Sonya L Heath

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc CD8 T-cell proliferative capacity is compromised in primary HIV-1 infection
    Sonya L Heath
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 56:213-21. 2011
  2. pmc Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers
    Latonya D Williams
    University of Alabama at Birmingham, Department of Medicine, Birmingham, AL 35294, USA
    J Virol 85:2316-24. 2011
  3. pmc HIV-specific CD8+ T cells from elite controllers are primed for survival
    Jiyu Yan
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Virol 87:5170-81. 2013
  4. ncbi request reprint Functionally competent antigen-specific CD127(hi) memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatment
    Steffanie Sabbaj
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Infect Dis 195:108-17. 2007
  5. pmc Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppression
    Olusimidele T Akinsiku
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 58:132-40. 2011
  6. pmc Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway
    Nathan L Bowers
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Pathog 10:e1003993. 2014

Collaborators

Detail Information

Publications6

  1. pmc CD8 T-cell proliferative capacity is compromised in primary HIV-1 infection
    Sonya L Heath
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 56:213-21. 2011
    ..Furthermore, the heterogeneity of this population suggests that a simple measure of an effective vaccine response remains elusive...
  2. pmc Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers
    Latonya D Williams
    University of Alabama at Birmingham, Department of Medicine, Birmingham, AL 35294, USA
    J Virol 85:2316-24. 2011
    ..Our results demonstrate that HIV-1-specific IL-21-producing CD8 T cells are induced following primary infection and enriched in elite controllers, suggesting a critical role for these cells in the maintenance of viremia control...
  3. pmc HIV-specific CD8+ T cells from elite controllers are primed for survival
    Jiyu Yan
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Virol 87:5170-81. 2013
    ..Furthermore, a better understanding of cellular markers that can be utilized to predict response durability in disease- or vaccine-elicited responses will advance the field...
  4. ncbi request reprint Functionally competent antigen-specific CD127(hi) memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatment
    Steffanie Sabbaj
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Infect Dis 195:108-17. 2007
    ..These studies show that functionally competent subsets of antigen-specific memory CD8+ T cells in HIV-infected individuals are maintained but only if control of viremia is attained early during the course of infection...
  5. pmc Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppression
    Olusimidele T Akinsiku
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 58:132-40. 2011
    ..To further investigate this, we measured the capacity of virus-specific CD8 T cells to inhibit HIV-1 replication in an in vitro suppression assay...
  6. pmc Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway
    Nathan L Bowers
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS Pathog 10:e1003993. 2014
    ..Collectively, the accumulated data suggest that chronic HIV-1 infection results in an induction of immunosuppressive activity of neutrophils characterized by high expression of PD-L1 and an inhibitory effect on T cell function. ..

Research Grants2

  1. Survival Factors Regulating the HIV-Specific Cytotoxic T Lymphocyte Response
    Sonya Heath; Fiscal Year: 2007
    ..Lay Statement- Understanding the effective immune response in HIV infected patients who control virus will help us design better therapeutic and preventative vaccines. ..