Lynn E Heasley

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. pmc Signalling in stem cells: meeting on signal transduction determining the fate of stem cells
    Lynn E Heasley
    Department of Renal Medicine, C 281, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, Colorado 80262, USA
    EMBO Rep 5:241-4. 2004
  2. ncbi request reprint JNK regulation of oncogenesis
    Lynn E Heasley
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Mol Cells 21:167-73. 2006
  3. ncbi request reprint Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma
    Robert A Winn
    Veterans Administration Medical Center, Denver, and Department of Medicine, University of Colorado Health Sciences Center, 80220, USA
    J Biol Chem 281:26943-50. 2006
  4. ncbi request reprint Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB
    Yvette Bren-Mattison
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Box C 281, 4200 East 9th Avenue, Denver, CO 80262, USA
    Mol Pharmacol 73:709-17. 2008
  5. pmc Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1
    Meredith A Tennis
    Department of Medicine, University of Colorado Health Sciences Center, 12700 E 19th Ave, Aurora, CO 80045, USA
    Neoplasia 12:244-53. 2010
  6. ncbi request reprint Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation
    Robert A Winn
    Veterans Affairs Medical Center, Denver, Colorado 80220, USA
    J Biol Chem 280:19625-34. 2005
  7. ncbi request reprint Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells
    Lindsay Marek
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Cell Physiol 201:459-69. 2004
  8. pmc Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9
    Xue Qing Wang
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    Mol Biol Cell 20:791-800. 2009
  9. pmc Inhibited neurogenesis in JNK1-deficient embryonic stem cells
    Claudia R Amura
    Department of Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA
    Mol Cell Biol 25:10791-802. 2005
  10. doi request reprint Analysis of Wnt7a-stimulated JNK activity and cJun phosphorylation in non-small cell lung cancer cells
    Lynn E Heasley
    Department of Medicine, University of Colorado Health Sciences Centre, Denver, USA
    Methods Mol Biol 468:187-96. 2008

Research Grants

  1. Role of JNK Pathway in Lung Tumorigenesis
    Lynn Heasley; Fiscal Year: 2007

Collaborators

Detail Information

Publications19

  1. pmc Signalling in stem cells: meeting on signal transduction determining the fate of stem cells
    Lynn E Heasley
    Department of Renal Medicine, C 281, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Denver, Colorado 80262, USA
    EMBO Rep 5:241-4. 2004
  2. ncbi request reprint JNK regulation of oncogenesis
    Lynn E Heasley
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Mol Cells 21:167-73. 2006
    ..Further illumination of the complex and context-dependent functions of the JNKs in cancer cells is of obvious importance for the rational use of small molecule JNK inhibitors as therapeutics...
  3. ncbi request reprint Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma
    Robert A Winn
    Veterans Administration Medical Center, Denver, and Department of Medicine, University of Colorado Health Sciences Center, 80220, USA
    J Biol Chem 281:26943-50. 2006
    ..These data suggest that ERK5-dependent activation of PPARgamma represents a major effector pathway mediating the anti-tumorigenic effects of Wnt 7a and Fzd 9 in NSCLC...
  4. ncbi request reprint Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB
    Yvette Bren-Mattison
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Box C 281, 4200 East 9th Avenue, Denver, CO 80262, USA
    Mol Pharmacol 73:709-17. 2008
    ..These data indicate that high levels of PGE(2) as a result of elevated COX-2 expression are critical for promoting lung tumorigenesis and that the antitumorigenic effects of PPARgamma are mediated in part through blocking this pathway...
  5. pmc Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1
    Meredith A Tennis
    Department of Medicine, University of Colorado Health Sciences Center, 12700 E 19th Ave, Aurora, CO 80045, USA
    Neoplasia 12:244-53. 2010
    ....
  6. ncbi request reprint Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation
    Robert A Winn
    Veterans Affairs Medical Center, Denver, Colorado 80220, USA
    J Biol Chem 280:19625-34. 2005
    ....
  7. ncbi request reprint Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells
    Lindsay Marek
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Cell Physiol 201:459-69. 2004
    ..Thus, multiple signaling conduits control global differentiation-specific gene expression in PC12 cells...
  8. pmc Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9
    Xue Qing Wang
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    Mol Biol Cell 20:791-800. 2009
    ....
  9. pmc Inhibited neurogenesis in JNK1-deficient embryonic stem cells
    Claudia R Amura
    Department of Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA
    Mol Cell Biol 25:10791-802. 2005
    ..Thus, a genetic approach using JNK-deficient ES cells reveals a novel role for JNK1 involving repression of Wnt expression in neural differentiation modeled in murine ES cells...
  10. doi request reprint Analysis of Wnt7a-stimulated JNK activity and cJun phosphorylation in non-small cell lung cancer cells
    Lynn E Heasley
    Department of Medicine, University of Colorado Health Sciences Centre, Denver, USA
    Methods Mol Biol 468:187-96. 2008
    ..We find that the tight binding of JNKs by their substrate, cJun, provides the basis for a simple and reliable assay for measuring JNK activity in cells stimulated with Wnt proteins and growth factors...
  11. ncbi request reprint Differential gene regulation by specific gain-of-function JNK1 proteins expressed in Swiss 3T3 fibroblasts
    Sun young Han
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:47167-74. 2002
    ..These findings reveal evidence for JNK isoform-selective gene regulation and support a role for distinct JNK isoforms in specific cellular responses...
  12. ncbi request reprint Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growth
    Robert A Winn
    Veterans Administration Medical Center, Denver, Denver, CO 80262, USA
    Chest 125:122S-3S. 2004
  13. ncbi request reprint Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth
    Marilee Wick
    Department of Medicine, University of Colorado Health Science Center, Denver, Colorado 80262, USA
    Mol Pharmacol 62:1207-14. 2002
    ..We propose that PPARgamma serves as a target for NSAIDs that accounts for COX-independent inhibition of lung cancer cell growth...
  14. pmc The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer
    Scott A Kono
    Department of Medicine, University of Colorado at Denver Anschutz Medical Campus, Aurora, CO 80045, USA
    Drug Resist Updat 12:95-102. 2009
    ....
  15. ncbi request reprint gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth
    Robert A Winn
    Veterans Administration Medical Center, Denver, Colorado, CO 80220, USA
    Oncogene 21:7497-506. 2002
    ..This study shows that gamma-catenin can function as an inhibitor of beta-catenin/TCF-dependent gene transcription and highlights gamma-catenin as a potentially novel tumor suppressor protein in a subset of human NSCLC cancers...
  16. ncbi request reprint Collaboration of JNKs and ERKs in nerve growth factor regulation of the neurofilament light chain promoter in PC12 cells
    Eve Zentrich
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 277:4110-8. 2002
    ..Cumulatively, these findings indicate that the ERK pathway requires collaboration with the JNK pathway for maximal activation of the NFLC gene in PC12 cells through the integrated control of c-Jun function...
  17. pmc Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer
    Robert C Doebele
    Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80209, USA
    Clin Cancer Res 18:1472-82. 2012
    ..This study aimed to define molecular mechanisms of resistance to crizotinib in patients with ALK(+) non-small cell lung cancer (NSCLC)...
  18. ncbi request reprint Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells
    Valerie Levresse
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Pharmacol 62:689-97. 2002
    ..The findings indicate that inhibition of the JNK pathway is a potential means to enhance the sensitivity of SCLC cells to platinum compounds...
  19. pmc Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo
    Amy N Abell
    Department of Pharmacology, University of North Carolina, Chapel Hill, 27599 7365, USA
    Mol Cell Biol 25:8948-59. 2005
    ..Together, these data demonstrate MEKK4 regulation of p38 and that substrates downstream of p38 control cellular homeostasis. The findings are the first demonstration that MEKK4-regulated p38 activity is critical for neurulation...

Research Grants2

  1. Role of JNK Pathway in Lung Tumorigenesis
    Lynn Heasley; Fiscal Year: 2007
    ..Furthermore, a detailed understanding of the multi-faceted role of the JNK MAP kinases in lung cancer is absolutely required for rationale and precise therapeutic targeting of this pathway to combat lung cancer. ..