David Heber

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 52:2512-7. 2004
  2. ncbi request reprint Overview of mechanisms of action of lycopene
    David Heber
    University of California Center for Human Nutrition, 900 Veteran Avenue, Room 1 2 213, Los Angeles, CA 90095 1742, USA
    Exp Biol Med (Maywood) 227:920-3. 2002
  3. doi request reprint Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles
    David Heber
    UCLA Center for Human Nutrition and the Division of NanoMedicine, David Geffen School of Medicine at UCLA, 900 Veteran Avenue, Room 12 217, 12 217 Warren Hall, Box 951742, Los Angeles, California 90095, USA
    Food Funct 5:35-41. 2014
  4. pmc Absorption of silicon from artesian aquifer water and its impact on bone health in postmenopausal women: a 12 week pilot study
    Zhaoping Li
    Center for Human Nutrition, University of California Los Angeles, Los Angeles, CA, USA
    Nutr J 9:44. 2010
  5. pmc Effects of dihydrocapsiate on adaptive and diet-induced thermogenesis with a high protein very low calorie diet: a randomized control trial
    Tszying Amy Lee
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Nutr Metab (Lond) 7:78. 2010
  6. pmc An integrative view of obesity
    David Heber
    UCLA Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Clin Nutr 91:280S-283S. 2010
  7. doi request reprint Multitargeted therapy of cancer by ellagitannins
    David Heber
    UCLA Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, United States
    Cancer Lett 269:262-8. 2008
  8. ncbi request reprint Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size
    David Heber
    Center for Human Nutrition, University of California, Los Angeles, CA 90095, USA
    J Agric Food Chem 55:10050-4. 2007
  9. ncbi request reprint Herbal preparations for obesity: are they useful?
    David Heber
    UCLA Center for Human Nutrition, University of California, 900 Veteran Avenue, Room 12 217, Los Angeles, CA 90095 1742, USA
    Prim Care 30:441-63. 2003
  10. ncbi request reprint Vegetables, fruits and phytoestrogens in the prevention of diseases
    David Heber
    UCLA Center for Human Nutrition, Los Angeles, CA, USA
    J Postgrad Med 50:145-9. 2004

Research Grants

  1. THE UCLA CLINICAL NUTRITION RESEARCH UNIT
    David Heber; Fiscal Year: 2006
  2. UCLA TRAINING PROGRAM IN NUTRITION AND OBESITY
    David Heber; Fiscal Year: 2007

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Total cranberry extract versus its phytochemical constituents: antiproliferative and synergistic effects against human tumor cell lines
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 52:2512-7. 2004
    ....
  2. ncbi request reprint Overview of mechanisms of action of lycopene
    David Heber
    University of California Center for Human Nutrition, 900 Veteran Avenue, Room 1 2 213, Los Angeles, CA 90095 1742, USA
    Exp Biol Med (Maywood) 227:920-3. 2002
    ..This review will point out areas for future research where more evidence is needed on the effects of lycopene on the etiology of chronic disease...
  3. doi request reprint Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles
    David Heber
    UCLA Center for Human Nutrition and the Division of NanoMedicine, David Geffen School of Medicine at UCLA, 900 Veteran Avenue, Room 12 217, 12 217 Warren Hall, Box 951742, Los Angeles, California 90095, USA
    Food Funct 5:35-41. 2014
    ....
  4. pmc Absorption of silicon from artesian aquifer water and its impact on bone health in postmenopausal women: a 12 week pilot study
    Zhaoping Li
    Center for Human Nutrition, University of California Los Angeles, Los Angeles, CA, USA
    Nutr J 9:44. 2010
    ..This study evaluated the absorption of silicon from bottled artesian aquifer water and its effect on markers of bone metabolism...
  5. pmc Effects of dihydrocapsiate on adaptive and diet-induced thermogenesis with a high protein very low calorie diet: a randomized control trial
    Tszying Amy Lee
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Nutr Metab (Lond) 7:78. 2010
    ..It has been shown to elicit the thermogenic effects of capsaicin but without its gastrointestinal side effects...
  6. pmc An integrative view of obesity
    David Heber
    UCLA Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Clin Nutr 91:280S-283S. 2010
    ..Both public health and medical nutrition approaches can benefit from this integrative view of obesity...
  7. doi request reprint Multitargeted therapy of cancer by ellagitannins
    David Heber
    UCLA Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, United States
    Cancer Lett 269:262-8. 2008
    ..Continued translational research on the chemopreventive potential of pomegranate ellagitannins is ongoing...
  8. ncbi request reprint Safety and antioxidant activity of a pomegranate ellagitannin-enriched polyphenol dietary supplement in overweight individuals with increased waist size
    David Heber
    Center for Human Nutrition, University of California, Los Angeles, CA 90095, USA
    J Agric Food Chem 55:10050-4. 2007
    ..These studies demonstrate the safety of a pomegranate ellagitannin-enriched polyphenol dietary supplement in humans and provide evidence of antioxidant activity in humans...
  9. ncbi request reprint Herbal preparations for obesity: are they useful?
    David Heber
    UCLA Center for Human Nutrition, University of California, 900 Veteran Avenue, Room 12 217, Los Angeles, CA 90095 1742, USA
    Prim Care 30:441-63. 2003
    ....
  10. ncbi request reprint Vegetables, fruits and phytoestrogens in the prevention of diseases
    David Heber
    UCLA Center for Human Nutrition, Los Angeles, CA, USA
    J Postgrad Med 50:145-9. 2004
    ..Grouping plant foods by colour provides simplification, but it is also important as a method to help consumers make wise food choices and promote health...
  11. ncbi request reprint Phytochemicals beyond antioxidation
    David Heber
    UCLA Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1742, USA
    J Nutr 134:3175S-3176S. 2004
  12. ncbi request reprint Applying science to changing dietary patterns
    D Heber
    UCLA Center for Human Nutrition, Los Angeles, CA, USA
    J Nutr 131:3078S-81S. 2001
    ..At home, simple ways of preparing foods rapidly and easily are needed to influence dietary patterns...
  13. ncbi request reprint An analysis of nine proprietary Chinese red yeast rice dietary supplements: implications of variability in chemical profile and contents
    D Heber
    UCLA Center for Human Nutrition, UCLA School of Medicine, Los Angeles, California 90095 1742, USA
    J Altern Complement Med 7:133-9. 2001
    ....
  14. pmc Addictive genes and the relationship to obesity and inflammation
    David Heber
    Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Neurobiol 44:160-5. 2011
    ..This new area of interdisciplinary research holds the promise of developing new approaches to treating drug abuse and obesity...
  15. ncbi request reprint Herbs and atherosclerosis
    D Heber
    Center for Human Nutrition, University of California, Los Angeles, 900 Veteran Avenue, Room 12 217, Los Angeles, CA 90095 1742, USA
    Curr Atheroscler Rep 3:93-6. 2001
    ..This herb is likely to be able to directly impact the process of atherosclerosis, but large-scale clinical trials are needed to assess the public health potential of this herbal supplement...
  16. pmc Weight loss reduces breast ductal fluid estrogens in obese postmenopausal women: a single arm intervention pilot study
    Catherine L Carpenter
    Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Nutr J 11:102. 2012
    ..Our purpose was to demonstrate feasibility and preliminarily evaluate serum-based and localized breast biomarker changes resulting from a weight loss intervention among obese postmenopausal women...
  17. pmc Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, Los Angeles California, USA
    J Med Food 11:390-4. 2008
    ..This study demonstrates that ellagitannin metabolites, delivered from pomegranate fruits, as PJ, POMxl, and POMxp, reach equivalent levels with a delay in time of maximum concentration of POMxp compared to PJ and POMxl...
  18. ncbi request reprint Green tea induces annexin-I expression in human lung adenocarcinoma A549 cells: involvement of annexin-I in actin remodeling
    Qing Yi Lu
    Department of Medicine, Center for Human Nutrition, University of California at Los Angeles, Los Angeles, CA 90095 1732, USA
    Lab Invest 87:456-65. 2007
    ..Together, annexin-I plays an important role in GTE-induced actin remodeling, and it may serve as a potential molecular target associated with the anticancer activities of green tea...
  19. ncbi request reprint Ellagitannin-rich pomegranate extract inhibits angiogenesis in prostate cancer in vitro and in vivo
    Maryam R Sartippour
    Center for Human Nutrition, Los Angeles, CA 90095 1742, USA
    Int J Oncol 32:475-80. 2008
    ..Further studies in humans are needed to confirm that angiogenesis can be inhibited by an ellagitannin-rich pomegranate extract administered orally as a dietary supplement...
  20. pmc Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2
    Naoko Kobayashi
    Department of Urology, Division of Clinical Nutrition and Hematology Oncology, University of California, Los Angeles School of Medicine, 90095 1738, USA
    Clin Cancer Res 12:4662-70. 2006
    ....
  21. pmc Pomegranate extract inhibits androgen-independent prostate cancer growth through a nuclear factor-kappaB-dependent mechanism
    Matthew B Rettig
    Department of Medicine, Division of Hematology Oncology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA
    Mol Cancer Ther 7:2662-71. 2008
    ..Our study represents the first description of PE as a promising dietary agent for the prevention of the emergence of androgen independence that is driven in part by heightened NF-kappaB activity...
  22. ncbi request reprint In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Nutr Biochem 16:360-7. 2005
    ..The superior bioactivity of PJ compared to its purified polyphenols illustrated the multifactorial effects and chemical synergy of the action of multiple compounds compared to single purified active ingredients...
  23. pmc Chemoprevention of prostate cancer with lycopene in the TRAMP model
    Ramdev Konijeti
    Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Prostate 70:1547-54. 2010
    ..We hypothesized that tomato paste would have greater chemopreventive effects in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice relative to equivalent lycopene doses provided from lycopene beadlets...
  24. pmc Green tea polyphenols and metabolites in prostatectomy tissue: implications for cancer prevention
    Piwen Wang
    Center for Human Nutrition, University of California Los Angeles, 90095, USA
    Cancer Prev Res (Phila) 3:985-93. 2010
    ....
  25. ncbi request reprint Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland
    Navindra P Seeram
    Center for Human Nutrition, Greater Los Angeles VA Medical Center, Los Angeles, California, USA
    J Agric Food Chem 55:7732-7. 2007
    ..This warrants future human tissue bioavailability studies and further clinical studies in men with CaP...
  26. pmc Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor
    Mee Young Hong
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Nutr Biochem 19:848-55. 2008
    ....
  27. pmc Body fat and body-mass index among a multiethnic sample of college-age men and women
    Catherine L Carpenter
    Center for Human Nutrition, David Geffen School of Medicine at UCLA, 14 193 Warren Hall, 900 Veteran Avenue, P O Box 951742, Los Angeles, CA 90095, USA
    J Obes 2013:790654. 2013
    ..The high PBF with low BMI pattern exhibited by Asian-American women suggests that they could escape detection for obesity-related disease if BMI is the sole measure that estimates body composition...
  28. doi request reprint Hass avocado modulates postprandial vascular reactivity and postprandial inflammatory responses to a hamburger meal in healthy volunteers
    Zhaoping Li
    UCLA Center for Human Nutrition, David Geffen School of Medicine at UCLA, 900 Veteran Avenue, Room 12 217 12 217 Warren Hall Box 951742, Los Angeles, California 90095, USA
    Food Funct 4:384-91. 2013
    ..These observations are suggestive of beneficial anti-inflammatory and vascular health effects of ingesting added Hass avocado with a hamburger patty...
  29. ncbi request reprint Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Nutr Biochem 16:610-6. 2005
    ..In future studies of dietary effects on the plasma antioxidant capacity, changes in plasma uric acid will need to be closely monitored...
  30. pmc Antioxidant-rich spice added to hamburger meat during cooking results in reduced meat, plasma, and urine malondialdehyde concentrations
    Zhaoping Li
    University of California, Los Angeles Center for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Am J Clin Nutr 91:1180-4. 2010
    ..Emerging science has shown the effect of oxidation products and inflammation on atherogenesis and carcinogenesis. Cooking hamburger meat can promote the formation of malondialdehyde that can be absorbed after ingestion...
  31. pmc Phenolic acid concentrations in plasma and urine from men consuming green or black tea and potential chemopreventive properties for colon cancer
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Mol Nutr Food Res 57:483-93. 2013
    ....
  32. pmc Chinese red yeast rice inhibition of prostate tumor growth in SCID mice
    Mee Young Hong
    Center for Human Nutrition, 900 Veteran Ave Room 1 2 217, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Cancer Prev Res (Phila) 4:608-15. 2011
    ..05). Clinical studies of RYR for prostate cancer prevention in the increasing population of men undergoing active surveillance should be considered...
  33. ncbi request reprint The combination of green tea and tamoxifen is effective against breast cancer
    Maryam R Sartippour
    Department of Surgery, Center for Human Nutrition, University of California, Los Angeles, CA 90095 1782, USA
    Carcinogenesis 27:2424-33. 2006
    ..These results may lead to future improvements in breast cancer treatment and prevention...
  34. ncbi request reprint Pistachio nuts reduce triglycerides and body weight by comparison to refined carbohydrate snack in obese subjects on a 12-week weight loss program
    Zhaoping Li
    Center for Human Nutrition, Warren Hall, Room 12 217, 900 Veteran Ave, Los Angeles, CA 90095, USA
    J Am Coll Nutr 29:198-203. 2010
    ..This study is designed to study the effects of pistachio snack consumption on body weight and lipid levels in obese participants under real-world conditions...
  35. ncbi request reprint Bioavailability and antioxidant activity of tea flavanols after consumption of green tea, black tea, or a green tea extract supplement
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine and the Department of Biostatistics, School of Public Health, University of California, Los Angeles, 90095, USA
    Am J Clin Nutr 80:1558-64. 2004
    ..Additional in vivo studies are needed to examine the pharmacokinetic relation of absorption and antioxidant activity of tea polyphenols administered in the form of green or black tea or tea extract supplements...
  36. ncbi request reprint Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer
    Allan J Pantuck
    Department of Urology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 1738, USA
    Clin Cancer Res 12:4018-26. 2006
    ..We sought to determine the effects of pomegranate juice (a major source of antioxidants) consumption on prostate-specific antigen (PSA) progression in men with a rising PSA following primary therapy...
  37. ncbi request reprint Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines
    Takashi Kumagai
    Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Leuk Res 31:523-30. 2007
    ..HPLC analysis of S.B. showed it contains 21% baicalin and further studies confirmed it was the major anti-cancer component of S.B. Thus, Scutellaria baicalensis should be tested in clinical trials for these hematopoietic malignancies...
  38. ncbi request reprint Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Agric Food Chem 54:9329-39. 2006
    ..The data provided by the current study and from other laboratories warrants further investigation into the chemopreventive and chemotherapeutic effects of berries using in vivo models...
  39. doi request reprint Strawberry consumption is associated with increased antioxidant capacity in serum
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Med Food 13:116-22. 2010
    ..In summary, daily consumption of strawberries resulted in a modest but significant increase in antioxidant capacity in a healthy population...
  40. pmc Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis
    Satomi Koyama
    Division of Pediatric Endocrinology, Mattel Children s Hospital, David Geffen School of Medicine, University of California, Los Angeles, USA
    Growth Horm IGF Res 20:55-62. 2010
    ..These studies revealed novel interactions between the IGF system and pomegranate-induced apoptosis...
  41. doi request reprint Chinese red yeast rice versus lovastatin effects on prostate cancer cells with and without androgen receptor overexpression
    Mee Young Hong
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Med Food 11:657-66. 2008
    ..In vivo studies are needed to further establish the potential advantages of RYR over LV in prostate cancer chemoprevention and in the prevention of the emergence of androgen independence...
  42. pmc Effects of green tea extract on lung cancer A549 cells: proteomic identification of proteins associated with cell migration
    Qing Yi Lu
    Department of Medicine, Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1569, USA
    Proteomics 9:757-67. 2009
    ..The result of the study demonstrates that GTE alters the levels of many proteins involved in growth, motility and apoptosis of A549 cells and their identification may explain the multiple antitumor activities of GTE...
  43. pmc Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer
    William J Aronson
    Urology Section, Department of Surgery, Veterans Administration, Greater Los Angeles Healthcare System, Los Angeles, California 90095 1738, USA
    J Urol 183:345-50. 2010
    ..We evaluated the effect of a low fat diet on serum factors affecting prostate cancer cell growth by performing a prospective, randomized dietary intervention trial in men with prostate cancer...
  44. ncbi request reprint Catechin and caffeine content of green tea dietary supplements and correlation with antioxidant capacity
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 54:1599-603. 2006
    ..Reliable labeling information and standardized manufacturing practices, based on both chemical standardization and biological assays, are recommended for the quality control of botanical dietary supplements...
  45. doi request reprint Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 56:1415-22. 2008
    ..Although in vitro antioxidant potency does not prove in vivo biological activity, there is also consistent clinical evidence of antioxidant potency for the most potent beverages including both PJ and red wine...
  46. doi request reprint Antioxidant capacity and phytochemical content of herbs and spices in dry, fresh and blended herb paste form
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Int J Food Sci Nutr 62:219-25. 2011
    ..However, there was no significant correlation between the AC and the concentration of chemical marker compounds. In summary, processed herbs contribute significant amounts of AC to the diet...
  47. ncbi request reprint Rabdosia rubescens inhibits breast cancer growth and angiogenesis
    Maryam R Sartippour
    Department of Surgery, University of California, Los Angeles, CA, USA
    Int J Oncol 26:121-7. 2005
    ..We conclude that Rabdosia rubescens may potentially be used to treat or prevent breast cancer, and that the extract from this herbal source deserves further studies...
  48. ncbi request reprint Inhibition of prostate cancer cell growth by an avocado extract: role of lipid-soluble bioactive substances
    Qing Yi Lu
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1742, USA
    J Nutr Biochem 16:23-30. 2005
    ....
  49. ncbi request reprint Plasma clearance of lovastatin versus chinese red yeast rice in healthy volunteers
    Zhaoping Li
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA90095 1742, USA
    J Altern Complement Med 11:1031-8. 2005
    ..The current study compared the pharmacokinetics of CRYR with lovastatin at the same bioeffective dose for lowering cholesterol...
  50. pmc Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Nutr Biochem 23:1537-42. 2012
    ..Our results suggest that the inhibition of tumor growth is due to GTP-mediated inhibition of oxidative stress and angiogenesis in the LAPC4 xenograft prostate tumor in SCID mice...
  51. ncbi request reprint Prostate cancer in native Japanese and Japanese-American men: effects of dietary differences on prostatic tissue
    Leonard S Marks
    Department of Urology, University of California, Los Angeles, Geffen School of Medicine, Los Angeles, California, USA
    Urology 64:765-71. 2004
    ..To investigate the relationship between diet and prostate cancer (CaP) among native Japanese (NJ) and second-generation or third-generation Japanese-American (J-A) men--focusing on the effects of animal fat and soy on prostatic tissues...
  52. pmc Chemopreventive effects of tea in prostate cancer: green tea versus black tea
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Mol Nutr Food Res 55:905-20. 2011
    ..This article will review in detail the available epidemiological and human clinical studies, as well as animal and basic mechanistic studies on GT and BT supporting a chemopreventive role in CaP...
  53. pmc Green tea inhibits cycolooxygenase-2 in non-small cell lung cancer cells through the induction of Annexin-1
    Qing Yi Lu
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Biochem Biophys Res Commun 427:725-30. 2012
    ..Our study may provide a new mechanism of GTE on the prevention of lung cancer and other diseases related to inflammation...
  54. ncbi request reprint Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells
    Claudia I Muller
    Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
    Leuk Res 30:841-8. 2006
    ..These results indicate that G. lucidum extract has a profound activity against leukemia, lymphoma and multiple myeloma cells and may be a novel adjunctive therapy for the treatment of hematologic malignancies...
  55. pmc California Hass avocado: profiling of carotenoids, tocopherol, fatty acid, and fat content during maturation and from different growing areas
    Qing Yi Lu
    UCLA Center for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 57:10408-13. 2009
    ..These steps will enable researchers to account for potential nutrient-nutrient interactions that might affect the research outcomes...
  56. ncbi request reprint PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells
    Takayuki Ikezoe
    Division of Hematology Oncology and Thoracic Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Int J Oncol 29:453-61. 2006
    ..PC-SPES might be useful in the adjuvant setting for the treatment of individuals with resected NSCLC as well as other types of cancer in which COX-2 is activated...
  57. doi request reprint Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiproliferative properties
    Yanjun Zhang
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 56:670-5. 2008
    ..This study adds to the growing body of data supporting the bioactivities of berry fruit phenolics and their potential impact on human health...
  58. pmc Quercetin increased the antiproliferative activity of green tea polyphenol (-)-epigallocatechin gallate in prostate cancer cells
    Piwen Wang
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nutr Cancer 64:580-7. 2012
    ..In summary, quercetin combined with EGCG in vitro demonstrated enhanced inhibition of cell proliferation by increasing the intracellular concentration of EGCG and decreasing EGCG methylation...
  59. pmc Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy
    William J Aronson
    Department of Urology, School of Medicine, University of California Los Angeles, Box 951738, Los Angeles, CA 90095, USA
    Cancer Prev Res (Phila) 4:2062-71. 2011
    ..These results support further studies evaluating reduction of dietary fat with fish oil supplementation on modulating prostate cancer biology...
  60. ncbi request reprint Pistachio skin phenolics are destroyed by bleaching resulting in reduced antioxidative capacities
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 54:7036-40. 2006
    ..The destruction of bioactive phenolics in pistachio skins may negatively impact the potential health benefits arising from pistachio consumption...
  61. ncbi request reprint Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours
    Navindra P Seeram
    Departments of Biomathematics and Human Genetics, University of California, Los Angeles, CA, USA
    J Nutr 136:2481-5. 2006
    ..Whether genetic polymorphisms in EA-metabolizing enzymes (e.g., catechol-O-methyl transferase and glucuronosyl transferase) are related to variations in response to PJ remains to be established...
  62. doi request reprint Absence of pomegranate ellagitannins in the majority of commercial Pomegranate extracts: implications for standardization and quality control
    Yanjun Zhang
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 57:7395-400. 2009
    ..Future research is needed to assess the health impact of substituting ellagic acid for the complex mix of phytochemicals in a pomegranate extract dietary supplement...
  63. ncbi request reprint Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independence
    Tung H Ngo
    Department of Physiological Science, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cancer Res 64:1252-4. 2004
    ..Reduced dietary fat intake delayed conversion from androgen-sensitive to -insensitive prostate cancer and significantly prolonged survival of severe combined immunodeficient mice bearing LAPC-4 xenografts...
  64. doi request reprint International multidimensional authenticity specification (IMAS) algorithm for detection of commercial pomegranate juice adulteration
    Yanjun Zhang
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 57:2550-7. 2009
    ..In this survey of commercial pomegranate juices, only 6 of 23 strictly met all of the IMAS criteria...
  65. pmc Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells
    Mee Young Hong
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Nutr Biochem 19:448-58. 2008
    ..These results suggest that the matrix effects of RYR beyond MK alone may be active in inhibiting colon cancer growth. RYR with or without MK may be a botanical approach to colon cancer chemoprevention worthy of further investigation...
  66. ncbi request reprint Ganoderma lucidum spore extract inhibits endothelial and breast cancer cells in vitro
    Qing Yi Lu
    Department of Medicine, Center for Human Nutrition, University of California Los Angeles, Los Angeles, CA 90095, USA
    Oncol Rep 12:659-62. 2004
    ..Our results suggest that the alcohol extract from the spore of Ganoderma lucidum may possess potential anti-tumor and anti-angiogenic activities...
  67. ncbi request reprint PC-SPES: Molecular mechanism to induce apoptosis and down-regulate expression of PSA in LNCaP human prostate cancer cells
    Takayuki Ikezoe
    Division of Hematology Oncology, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Int J Oncol 23:1461-70. 2003
    ..Also, PC-SPES activated the JNK/c-Jun/AP-1 signal pathway resulting in growth arrest and apoptosis of prostate cancer cells...
  68. ncbi request reprint Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenic model
    Qing Yi Lu
    Center for Human Nutrition, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Clin Cancer Res 11:1675-83. 2005
    ..This study shows that GTE exerts an effect on cytoskeletal actin remodeling and provides further support for the use of GTE as a chemopreventive agent...
  69. ncbi request reprint The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells
    Kun Gao
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Nutr Biochem 17:89-95. 2006
    ....
  70. ncbi request reprint Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells
    Lynn S Adams
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Agric Food Chem 54:980-5. 2006
    ..Therefore, the polyphenolic phytochemicals in the pomegranate can play an important role in the modulation of inflammatory cell signaling in colon cancer cells...
  71. pmc Limitations of MTT and MTS-based assays for measurement of antiproliferative activity of green tea polyphenols
    Piwen Wang
    Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 5:e10202. 2010
    ..Although the susceptibility to EGCG treatment is largely dependent on cancer cell type, the particular cell viability and proliferation assays utilized may significantly influence quantitative results reported in the literature...
  72. ncbi request reprint Ganoderma lucidum extracts inhibit growth and induce actin polymerization in bladder cancer cells in vitro
    Qing Yi Lu
    Center for Human Nutrition, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Cancer Lett 216:9-20. 2004
    ....
  73. ncbi request reprint Liquid meal replacements and glycemic control in obese type 2 diabetes patients
    I Yip
    Center for Human Nutrition, University of California, Los Angeles School of Medicine, Los Angeles, California 90095-1742, USA
    Obes Res 9:341S-347S. 2001
    ..DISCUSSION: We have shown that liquid MRs are a safe and effective weight loss tool for obese subjects with type 2 diabetes, and can result in improvements in body weight, glucose, insulin, hemoglobin A1c and lipid levels...
  74. ncbi request reprint PC-SPES inhibits colon cancer growth in vitro and in vivo
    Sergio Huerta
    University of California Los Angeles UCLA Center for Human Nutrition, UCLA School of Medicine, 900 Veteran Avenue, 12 217 Warren Hall, Los Angeles, CA 90095, USA
    Cancer Res 62:5204-9. 2002
    ..This suggests that the components of this herbal mixture, either independently or in combination, acted in colon cancer, resulting in a drastic effect on tumor initiation and tumor progression...
  75. ncbi request reprint Characterization of human fibrocytes as circulating adipocyte progenitors and the formation of human adipose tissue in SCID mice
    Kurt M Hong
    Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1786, USA
    FASEB J 19:2029-31. 2005
    ....
  76. ncbi request reprint Catechin content of 18 teas and a green tea extract supplement correlates with the antioxidant capacity
    Susanne M Henning
    UCLA Center for Human Nutrition, School of Medicine, Warren Hall 14 166, 900 Veteran Avenue, Los Angeles, CA 90095, USA
    Nutr Cancer 45:226-35. 2003
    ..The large variation in flavanol content and ORAC value among various brands and types of tea provides critical information for investigators using tea in studies of nutrition and cancer prevention...
  77. ncbi request reprint Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis
    Tung H Ngo
    Departments of Physiological Science, University of California, Los Angeles, California 90095 1738, USA
    Clin Cancer Res 9:2734-43. 2003
    ....
  78. ncbi request reprint Bacterial lipopolysaccharide shifts fasted plasma ghrelin to postprandial levels in rats
    Nicole R Basa
    CURE Digestive Diseases Research Center, Digestive Diseases Division, David Geffen School of Medicine and Brain Research Institute, University of California at Los Angeles, Building 115, Room 203, 11301 Wilshire Boulevard, 90073, USA
    Neurosci Lett 343:25-8. 2003
    ..Re-feeding decreased plasma ghrelin levels by 58+/-3% compared with pre-feeding fasting values in i.p. vehicle group. These data provide the first evidence that LPS shifts fasting ghrelin levels to those observed postprandially...
  79. pmc Reduced body weight and adiposity with a high-protein diet improves functional status, lipid profiles, glycemic control, and quality of life in patients with heart failure: a feasibility study
    Lorraine S Evangelista
    School of Nursing, University of California, Los Angeles, CA 90095 6918, USA
    J Cardiovasc Nurs 24:207-15. 2009
    ..The effectiveness of high-protein (HP) diets in reducing body weight and adiposity and potentially improving clinical outcomes in heart failure (HF) is not known...
  80. pmc Nongallated compared with gallated flavan-3-ols in green and black tea are more bioavailable
    Susanne M Henning
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    J Nutr 138:1529S-1534S. 2008
    ..Future intervention studies will need to focus on the bioactivity not only of green tea and BT PP but also of their metabolites and biotransformation products...
  81. pmc Male gender is a predictor of morbidity and age a predictor of mortality for patients undergoing gastric bypass surgery
    Edward H Livingston
    VAMC Greater Los Angeles Health Care System, the UCLA Bariatric Surgery Program, and the UCLA Center for Human Nutrition, Los Angeles, California 90095 6904, USA
    Ann Surg 236:576-82. 2002
    ..To determine preoperative risk factors predictive of adverse outcomes after gastric bypass surgery...
  82. doi request reprint Insulin, hs-CRP, leptin, and adiponectin. An analysis of their relationship to the metabolic syndrome in an obese population with an elevated waist circumference
    Eric Yan
    Center for Human Nutrition, David Geffen School of Medicine, University California, Los Angeles, CA 90095 1742, USA
    Metab Syndr Relat Disord 6:64-73. 2008
    ..The objective of this study was to assess which specific adipose tissue factors would discriminate the presence of MS in a strictly obese population meeting waist circumference (WC) criteria for the MS...
  83. ncbi request reprint LPS inhibits fasted plasma ghrelin levels in rats: role of IL-1 and PGs and functional implications
    Lixin Wang
    CURE Bldg 115, Rm 117B, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 291:G611-20. 2006
    ..These data showed that IL-1 and PG pathways are part of the early mechanisms by which LPS suppresses fasted plasma ghrelin and that exogenous ghrelin can normalize LPS-induced-altered digestive functions...
  84. ncbi request reprint Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Clin Chim Acta 348:63-8. 2004
    ..We conducted in vivo studies whereby a human subject consumed pomegranate juice (PJ) (180 ml) containing EA (25 mg) and ETs (318 mg, as punicalagins, the major fruit ellagitannin)...
  85. ncbi request reprint Health ramifications of the obesity epidemic
    Zhaoping Li
    David Geffen School of Medicine at UCLA, 12 105 Center for Health Sciences, Box 957035, Los Angeles, CA 90095 7035, USA
    Surg Clin North Am 85:681-701, v. 2005
    ..Obesity and overweight account for a significant percentage of overall health care costs and contribute significantly to morbidity and mortality in the United States and around the world...
  86. ncbi request reprint Biexponential model for predicting weight loss after gastric surgery for obesity
    E H Livingston
    Department of Surgery, VA Greater Los Angeles Health Care System, Los Angeles, California 90073, USA
    J Surg Res 101:216-24. 2001
    ..The purpose of this study was to develop a mathematical model that accurately estimates the rate and extent of weight loss following gastric bypass surgery...
  87. ncbi request reprint Feasibility of a partial meal replacement plan for weight loss in low-income patients
    S Huerta
    UCLA Center for Human Nutrition, David Geffen School of Medicine at UCLA, Los Angeles, CA 92801, USA
    Int J Obes Relat Metab Disord 28:1575-9. 2004
    ..FL, USA) in low-income patients over a 6-month period compared with the routine care by their primary care physician (PMD) prior to enrolling in the nutrition clinic at similar time intervals...
  88. ncbi request reprint Implementation of a primary care physician network obesity management program
    S Bowerman
    Center for Human Nutrition, University of California Los Angeles, 90095 1742, USA
    Obes Res 9:321S-325S. 2001
    ..Physicians reported a high degree of satisfaction with the program, suggesting that a brief, effective physician-directed program with nutritionist support by telephone can be implemented in a busy primary care office...
  89. ncbi request reprint Evidence of an inhibitory effect of diet and exercise on prostate cancer cell growth
    C N Tymchuk
    Department of Physiological Science, University of California-Los Angeles, Los Angeles, CA, USA
    J Urol 166:1185-9. 2001
    ..CONCLUSIONS: A low fat, high fiber diet and exercise intervention resulted in serum changes that significantly reduced the growth of androgen responsive LNCaP prostate cancer cells in vitro...
  90. ncbi request reprint Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer
    W J Aronson
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095-1738, USA
    Urology 58:283-8. 2001
    ..The potential for this diet to prevent the development and progression of prostate cancer by way of altered COX-2 expression and prostaglandin production in prostatic tissue requires further study...
  91. ncbi request reprint Insulin-leptin-visceral fat relation during weight loss
    I Yip
    Center for Human Nutrition, School of Medicine, University of California at Los Angeles, 90095 1742, USA
    Pancreas 23:197-203. 2001
    ..The relation between insulin-leptin-visceral fat axis during weight loss has not been studied previously...
  92. ncbi request reprint Long-term efficacy of soy-based meal replacements vs an individualized diet plan in obese type II DM patients: relative effects on weight loss, metabolic parameters, and C-reactive protein
    Z Li
    David Geffen School of Medicine, Center for Human Nutrition, University of California, Los Angeles, CA 90095 1742, USA
    Eur J Clin Nutr 59:411-8. 2005
    ..Achieving significant weight loss and glycemic control in diabetic patients remains a challenging task...
  93. ncbi request reprint Weight cycling in a very low-calorie diet programme has no effect on weight loss velocity, blood pressure and serum lipid profile
    Z Li
    David Geffen School of Medicine at University of California, Los Angeles, UCLA Center for Human Nutrition, Los Angeles, CA 90095, USA
    Diabetes Obes Metab 9:379-85. 2007
    ..Many dieters lose and regain weight many times. It is unclear whether weight cycling is associated with adverse metabolic alterations or becomes more difficult with each attempt...
  94. ncbi request reprint Analysis of weight loss outcomes using VLCD in black and white overweight and obese women with and without metabolic syndrome
    K Hong
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1742, USA
    Int J Obes (Lond) 29:436-42. 2005
    ..To evaluate the efficacy of very low calorie diet (VLCD) in black and white obese women. Changes in weight, metabolic profile, and body composition are assessed...
  95. ncbi request reprint Inverse associations between plasma lycopene and other carotenoids and prostate cancer
    Q Y Lu
    Center for Human Nutrition, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Cancer Epidemiol Biomarkers Prev 10:749-56. 2001
    ..This study provides justification for further research on the associations between lycopene and other antioxidants and the risk of prostate cancer...
  96. ncbi request reprint Decreased growth of human prostate LNCaP tumors in SCID mice fed a low-fat, soy protein diet with isoflavones
    W J Aronson
    Department of Urology, University of California, Los Angeles 90095, USA
    Nutr Cancer 35:130-6. 1999
    ..05). In this xenograft model for prostate cancer, there were statistically significant effects on tumor growth rate and final tumor weight attributable to a low-fat + soy protein + isoflavone extract diet...
  97. ncbi request reprint Feasibility of a low-fat/high-fiber diet intervention with soy supplementation in prostate cancer patients after prostatectomy
    Z Li
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Eur J Clin Nutr 62:526-36. 2008
    ..To evaluate the feasibility and long-term compliance with a low-fat diet supplemented with soy protein in men at increased risk for recurrence after radical prostatectomy...
  98. ncbi request reprint Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement
    D Heber
    Center for Human Nutrition, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095 1742, USA
    Am J Clin Nutr 69:231-6. 1999
    ....
  99. ncbi request reprint Phytoestrogens induce differential estrogen receptor alpha- or Beta-mediated responses in transfected breast cancer cells
    D M Harris
    The UCLA Center for Human Nutrition, 13 145 Warren Hall, 900 Veteran Avenue, Los Angeles, CA 90095 1742, USA
    Exp Biol Med (Maywood) 230:558-68. 2005
    ....
  100. ncbi request reprint Inhibition of fibroblast growth factors by green tea
    Maryam R Sartippour
    Department of Surgery, Division of Oncology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Int J Oncol 21:487-91. 2002
    ..Since cancer is angiogenesis dependent, this may partially explain the antineoplastic effects associated with green tea consumption...
  101. pmc Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    E Elstner
    Division of Hematology Oncology, University of California Los Angeles School of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048 0750, USA
    Proc Natl Acad Sci U S A 95:8806-11. 1998
    ..Taken together, this combination may provide a novel, nontoxic and selective therapy for human breast cancers...

Research Grants2

  1. THE UCLA CLINICAL NUTRITION RESEARCH UNIT
    David Heber; Fiscal Year: 2006
    ..The UCLA CNRU is serving as a regional and national resource at the cutting edge of nutrition and cancer prevention research...
  2. UCLA TRAINING PROGRAM IN NUTRITION AND OBESITY
    David Heber; Fiscal Year: 2007
    ..abstract_text> ..