Research Topics
Species | Rp HebbelSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Differential endothelial cell gene expression by African Americans versus Caucasian Americans: a possible contribution to health disparity in vascular disease and cancerP Wei
Vascular Biology Center, Department of Medicine, Medical School, University of Minnesota, Minneapolis, MN 55455, USA
BMC Med 9:2. 2011....
The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathyRobert P Hebbel
Vascular Biology Center and Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Microcirculation 11:129-51. 2004..Sickle cell anemia is truly an endothelial disease, and it is likely that genetic differences in endothelial function help govern its astonishing phenotypic diversity...- Special issue of Microcirculation: examination of the vascular pathobiology of sickle cell anemia. ForewordRobert P Hebbel
Department of Medicine, University of Medicine, Minneapolis, Minnesota 55455, USA
Microcirculation 11:99-100. 2004 
Reconstructing sickle cell disease: a data-based analysis of the "hyperhemolysis paradigm" for pulmonary hypertension from the perspective of evidence-based medicineRobert P Hebbel
Department of Medicine, Vascular Biology Center, University of Minnesota Medical School, Minneapolis, MN, USA
Am J Hematol 86:123-54. 2011..The extant research questions identified by these analyses are delineated, and a conservative, evidence-based approach is suggested for application in clinical medicine...- Adhesion of sickle red cells to endothelium: myths and future directionsR P Hebbel
Department of Medicine, University of Minnesota, MMC 480, 420 Delaware Street S E, Minneapolis, MN 55455, USA
Transfus Clin Biol 15:14-8. 2008..The relationship of this phenomenon of RBC-endothelial adhesion to the cytoadherence of parasitized sickle RBC is not yet clear... - A systems biology consideration of the vasculopathy of sickle cell anemia: the need for multi-modality chemo-prophylaxsisRobert P Hebbel
Vascular Biology Center and Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Cardiovasc Hematol Disord Drug Targets 9:271-92. 2009..It is proposed here that the specific combination of a statin with suberoylanilide hydroxamic acid would provide a suitable, broad, multi-modality approach to chemo-prophylaxis for sickle vasculopathy... - The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic miceRobert P Hebbel
Vascular Biology Center and the Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Blood 115:2483-90. 2010..We suggest that SAHA possibly could provide true, multimodality, salubrious effects for prevention and treatment of the chronic vasculopathy of sickle cell anemia... - Modulation of endothelial cell activation in sickle cell disease: a pilot studyA A Solovey
Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
Blood 97:1937-41. 2001..This pilot study suggests that endothelial cell activation state can be modified and down-regulated in vivo by sulfasalazine. (Blood. 2001;97:1937-1941).. - Systemic inhibition of tumour angiogenesis by endothelial cell-based gene therapyA Z Dudek
Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Br J Cancer 97:513-22. 2007..These cells maintained an endothelial phenotype and decreased tumour vascularisation and tumour volume in mice. We conclude that BOECs have the potential for tumour-specific delivery of cancer gene therapy... - Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparinK Gupta
Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
Biochim Biophys Acta 1453:63-73. 1999..These data imply that cell surface HS-mediated mechanisms play a key role in TSP-mediated sickle erythrocyte adhesion to endothelium, and heparin may be of use for inhibition of this adhesion... - VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signalingK Gupta
Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, 55455, USA
Exp Cell Res 247:495-504. 1999..Activation of the MAPK pathway together with inhibition of SAPK/JNK activity by VEGF appears to be a key event in determining whether an endothelial cell survives or undergoes programmed cell death... - Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusionJ D Belcher
Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Blood 96:2451-9. 2000..It is speculated that vascular inflammation, marked by activated monocytes and endothelium, plays a significant role in the pathophysiology of vaso-occlusion in sickle cell anemia... - Reperfusion injury pathophysiology in sickle transgenic miceU R Osarogiagbon
Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
Blood 96:314-20. 2000..We suggest that reperfusion injury physiology may contribute to the evolution of the chronic organ damage characteristic of sickle cell disease. If so, novel therapeutic approaches might be of value... - Measuring circulating cell-derived microparticlesW Jy
Wallace H. Coulter Platelet Laboratory, Department of Medicine, University of Miami School of Medicine, Miami, Florida, USA
J Thromb Haemost 2:1842-51. 2004 - Identification and functional assessment of endothelial P1H12A N Solovey
Department of Medicine, University of Minnesota, Minneapolis, USA
J Lab Clin Med 138:322-31. 2001..CD146 thus joins VE-cadherin and PECAM-1 as a molecule that mediates homotypic endothelial cell adhesion. CD146 has both structural functions and signaling functions important for endothelial monolayer integrity... - Nonrandom association of free iron with membranes of sickle and beta-thalassemic erythrocytesT Repka
Department of Medicine, Hennepin County Medical Center, Minneapolis, MN
Blood 82:3204-10. 1993..These results document that free iron is nonrandomly associated with the membranes of sickle and beta-thalassemic RBCs. Whether this plays a causative role in the premature removal of such cells from the circulation remains to be seen... - Nonheme iron in sickle erythrocyte membranes: association with phospholipids and potential role in lipid peroxidationS A Kuross
Department of Medicine, University of Minnesota Medical School, Minneapolis
Blood 72:1278-85. 1988..These data provide additional support for the concept that iron decompartmentalization is a characteristic of sickle RBCs... - Desferrioxamine (DFO) conjugated with starch decreases NAD redox potential of intact red blood cells (RBC): evidence for DFO as an extracellular inducer of oxidant stress in RBCY Niihara
Department of Medicine, Harbor UCLA Medical Center, UCLA School of Medicine, Torrance, California, USA
Am J Hematol 65:281-4. 2000..Conjugation with starch further ensured impermeability of DFO. The data presented here confirm the oxidant effect of DFO on RBC. The data also demonstrate that the effect of DFO on RBC's NAD redox potential originates extracellularly... - Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migrationAmitava Das
Gastroenterology Research Unit, Department of Physiology and Cancer Cell Biology Program, Mayo Clinic, Rochester, Minnesota 55905, USA
J Biol Chem 281:39105-13. 2006..Thus, together, these studies identify a mechanism for antagonizing Sp/KLF protein repression function via SHP, with this process regulating endothelial cell motility... - Semi-supervised learning via penalized mixture model with application to microarray sample classificationWei Pan
Division of Biostatistics, School of Public Health, University of Minnesota, MN, USA
Bioinformatics 22:2388-95. 2006..The penalized mixture model seems to be promising for high-dimensional data with the capability of novel class discovery and automatic feature selection... - Cholesterol-modified polyurethane valve cusps demonstrate blood outgrowth endothelial cell adhesion post-seeding in vitro and in vivoStanley J Stachelek
Department of Pediatrics, The Children's Hospital of Philadelphia, Pennsylvania 19104-4318, USA
Ann Thorac Surg 81:47-55. 2006..CONCLUSIONS: Polyurethane-cholesterol represents a polyurethane formulation with very high adhesive properties for BOECs under heart valve level shear forces both in vitro and in vivo... - Robust vascular protective effect of hydroxamic acid derivatives in a sickle mouse model of inflammationDhananjay K Kaul
Department of Medicine, Albert Einstein College of Medicine, New York, Bronx, USA
Microcirculation 13:489-97. 2006..Thus, these novel compounds offer the advantage of having multiple therapeutic benefits in a single agent... - Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle miceJohn D Belcher
Division of Hematology, Oncology, and Transplantation, Department of Medicine and Vascular Biology Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Clin Invest 116:808-16. 2006..Heme oxygenase-1 plays a vital role in the inhibition of vaso-occlusion in transgenic sickle mice... - Anomalous renal effects of tin protoporphyrin in a murine model of sickle cell diseaseJulio P Juncos
Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Am J Pathol 169:21-31. 2006..These findings suggest that induction of HO-1, at least as assessed by this approach, may contribute to renal injury in this murine model of SCD and uncover an experimental maneuver that protects the kidney in murine SCD... - Critical role of endothelial cell-derived nitric oxide synthase in sickle cell disease-induced microvascular dysfunctionKatherine C Wood
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
Free Radic Biol Med 40:1443-53. 2006.... - Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemiaMary M Lunzer
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 104:6061-5. 2007..The present study suggests that naloxone may be clinically useful in the treatment of pain associated with sickle cell disease and other disorders involving inflammation... - Blood outgrowth endothelial cells as a vehicle for transgene expression of hepatocyte-secreted proteins via Sleeping BeautyBetsy T Kren
Department of Medicine, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Endothelium 14:97-104. 2007..Thus, BOECs have the potential to provide clinically relevant secreted proteins for diseases other than those of endothelial origin... - The establishment of murine blood outgrowth endothelial cells and observations relevant to gene therapyArif Somani
Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
Transl Res 150:30-9. 2007..Furthermore, murine blood outgrowth endothelial cells (BOECs) demonstrated persistent in vivo seeding in the liver, lung, spleen, and bone morrow of recipient mice... - Ex vivo gene therapy for hemophilia A that enhances safe delivery and sustained in vivo factor VIII expression from lentivirally engineered endothelial progenitorsHideto Matsui
Department of Pathology and Molecular Medicine, Queen s University, Kingston, Ontario, Canada
Stem Cells 25:2660-9. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - A practical question based on cross-platform microarray data normalization: are BOEC more like large vessel or microvascular endothelial cells or neither of them?Aixiang Jiang
Division of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University, Nashville, TN 37232, USA
J Bioinform Comput Biol 5:875-93. 2007..Based on all the common genes between the two platforms, SVM analysis further confirmed this conclusion... - Protective effect of arginine on oxidative stress in transgenic sickle mouse modelsTrisha Dasgupta
Department of Medicine, Room U 917, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Free Radic Biol Med 41:1771-80. 2006..Thus, the attenuating effect of arginine on oxidative stress in SCD mice suggests its potential application in the management of this disease... - Genetic endothelial systems biology of sickle stroke riskLiming Chang Milbauer
Vascular Biology Center and Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, and Minneapolis Children s Hospital 55455, USA
Blood 111:3872-9. 2008.... - Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptorsMarc L Weber
Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Am J Physiol Renal Physiol 294:F1388-97. 2008..MS and KOR agonists induced STAT3 phosphorylation, and STAT3 inhibitor blocked KOR agonist-induced MC proliferation. We show that MS stimulates glomerulopathy and MC proliferation via KOR and STAT3 signaling... - Blood outgrowth endothelial cells from Hereditary Haemorrhagic Telangiectasia patients reveal abnormalities compatible with vascular lesionsAfrica Fernandez-L
Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu, 9. Madrid, Spain
Cardiovasc Res 68:235-48. 2005..These features may lead to fragility of small vessels and bleeding characteristic of the HHT vascular dysplasia and to a disrupted and abnormal angiogenesis, which may explain the clinical symptoms associated with this disease... - Polynitroxyl albumin inhibits inflammation and vasoocclusion in transgenic sickle miceHemchandra Mahaseth
Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota, Minneapolis 554455, USA
J Lab Clin Med 145:204-11. 2005..001). Control albumin had no effect on NF-kappaB, VCAM-1, ICAM-1, rolling, adhesion, or vasoocclusion. We speculate that therapies to reduce oxidative stress will inhibit inflammation and vasoocclusion in SCD... - Endothelial cell NADPH oxidase mediates the cerebral microvascular dysfunction in sickle cell transgenic miceKatherine C Wood
Department of Molecular and Cellular Physiology, LSU Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
FASEB J 19:989-91. 2005..These findings suggest that superoxide derived from endothelial cell NADPH-oxidase and catalytically active iron contribute to the proinflammatory and prothrombogenic responses associated with sickle cell disease... - Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemiaOmer Aras
Departments of Medicine (Hematology, Oncology and Transplantation) and Vascular Biology Center, University of Minnesota Medical School, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 103:4545-53. 2004..MP-associated TF PCA was highly correlated with whole-blood TF PCA and total number of circulating MPs, and whole-blood TF PCA was highly correlated with TF mRNA levels... - Sickle hemoglobin instability: a mechanism for malarial protectionRobert P Hebbel
Division of Hematology Oncology and Transplantation, Department of Medicine, and Vascular Biology Center, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Redox Rep 8:238-40. 2003..The mechanism also implicates splenic function as a determinant of the protective effect... - Metabolism of opioids is altered in liver microsomes of sickle cell transgenic miceSwati Nagar
Department of Pharmaceutics, University of Minnesota, 308 Harvard St. S.E, Minneapolis, MN 55455, USA
Drug Metab Dispos 32:98-104. 2004..4- and 2.2-fold greater than in SC and SCKO microsomes. Thus, in vitro metabolism of opioids is altered in SCA mouse models, which may lead to altered clearances of these drugs... - Endothelial cell P-selectin mediates a proinflammatory and prothrombogenic phenotype in cerebral venules of sickle cell transgenic miceKatherine C Wood
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130 3932, USA
Am J Physiol Heart Circ Physiol 286:H1608-14. 2004..These findings indicate that betaS mice assume both an inflammatory and prothrombogenic phenotype, with endothelial cell P-selectin playing a major role in mediating these microvascular responses... - Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytesArun S Shet
Vascular Biology Center, University of Minnesota Medical School, Minneapolis, USA
Blood 102:2678-83. 2003..01 for both). These data support the concept that SCD is an inflammatory state with monocyte and endothelial activation and abnormal TF activity... - Transgenic sickle mice have vascular inflammationJohn D Belcher
Department of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis 55455, USA
Blood 101:3953-9. 2003..006) in NY-S sickle mouse lungs. We conclude that transgenic sickle mice are good models to study vascular inflammation and the potential benefit of anti-inflammatory therapies to prevent vaso-occlusion in sickle cell disease... - Morphine stimulates angiogenesis by activating proangiogenic and survival-promoting signaling and promotes breast tumor growthKalpna Gupta
Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Cancer Res 62:4491-8. 2002..These results indicate that clinical use of morphine could potentially be harmful in patients with angiogenesis-dependent cancers... - Use of blood outgrowth endothelial cells for gene therapy for hemophilia AYi Lin
Department of Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
Blood 99:457-62. 2002..Thus, the use of engineered autologous BOECs, which here resulted in sustained and therapeutic levels of FVIII, may comprise an effective therapeutic strategy for use in gene therapy for hemophilia A... - Anti-inflammatory therapy ameliorates leukocyte adhesion and microvascular flow abnormalities in transgenic sickle miceDhananjay K Kaul
Division of Hematology, Department of Medicine, Albert Einstein College of Medicine, Rm U 917, 1300 Morris Park Ave, Bronx, NY 10461, USA
Am J Physiol Heart Circ Physiol 287:H293-301. 2004..Thus targeting oxidant generation and/or NF-kappaB activation may constitute promising therapeutic approaches in sickle cell disease... - Endothelial cell expression of tissue factor in sickle mice is augmented by hypoxia/reoxygenation and inhibited by lovastatinAnna Solovey
Vascular Biology Center and Divisions of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
Blood 104:840-6. 2004..In addition to identifying tissue expression of endothelial TF in the sickle lung, these studies implicate reperfusion injury physiology in its expression and suggest a rationale for use of statins in sickle disease... - Differential expression of E- and P-selectin in the microvasculature of sickle cell transgenic miceKatherine Wood
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, LA 71130 3932, USA
Microcirculation 11:377-85. 2004.... - Opioids heal ischemic wounds in the ratTasneem Poonawala
Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Wound Repair Regen 13:165-74. 2005..We envision that opioids can be used topically to accelerate wound healing in diverse clinical conditions ranging from surgical incisions to nonhealing ischemic ulcers in pathophysiological conditions and in hospice patients... - Transgenic sickle mice are markedly sensitive to renal ischemia-reperfusion injuryKarl A Nath
Division of Nephrology, Mayo Clinic College of Medicine, 200 First St, SW, Guggenheim 542, Rochester, MN 55905, USA
Am J Pathol 166:963-72. 2005..We conclude that tissues in SCD exhibit heightened vascular congestion and sensitivity to ischemia and that clinically apparent or silent episodes of ischemia may contribute to the complications of SCD... - Circulating endothelial cells. Biomarker of vascular diseaseAndrew D Blann
Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, B18 7QH, UK
Thromb Haemost 93:228-35. 2005..The objective of the present communication is to condense existing data on CECs, briefly compare them with progenitor cells, and summarise possible mechanism(s) by which they may contribute to vascular pathology... - Critical role of endothelial cell activation in hypoxia-induced vasoocclusion in transgenic sickle miceJohn D Belcher
Division of Hematology, Oncology, and Transplantation, Dept of Medicine, Univ of Minnesota, MMC 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
Am J Physiol Heart Circ Physiol 288:H2715-25. 2005..Rebounds in vasoocclusive crises after dexamethasone withdrawal are caused by rebounds in endothelial cell activation... - Microvascular blood flow and stasis in transgenic sickle mice: utility of a dorsal skin fold chamber for intravital microscopyVenkatasubramaniam S Kalambur
Department of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA
Am J Hematol 77:117-25. 2004..01), but not in normal mice, after hypoxia-reoxygenation. Plugs of adherent leukocytes were seen at bifurcations at the beginning of static venules. Misshapen RBCs were also seen in subcutaneous venules... - Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50Yi-Feng Xia
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China
J Immunol 173:4207-17. 2004..Notably, it had no suppressive effect on IkappaBalpha degradation, p50 and p65 nuclear translocation, or cell growth rates. Our results thus reveal a unique pharmacological mechanism of Andro's protective anti-inflammatory actions... - Circulating endothelial cells in pulmonary hypertensionTodd M Bull
Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver, CO 80262, USA
Thromb Haemost 90:698-703. 2003..CECs may provide a non-invasive mean of accessing cells important to the pathobiology of severe pulmonary hypertension... - Cholesterol-derivatized polyurethane: characterization and endothelial cell adhesionStanley J Stachelek
Division of Cardiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA
J Biomed Mater Res A 72:200-12. 2005..56 +/- 0.85% (p < 0.001). It is concluded that covalently linking cholesterol to polyurethane results in improved material properties that permit increased endothelial cell retention compared with unmodified polyurethane... - Spontaneous circulation of myeloid-lymphoid-initiating cells and SCID-repopulating cells in sickle cell crisisChristopher E D Lamming
Stem Cell Institute, Division of Gastroenterology, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Clin Invest 111:811-9. 2003.... - Fibroblast growth factor receptor-1 is expressed by endothelial progenitor cellsPatricia E Burger
Department of Immunology, University of Cape Town, Cape Town, South Africa
Blood 100:3527-35. 2002..These experiments show that FGFR-1 is expressed by a subpopulation of CD34(+) cells that give rise to endothelial cells in vitro, indicating that this population contains endothelial stem/progenitor cells... - Phenotypic correction of von Willebrand disease type 3 blood-derived endothelial cells with lentiviral vectors expressing von Willebrand factorSimon F De Meyer
Laboratory for Thrombosis Research, Catholic University of Leuven, Belgium
Blood 107:4728-36. 2006..These results indicate for the first time that gene therapy of type 3 VWD is feasible and that BOECs are attractive target cells for this purpose... - Local irradiation in combination with bevacizumab enhances radiation control of bone destruction and cancer-induced pain in a model of bone metastasesPawel Zwolak
Department of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Int J Cancer 122:681-8. 2008..We conclude that concurrent antiangiogenic therapy and localized radiotherapy for the treatment of bone metastases warrants further evaluation in human clinical trials...
Research Grants
- ENDOTHELIAL CELL OUTGROWTH FROM BLOODRobert Hebbel; Fiscal Year: 2001..abstract_text> ..
- DEVELOPMENTAL HEMATO-ENDOTHELIAL BIOLOGY OF P1H12Robert Hebbel; Fiscal Year: 2002..These studies represent a first step towards defining the role of P1H12 in embryology, with an emphasis on hematopoiesis and vasculogenesis (as rationalized by exciting preliminary data). ..
- ERYTHROCYTE MEMBRANE ABNORMALITIES IN SICKLE DISEASERobert Hebbel; Fiscal Year: 2002..These studies will rigorously test our hypotheses regarding the participation of TSP and CD36 in mediating sickle RBC adhesion to endothelium. ..
- ERYTHROCYTE MEMBRANE ABNORMALITIES IN SICKLE DISEASERobert Hebbel; Fiscal Year: 1993..Finally, using the exchange transfused rat, we will examine the hypothesis that sickle disease vascular pathobiology has critical features in common with reperfusion injury physiology...
- BOEC in BiologyRobert Hebbel; Fiscal Year: 2005..Aside from eventual therapeutics, these studies will define aspects of this unique cell type. ..