Frederick M Hecht

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy
    S G Deeks
    University of California, San Francisco and San Francisco General Hospital, 94110, USA
    AIDS 13:F35-43. 1999
  2. pmc Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009
    Vivek Jain
    HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e15510. 2010
  3. pmc Physicians' communication with patients about adherence to HIV medication in San Francisco and Copenhagen: a qualitative study using Grounded Theory
    Toke S Barfod
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    BMC Health Serv Res 6:154. 2006
  4. ncbi request reprint A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection
    Frederick M Hecht
    University of California San Francisco, San Francisco, CA 94110, USA
    J Infect Dis 194:725-33. 2006
  5. pmc Identifying the early post-HIV antibody seroconversion period
    Frederick M Hecht
    University of California, San Francisco, CA, USA
    J Infect Dis 204:526-33. 2011
  6. ncbi request reprint Does HIV reporting by name deter testing? MESH Study Group
    F M Hecht
    Positive Health Program HIV Section, University of California at San Francisco, 94110, USA
    AIDS 14:1801-8. 2000
  7. ncbi request reprint Lessons from an HIV transmission pair
    Frederick M Hecht
    Division of HIV AIDS, Department of Medicine, University of California, San Francisco, CA 94110, USA
    J Infect Dis 195:1239-41. 2007
  8. pmc HIV RNA level in early infection is predicted by viral load in the transmission source
    Frederick M Hecht
    HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California, CA 94110, USA
    AIDS 24:941-5. 2010
  9. ncbi request reprint A piece of my mind. The CBC
    Frederick M Hecht
    JAMA 296:149-50. 2006
  10. ncbi request reprint Persistence of primary drug resistance among recently HIV-1 infected adults
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, San Francisco, California 94141 9100, USA
    AIDS 18:1683-9. 2004

Research Grants

  1. Yoga, Health, and Meditation
    Frederick Hecht; Fiscal Year: 2004

Detail Information

Publications99

  1. ncbi request reprint HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy
    S G Deeks
    University of California, San Francisco and San Francisco General Hospital, 94110, USA
    AIDS 13:F35-43. 1999
    ..To determine the HIV RNA and CD4 cell response to both initial and salvage therapy with protease inhibitor-based therapy, and to examine the relationship between the virological response and pre-therapy characteristics...
  2. pmc Transmitted drug resistance in persons with acute/early HIV-1 in San Francisco, 2002-2009
    Vivek Jain
    HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e15510. 2010
    ..Although several new HIV medications were introduced starting in late 2007, including raltegravir, maraviroc, and etravirine, it is not known whether the prevalence of TDR was subsequently affected in 2008-2009...
  3. pmc Physicians' communication with patients about adherence to HIV medication in San Francisco and Copenhagen: a qualitative study using Grounded Theory
    Toke S Barfod
    Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    BMC Health Serv Res 6:154. 2006
    ..The objective of this study was to explore and conceptualize patterns and difficulties in physicians' work with patients' adherence to HIV medication. No previous studies on this subject have directly observed physicians' behavior...
  4. ncbi request reprint A multicenter observational study of the potential benefits of initiating combination antiretroviral therapy during acute HIV infection
    Frederick M Hecht
    University of California San Francisco, San Francisco, CA 94110, USA
    J Infect Dis 194:725-33. 2006
    ....
  5. pmc Identifying the early post-HIV antibody seroconversion period
    Frederick M Hecht
    University of California, San Francisco, CA, USA
    J Infect Dis 204:526-33. 2011
    ..Identifying persons with recent human immunodeficiency virus (HIV) antibody seroconversion is useful for treatment, research, and prevention, but the sensitivity and specificity of tests for this purpose are uncertain...
  6. ncbi request reprint Does HIV reporting by name deter testing? MESH Study Group
    F M Hecht
    Positive Health Program HIV Section, University of California at San Francisco, 94110, USA
    AIDS 14:1801-8. 2000
    ..We sought to determine whether persons at risk of HIV infection knew their state's HIV reporting policy and whether they had delayed or avoided testing because of it...
  7. ncbi request reprint Lessons from an HIV transmission pair
    Frederick M Hecht
    Division of HIV AIDS, Department of Medicine, University of California, San Francisco, CA 94110, USA
    J Infect Dis 195:1239-41. 2007
  8. pmc HIV RNA level in early infection is predicted by viral load in the transmission source
    Frederick M Hecht
    HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California, CA 94110, USA
    AIDS 24:941-5. 2010
    ..We sought to determine the relationship between HIV-1 RNA levels in the source partner and recently infected recipient partners within transmission pairs...
  9. ncbi request reprint A piece of my mind. The CBC
    Frederick M Hecht
    JAMA 296:149-50. 2006
  10. ncbi request reprint Persistence of primary drug resistance among recently HIV-1 infected adults
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, San Francisco, California 94141 9100, USA
    AIDS 18:1683-9. 2004
    ..We sought to determine if primary drug resistance would be lost at a rapid rate, and viral pol replication capacity would increase, in the absence of treatment...
  11. pmc Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, USA
    J Virol 82:4785-92. 2008
    ....
  12. ncbi request reprint Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity
    Jason D Barbour
    Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    AIDS 20:2123-5. 2006
    ..Viral polRC was measured before starting ART in all subjects. We examined 243 individuals for a median 260 days after initiating ART. Low baseline polRC was associated with greater CD4 T-cell gains independent of virological responses...
  13. doi request reprint CD8+ cell anti-HIV activity rapidly increases upon discontinuation of early antiretroviral therapy
    M Scott Killian
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    J Clin Immunol 29:311-8. 2009
    ..CD8+ lymphocytes can suppress HIV replication without killing the infected cells. This CD8+ cell noncytotoxic anti-HIV response (CNAR) is associated with a beneficial clinical course...
  14. pmc Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes
    Christian B Willberg
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e10249. 2010
    ..The HLA-B*35-Px allele has been associated with rapid disease progression in HIV-1 infection, in contrast to the HLA-B*35-Py allele...
  15. ncbi request reprint Time trends in primary HIV-1 drug resistance among recently infected persons
    Robert M Grant
    Gladstone Institute of Virology and Immunology, PO Box 914100, San Francisco, CA 94141, USA
    JAMA 288:181-8. 2002
    ..Transmission of multiclass drug-resistant human immunodeficiency virus type 1 (HIV-1) may increase with wider use of antiretroviral therapy...
  16. pmc Antiretroviral therapy initiated within 6 months of HIV infection is associated with lower T-cell activation and smaller HIV reservoir size
    Vivek Jain
    HIV AIDS Division, San Francisco General Hospital
    J Infect Dis 208:1202-11. 2013
    ..2; P = .035). Conclusions. ART initiation <6 months after infection is associated with lower levels of T-cell activation and smaller HIV DNA and RNA reservoir size during long-term therapy...
  17. pmc Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape
    Annika C Karlsson
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America
    PLoS ONE 2:e225. 2007
    ....
  18. pmc T cell responses to human endogenous retroviruses in HIV-1 infection
    Keith E Garrison
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 3:e165. 2007
    ..HERV-specific immunity is an important new avenue for investigation in HIV-1 pathogenesis and vaccine design...
  19. pmc Differential expression of CD96 surface molecule represents CD8⁺ T cells with dissimilar effector function during HIV-1 infection
    Emily M Eriksson
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e51696. 2012
    ..Overall, these findings indicate that down-regulation of CD96 is an important aspect of HIV-1 pathogenesis and differential expression is related to cell effector functions and HIV-1 disease course...
  20. pmc High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replication
    Jason D Barbour
    Department of Medicine, HIV AIDS Division, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 4:e4408. 2009
    ..We hypothesized that anti-retroviral suppression of T cell activation levels would lead to alterations in the T cell differentiation of total and HIV-1 specific CD8+ T cell responses among recently HIV-1 infected adults...
  21. pmc Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses
    Steven G Deeks
    Department of Medicine, University of California at San Francisco, San Francisco General Hospital, CA 94110, USA
    J Virol 80:6155-64. 2006
    ..These observations also suggest that the neutralizing antibody response may contribute to the long-term control of HIV in some patients while protecting against HIV superinfection in most patients...
  22. ncbi request reprint The effects of early antiretroviral therapy and its discontinuation on the HIV-specific antibody response
    M Scott Killian
    Department of Medicine, University of California San Francisco, 94143, USA
    AIDS Res Hum Retroviruses 22:640-7. 2006
    ..These results demonstrate that early ART prevents the typical evolution of the HIV-1-specific antibody response and can alter the expected kinetics of this response in subjects discontinuing therapy...
  23. ncbi request reprint Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load
    Steven G Deeks
    San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
    Blood 104:942-7. 2004
    ..These data indicate that immunologic activation set point is established early in HIV infection, and that this set point determines the rate at which CD4+ T cells are lost over time...
  24. ncbi request reprint Frequent methamphetamine use is associated with primary non-nucleoside reverse transcriptase inhibitor resistance
    Grant Nash Colfax
    AIDS Office, San Francisco Department of Public Health, San Francisco, California, USA
    AIDS 21:239-41. 2007
    ..We postulate that this association may be caused by methamphetamine-associated treatment interruptions among source partners...
  25. ncbi request reprint Higher CD4+ T cell counts associated with low viral pol replication capacity among treatment-naive adults in early HIV-1 infection
    Jason D Barbour
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA
    J Infect Dis 190:251-6. 2004
    ....
  26. pmc HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells
    David Favre
    Division of Experimental Medicine, University of California at San Francisco, San Francisco, CA, USA
    Blood 117:2189-99. 2011
    ..This study is registered at www.clinicaltrials.gov as NCT00187512...
  27. ncbi request reprint Similar changes in plasmacytoid dendritic cell and CD4 T-cell counts during primary HIV-1 infection and treatment
    M Scott Killian
    Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    AIDS 20:1247-52. 2006
    ....
  28. pmc Differential persistence of transmitted HIV-1 drug resistance mutation classes
    Vivek Jain
    HIV AIDS Division, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94143, USA
    J Infect Dis 203:1174-81. 2011
    ..The impact of class-specific mutations on this rate of mutation replacement is uncertain...
  29. ncbi request reprint Seroreversion in subjects receiving antiretroviral therapy during acute/early HIV infection
    C Bradley Hare
    Positive Health Program, University of California, San Francisco, San Francisco, CA, USA
    Clin Infect Dis 42:700-8. 2006
    ....
  30. ncbi request reprint FOXP3 expressing CD127lo CD4+ T cells inversely correlate with CD38+ CD8+ T cell activation levels in primary HIV-1 infection
    Lishomwa C Ndhlovu
    Division of Experimental Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA 94110, USA
    J Leukoc Biol 83:254-62. 2008
    ....
  31. ncbi request reprint The relation between symptoms, viral load, and viral load set point in primary HIV infection
    Colleen F Kelley
    Department of Medicine, San Francisco General Hospital, University of California at San Francisco, 995 Potrero Avenue, San Francisco, CA 94110, USA
    J Acquir Immune Defic Syndr 45:445-8. 2007
    ..To examine the relation between symptoms, initial viral load, and viral load set point in primary HIV infection (PHI)...
  32. ncbi request reprint Seroconversion following nonoccupational postexposure prophylaxis against HIV
    Michelle E Roland
    Positive Health Program at San Francisco General Hospital, California, USA
    Clin Infect Dis 41:1507-13. 2005
    ..We sought to describe the occurrence and circumstances of HIV seroconversion following nonoccupational PEP...
  33. pmc Cortisol patterns are associated with T cell activation in HIV
    Sarah Patterson
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e63429. 2013
    ..Since endogenous glucocorticoids are important in regulating inflammation, we sought to determine whether less optimal diurnal cortisol patterns are associated with greater T cell activation...
  34. pmc Expansion of CD8+ T cells lacking Sema4D/CD100 during HIV-1 infection identifies a subset of T cells with decreased functional capacity
    Emily M Eriksson
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, USA
    Blood 119:745-55. 2012
    ..These data suggest that loss of CD100 expression probably plays an important role in dysfunctional immunity in HIV-1 infection...
  35. pmc Strong human endogenous retrovirus-specific T cell responses are associated with control of HIV-1 in chronic infection
    Devi SenGupta
    UCSF Division of Experimental Medicine, Building 3, Room 603, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    J Virol 85:6977-85. 2011
    ..These findings suggest a possible role for anti-HERV immunity in the control of chronic HIV-1 infection and provide support for a larger effort to design an HIV-1 vaccine that targets conserved antigens such as HERV...
  36. pmc IL-2 immunotherapy to recently HIV-1 infected adults maintains the numbers of IL-17 expressing CD4+ T (T(H)17) cells in the periphery
    Lishomwa C Ndhlovu
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA, USA
    J Clin Immunol 30:681-92. 2010
    ..However, IL-2-mediated T-reg expansions may selectively reduce responses to certain antigen-specific populations, such as HIV-1 Gag...
  37. pmc Transcriptional errors in human immunodeficiency virus type 1 generate targets for T-cell responses
    Keith E Garrison
    Division of Experimental Medicine, Department of Medicine, UCSF, San Francisco, California 94110, USA
    Clin Vaccine Immunol 16:1369-71. 2009
    ..T-cell responses to cryptic epitopes and to regions normally spliced out of the HIV-1 viral proteins Rev and Tat were detected in HIV-1-infected subjects...
  38. pmc HIV-1-specific T Cell-dependent natural killer (NK) cell activation: major contribution by NK cells to interferon-gamma production in response to HIV-1 antigens
    Christopher P Loo
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, California, USA
    AIDS Res Hum Retroviruses 25:603-5. 2009
    ..These results indicate that T cell-dependent NK cell IFN-gamma production can be important for immune control of HIV-1, and have implications for the interpretation of data from vaccine trials using ELISPOT and ELISA...
  39. doi request reprint Lower cytokine secretion ex vivo by natural killer T cells in HIV-infected individuals is associated with higher CD161 expression
    Jennifer E Snyder-Cappione
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    AIDS 23:1965-70. 2009
    ..This study measured NKT cell cytokine production directly ex vivo and compared these responses with both the disease status and NKT subset distribution of individual patients...
  40. pmc Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    David Favre
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Sci Transl Med 2:32ra36. 2010
    ..We postulate that induction of IDO may represent a critical initiating event that results in inversion of the T(H)17/T(reg) balance and in the consequent maintenance of a chronic inflammatory state in progressive HIV disease...
  41. ncbi request reprint Interleukin-2 therapy restores CD8 cell non-cytotoxic anti-HIV responses in primary infection subjects receiving HAART
    Beatriz Martinez-Mariño
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 1270, USA
    AIDS 18:1991-9. 2004
    ..To determine the effect of interleukin-2 (IL-2) therapy on immunologic and virologic responses in subjects with acute or recent HIV infection already receiving highly active antiretroviral therapy (HAART)...
  42. pmc CD56negCD16⁺ NK cells are activated mature NK cells with impaired effector function during HIV-1 infection
    Jeffrey M Milush
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Retrovirology 10:158. 2013
    ..The role of this subset in HIV-1 pathogenesis remains unclear. The lack of NK cell lineage-specific markers has complicated the study of minor NK cell subpopulations...
  43. pmc Environmental enrichment alters splenic immune cell composition and enhances secondary influenza vaccine responses in mice
    Blake T Gurfein
    Osher Center for Integrative Medicine, University of California, San Francisco, California, United States of America Division of Experimental Medicine, University of California, San Francisco, California, United States of America
    Mol Med 20:179-90. 2014
    ..These findings help identify differences in primary and secondary vaccine responses in relationship to stress mediators that may be relevant in clinical studies. ..
  44. pmc Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and aging
    Sulggi A Lee
    Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e89444. 2014
    ..Whether chronic HIV infection causes similar effects is currently unclear...
  45. pmc Stimulant use is associated with immune activation and depleted tryptophan among HIV-positive persons on anti-retroviral therapy
    Adam W Carrico
    Center for AIDS Prevention Studies, University of California, San Francisco, 50 Beale Street, Suite 1300, San Francisco, CA 94105, USA
    Brain Behav Immun 22:1257-62. 2008
    ..Further research is needed to replicate these findings and examine the plausible bio-behavioral pathways that may account for the effects of stimulant use on HIV disease markers and depleted tryptophan...
  46. pmc Loss of T cell responses following long-term cryopreservation
    Rachel E Owen
    Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
    J Immunol Methods 326:93-115. 2007
    ..Long-term cryopreservation, however, may lead to the loss of CD4(+) T cell responses and mild skewing of T cell phenotypic marker expression...
  47. pmc Elevated frequency of gamma interferon-producing NK cells in healthy adults vaccinated against influenza virus
    Brian R Long
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, California 941101, USA
    Clin Vaccine Immunol 15:120-30. 2008
    ..These results may form the basis for further investigations of the role of NK cells in immunity to influenza...
  48. ncbi request reprint Use of laboratory tests and clinical symptoms for identification of primary HIV infection
    Frederick M Hecht
    Positive Health Program HIV Section at San Francisco General Hospital, tUniversity of California at San Francisco, 94110, USA
    AIDS 16:1119-29. 2002
    ..To determine the sensitivity and specificity of symptoms, three HIV-1 RNA assays, a p24 antigen EIA and a third-generation enzyme immunoassay (EIA) antibody test for diagnosis of primary HIV infection (PHI)...
  49. ncbi request reprint Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 T-cell apoptosis and CD4 T-cell depletion
    Ronnie L Gascon
    University of California at San Francisco, Department of Medicine, 94110, USA
    J Acquir Immune Defic Syndr 30:146-53. 2002
    ..002). We conclude that monocyte activation as defined by elevation of CD14/DR expression correlates to CD4 T-cell depletion in primary HIV infection, and is predictive of a poor CD4 T-cell response to HAART in a subset of patients...
  50. pmc Central nervous system immune activation characterizes primary human immunodeficiency virus 1 infection even in participants with minimal cerebrospinal fluid viral burden
    Serena Spudich
    Department of Neurology, University of California San Francisco, USA
    J Infect Dis 204:753-60. 2011
    ..Although HIV enters the nervous system soon after transmission, the magnitude of infection and immunoactivation within the CNS during primary HIV infection (PHI) has not been characterized...
  51. pmc Reduction in CD8+ cell noncytotoxic anti-HIV activity in individuals receiving highly active antiretroviral therapy during primary infection
    S A Stranford
    Department of Medicine, University of California, San Francisco, CA 94143; Blood Centers of the Pacific, San Francisco, CA 94118, USA
    Proc Natl Acad Sci U S A 98:597-602. 2001
    ....
  52. ncbi request reprint Low Proportions of CD28- CD8+ T cells Expressing CD57 Can Be Reversed by Early ART Initiation and Predict Mortality in Treated HIV Infection
    Sulggi A Lee
    University of California San Francisco, San Francisco, California
    J Infect Dis 210:374-82. 2014
    ..Whether this abnormality predicts mortality in treated HIV infection and can be reversed by early antiretroviral therapy (ART) remains unknown...
  53. ncbi request reprint Absolute or total lymphocyte count as a marker for the CD4 T lymphocyte criterion for initiating antiretroviral therapy
    Mark A Jacobson
    Positive Health Program, Department of Medicine, University of California, San Francisco, USA
    AIDS 17:917-9. 2003
  54. pmc Synergy or independence? Deciphering the interaction of HLA Class I and NK cell KIR alleles in early HIV-1 disease progression
    Jason D Barbour
    HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, California, United States of America
    PLoS Pathog 3:e43. 2007
  55. pmc Elevations in IL-10, TNF-alpha, and IFN-gamma from the earliest point of HIV Type 1 infection
    Philip J Norris
    Blood Systems Research Institute, San Francisco, California 94118, USA
    AIDS Res Hum Retroviruses 22:757-62. 2006
    ..Cytokine alterations occurred within 7 days of detectable HIV-1 viremia, emphasizing the need to study the earliest events of infection...
  56. ncbi request reprint Effect of IL-2 therapy on CD8+ cell noncytotoxic anti-HIV response during primary HIV-1 infection
    B Martinez-Marino
    Department of Medicine, University of California, San Francisco, USA
    J Clin Immunol 24:135-44. 2004
    ..The first cycle of IL-2 enhanced CNAR; later cycles showed no substantial effect. This study suggests that HAART combined with IL-2 could provide an immunologic benefit in the treatment of early HIV infection...
  57. ncbi request reprint Programmed death-1 expression on CD4+ and CD8+ T cells in treated and untreated HIV disease
    Leslie R Cockerham
    aHIV AIDS Division, San Francisco General Hospital bDivision of Experimental Medicine cDepartment Epidemiology and Biostatistics, UCSF, San Francisco, California dVaccine and Gene Therapy Institute of Florida, Port St Lucie, Florida, USA
    AIDS 28:1749-58. 2014
    ..However, the impact of HIV infection and antiretroviral treatment (ART) on the expression of PD-1 on T cells is still poorly defined...
  58. pmc Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection
    Henri Alexandre Michaud
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, USA
    Retrovirology 11:10. 2014
    ..We also mapped the specificity of the humoral response to HERV-K (HML-2) Envelope protein in HIV-1 infected subjects at different stages of disease, and correlated the response with plasma viral load...
  59. pmc The association of CD4+ T-cell counts and cardiovascular risk in treated HIV disease
    Jennifer E Ho
    Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    AIDS 26:1115-20. 2012
    ..HIV-infected individuals are at high risk of developing cardiovascular disease. Whether earlier initiation of HIV therapy at higher CD4 cell counts has any effect on cardiovascular risk as assessed by endothelial function is unknown...
  60. pmc Initiation of antiretroviral therapy at higher nadir CD4+ T-cell counts is associated with reduced arterial stiffness in HIV-infected individuals
    Jennifer E Ho
    Division of Cardiology, San Francisco General Hospital, San Francisco, California 94110, USA
    AIDS 24:1897-905. 2010
    ..HIV infection is associated with increased rates of cardiovascular disease. We sought to evaluate whether initiation of HIV therapy at higher nadir CD4(+) T-cell counts might reduce cardiovascular risk, as measured by arterial stiffness...
  61. ncbi request reprint Development of a new less-sensitive enzyme immunoassay for detection of early HIV-1 infection
    Bhupat D Rawal
    Blood Centers of the Pacific, San Francisco, California 94118, USA
    J Acquir Immune Defic Syndr 33:349-55. 2003
    ..These results support the potential use of the Vironostika-LS EIA for detection of recent HIV-1 infections for incidence projections and for other epidemiologic, clinical, and molecular surveillance applications...
  62. pmc Mindfulness-based stress reduction for HIV treatment side effects: a randomized, wait-list controlled trial
    Larissa G Duncan
    Osher Center for Integrative Medicine, University of California at San Francisco School of Medicine, San Francisco, California, USA
    J Pain Symptom Manage 43:161-71. 2012
    ..Advances in antiretroviral therapy (ART) for HIV offer life-extending benefit; however, the side effects associated with ART use negatively impact quality of life and medication adherence among people living with HIV...
  63. ncbi request reprint Symptom management with massage and acupuncture in postoperative cancer patients: a randomized controlled trial
    Wolf E Mehling
    Osher Center for Integrative Medicine, and Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94115, USA
    J Pain Symptom Manage 33:258-66. 2007
    ..These findings merit independent confirmation using larger sample sizes and attention control...
  64. pmc Body awareness: construct and self-report measures
    Wolf E Mehling
    Osher Center for Integrative Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 4:e5614. 2009
    ..We assessed the psychometric quality of selected self-report measures and examined their items for underlying definitions of the construct...
  65. ncbi request reprint Optimizing care for persons with HIV infection. Society of General Internal Medicine AIDS Task Force
    F M Hecht
    San Francisco General Hospital, University of California, San Francisco, AIDS Program, 94143 0874, USA
    Ann Intern Med 131:136-43. 1999
    ..Primary care physicians need to strengthen these basic HIV-related medical skills...
  66. ncbi request reprint Multistate evaluation of anonymous HIV testing and access to medical care. Multistate Evaluation of Surveillance of HIV (MESH) Study Group
    A B Bindman
    Primary Care Research Center, San Francisco General Hospital, and Department of Medicine, University of California, 94110, USA
    JAMA 280:1416-20. 1998
    ..Infection with the human immunodeficiency virus (HIV) is the only infectious disease for which anonymous testing is publicly funded, an exception that has been controversial...
  67. ncbi request reprint Provider assessment of adherence to HIV antiretroviral therapy
    D R Bangsberg
    Epidemiology and Prevention Interventions Center, Division of Infectious Diseases and the Positive Health Program, San Francisco General Hospital University of California, San Francisco UCSF 94110, USA
    J Acquir Immune Defic Syndr 26:435-42. 2001
    ..Adherence assessment is an essential component of monitoring HIV antiretroviral therapy. Prior studies suggest that medical providers frequently estimate individual patient adherence inaccurately...
  68. ncbi request reprint Name-based surveillance and public health interventions for persons with HIV infection. Multistate Evaluation of Surveillance for HIV Study Group
    D H Osmond
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94143, USA
    Ann Intern Med 131:775-9. 1999
    ..These results suggest that the potential for such effects has been exaggerated...
  69. pmc Quantitative and cost comparison of ultrasensitive human immunodeficiency virus type 1 RNA viral load assays: Bayer bDNA quantiplex versions 3.0 and 2.0 and Roche PCR Amplicor monitor version 1.5
    T Elbeik
    Departments of Laboratory Medicine, University of California, San Francisco, USA
    J Clin Microbiol 38:1113-20. 2000
    ..5 assay. Moreover, cost analysis based on labor, disposables, and biohazardous wastes showed significant savings with the bDNA 3.0 assay as compared to the costs of the Amplicor 1.5 assay...
  70. ncbi request reprint Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
    D R Bangsberg
    Epidemiology and Prevention Interventions Center, Division of Infectious Diseases, San Francisco General Hospital, University of California San Francisco, 94110, USA
    AIDS 14:357-66. 2000
    ..To examine the relationship between adherence, viral suppression and antiretroviral resistance in HIV-infected homeless and marginally housed people on protease inhibitor (PI) therapy...
  71. pmc Correlating traditional Ayurvedic and modern medical perspectives on cancer: results of a qualitative study
    Anand Dhruva
    1 University of California, San Francisco, Osher Center for Integrative Medicine, San Francisco, CA
    J Altern Complement Med 20:364-70. 2014
    ..To characterize Ayurvedic perspectives on the etiopathogenesis and supportive treatments for a biomedical diagnosis of cancer...
  72. doi request reprint A new biomarker of hedonic eating? A preliminary investigation of cortisol and nausea responses to acute opioid blockade
    JENNIFER DAUBENMIER
    Osher Center for Integrative Medicine, Department of Medicine, University of California, San Francisco, United States Electronic address
    Appetite 74:92-100. 2014
    ..Future research is needed to confirm this finding and to test if these markers of opioidergic tone might help predict success in certain types of weight management programs. ..
  73. pmc Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot study
    JENNIFER DAUBENMIER
    Osher Center for Integrative Medicine, Department of Medicine, University of California, San Francisco, CA, USA
    Psychoneuroendocrinology 37:917-28. 2012
    ....
  74. doi request reprint The detection of acute HIV infection
    Myron S Cohen
    Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7030, USA
    J Infect Dis 202:S270-7. 2010
    ..We conclude that further technical advances are essential to allow more widespread detection of patients with AHI and to affect HIV treatment outcomes and transmission prevention...
  75. pmc Human CD4+ CD25+ regulatory T cells control T-cell responses to human immunodeficiency virus and cytomegalovirus antigens
    Einar M Aandahl
    Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California 94110, USA
    J Virol 78:2454-9. 2004
    ..We propose that chronic viral infections lead to induction of suppressive T(R) cells that inhibit the antiviral immune response...
  76. ncbi request reprint What happened to home HIV test collection kits? Intent to use kits, actual use, and barriers to use among persons at risk for HIV infection
    G N Colfax
    HIV Research Branch, San Francisco Department of Public Health, 25 Van Ness Avenue, Suite 500, San Francisco, CA 94102 6033, USA
    AIDS Care 14:675-82. 2002
    ..Increasing awareness of kits, reducing price and addressing concerns about kit testing procedures may increase kit use, leading to more HIV testing by at-risk individuals...
  77. pmc Performance of rapid point-of-care and laboratory tests for acute and established HIV infection in San Francisco
    Christopher D Pilcher
    HIV AIDS Division, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e80629. 2013
    ..Current laboratory and point-of-care tests for HIV detect different analytes and use different sample types. Some have fast turnaround times (<1 hour). We investigated how HIV test choice could impact case finding by testing programs...
  78. pmc Yoga breathing for cancer chemotherapy-associated symptoms and quality of life: results of a pilot randomized controlled trial
    Anand Dhruva
    Osher Center for Integrative Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Altern Complement Med 18:473-9. 2012
    ..Pranayama, a series of yogic breathing techniques, may improve cancer-related symptoms and quality of life, but it has not been studied for this purpose...
  79. pmc The calm mouse: an animal model of stress reduction
    Blake T Gurfein
    Osher Center for Integrative Medicine, University of California, San Francisco, California, United States of America
    Mol Med 18:606-17. 2012
    ..Together, our results suggest that the Calm mouse model represents a promising approach to studying the biological effects of stress reduction in the context of health and in conjunction with existing disease models...
  80. ncbi request reprint Longitudinal analysis of B cell repertoire and antibody gene rearrangements during early HIV infection
    M K Elkins
    Department of Neurology, University of California at San Francisco, CA 94143 0435, USA
    Genes Immun 6:66-9. 2005
    ..A modest association between B cell repertoire integrity and viremia levels as well as treatment was detected...
  81. pmc Antiretroviral drug therapy alters the profile of human immunodeficiency virus type 1-specific T-cell responses and shifts the immunodominant cytotoxic T-lymphocyte response from Gag to Pol
    A C Karlsson
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA
    J Virol 81:11543-8. 2007
    ..The consequences of dual pressures from treatment and CTL need to be considered in monitoring of drug therapy...
  82. ncbi request reprint Influence of HLA-B57 on clinical presentation and viral control during acute HIV-1 infection
    Marcus Altfeld
    Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital, Boston, Massachusetts, USA
    AIDS 17:2581-91. 2003
    ..However, their impact on viral replication during acute HIV-1 infection is not known...
  83. ncbi request reprint Greater reversal of CD4+ cell abnormalities and viral load reduction after initiation of antiretroviral therapy with zidovudine, lamivudine, and nelfinavir before complete HIV type 1 seroconversion
    Don E Smith
    National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW 2010, Australia
    AIDS Res Hum Retroviruses 19:189-99. 2003
    ..Despite poorer prognostic markers at baseline ES subjects achieved responses similar to those of LS subjects after 1 year of treatment...
  84. ncbi request reprint Expansion of CD7(low) and CD7(negative) CD8 T-cell effector subsets in HIV-1 infection: correlation with antigenic load and reversion by antiretroviral treatment
    Einar M Aandahl
    The Biotechnology Centre of Oslo, University of Oslo, Norway
    Blood 104:3672-8. 2004
    ..The results are discussed in relation to the dual roles of CD7 as a receptor of both costimulation and cell death...
  85. ncbi request reprint Nucleic acid amplification testing for diagnosis of acute HIV infection: has the time come?
    Michael P Busch
    AIDS 19:1317-9. 2005
  86. ncbi request reprint Potential herpesvirus interaction during HIV type 1 primary infection
    Evelyne T Lennette
    Nectandra Institute, San Ramon, Costa Rica
    AIDS Res Hum Retroviruses 21:869-75. 2005
    ..uninfected individuals. Notably, lower HIV-1 viremia (7,313 vs. 55,548 geometric mean RNA copies/ml) at baseline was significantly associated with HHV-8 seropositivity (p < 0.004)...
  87. ncbi request reprint HIV testing within at-risk populations in the United States and the reasons for seeking or avoiding HIV testing
    Scott E Kellerman
    National Center for HIV, STD, and TB Prevention, Division of HIV AIDS Prevention Surveillance and Epidemiology, Surveillance Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Acquir Immune Defic Syndr 31:202-10. 2002
    ..We determined proportions of high-risk persons tested for HIV, the reasons for testing and not testing, and attitudes and perceptions regarding HIV testing, information that is critical for planning prevention programs...
  88. pmc Expansion of CD1d-restricted NKT cells in patients with primary HIV-1 infection treated with interleukin-2
    Markus Moll
    CIM, Department of Medicine, F59, Karolinska Institute, Karolinska University Hospital, Huddinge, 14186 Stockholm, Sweden
    Blood 107:3081-3. 2006
    ..These data indicate that IL-2 treatment in combination with effective ART is beneficial for the restoration of innate NKT cell immunity in patients with primary HIV-1 infection...
  89. pmc CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals
    Sunil K Ahuja
    Veterans Administration Research Center for AIDS and HIV 1 Infection, South Texas Veterans Health Care System, 7400 Merton Minter, San Antonio, Texas 78229, USA
    Nat Med 14:413-20. 2008
    ..Furthermore, as reconstitution of CD4(+) cells during HAART is more sensitive to CCL3L1 dose than to CCR5 genotypes, CCL3L1 analogs might be efficacious in supporting immunological reconstitution...
  90. pmc Immune reconstitution of CD56(dim) NK cells in individuals with primary HIV-1 infection treated with interleukin-2
    Jakob Michaelsson
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
    J Infect Dis 197:117-25. 2008
    ..Importantly, NK cell receptor expression and IFN-gamma production were maintained over time. This reconstitution of NK cells may be useful in helping contain viremia if patients discontinue therapy or develop drug resistance...
  91. ncbi request reprint CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms
    Matthew J Dolan
    Infectious Disease Clinical Research Program, Wilford Hall United States Air Force Medical Center, Lackland Air Force Base, Texas 78236, USA
    Nat Immunol 8:1324-36. 2007
    ..These results identify CCL3L1 and CCR5 as major determinants of CMI and demonstrate that these host factors influence HIV pathogenesis through their effects on both CMI and other viral entry-independent mechanisms...
  92. ncbi request reprint Quantitative longitudinal analysis of T cell receptor repertoire expression in HIV-infected patients on antiretroviral and interleukin-2 therapy
    Uma Sriram
    Department of Neurology University of California at San Francisco, California 94143, USA
    AIDS Res Hum Retroviruses 23:741-7. 2007
    ..These results suggest that homeostasis in the T cell receptor repertoire is more robust in those patients who stay on HAART for a long time and confirm the polyclonal stimulating capacity of IL-2...
  93. pmc Human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T(EMRA) cells in early infection are linked to control of HIV-1 viremia and predict the subsequent viral load set point
    John W Northfield
    Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom
    J Virol 81:5759-65. 2007
    ....
  94. ncbi request reprint Microbial translocation is a cause of systemic immune activation in chronic HIV infection
    Jason M Brenchley
    Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Med 12:1365-71. 2006
    ..These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection...
  95. pmc Human immunodeficiency virus type 1 Vpr induces DNA replication stress in vitro and in vivo
    Erik S Zimmerman
    Division of Cellular Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Virol 80:10407-18. 2006
    ..We report that infected cells in vivo display an aberrant cell cycle profile whereby a majority of cells have a 4N DNA content, consistent with the onset of G2 arrest...
  96. pmc Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance
    Lin Liu
    University of California San Diego, La Jolla, California 92093 0679, USA
    AIDS 22:835-9. 2008
    ..We compared eight genotypic interpretation methods to determine whether the method used would affect the rates of reported transmitted drug resistance...
  97. ncbi request reprint Newly diagnosed HIV infection
    Peter V Chin-Hong
    N Engl J Med 354:771-2; author reply 771-2. 2006
  98. ncbi request reprint Resistance testing in drug-naive HIV-infected patients: is it time?
    Frederick M Hecht
    Clin Infect Dis 41:1324-5. 2005
  99. pmc Changes in HIV testing after implementation of name-based HIV case surveillance in New Mexico
    Amy Lansky
    Division of HIV AIDS Prevention, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Public Health 92:1757. 2002

Research Grants4

  1. Yoga, Health, and Meditation
    Frederick Hecht; Fiscal Year: 2004
    ..abstract_text> ..