Matthias Hebrok

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Common activation of canonical Wnt signaling in pancreatic adenocarcinoma
    Marina Pasca di Magliano
    Diabetes Center, Department of Medicine, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1155. 2007
  2. pmc Pancreatic mesenchyme regulates epithelial organogenesis throughout development
    Limor Landsman
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Biol 9:e1001143. 2011
  3. pmc Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function
    Janet Lau
    Diabetes Center, University of California, San Francisco, San Francisco, California, USA
    Diabetes 59:1211-21. 2010
  4. pmc Generating β cells from stem cells-the story so far
    Matthias Hebrok
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Cold Spring Harb Perspect Med 2:a007674. 2012
  5. pmc Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration
    Matthias Hebrok
    Diabetes Center and Department of Medicine, University of California, San Francisco, USA
    Trends Cell Biol 14:153-5. 2004
  6. ncbi request reprint Stabilization of beta-catenin impacts pancreas growth
    Patrick W Heiser
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 133:2023-32. 2006
  7. ncbi request reprint Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
    David A Cano
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 131:3457-67. 2004
  8. pmc Stabilization of beta-catenin induces pancreas tumor formation
    Patrick W Heiser
    Diabetes Center, University of California, San Francisco, CA, USA
    Gastroenterology 135:1288-300. 2008
  9. pmc Dynamics of embryonic pancreas development using real-time imaging
    Sapna Puri
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Dev Biol 306:82-93. 2007
  10. pmc Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    John P Morris
    Diabetes Center, Department of Medicine, UCSF, San Francisco, California 94143, USA
    J Clin Invest 120:508-20. 2010

Research Grants

Collaborators

Detail Information

Publications54

  1. pmc Common activation of canonical Wnt signaling in pancreatic adenocarcinoma
    Marina Pasca di Magliano
    Diabetes Center, Department of Medicine, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1155. 2007
    ..Wnt inhibition blocked proliferation and induced apoptosis of cultured adenocarcinoma cells, thereby providing evidence to support the development of novel therapeutical strategies for Wnt inhibition in pancreatic adenocarcinoma...
  2. pmc Pancreatic mesenchyme regulates epithelial organogenesis throughout development
    Limor Landsman
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Biol 9:e1001143. 2011
    ..These results have implications for developing strategies to expand pancreas progenitors and β-cells for clinical transplantation...
  3. pmc Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function
    Janet Lau
    Diabetes Center, University of California, San Francisco, San Francisco, California, USA
    Diabetes 59:1211-21. 2010
    ..The objective of this study was to address these discrepancies by assessing the in vivo role of epithelial Hh signaling in the pancreas...
  4. pmc Generating β cells from stem cells-the story so far
    Matthias Hebrok
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Cold Spring Harb Perspect Med 2:a007674. 2012
    ....
  5. pmc Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration
    Matthias Hebrok
    Diabetes Center and Department of Medicine, University of California, San Francisco, USA
    Trends Cell Biol 14:153-5. 2004
    ..Data also indicate that alpha3beta1 mediates HGF-stimulated cell migration on netrin-coated substrata. These results indicate that netrins might have much broader functions than previously suspected...
  6. ncbi request reprint Stabilization of beta-catenin impacts pancreas growth
    Patrick W Heiser
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 133:2023-32. 2006
    ..Taken together, these data suggest a previously unappreciated temporal/spatial role for beta-catenin signaling in the regulation of pancreas organ growth...
  7. ncbi request reprint Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
    David A Cano
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 131:3457-67. 2004
    ..Thus, polaris and primary cilia function are required for the maturation and maintenance of proper tissue organization in the pancreas...
  8. pmc Stabilization of beta-catenin induces pancreas tumor formation
    Patrick W Heiser
    Diabetes Center, University of California, San Francisco, CA, USA
    Gastroenterology 135:1288-300. 2008
    ..Here, we sought to address the role of beta-catenin signaling in pancreas tumorigenesis...
  9. pmc Dynamics of embryonic pancreas development using real-time imaging
    Sapna Puri
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Dev Biol 306:82-93. 2007
    ..Thus, pancreas growth in vitro can be documented by live imaging, allowing visualization of the developing pancreas in real-time...
  10. pmc Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    John P Morris
    Diabetes Center, Department of Medicine, UCSF, San Francisco, California 94143, USA
    J Clin Invest 120:508-20. 2010
    ....
  11. ncbi request reprint The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma
    Guido von Figura
    1 Diabetes Center, Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, HSW 1116, Box 0540 San Francisco, California 94143, USA 2 II Medizinische Klinik, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany 3
    Nat Cell Biol 16:255-67. 2014
    ..Therefore, this study implicates Brg1 as a determinant of context-dependent Kras-driven pancreatic tumorigenesis and suggests that chromatin remodelling may underlie the development of distinct PDA subsets. ..
  12. pmc Primary cilia regulate Gli/Hedgehog activation in pancreas
    Sara Cervantes
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:10109-14. 2010
    ..Increased Hh activity also induced the expansion of an undifferentiated cell population expressing progenitor markers. Thus, our findings suggest that Hh signaling plays a critical role in regulating pancreatic epithelial plasticity...
  13. pmc Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo
    Sabina E Perez
    Diabetes Center, Department of Medicine, University of California, San Francisco, California, 94143 0573, USA
    Diabetes 54:694-701. 2005
    ..However, islet formation is unaffected in transgenic mice with modified tissue inhibitor of metalloproteinase-1 (TIMP1) levels, suggesting that MMP activity may contribute little to islet morphogenesis in vivo...
  14. pmc Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
    Akihisa Fukuda
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 19:441-55. 2011
    ..Finally, we demonstrate that serum MMP7 level in human patients with PDA correlated with metastatic disease and survival...
  15. pmc Bmi1 is required for regeneration of the exocrine pancreas in mice
    Akihisa Fukuda
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California 94143 0573, USA
    Gastroenterology 143:821-31.e1-2. 2012
    ..Bmi1 is present in a subpopulation of self-renewing pancreatic acinar cells and is expressed in response to pancreatic damage. We investigated the role of Bmi1 in regeneration of exocrine pancreas...
  16. ncbi request reprint Liver-specific loss of beta-catenin results in delayed hepatocyte proliferation after partial hepatectomy
    Shigeki Sekine
    Diabetes Center, Department of Medicine, Division of Transplantation, University of California San Francisco, San Francisco, CA 94143, USA
    Hepatology 45:361-8. 2007
    ....
  17. pmc Wnt5a is essential for intestinal elongation in mice
    Sara Cervantes
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Dev Biol 326:285-94. 2009
    ..Thus, our study demonstrates that Wnt5a functions as a critical regulator of midgut formation and morphogenesis in mammals...
  18. pmc GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation
    Olivier Nolan-Stevaux
    Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 23:24-36. 2009
    ....
  19. ncbi request reprint Hedgehog signaling regulates expansion of pancreatic epithelial cells
    Hiroshi Kawahira
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Dev Biol 280:111-21. 2005
    ..epithelial tissue differentiation and that pathway activation impairs formation of epithelial progenitors. Thus, tight control of Hedgehog pathway activity throughout embryonic development ensures proper pancreas organogenesis...
  20. pmc Hedgehog/Ras interactions regulate early stages of pancreatic cancer
    Marina Pasca di Magliano
    Diabetes Center, Department of Medicine, University of California, San Francisco, California 94143, USA
    Genes Dev 20:3161-73. 2006
    ..They also mark Hedgehog pathway components as relevant therapeutic targets for both early and advanced stages of pancreatic ductal neoplasia...
  21. pmc Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia
    Renee L Greer
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California
    Gastroenterology 145:1088-1097.e8. 2013
    ..Numb regulates cell junctions, integrins, and the activity of embryonic signaling pathways; therefore, we investigated its effects on acinar cell dedifferentiation, regeneration, and metaplasia...
  22. pmc Control of cell identity in pancreas development and regeneration
    Ben Z Stanger
    Division of Gastroenterology, Department of Medicine, Department of Cell and Developmental Biology and Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Gastroenterology 144:1170-9. 2013
    ..We review different aspects of cell identity in the pancreas, discussing how cells achieve their identity during embryonic development and maturation, and how this identity remains plastic, even in the adult pancreas...
  23. pmc Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice
    Limor Landsman
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 108:17010-5. 2011
    ..Summarily, our results indicate that deregulation of the Hh pathway impairs β-cell function by interfering with the mature β-cell differentiation state...
  24. ncbi request reprint Pancreatic development and disease
    David A Cano
    Diabetes Center, Department of Medicine, University of California San Francisco, 94143, USA
    Gastroenterology 132:745-62. 2007
  25. ncbi request reprint Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis
    David A Cano
    Diabetes Center, Department of Medicine, University of California San Francisco, California 94143, USA
    Gastroenterology 131:1856-69. 2006
    ..Here, we investigate the role of cilia in pancreas formation and function by analyzing mice that lack cilia in pancreatic cells...
  26. pmc Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells
    Roman Nawroth
    Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e392. 2007
    ..Emerging evidence indicates the importance of reactivated Wnt signaling in a number of cancers, including pancreatic adenocarcinoma...
  27. pmc Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion
    Jean B Regard
    Cardiovascular Research Institute, Diabetes Center, Department of Cellular and Molecular Pharmacology, UCSF School of Medicine, San Francisco, California 94143 2240, USA
    J Clin Invest 117:4034-43. 2007
    ....
  28. pmc Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs
    Tingxia Guo
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Diabetes 62:1581-92. 2013
    ..These studies illustrate the need to precisely mimic the in vivo conditions to fully recapitulate pancreatic lineage specification in vitro...
  29. ncbi request reprint Regulated beta-cell regeneration in the adult mouse pancreas
    David A Cano
    Diabetes Center, University of California San Francisco, California, USA
    Diabetes 57:958-66. 2008
    ..Our results also suggest the regeneration of beta-cells is mediated by replication of beta-cells rather than neogenesis from pancreatic ducts...
  30. pmc VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus
    Sapna Puri
    Diabetes Center, Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA
    Genes Dev 27:2563-75. 2013
    ..These findings reveal that assaults on the β cell that impact the differentiation state of the cell have clear implications toward our understanding of diabetes mellitus...
  31. ncbi request reprint Development and cancer: lessons learned in the pancreas
    Patrick W Heiser
    Diabetes Center, Department of Medicine, University of California, San Francisco, California 94143, USA
    Cell Cycle 3:270-2. 2004
    ..Here we discuss recent studies have indicated important roles for two major developmental signaling pathways in pancreatic cancer: Notch and Hedgehog (Hh)...
  32. ncbi request reprint Hedgehog signalling in cancer formation and maintenance
    Marina Pasca di Magliano
    Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Nat Rev Cancer 3:903-11. 2003
  33. pmc A role for von Hippel-Lindau protein in pancreatic beta-cell function
    Sapna Puri
    Diabetes Center, Department of Medicine, University of California, San Francisco, California, USA
    Diabetes 58:433-41. 2009
    ..In humans, a germline mutation in the VHL gene leads to the von Hippel-Lindau disease, a familial syndrome characterized by benign and malignant tumors of the kidney, central nervous system, and pancreas...
  34. pmc KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
    John P Morris
    Diabetes Center, University of California, San Francisco, 513 Parnassus Ave, San Francisco, California 94143, USA
    Nat Rev Cancer 10:683-95. 2010
    ..Here we examine the central part that KRAS plays in the biology of PDAC, and how the timing and location of Hh and Wnt-β-catenin signalling dictate the specification and oncogenic properties of PDAC...
  35. pmc Cellular plasticity within the pancreas--lessons learned from development
    Sapna Puri
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Dev Cell 18:342-56. 2010
    ....
  36. ncbi request reprint It's a free for all--insulin-positive cells join the group of potential progenitors for pancreatic ductal adenocarcinoma
    John P Morris
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Cancer Cell 16:359-61. 2009
    ..In this issue of Cancer Cell, Gidekel Friedlander and colleagues demonstrate that under conditions of tissue damage, mutant Kras can drive previously unsuspected insulin-positive endocrine cells into PDA...
  37. pmc Dicer Regulates Differentiation and Viability during Mouse Pancreatic Cancer Initiation
    John P Morris
    Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e95486. 2014
    ..Our data suggest that intact miRNA processing is involved in both constraining pro-tumorigenic changes in pancreatic differentiation as well as maintaining viability during PDA initiation. ..
  38. pmc Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation
    Guido von Figura
    Department of Medicine, Diabetes Center, University of California San Francisco, San Francisco, California, USA
    Gut 63:656-64. 2014
    ..We investigated the role of Nr5a2 in exocrine maintenance, regeneration and Kras driven neoplasia...
  39. pmc Elimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in mice
    Sapna Puri
    Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, United States of America
    PLoS ONE 8:e72213. 2013
    ..Our results reveal a novel role for the hypoxia/HIF pathway in islet hormone secretion and maintenance of the fine balance that allows for the establishment of normoglycemia. ..
  40. pmc Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling
    Lutz Kockel
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1000990. 2010
    ..These results illustrate how the Akt-TOR pathway dynamically adapts the routing of negative feedback in response to the activity load of its signaling circuit in vivo...
  41. ncbi request reprint Combined activities of hedgehog signaling inhibitors regulate pancreas development
    Hiroshi Kawahira
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 130:4871-9. 2003
    ..Reduction of Fgf10 expression in Hhip homozygous mutants suggests that at least some of the observed phenotypes result from hedgehog-mediated inhibition of Fgf signaling at early stages...
  42. pmc Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development
    Audrey V Parent
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0540, USA
    Cell Stem Cell 13:219-29. 2013
    ..Thus, hESC-derived TEP grafts may have broad applications for enhancing engraftment in cell-based therapies as well as restoring age- and stress-related thymic decline. ..
  43. pmc Aberrant innate immune activation following tissue injury impairs pancreatic regeneration
    Alexandra E Folias
    Diabetes Center, Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 9:e102125. 2014
    ..Collectively these studies identify targetable inflammatory factors that can be used to influence the development of non-resolving inflammation and pancreatic regeneration following injury. ..
  44. pmc Stem cells to pancreatic beta-cells: new sources for diabetes cell therapy
    Tingxia Guo
    Department of Medicine, Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA
    Endocr Rev 30:214-27. 2009
    ....
  45. pmc Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
    Yuki Ohi
    Department of Ob Gyn and Center for Reproductive Sciences, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nat Cell Biol 13:541-9. 2011
    ..Knockdown of the incompletely reprogrammed gene C9orf64 (chromosome 9 open reading frame 64) reduces the efficiency of human iPS cell generation, indicating that somatic memory genes may be functionally relevant during reprogramming...
  46. ncbi request reprint Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice
    Shigeki Sekine
    Department of Medicine, Diabetes Center, University of California San Francisco, San Francisco, CA 94143 0573, USA
    Hepatology 43:817-25. 2006
    ..In conclusion, in addition to regulating hepatocyte proliferation, beta-catenin may also control multiple aspects of normal liver function...
  47. ncbi request reprint Diabetes. Solving human β-cell development--what does the mouse say?
    Alexandra E Folias
    Diabetes Center, Department of Medicine, University of California San Francisco, 513 Parnassus Avenue, HSW 1116, Box 0540, San Francisco, CA 94143, USA
    Nat Rev Endocrinol 10:253-5. 2014
    ..This finding supports the use of mice for modelling human disease but also highlights the need for additional human-specific studies of β-cell function...
  48. ncbi request reprint Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages
    Ke Li
    Gladstone Institute of Cardiovascular Disease and Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell Stem Cell 14:228-36. 2014
    ..Our findings may therefore provide a useful approach for generating large numbers of functional β cells for disease modeling and, ultimately, cell-based therapy. ..
  49. ncbi request reprint Hedgehog signaling in pancreas development
    Matthias Hebrok
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143 0540, USA
    Mech Dev 120:45-57. 2003
    ....
  50. ncbi request reprint Diabetic β Cells: To Be or Not To Be?
    Sapna Puri
    Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 150:1103-4. 2012
    ..Emerging data from Talchai et al. suggest β cell dedifferentiation as an alternative mechanism of insulin insufficiency that might be more amenable to intervention in at least a subset of patients...
  51. pmc Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
    Jennifer P Morton
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 104:5103-8. 2007
    ..Collectively, our findings demonstrate crucial roles for Shh signaling in multiple stages of pancreatic carcinogenesis...
  52. pmc Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
    Sarah P Thayer
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 425:851-6. 2003
    ..These data suggest that this pathway may have an early and critical role in the genesis of this cancer, and that maintenance of hedgehog signalling is important for aberrant proliferation and tumorigenesis...
  53. pmc Hedgehogs: la dolce vita. Workshop on Hedgehog-Gli Signaling in Cancer and Stem Cells
    David J Robbins
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, USA
    EMBO Rep 8:451-5. 2007
  54. doi request reprint Hedgehog spikes pancreas regeneration
    David A Cano
    Gastroenterology 135:347-51. 2008

Research Grants17

  1. Effects of Hedgehog Signaling on Pancreas Organogenesis
    Matthias Hebrok; Fiscal Year: 2003
    ..We expect that knowledge derived from these studies may contribute to the development of new cell-replacement strategies for treatment of patients suffering from diabetes. ..
  2. Effects of Hedgehog Signaling on Pancreas Organogenesis
    Matthias Hebrok; Fiscal Year: 2010
    ....
  3. Embryonic Signaling Pathways in Pancreatic Cancer
    Matthias Hebrok; Fiscal Year: 2010
    ....
  4. Effects of Hedgehog Signaling on Pancreas Organogenesis
    Matthias Hebrok; Fiscal Year: 2010
    ....
  5. Effects of Hedgehog Signaling on Pancreas Organogenesis
    Matthias Hebrok; Fiscal Year: 2009
    ....
  6. Embryonic Signaling Pathways in Pancreatic Cancer
    Matthias Hebrok; Fiscal Year: 2007
    ..In the best case, they will help to design new strategies for treatment of human patients suffering from this disease. ..
  7. Effects of Hedgehog Signaling on Pancreas Organogenesis
    Matthias Hebrok; Fiscal Year: 2007
    ..We expect that knowledge derived from these studies may contribute to the development of new cell-replacement strategies for treatment of patients suffering from diabetes. ..
  8. Embryonic Signaling Pathways in Pancreatic Cancer
    Matthias Hebrok; Fiscal Year: 2006
    ..In the best case, they will help to design new strategies for treatment of human patients suffering from this disease. ..
  9. Effects of Hedgehog Signaling on Pancreas Organogenesis
    Matthias Hebrok; Fiscal Year: 2006
    ..We expect that knowledge derived from these studies may contribute to the development of new cell-replacement strategies for treatment of patients suffering from diabetes. ..
  10. Embryonic Signaling Pathways in Pancreatic Cancer
    Matthias Hebrok; Fiscal Year: 2005
    ..In the best case, they will help to design new strategies for treatment of human patients suffering from this disease. ..
  11. Effects of Hedgehog Signaling on Pancreas Organogenesis
    Matthias Hebrok; Fiscal Year: 2004
    ..We expect that knowledge derived from these studies may contribute to the development of new cell-replacement strategies for treatment of patients suffering from diabetes. ..
  12. Effects of Hedgehog Signaling on Pancreas Organogenesis
    Matthias Hebrok; Fiscal Year: 2005
    ..We expect that knowledge derived from these studies may contribute to the development of new cell-replacement strategies for treatment of patients suffering from diabetes. ..
  13. Embryonic Signaling Pathways in Pancreatic Cancer
    Matthias Hebrok; Fiscal Year: 2004
    ..In the best case, they will help to design new strategies for treatment of human patients suffering from this disease. ..
  14. Effects of Hedgehog Signaling on Pancreas Organogenesis
    Matthias Hebrok; Fiscal Year: 2004
    ..We expect that knowledge derived from these studies may contribute to the development of new cell-replacement strategies for treatment of patients suffering from diabetes. ..
  15. Embryonic Signaling Pathways in Pancreatic Cancer
    Matthias Hebrok; Fiscal Year: 2011
    ....