Research Topics
Genomes and Genes | Lynn E HeasleySummaryAffiliation: University of Colorado Health Sciences Center Country: USA Publications
Research Grants
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Publications
Signalling in stem cells: meeting on signal transduction determining the fate of stem cellsLynn E Heasley
Department of Renal Medicine, C-281, University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Denver, Colorado 80262, USA
EMBO Rep 5:241-4. 2004
JNK regulation of oncogenesisLynn E Heasley
Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Mol Cells 21:167-73. 2006..Further illumination of the complex and context-dependent functions of the JNKs in cancer cells is of obvious importance for the rational use of small molecule JNK inhibitors as therapeutics...- Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gammaRobert A Winn
Veterans Administration Medical Center, Denver, and Department of Medicine, University of Colorado Health Sciences Center, 80220, USA
J Biol Chem 281:26943-50. 2006..These data suggest that ERK5-dependent activation of PPARgamma represents a major effector pathway mediating the anti-tumorigenic effects of Wnt 7a and Fzd 9 in NSCLC... - Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaBYvette Bren-Mattison
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Box C 281, 4200 East 9th Avenue, Denver, CO 80262, USA
Mol Pharmacol 73:709-17. 2008..These data indicate that high levels of PGE(2) as a result of elevated COX-2 expression are critical for promoting lung tumorigenesis and that the antitumorigenic effects of PPARgamma are mediated in part through blocking this pathway... - Prostacyclin inhibits non-small cell lung cancer growth by a frizzled 9-dependent pathway that is blocked by secreted frizzled-related protein 1Meredith A Tennis
Department of Medicine, University of Colorado Health Sciences Center, 12700 E 19th Ave, Aurora, CO 80045, USA
Neoplasia 12:244-53. 2010.... - Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiationRobert A Winn
Veterans Affairs Medical Center, Denver, Colorado 80220, USA
J Biol Chem 280:19625-34. 2005.... - Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cellsLindsay Marek
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Cell Physiol 201:459-69. 2004..Thus, multiple signaling conduits control global differentiation-specific gene expression in PC12 cells... - Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9Xue Qing Wang
Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
Mol Biol Cell 20:791-800. 2009.... - Inhibited neurogenesis in JNK1-deficient embryonic stem cellsClaudia R Amura
Department of Medicine, University of Colorado Health Sciences Center, Denver, 80262, USA
Mol Cell Biol 25:10791-802. 2005..Thus, a genetic approach using JNK-deficient ES cells reveals a novel role for JNK1 involving repression of Wnt expression in neural differentiation modeled in murine ES cells... 
Analysis of Wnt7a-stimulated JNK activity and cJun phosphorylation in non-small cell lung cancer cellsLynn E Heasley
Department of Medicine, University of Colorado Health Sciences Centre, Denver, USA
Methods Mol Biol 468:187-96. 2008..We find that the tight binding of JNKs by their substrate, cJun, provides the basis for a simple and reliable assay for measuring JNK activity in cells stimulated with Wnt proteins and growth factors...- Differential gene regulation by specific gain-of-function JNK1 proteins expressed in Swiss 3T3 fibroblastsSun young Han
Department of Pharmacology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 277:47167-74. 2002..These findings reveal evidence for JNK isoform-selective gene regulation and support a role for distinct JNK isoforms in specific cellular responses... - Gamma-catenin expression is reduced or absent in a subset of human non-small cell lung cancers, and its re-expression inhibits cell growthRobert A Winn
Veterans Administration Medical Center, Denver, Denver, CO 80262, USA
Chest 125:122S-3S. 2004 - Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growthMarilee Wick
Department of Medicine, University of Colorado Health Science Center, Denver, Colorado 80262, USA
Mol Pharmacol 62:1207-14. 2002..We propose that PPARgamma serves as a target for NSAIDs that accounts for COX-independent inhibition of lung cancer cell growth... - The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancerScott A Kono
Department of Medicine, University of Colorado at Denver Anschutz Medical Campus, Aurora, CO 80045, USA
Drug Resist Updat 12:95-102. 2009.... - gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growthRobert A Winn
Veterans Administration Medical Center, Denver, Colorado, CO 80220, USA
Oncogene 21:7497-506. 2002..This study shows that gamma-catenin can function as an inhibitor of beta-catenin/TCF-dependent gene transcription and highlights gamma-catenin as a potentially novel tumor suppressor protein in a subset of human NSCLC cancers... - Collaboration of JNKs and ERKs in nerve growth factor regulation of the neurofilament light chain promoter in PC12 cellsEve Zentrich
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
J Biol Chem 277:4110-8. 2002..Cumulatively, these findings indicate that the ERK pathway requires collaboration with the JNK pathway for maximal activation of the NFLC gene in PC12 cells through the integrated control of c-Jun function... - Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancerRobert C Doebele
Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80209, USA
Clin Cancer Res 18:1472-82. 2012..This study aimed to define molecular mechanisms of resistance to crizotinib in patients with ALK(+) non-small cell lung cancer (NSCLC)... - Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cellsValerie Levresse
Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
Mol Pharmacol 62:689-97. 2002..The findings indicate that inhibition of the JNK pathway is a potential means to enhance the sensitivity of SCLC cells to platinum compounds... - Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryoAmy N Abell
Department of Pharmacology, University of North Carolina, Chapel Hill, 27599 7365, USA
Mol Cell Biol 25:8948-59. 2005..Together, these data demonstrate MEKK4 regulation of p38 and that substrates downstream of p38 control cellular homeostasis. The findings are the first demonstration that MEKK4-regulated p38 activity is critical for neurulation...
Research Grants
- Role of JNK Pathway in Lung TumorigenesisLynn Heasley; Fiscal Year: 2007..Furthermore, a detailed understanding of the multi-faceted role of the JNK MAP kinases in lung cancer is absolutely required for rationale and precise therapeutic targeting of this pathway to combat lung cancer. ..