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
  35. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2003
    ..The results of the research proposed here will provide critical data, which will be the framework for testing our hypothesis that acetaldehyde is a human carcinogen. ..
  36. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen Hecht; Fiscal Year: 2004
    ..This grant proposal will replace the corresponding portion of the Principal Investigator's Outstanding Investigator Grant, as the latter program is being phased out by the National Cancer Institute. ..