Ellen Heber-Katz

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Spallanzani's mouse: a model of restoration and regeneration
    E Heber-Katz
    The Wistar Institute, 3602 Spruce Street, Philadelphia, PA 19104, USA
    Curr Top Microbiol Immunol 280:165-89. 2004
  2. ncbi request reprint Sense and antisense transcripts of the apolipoprotein E gene in normal and ApoE knockout mice, their expression after spinal cord injury and corresponding human transcripts
    Alexander Seitz
    The Wistar Institute, Philadelphia, PA 19104, USA
    Hum Mol Genet 14:2661-70. 2005
  3. pmc The scarless heart and the MRL mouse
    Ellen Heber-Katz
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Philos Trans R Soc Lond B Biol Sci 359:785-93. 2004
  4. ncbi request reprint Regeneration in MRL mice: further genetic loci controlling the ear hole closure trait using MRL and M.m. Castaneus mice
    Ellen Heber-Katz
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Wound Repair Regen 12:384-92. 2004
  5. ncbi request reprint Sexually dimorphic genes regulate healing and regeneration in MRL mice
    Elizabeth P Blankenhorn
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA
    Mamm Genome 14:250-60. 2003
  6. pmc Genetic loci that regulate healing and regeneration in LG/J and SM/J mice
    Elizabeth P Blankenhorn
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA gt
    Mamm Genome 20:720-33. 2009
  7. ncbi request reprint Matrix metalloproteinase activity correlates with blastema formation in the regenerating MRL mouse ear hole model
    Dmitri Gourevitch
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Dev Dyn 226:377-87. 2003
  8. pmc Lack of p21 expression links cell cycle control and appendage regeneration in mice
    Khamilia Bedelbaeva
    Cellular and Molecular Oncogenesis and Gene Expression, The Wistar Institute, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:5845-50. 2010
  9. ncbi request reprint Apolipoprotein E expression after spinal cord injury in the mouse
    Alexander Seitz
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Neurosci Res 71:417-26. 2003
  10. ncbi request reprint The MRL mouse heart healing response shows donor dominance in allogeneic fetal liver chimeric mice
    Khamilia Bedelbaeva
    The Wistar Institute, 3400 Spruce St, Philadelphia, PA 19104, USA
    Cloning Stem Cells 6:352-63. 2004

Research Grants

  1. Mapping Murine Regeneation Genes
    ELLEN S HEBER KATZ; Fiscal Year: 2009
  2. Mapping Murine Regeneation Genes
    ELLEN S HEBER KATZ; Fiscal Year: 2009
  3. IMMUNOBIOLOGY AND GENETICS OF WOUND HEALING REGENERATION
    Ellen Heber Katz; Fiscal Year: 2001
  4. Does Inflammation Enhance Rengeneration?
    Phillip B Messersmith; Fiscal Year: 2010

Collaborators

  • Pan Chen
  • Elizabeth P Blankenhorn
  • Yong Zhang
  • Paweł Sachadyn
  • Robert K Naviaux
  • ELLEN S HEBER KATZ
  • Ellen Heber Katz
  • Alexander Seitz
  • Phillip B Messersmith
  • Lise Clark
  • Khamilia Bedelbaeva
  • Dmitri Gourevitch
  • Xiang Ming Zhang
  • John Leferovich
  • Dimitri L Gourevitch
  • John M Leferovich
  • Maja Kragol
  • Elsa Aglow
  • Stefan Jude Samulewicz
  • Kazumi Norose
  • Andrew Snyder
  • James M Cheverud
  • Paul Lieberman
  • Natasha Levenkova
  • Stefan Samulewicz
  • John Rux
  • Stefan J Samulewicz
  • Louise Showe
  • Akihiko Yano

Detail Information

Publications19

  1. ncbi request reprint Spallanzani's mouse: a model of restoration and regeneration
    E Heber-Katz
    The Wistar Institute, 3602 Spruce Street, Philadelphia, PA 19104, USA
    Curr Top Microbiol Immunol 280:165-89. 2004
    ..This does not occur in the control mouse. Function in the MRL heart, as measured by echocardiography, returns to normal...
  2. ncbi request reprint Sense and antisense transcripts of the apolipoprotein E gene in normal and ApoE knockout mice, their expression after spinal cord injury and corresponding human transcripts
    Alexander Seitz
    The Wistar Institute, Philadelphia, PA 19104, USA
    Hum Mol Genet 14:2661-70. 2005
    ..Such data suggest that these alternate transcripts are involved in the molecular pathogenesis of CNS disease and perhaps in ApoE expression in general, as we show that ApoE S2 and AS1 are also transcribed in human...
  3. pmc The scarless heart and the MRL mouse
    Ellen Heber-Katz
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Philos Trans R Soc Lond B Biol Sci 359:785-93. 2004
    ..Studies as to the source of the cells in the regenerating MRL tissue are discussed. Such studies appear to support multiple mechanisms for cell replacement...
  4. ncbi request reprint Regeneration in MRL mice: further genetic loci controlling the ear hole closure trait using MRL and M.m. Castaneus mice
    Ellen Heber-Katz
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Wound Repair Regen 12:384-92. 2004
    ..In addition, we report three new healing QTL. Furthermore, in this strain combination, we note a strong sexual dimorphism also observed in the MRL x C57BL/6 cross, both in the healing trait and in the QTL that control it...
  5. ncbi request reprint Sexually dimorphic genes regulate healing and regeneration in MRL mice
    Elizabeth P Blankenhorn
    Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, Pennsylvania 19129, USA
    Mamm Genome 14:250-60. 2003
    ..Thus, sex plays a highly significant role in the closure of wounded tissue in this mammalian model of healing and regeneration...
  6. pmc Genetic loci that regulate healing and regeneration in LG/J and SM/J mice
    Elizabeth P Blankenhorn
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA gt
    Mamm Genome 20:720-33. 2009
    ....
  7. ncbi request reprint Matrix metalloproteinase activity correlates with blastema formation in the regenerating MRL mouse ear hole model
    Dmitri Gourevitch
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Dev Dyn 226:377-87. 2003
    ..This finding was further supported by enzyme activity as determined by gelatin zymography...
  8. pmc Lack of p21 expression links cell cycle control and appendage regeneration in mice
    Khamilia Bedelbaeva
    Cellular and Molecular Oncogenesis and Gene Expression, The Wistar Institute, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:5845-50. 2010
    ....
  9. ncbi request reprint Apolipoprotein E expression after spinal cord injury in the mouse
    Alexander Seitz
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Neurosci Res 71:417-26. 2003
    ..Early on, the protein can be found in neutrophils and macrophages at the injury site and only at later times in astrocytes during the remodeling of white matter tracts, most prominently in degenerating parts of the fasciculus gracilis...
  10. ncbi request reprint The MRL mouse heart healing response shows donor dominance in allogeneic fetal liver chimeric mice
    Khamilia Bedelbaeva
    The Wistar Institute, 3400 Spruce St, Philadelphia, PA 19104, USA
    Cloning Stem Cells 6:352-63. 2004
    ..These results are in contrast to the ear hole closure response which was of the recipient phenotype. We conclude that, in the case of the heart, fetal liver-derived stem cells regulate regenerative healing...
  11. ncbi request reprint Conjecture: Can continuous regeneration lead to immortality? Studies in the MRL mouse
    Ellen Heber-Katz
    The Wistar Institute, Philadelphia, Pennsylvania, USA
    Rejuvenation Res 9:3-9. 2006
    ..The phenotypes to be examined include the rate of proliferation and the rate of cell death, which leads to a continual turnover in cells without an increase in mass...
  12. pmc Dynamic changes after murine digit amputation: the MRL mouse digit shows waves of tissue remodeling, growth, and apoptosis
    Dimitri L Gourevitch
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 17:447-55. 2009
    ..On the other hand, SW and B6 digits did not show evidence of growth with little mesenchymal BrdU incorporation or phosphorylation of H3...
  13. ncbi request reprint The scarless heart
    John M Leferovich
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Semin Cell Dev Biol 13:327-33. 2002
    ..One exception to this response is the MRL mouse, which heals with little scarring and shows nearly full myocardial replacement after injury. Results obtained with this model will be discussed...
  14. ncbi request reprint Expression of preadipocyte factor-1(Pref-1), a delta-like protein, in healing mouse ears
    Stefan Jude Samulewicz
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Wound Repair Regen 10:215-21. 2002
    ..Pref-1 is more highly expressed in the MRL wounds, is uniquely found in a condensation of cells within the regenerating tissue of the blastema, and may contribute to the regenerative capacity of the MRL ear wound...
  15. pmc Naturally occurring mitochondrial DNA heteroplasmy in the MRL mouse
    Paweł Sachadyn
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Mitochondrion 8:358-66. 2008
    ..The finding of naturally occurring mtDNA heteroplasmy in an inbred strain of mouse makes the MRL mouse a powerful new experimental model for studies designed to explore therapeutic measures to alter the cellular burden of heteroplasmy...
  16. pmc The relationship between inflammation and regeneration in the MRL mouse: potential relevance for putative human regenerative(scarless wound healing) capacities?
    Ellen Heber-Katz
    The Wistar Institute, Philadelphia, Pennsylvania, USA
    Ann N Y Acad Sci 1172:110-4. 2009
    ....
  17. doi request reprint Cell cycle regulation and regeneration
    Ellen Heber-Katz
    Wistar Institute, Philadelphia, PA 19104, USA
    Curr Top Microbiol Immunol 367:253-76. 2013
    ..Whether the same is true for entry into the cell cycle in regenerating urodele limbs is presently unknown...
  18. ncbi request reprint Recovery from spinal cord injury: a new transection model in the C57Bl/6 mouse
    Alexander Seitz
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Neurosci Res 67:337-45. 2002
    ..Such studies suggest a new murine model for the study of spinal cord regeneration...
  19. pmc Mapping of genes involved in murine herpes simplex virus keratitis: identification of genes and their modifiers
    Kazumi Norose
    Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    J Virol 76:3502-10. 2002
    ..Loci on chromosomes 4, 5, 12, 13, and 14 were shown to be involved in general susceptibility to clinical disease, whereas loci on chromosomes 10 and 17 were shown to be unique to ocular disease...

Research Grants10

  1. Mapping Murine Regeneation Genes
    ELLEN S HEBER KATZ; Fiscal Year: 2009
    ..Our study of regenerative healing using the well-defined LGXSM mouse resource enables us to realize the promising potential of this genetically powerful and unique healing model system. ..
  2. Mapping Murine Regeneation Genes
    ELLEN S HEBER KATZ; Fiscal Year: 2009
    ..Our study of regenerative healing using the well-defined LGXSM mouse resource enables us to realize the promising potential of this genetically powerful and unique healing model system. ..
  3. IMMUNOBIOLOGY AND GENETICS OF WOUND HEALING REGENERATION
    Ellen Heber Katz; Fiscal Year: 2001
    ....
  4. Does Inflammation Enhance Rengeneration?
    Phillip B Messersmith; Fiscal Year: 2010
    ..In particular, we will examine the role of implantable "smart" biomaterials that release regeneration-specific drugs under biological control. ..