Robert Heaton

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon
    Georgette D Kanmogne
    Department of Pharmacology and Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE, USA
    BMC Neurol 10:60. 2010
  2. ncbi request reprint Further crossvalidation of regression-based neuropsychological norms with an update for the Boston Naming Test
    R K Heaton
    Department of Psychiatry, University of California at San Diego, CA 92103 4910, USA
    J Clin Exp Neuropsychol 21:572-82. 1999
  3. ncbi request reprint Stability and course of neuropsychological deficits in schizophrenia
    R K Heaton
    Department of Psychiatry, University of California, San Diego, 140 Arbor Dr, San Diego, CA 92103, USA
    Arch Gen Psychiatry 58:24-32. 2001
  4. pmc Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China
    Robert K Heaton
    HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
    J Neurovirol 14:536-49. 2008
  5. pmc HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
    Robert K Heaton
    University of California, San Diego, CA, USA
    J Neurovirol 17:3-16. 2011
  6. pmc HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    R K Heaton
    University of California, San Diego, USA
    Neurology 75:2087-96. 2010
  7. ncbi request reprint The impact of neuropsychological functioning and depressed mood on functional complaints in HIV-1 infection and methamphetamine dependence
    Joseph R Sadek
    University of California, San Diego, CA, USA
    J Clin Exp Neuropsychol 29:266-76. 2007
  8. ncbi request reprint The impact of HIV-associated neuropsychological impairment on everyday functioning
    Robert K Heaton
    Department of Psychiatry, University of California at San Diego, and VA San Diego Health Care System, La Jolla, 92093 0603, USA
    J Int Neuropsychol Soc 10:317-31. 2004
  9. pmc Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders
    Abraham Reichenberg
    Department of Psychiatry, Emory University School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Schizophr Bull 35:1022-9. 2009
  10. pmc Variable patterns of neuropsychological performance in HIV-1 infection
    S Dawes
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
    J Clin Exp Neuropsychol 30:613-26. 2008

Research Grants

Detail Information

Publications92

  1. pmc HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon
    Georgette D Kanmogne
    Department of Pharmacology and Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE, USA
    BMC Neurol 10:60. 2010
    ..The objectives of this study were to determine whether Western neuropsychological (NP) methods are appropriate for use in Cameroon, and to evaluate cognitive function in a sample of HIV-infected adults...
  2. ncbi request reprint Further crossvalidation of regression-based neuropsychological norms with an update for the Boston Naming Test
    R K Heaton
    Department of Psychiatry, University of California at San Diego, CA 92103 4910, USA
    J Clin Exp Neuropsychol 21:572-82. 1999
    ..We address this by providing updated norms based on a much larger and more representative sample (N = 531)...
  3. ncbi request reprint Stability and course of neuropsychological deficits in schizophrenia
    R K Heaton
    Department of Psychiatry, University of California, San Diego, 140 Arbor Dr, San Diego, CA 92103, USA
    Arch Gen Psychiatry 58:24-32. 2001
    ..Neuropsychological deficits in schizophrenia appear to predate clinical symptoms of the disease and become more pronounced at illness onset, but controversy exists about whether and when further neuropsychological progression may occur...
  4. pmc Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China
    Robert K Heaton
    HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
    J Neurovirol 14:536-49. 2008
    ..These findings indicate that HAND is likely to be an important feature of HIV infection in developing countries, underscoring the need for international efforts to develop CNS-relevant treatments...
  5. pmc HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
    Robert K Heaton
    University of California, San Diego, CA, USA
    J Neurovirol 17:3-16. 2011
    ..Clinical trials targeting HAND prevention should specifically examine timing of ART initiation...
  6. pmc HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    R K Heaton
    University of California, San Diego, USA
    Neurology 75:2087-96. 2010
    ....
  7. ncbi request reprint The impact of neuropsychological functioning and depressed mood on functional complaints in HIV-1 infection and methamphetamine dependence
    Joseph R Sadek
    University of California, San Diego, CA, USA
    J Clin Exp Neuropsychol 29:266-76. 2007
    ..Additional research is needed to clarify the potentially reciprocal causal relationships between depressive symptoms and impairment in everyday functioning...
  8. ncbi request reprint The impact of HIV-associated neuropsychological impairment on everyday functioning
    Robert K Heaton
    Department of Psychiatry, University of California at San Diego, and VA San Diego Health Care System, La Jolla, 92093 0603, USA
    J Int Neuropsychol Soc 10:317-31. 2004
    ..Finally, there is a need for additional research investigating the apparently independent effect of depression on level of everyday functioning in HIV infected persons...
  9. pmc Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders
    Abraham Reichenberg
    Department of Psychiatry, Emory University School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Schizophr Bull 35:1022-9. 2009
    ..NP normality in psychotic affective disorders has not been systematically studied...
  10. pmc Variable patterns of neuropsychological performance in HIV-1 infection
    S Dawes
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
    J Clin Exp Neuropsychol 30:613-26. 2008
    ..Thus, there does not appear to be a single, prototypical pattern of neuropsychological impairment associated with HIV infection for this battery of representative neuropsychological tests...
  11. ncbi request reprint Work-related abilities in schizophrenia and HIV infection
    Elizabeth W Twamley
    University of California, San Diego, Department of Psychiatry, San Diego, California 92103, USA
    J Nerv Ment Dis 194:268-74. 2006
    ....
  12. pmc Predicting schizophrenia patients' real-world behavior with specific neuropsychological and functional capacity measures
    Christopher R Bowie
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Biol Psychiatry 63:505-11. 2008
    ..This study examined the different predictive relationships between NP domains, functional competence, social competence, symptoms, and real-world behavior in domains of work skills, interpersonal relationships, and community activities...
  13. ncbi request reprint The relationship of neuropsychological abilities to specific domains of functional capacity in older schizophrenia patients
    Jovier D Evans
    Department of Psychiatry, University of California, San Diego, California, USA
    Biol Psychiatry 53:422-30. 2003
    ..This study sought to determine the relative importance of cognitive measures in predicting various domains of everyday functional capacity in older outpatients with schizophrenia...
  14. pmc Methamphetamine use parameters do not predict neuropsychological impairment in currently abstinent dependent adults
    Mariana Cherner
    Department of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0847, USA
    Drug Alcohol Depend 106:154-63. 2010
    ..The apparent lack of correspondence between substance use parameters and cognitive impairment suggests the need for further study of individual differences in vulnerability to the neurotoxic effects of methamphetamine...
  15. ncbi request reprint Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms
    Christopher R Bowie
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 163:418-25. 2006
    ..Assessment of the ability to perform life skills under optimal conditions (i.e., assessment of functional capacity) has been proposed as a means to clarify these relationships...
  16. ncbi request reprint Stability of cognitive performance in older patients with schizophrenia: an 8-week test-retest study
    Philip D Harvey
    Department of Psychiatry, Mt Sinai School of Medicine, New York, NY 10029, USA
    Am J Psychiatry 162:110-7. 2005
    ..There are several factors that could lead to spurious improvements in cognitive test scores, including practice effects and random test-retest errors...
  17. pmc Subjective and objective quality of life in schizophrenia
    Jenille M Narvaez
    University of California, San Diego, Department of Psychiatry, 9500 Gilman Drive 0851, La Jolla, CA 92093, USA
    Schizophr Res 98:201-8. 2008
    ....
  18. pmc Course of neurocognitive deficits in the prodrome and first episode of schizophrenia
    Carol Jahshan
    Joint Doctoral Program in Clinical Psychology, San Diego State University University of California, San Diego, USA
    Neuropsychology 24:109-20. 2010
    ....
  19. pmc Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings
    Mariana Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
    J Int Neuropsychol Soc 16:890-901. 2010
    ..This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury...
  20. ncbi request reprint The 50 and 100-item short forms of the Paced Auditory Serial Addition Task (PASAT): demographically corrected norms and comparisons with the full PASAT in normal and clinical samples
    Michael C Diehr
    College of Business Administration, California State University San Marcos, San Marcos, CA, USA
    J Clin Exp Neuropsychol 25:571-85. 2003
    ..0 vs. 5.9 on a 10-point scale, p < .05). We conclude that in many cases the PASAT-50 and PASAT-100 provide equivalent diagnostic accuracy with a significant reduction in administration time and patient discomfort...
  21. pmc The functional impact of HIV-associated neuropsychological impairment in Spanish-speaking adults: a pilot study
    Monica Rivera Mindt
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 25:122-32. 2003
    ..These results, though preliminary, suggest that Spanish language functional assessments are potentially valid tools for detecting everyday functioning deficits associated with NP impairments in HIV-infected Spanish-speakers...
  22. ncbi request reprint Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findings
    Marianna Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, 92093 0603, USA
    AIDS 18:S27-34. 2004
    ..In a cross-sectional observational study, we compared the neuropsychological profiles of 67 HIV-positive patients aged at least 50 years with those of 52 participants aged 35 years or less...
  23. ncbi request reprint Additive deleterious effects of methamphetamine dependence and immunosuppression on neuropsychological functioning in HIV infection
    Catherine L Carey
    Department of Psychiatry, HIV Neurobehavioral Research Center, San Diego State University and University of California San Diego, 150 W Washington Street, San Diego, CA 92103, USA
    AIDS Behav 10:185-90. 2006
    ....
  24. ncbi request reprint Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDS
    Susanne May
    Division of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, and Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive M C 0717, La Jolla, CA 92093 0717, USA
    J Neuroimmune Pharmacol 2:97-104. 2007
    ..A small pilot study demonstrated the feasibility and acceptability to providers. In conclusion, an innovative design can provide solutions to challenging practical issues in trials with multiple treatment options...
  25. pmc Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals
    Kenny Lin
    University of California San Diego, San Diego, CA 92093, USA
    J Clin Exp Neuropsychol 33:326-34. 2011
    ..One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms...
  26. ncbi request reprint Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection
    Catherine L Carey
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 26:307-19. 2004
    ..71 to 1.00. These findings support the validity of the GDS as a clinically useful way of summarizing results on NP testing...
  27. pmc White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals
    Assawin Gongvatana
    San Diego State University University of California, San Diego, Joint Doctoral Program in Clinical Psychology, San Diego and La Jolla, California, USA
    J Neurovirol 15:187-95. 2009
    ..The study also confirms that CNS injury is evident in persons infected with HIV despite effective antiretroviral treatment...
  28. pmc Neurobehavioral effects of HIV-1 infection in China and the United States: a pilot study
    Lucette A Cysique
    Department of Psychiatry, University of California at San Diego, and VA San Diego Health Care System, La Jolla, California 92093 0603, USA
    J Int Neuropsychol Soc 13:781-90. 2007
    ..To inform the development of such norms, a much larger study of demographic effects will be needed, especially considering the wide range of education in that country...
  29. pmc Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIV
    C A Bousman
    University of California San Diego, HIV Neurobehavioral Research Center, Department of Psychiatry, La Jolla, California 92103, USA
    J Affect Disord 119:84-91. 2009
    ..This study examined the contextual influence of METH, HIV-infection and their combination on mood states and sexual behavior...
  30. ncbi request reprint Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders
    Scott L Letendre
    HIV Neurobehavioral Research Center, University of California at San Diego, San Diego, CA 92103, USA
    Ann Neurol 56:416-23. 2004
    ..Including CSF-penetrating drugs in the ART regimen and monitoring CSF viral load may be indicated for individuals with HIV-associated cognitive impairment...
  31. ncbi request reprint Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV
    Scott Letendre
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0624, USA
    J Infect Dis 196:361-70. 2007
    ..The results support the hypothesis that HCV traffics into the HIV-infected brain, where it might lead to a productive coinfection associated with cognitive impairment...
  32. ncbi request reprint A six-factor model of cognition in schizophrenia and related psychotic disorders: relationships with clinical symptoms and functional capacity
    Julie Akiko Gladsjo
    Department of Psychiatry, University of California, San Diego 92161, USA
    Schizophr Bull 30:739-54. 2004
    ..A simultaneous confirmatory factor analysis using the original sample and a group of healthy subjects (n = 131) demonstrated that the six-factor model of cognition was generalizable and applied equally well to both groups...
  33. ncbi request reprint Methamphetamine dependence increases risk of neuropsychological impairment in HIV infected persons
    Julie D Rippeth
    Department of Psychiatry, University of California, San Diego School of Medicine, San Diego, California, USA
    J Int Neuropsychol Soc 10:1-14. 2004
    ..This additivity may reflect common pathways to neural injury involving both cytotoxic and apoptotic mechanisms...
  34. ncbi request reprint Neurocognitive performance of methamphetamine users discordant for history of marijuana exposure
    Raul Gonzalez
    HIV Neurobehavioral Research Center, University of California, San Diego, 150 W Washington Street, 2nd Floor, San Diego, CA 92103, USA
    Drug Alcohol Depend 76:181-90. 2004
    ..Further investigations are needed to determine if the emerging literature, suggesting that certain cannabinoids might have neuroprotective actions, is generalizable to community-dwelling substance abusers...
  35. ncbi request reprint Recency effects in HIV-associated dementia are characterized by deficient encoding
    J Cobb Scott
    Department of Psychiatry 0847, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Neuropsychologia 44:1336-43. 2006
    ..Interestingly, HAD participants did not evidence significant improvement on measures of recognition, a finding that suggests that the serial position effects are most consistent with a primary encoding deficit...
  36. pmc Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis
    Larry J Seidman
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Gen Psychiatry 67:578-88. 2010
    ..Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset and for testing preventive interventions...
  37. ncbi request reprint HIV suppression by HAART preserves cognitive function in advanced, immune-reconstituted AIDS patients
    J Allen McCutchan
    University of California San Diego, 150 West Washington Street, San Diego, CA 92103, USA
    AIDS 21:1109-17. 2007
    ..Epidemiological observations suggest that neuropsychological impairment might progress despite successful HAART therapy, but available prevalence estimates are based on populations that were selected for impairment...
  38. ncbi request reprint Test-retest reliability of component process variables within the Hopkins Verbal Learning Test-Revised
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego 92103, USA
    Assessment 12:96-100. 2005
    ..g., semantic clustering) in 41 healthy, younger adults. These findings are discussed in relation to issues of clinical practice and research design in neuropsychological assessment...
  39. ncbi request reprint CCR2 polymorphisms affect neuropsychological impairment in HIV-1-infected adults
    Kumud K Singh
    Department of Pediatrics, Division of Infectious Diseases, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0672, USA
    J Neuroimmunol 157:185-92. 2004
    ....
  40. ncbi request reprint Construct validity of Hopkins Verbal Learning Test-Revised component process measures in an HIV-1 sample
    Steven Paul Woods
    HIV Neurobehavioral Research Center, Department of Psychiatry, 0603 H, University of California, San Diego, CA 92103 2005, USA
    Arch Clin Neuropsychol 20:1061-71. 2005
    ....
  41. pmc Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIV
    Steven Paul Woods
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Clin Neuropsychol 25:724-33. 2010
    ....
  42. ncbi request reprint Computerized reaction time battery versus a traditional neuropsychological battery: detecting HIV-related impairments
    Raul Gonzalez
    HIV Neurobehavioral Research Center HNRC, University of California, San Diego, 150 West Washington Street, 2nd Floor, San Diego, CA 92103, USA
    J Int Neuropsychol Soc 9:64-71. 2003
    ..44). Data from this study suggest that traditional NP batteries and computerized reaction time tests do not measure the same thing, and are not interchangeable in examining HIV-related NP impairments...
  43. pmc HIV-associated prospective memory impairment in the laboratory predicts failures on a semi-naturalistic measure of health care compliance
    Jennifer B Zogg
    Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Clin Neuropsychol 24:945-62. 2010
    ..g., depression). Results support the hypothesis that ProM plays a unique role in compliance with health care instructions for HIV disease management and may inform interventions designed to improve treatment outcomes...
  44. ncbi request reprint Retrograde amnesia in dementia: comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease
    Joseph R Sadek
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    Neuropsychology 18:692-9. 2004
    ..The temporally graded pattern and the abnormal cued retrieval performance in the AD group are consistent with a consolidation deficit associated with extrahippocampal (cortical) and hippocampal damage...
  45. pmc Two-year prospective study of major depressive disorder in HIV-infected men
    J Hampton Atkinson
    Department of Psychiatry, University of California San Diego, School of Medicine, La Jolla, California 92093, USA
    J Affect Disord 108:225-34. 2008
    ..This 2-year prospective study compared cumulative rates and predictors of a major depressive episode in HIV-infected (HIV+) men (N=297) and uninfected (HIV-) risk-group controls (N=90)...
  46. ncbi request reprint Transient and executive function working memory in schizophrenia
    Elizabeth W Twamley
    University of California, San Diego, Department of Psychiatry, 140 Arbor Drive, San Diego, CA 92103, USA
    Schizophr Res 87:185-90. 2006
    ..These results do not reflect differential executive function working memory dysfunction in schizophrenia, but appear to support transient and executive function working memory as separable constructs...
  47. pmc Prospective memory in HIV infection: is "remembering to remember" a unique predictor of self-reported medication management?
    Steven Paul Woods
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arch Clin Neuropsychol 23:257-70. 2008
    ..The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration...
  48. ncbi request reprint Interrater reliability of clinical ratings and neurocognitive diagnoses in HIV
    Steven Paul Woods
    University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 26:759-78. 2004
    ..Not surprisingly, most diagnostic disagreements concerned the etiology of impairments in persons with medical and neuropsychiatric risk factors in addition to HIV...
  49. doi request reprint Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER Study
    Ronald J Ellis
    HIV Neurobehavioral Research Center, Department of Neurosciences, University of California, San Diego, San Diego, CA 92103, USA
    Arch Neurol 67:552-8. 2010
    ..To provide updated estimates of the prevalence and clinical impact of human immunodeficiency virus-associated sensory neuropathy (HIV-SN) and neuropathic pain due to HIV-SN in the combination antiretroviral therapy (CART) era...
  50. ncbi request reprint Base rate of Hiscock Digit Memory Test failure in HIV-associated neurocognitive disorders
    Steven Paul Woods
    The HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
    Clin Neuropsychol 17:383-9. 2003
    ..Clinicians can therefore be confident that, in the absence of severe dementia or amnesia, HDMT scores below standard cutoffs are unlikely to be solely attributable to HIV-associated cognitive impairment...
  51. ncbi request reprint Correlation of in vivo neuroimaging abnormalities with postmortem human immunodeficiency virus encephalitis and dendritic loss
    Sarah L Archibald
    Department of Psychiatry, University of California, San Diego, and Veterans Affairs San Diego Healthcare System, La Jolla, 92093, USA
    Arch Neurol 61:369-76. 2004
    ..Although previous studies have linked brain viral levels to these alterations, other neuropathological mechanisms might also contribute to them...
  52. ncbi request reprint Qualitative aspects of verbal fluency in HIV-associated dementia: a deficit in rule-guided lexical-semantic search processes?
    Steven Paul Woods
    HIV Neurobehavioral Research Center, University of California San Diego, 150 West Washington Street, 2nd Floor, San Diego, CA 92103, USA
    Neuropsychologia 42:801-9. 2004
    ..Findings are interpreted as reflecting a disruption of rule-guided lexical-semantic search strategies in HAD, perhaps mediated by prefrontal-striatal circuit dysfunction, rather than depleted lexical-semantic memory stores...
  53. pmc What do we know about neuropsychological aspects of schizophrenia?
    Barton W Palmer
    University of California, San Diego, 9500 Gilman Drive 0603V, La Jolla, CA 92093 0603, USA
    Neuropsychol Rev 19:365-84. 2009
    ....
  54. pmc Select resistance-associated mutations in blood are associated with lower CSF viral loads and better neuropsychological performance
    George K Hightower
    University of California, San Diego, La Jolla, CA 92037, USA
    Virology 394:243-8. 2009
    ..Our study evaluated whether antiretroviral resistance was associated with viral loads in the cerebrospinal fluid (CSF) and better neuropsychological (NP) performance...
  55. ncbi request reprint Initial validation of a screening battery for the detection of HIV-associated cognitive impairment
    Catherine L Carey
    HIV Neurobehavioral Research Center, University of California, San Diego, CA 92103, USA
    Clin Neuropsychol 18:234-48. 2004
    ....
  56. ncbi request reprint Neuropathologic confirmation of definitional criteria for human immunodeficiency virus-associated neurocognitive disorders
    Mariana Cherner
    Departments of Psychiatry, University of California San Diego, San Diego, California 92103, USA
    J Neurovirol 13:23-8. 2007
    ..The modifications to the AAN 1991 criteria proposed by the HNRC and others in the field have served as a point of departure for a recently revised consensus nomenclature...
  57. ncbi request reprint Action (verb) fluency: test-retest reliability, normative standards, and construct validity
    Steven Paul Woods
    HIV Neurobehavioral Research Center, Department of Psychiatry 0603 H, University of California, San Diego, 150 W Washington St, 2nd Floor, San Diego, CA 92103, USA
    J Int Neuropsychol Soc 11:408-15. 2005
    ..In sum, this study enhances the potential clinical applicability of action fluency by providing demographically adjusted normative data and demonstrating evidence for its reliability and construct validity...
  58. ncbi request reprint A battery approach for measuring neuropsychological change
    Steven Paul Woods
    University of California, HIV Neurobehavioral Research Center, Department of Psychiatry 0603 H, 150 West Washington Street, 2nd Floor, San Diego, CA 92103, USA
    Arch Clin Neuropsychol 21:83-9. 2006
    ..Findings from this study may be useful for both clinicians and researchers seeking normative standards for determining reliable changes in performance across a commonly used battery of neuropsychological tests...
  59. ncbi request reprint An evaluation of longitudinal neurocognitive performance among middle-aged and older schizophrenia patients: use of mixed-model analyses
    Gauri Nayak Savla
    San Diego State University University of California, San Diego Joint Doctoral, Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA 92120 4913, USA
    Schizophr Res 83:215-23. 2006
    ..In sum, we found cognitive impairment to be stable over time among outpatients with schizophrenia, regardless of the statistical methodology used to analyze longitudinal data...
  60. ncbi request reprint Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment
    David J Moore
    HIV Neurobehavioral Research Center and University of California, San Diego, California 92161, USA
    AIDS 20:879-87. 2006
    ..To determine the association of markers of regional neurodegeneration (ND) at autopsy to degree of neurocognitive impairment in persons with HIV...
  61. doi request reprint Neuropsychological performance in mainland china: the effect of urban/rural residence and self-reported daily academic skill use
    Saurabh Gupta
    Department of Psychiatry, University of California, San Diego, San Diego, California, USA
    J Int Neuropsychol Soc 17:163-73. 2011
    ..Controlling for academic skill use abrogated most U/R differences but revealed rural advantages in select measures of visual reasoning and motor dexterity...
  62. ncbi request reprint Early environmental factors, ethnicity, and adult cognitive test performance
    Desiree A Byrd
    San Diego State University University of California Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    Clin Neuropsychol 20:243-60. 2006
    ..These results highlight the remaining need for ethnicity specific normative data until cross-cultural variation in neuropsychological test performance is better understood...
  63. ncbi request reprint Heterogeneity in functional status among older outpatients with schizophrenia: employment history, living situation, and driving
    Barton W Palmer
    Department of Psychiatry, University of California, San Diego, 92161, USA
    Schizophr Res 55:205-15. 2002
    ..These findings counter notions that functional impairment is inevitable in older schizophrenia patients, and highlight the importance of assessment of functional skills and possibly targeting them as a treatment focus...
  64. ncbi request reprint Depression and suicidality in HIV/AIDS in China
    Hua Jin
    HIV Neurobehavioral Research Center, University of California at San Diego, 150 W Washington, 2nd Floor, San Diego, CA 92103, USA
    J Affect Disord 94:269-75. 2006
    ..This pilot study examined rates of major depression and suicidality and their associations with daily functioning in HIV infected (HIV+) and uninfected (HIV-) persons in China...
  65. pmc The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infection
    Steven Paul Woods
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 32:398-407. 2010
    ....
  66. ncbi request reprint Deficient strategic control of verbal encoding and retrieval in individuals with methamphetamine dependence
    Steven Paul Woods
    HIV Neurobehavioral Research Center, University of California, San Diego, San Diego, CA 92103, USA
    Neuropsychology 19:35-43. 2005
    ..e., executive) control of verbal encoding and retrieval, which is consistent with the sequelae of MA-related prefronto-striatal circuit neurotoxicity...
  67. ncbi request reprint Generalized cognitive impairments, ability to perform everyday tasks, and level of independence in community living situations of older patients with psychosis
    Elizabeth W Twamley
    UCSD Department of Psychiatry, VA San Diego Healthcare System 116A 1, 3350 La Jolla Village Drive, La Jolla, CA 92161, USA
    Am J Psychiatry 159:2013-20. 2002
    ....
  68. pmc Neurocognitive functioning in acute or early HIV infection
    David J Moore
    Department of Psychiatry, University of California, San Diego UCSD, San Diego, CA, USA
    J Neurovirol 17:50-7. 2011
    ..Although a significant monotonic trend existed and patterns of the data suggest the AEH individuals may fall intermediate to HIV- and chronic participants, we were not able to statistically confirm this hypothesis...
  69. ncbi request reprint Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNA
    Ronald J Ellis
    HIV Neurobehavioral Research Center, University of California, San Diego, 150 W Washington St, 2nd Floor, San Diego, CA 92103, USA
    Arch Neurol 59:923-8. 2002
    ....
  70. ncbi request reprint Incident major depression does not affect neuropsychological functioning in HIV-infected men
    Lucette A Cysique
    Department of Psychiatry, University of California at San Diego, San Diego, California, USA
    J Int Neuropsychol Soc 13:1-11. 2007
    ..Our results suggest that neurocognitive impairment and major depression should be considered as two independent processes...
  71. pmc Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populations
    Davey M Smith
    University of California San Diego, La Jolla, 92093, USA
    Virology 385:204-8. 2009
    ....
  72. pmc Equivalency of Spanish language versions of the trail making test part B including or excluding "CH"
    Mariana Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, California, USA
    Clin Neuropsychol 22:662-5. 2008
    ..The findings suggest that both versions are equivalent and can be administered to Spanish speakers based on their preference without sacrificing comparability...
  73. pmc Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm
    Brook L Henry
    Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Psychopharmacology (Berl) 215:697-707. 2011
    ..Previous work demonstrated that manic bipolar subjects exhibit a disinhibited pattern of behavior in the hBPM characterized by increased object interactions...
  74. ncbi request reprint The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system
    Scott L Letendre
    University of California, 150 W Washington St, San Diego, CA 92103, USA
    J Neuroimmune Pharmacol 2:120-7. 2007
    ..Some of these drugs, such as serotonin reuptake inhibitors (SRIs) and HMG-CoA reductase inhibitors (statins), may do so by reducing HIV replication in the CNS and are already widely used by HIV-infected individuals...
  75. ncbi request reprint Verification of monitor unit calculations for non-IMRT clinical radiotherapy: report of AAPM Task Group 114
    Robin L Stern
    Department of Radiation Oncology, University of California, Davis, Sacramento, California 95817, USA
    Med Phys 38:504-30. 2011
    ..These recommendations are to be used as guidelines only and shall not be interpreted as requirements...
  76. ncbi request reprint The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease
    Scott L Letendre
    Department of Medicine, University of California San Diego, CA 92103, USA
    AIDS 19:S72-8. 2005
    ..To determine the effects of hepatitis C virus (HCV) infection on neuropsychological (NP) performance...
  77. ncbi request reprint Prediction of incident neurocognitive impairment by plasma HIV RNA and CD4 levels early after HIV seroconversion
    Thomas D Marcotte
    Department of Psychiatry, University of California San Diego, 92103, USA
    Arch Neurol 60:1406-12. 2003
    ..Neuropsychological (NP) impairment is a relatively common sequela in human immunodeficiency virus (HIV)-infected individuals with advanced disease. Early antecedents of NP dysfunction, however, remain poorly understood...
  78. ncbi request reprint Psychiatric and neurocognitive disorders among HIV-positive and negative veterans in care: Veterans Aging Cohort Five-Site Study
    Amy C Justice
    Veterans Aging Cohort Study Center, VA Pittsburgh Healthcare System, and University of Pittsburgh Center for Research on Health Care, School of Medicine, Division of General Internal Medicine, Pennsylvania, USA
    AIDS 18:S49-59. 2004
    ..The risk for psychiatric and neurocognitive disorders among middle-aged and older individuals with HIV infection has not been well characterized...
  79. pmc Prospective memory in HIV-1 infection
    Catherine L Carey
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, 92103, USA
    J Clin Exp Neuropsychol 28:536-48. 2006
    ..e., executive) aspects of retrieving future intentions, which is consistent with a prefronto-striatal circuit neuropathogenesis...
  80. ncbi request reprint Rohling's Interpretive Method and inherent limitations on the flexibility of "flexible batteries"
    Barton W Palmer
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0603, USA
    Neuropsychol Rev 14:171-6; discussion 155-69. 2004
    ..As an alternative, we suggest the value of developing and using co-normed comprehensive neuropsychological test batteries from which test users might select subsets of tests...
  81. ncbi request reprint Demographically adjusted normative standards for new indices of performance on the Paced Auditory Serial Addition Task (PASAT)
    Raul Gonzalez
    HIV Neurobehavioral Research Center, University of California, San Diego, CA, USA
    Clin Neuropsychol 20:396-413. 2006
    ....
  82. pmc Assessment of community functioning in people with schizophrenia and other severe mental illnesses: a white paper based on an NIMH-sponsored workshop
    Alan S Bellack
    University of Maryland School of Medicine, 737 West Lombard Street, Suite 551, Baltimore, MD 21201, USA
    Schizophr Bull 33:805-22. 2007
    ..This criterion is problematic because different observers and constituencies often have different opinions about what types of change are clinically important and how much change is significant...
  83. ncbi request reprint Correlations of functional capacity and neuropsychological performance in older patients with schizophrenia: evidence for specificity of relationships?
    Margaret M McClure
    Department of Veterans Affairs, VISN 3 Mental Illness Research, Education, and Clinical Center MIRECC, 130 West Kingsbridge Road Bronx, NY 10468, USA
    Schizophr Res 89:330-8. 2007
    ..This study examined the specificity of the relationships between different NP abilities and performance-based measures of social and living skills...
  84. ncbi request reprint Association between dyads and correct responses on the Paced Auditory Serial Addition Task (PASAT)
    Raul Gonzalez
    University of Illinois, Chicago, IL, USA
    Assessment 13:381-4. 2006
    ..96, p < .001); however, the magnitude of this association diminished in faster stimulus presentation trials, particularly among participants with impaired working memory abilities...
  85. pmc Neuropsychological effects of 2-week continuous positive airway pressure treatment and supplemental oxygen in patients with obstructive sleep apnea: a randomized placebo-controlled study
    Weonjeong Lim
    Department ofPsychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
    J Clin Sleep Med 3:380-6. 2007
    ....
  86. ncbi request reprint Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS
    Michael F Green
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
    Schizophr Res 72:41-51. 2004
    ..These steps are apt to have important implications for clinical trials of cognition-enhancing agents in schizophrenia...
  87. ncbi request reprint Identification of separable cognitive factors in schizophrenia
    Keith H Nuechterlein
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
    Schizophr Res 72:29-39. 2004
    ..These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia...
  88. ncbi request reprint Neurocognitive effects of methamphetamine: a critical review and meta-analysis
    J Cobb Scott
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA 92120, USA
    Neuropsychol Rev 17:275-97. 2007
    ..other substance-related disorders) and neuromedical (e.g., HIV infection) comorbidities. Finally, these findings are discussed with respect to their potential contribution to the clinical management of persons with MA abuse/dependence...
  89. doi request reprint The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity
    Keith H Nuechterlein
    Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
    Am J Psychiatry 165:203-13. 2008
    ....
  90. ncbi request reprint Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria
    Michael F Green
    Neuropsychiatric Institute, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 56:301-7. 2004
    ..The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia...
  91. pmc The relationship between AIDS retinal cotton wool spots and neuropsychological impairment in HIV-positive individuals in the pre-highly active antiretroviral therapy era
    William R Freeman
    Department of Ophthalmology, Shiley Eye Center, University of California San Diego, La Jolla, CA 92093, USA
    Ocul Immunol Inflamm 12:25-33. 2004
    ....
  92. ncbi request reprint Effects of methamphetamine dependence and HIV infection on cerebral morphology
    Terry L Jernigan
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 9151B, USA
    Am J Psychiatry 162:1461-72. 2005
    ..The authors examined the separate and combined effects of methamphetamine dependence and HIV infection on brain morphology...

Research Grants11

  1. Neurobehavioral Effects of HIV & Host Genetics in China
    Robert Heaton; Fiscal Year: 2009
    ..This increased understanding of the clinical significance of these complications and their determinants in China should better inform clinical management of affected populations. ..
  2. FUNCTIONAL IMPACT OF NEUROBEHAVIORAL IMPAIRMENTS IN HIV
    Robert Heaton; Fiscal Year: 2001
    ....