Patrick Heagerty

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Partly conditional survival models for longitudinal data
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B230, P O Box 19024, Seattle, Washington 98109 1024, USA
    Biometrics 61:379-91. 2005
  2. ncbi request reprint Prospective accuracy for longitudinal markers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2 B500, P O Box 19024, Seattle, Washington 98109 1024, USA
    Biometrics 63:332-41. 2007
  3. pmc On outcome-dependent sampling designs for longitudinal binary response data with time-varying covariates
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
    Biostatistics 9:735-49. 2008
  4. pmc Exploration of lagged associations using longitudinal data
    Patrick J Heagerty
    Department of Biostatistics, University of Washington, Seattle, Washington 98105 7232, USA
    Biometrics 69:197-205. 2013
  5. pmc Design, conduct, and analysis of a multicenter, pharmacogenomic, biomarker study in matched patients with severe sepsis treated with or without drotrecogin Alfa (activated)
    Djillali Annane
    Service de Reanimation Medicale, CIC IT805 INSERM, Hôpital R, Poincare AP HP, 104 Bd Raymond Poincaré, 92380, Garches, France
    Ann Intensive Care 2:15. 2012
  6. pmc Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease
    James Ronald
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
    Lipids Health Dis 8:52. 2009
  7. pmc A prospective cohort study of surgical treatment for back pain with degenerated discs; study protocol
    Richard A Deyo
    Department of Medicine, Seattle, Washington 98104, USA
    BMC Musculoskelet Disord 6:24. 2005
  8. pmc Towards standardized measurement of adverse events in spine surgery: conceptual model and pilot evaluation
    Sohail K Mirza
    Center for Cost and Outcomes Research, University of Washington, Seattle, Washington, USA
    BMC Musculoskelet Disord 7:53. 2006
  9. pmc Randomized clinical trial of surgery versus conservative therapy for carpal tunnel syndrome [ISRCTN84286481]
    Brook I Martin
    Department of Medicine, Division of General Internal Medicine, Multidisciplinary Clinical Research Center, Box 359736, 325 Ninth Ave Seattle, Washington 98104, USA
    BMC Musculoskelet Disord 6:2. 2005
  10. pmc Hearing aid effectiveness after aural rehabilitation - individual versus group (HEARING) trial: RCT design and baseline characteristics
    Margaret P Collins
    Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, 1100 Olive Way, Suite 1400, Seattle, WA 98101, USA
    BMC Health Serv Res 9:233. 2009

Research Grants

  1. STATISTICAL METHODS FOR LONGITUDINAL STUDIES
    Patrick Heagerty; Fiscal Year: 2006

Detail Information

Publications76

  1. ncbi request reprint Partly conditional survival models for longitudinal data
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B230, P O Box 19024, Seattle, Washington 98109 1024, USA
    Biometrics 61:379-91. 2005
    ..The proposed methods allow a flexible characterization of the association between a longitudinal covariate process and a survival time, and facilitate the direct prediction of survival probabilities in the time-varying covariate setting...
  2. ncbi request reprint Prospective accuracy for longitudinal markers
    Yingye Zheng
    Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, M2 B500, P O Box 19024, Seattle, Washington 98109 1024, USA
    Biometrics 63:332-41. 2007
    ..We illustrate the new methods by analyzing a well-known data set from HIV research, the Multicenter AIDS Cohort Study data...
  3. pmc On outcome-dependent sampling designs for longitudinal binary response data with time-varying covariates
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232 2158, USA
    Biostatistics 9:735-49. 2008
    ....
  4. pmc Exploration of lagged associations using longitudinal data
    Patrick J Heagerty
    Department of Biostatistics, University of Washington, Seattle, Washington 98105 7232, USA
    Biometrics 69:197-205. 2013
    ..We illustrate the concepts using an example from anemia treatment for dialysis patients and show how linear models can be specified with flexible dependence on exposure and/or outcome histories...
  5. pmc Design, conduct, and analysis of a multicenter, pharmacogenomic, biomarker study in matched patients with severe sepsis treated with or without drotrecogin Alfa (activated)
    Djillali Annane
    Service de Reanimation Medicale, CIC IT805 INSERM, Hôpital R, Poincare AP HP, 104 Bd Raymond Poincaré, 92380, Garches, France
    Ann Intensive Care 2:15. 2012
    ..abstract:..
  6. pmc Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease
    James Ronald
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
    Lipids Health Dis 8:52. 2009
    ....
  7. pmc A prospective cohort study of surgical treatment for back pain with degenerated discs; study protocol
    Richard A Deyo
    Department of Medicine, Seattle, Washington 98104, USA
    BMC Musculoskelet Disord 6:24. 2005
    ..Little is known about how patients undergoing lumbar fusion compare in preoperative physical and psychological function to patients who have degenerative discs, but receive only non-surgical care...
  8. pmc Towards standardized measurement of adverse events in spine surgery: conceptual model and pilot evaluation
    Sohail K Mirza
    Center for Cost and Outcomes Research, University of Washington, Seattle, Washington, USA
    BMC Musculoskelet Disord 7:53. 2006
    ....
  9. pmc Randomized clinical trial of surgery versus conservative therapy for carpal tunnel syndrome [ISRCTN84286481]
    Brook I Martin
    Department of Medicine, Division of General Internal Medicine, Multidisciplinary Clinical Research Center, Box 359736, 325 Ninth Ave Seattle, Washington 98104, USA
    BMC Musculoskelet Disord 6:2. 2005
    ..There is an increasing interest in the usefulness of wrist magnetic resonance imaging could play in predicting who will benefit for various treatments...
  10. pmc Hearing aid effectiveness after aural rehabilitation - individual versus group (HEARING) trial: RCT design and baseline characteristics
    Margaret P Collins
    Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, 1100 Olive Way, Suite 1400, Seattle, WA 98101, USA
    BMC Health Serv Res 9:233. 2009
    ..We describe the rationale, design, and characteristics of the baseline cohort of the first randomized clinical trial to study the impact of group versus individual hearing aid fitting and follow-up visits...
  11. ncbi request reprint Survival model predictive accuracy and ROC curves
    Patrick J Heagerty
    Department of Biostatistics, University of Washington, P O Box 357232, Seattle, Washington 98195 7232, USA
    Biometrics 61:92-105. 2005
    ..Semiparametric estimation methods appropriate for both proportional and nonproportional hazards data are introduced, evaluated in simulations, and illustrated using two familiar survival data sets...
  12. ncbi request reprint Marginalized transition models and likelihood inference for longitudinal categorical data
    Patrick J Heagerty
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 58:342-51. 2002
    ..The methods naturally extend the first-order Markov models of Azzalini (1994, Biometrika 81, 767-775) and prove computationally feasible for long series...
  13. pmc Study protocol: the Back Pain Outcomes using Longitudinal Data (BOLD) registry
    Jeffrey G Jarvik
    Department of Radiology, University of Washington, Seattle, WA, USA
    BMC Musculoskelet Disord 13:64. 2012
    ....
  14. ncbi request reprint Cost-effectiveness of collaborative care for depression in a primary care veteran population
    Chuan Fen Liu
    Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA
    Psychiatr Serv 54:698-704. 2003
    ..This study examined the incremental cost-effectiveness of a collaborative care intervention for depression compared with consult-liaison care...
  15. pmc Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study
    Cara L Carty
    Department of Epidemiology, University of Washington, WA, USA
    J Atheroscler Thromb 16:419-30. 2009
    ..Interaction of the SAA genes with genetic variants of their regulators, IL-1, IL-6 and TNF-alpha in influencing CVD was also explored...
  16. pmc Multi-modality mediastinal staging for lung cancer among medicare beneficiaries
    Farhood Farjah
    Surgical Outcomes Research Center, Department of Surgery, University of Washington, Seattle, WA 98195 6410, USA
    J Thorac Oncol 4:355-63. 2009
    ..It is unknown how frequently multimodality mediastinal staging is used, or whether its use is associated with better health outcomes...
  17. ncbi request reprint The influence of patient preference on depression treatment in primary care
    Patricia Lin
    Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, Seattle, WA 98108, USA
    Ann Behav Med 30:164-73. 2005
    ..The chronic illness model encourages consideration of patients' treatment preferences. Moreover, research suggests that matching treatment to preference might affect outcomes for patients with depression...
  18. ncbi request reprint Semiparametric estimation of time-dependent ROC curves for longitudinal marker data
    Yingye Zheng
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Biostatistics 5:615-32. 2004
    ..1999, Medical Decision Making, 19, 242-251) suggests that the ability to relax distributional assumptions may be important in practice...
  19. ncbi request reprint Marginalized models for moderate to long series of longitudinal binary response data
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biometrics 63:322-31. 2007
    ..Data from the Madras Longitudinal Schizophrenia Study (Thara et al., 1994, Acta Psychiatrica Scandinavica 90, 329-336) are analyzed...
  20. ncbi request reprint Winter respiratory viruses and health care use: a population-based study in the northwest United States
    Kathleen M Neuzil
    Department of Medicine, University of Washington School of Medicine, Seattle, USA
    Clin Infect Dis 37:201-7. 2003
    ..1-1.5) per 1000 low-risk individuals aged 18-49 years, to 10.6 (95% CI, 7.5-13.6) per 1000 high-risk individuals aged >or=65 years. Each year, circulation of influenza and RSV coincide with predictable increases in medical care use...
  21. ncbi request reprint A critical evaluation of critical pathways in head and neck cancer
    Bevan Yueh
    Health Services Research and Development Service, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Arch Otolaryngol Head Neck Surg 129:89-95. 2003
    ..Critical pathways have been purported to decrease resource utilization in the management of head and neck cancer. Prior reports have documented shorter lengths of stay (LOS) for pathway patients than for historical cohorts...
  22. pmc Physical activity, physical exertion, and miscarriage risk in women textile workers in Shanghai, China
    Eva Y Wong
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington, USA
    Am J Ind Med 53:497-505. 2010
    ..Strenuous occupational physical activity and physical demands may be risk factors for adverse reproductive outcomes...
  23. pmc Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms
    Ingegerd Hellstrom
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Cancer Lett 296:43-8. 2010
    ..5% of patients with serous ovarian carcinoma. Assaying serum and urine from the same patients showed similar sensitivity. Our data indicate that measuring HE4 in urine may aid diagnosis and the monitoring of response to therapy...
  24. ncbi request reprint Prediction of diabetic foot ulcer occurrence using commonly available clinical information: the Seattle Diabetic Foot Study
    Edward J Boyko
    Epidemiologic Research and Information Center, VA Puget Sound Health Care System S 152E, 1660 S Columbian Way, Seattle, WA 98108, USA
    Diabetes Care 29:1202-7. 2006
    ..We conducted a prospective study of the individual and combined effects of commonly available clinical information in the prediction of diabetic foot ulcer occurrence...
  25. doi request reprint Development of a predictive model for long-term survival after lung transplantation and implications for the lung allocation score
    Cynthia J Gries
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Heart Lung Transplant 29:731-8. 2010
    ..Validated survival modeling is important for guiding clinical decision-making, case-mix adjustment in comparative effectiveness research and refinement of the lung allocation system (LAS)...
  26. ncbi request reprint TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease
    Christopher S Carlson
    The Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, The University of Washington, Seattle, USA
    J Lipid Res 47:1014-24. 2006
    ....
  27. doi request reprint Development of an index to characterize the "invasiveness" of spine surgery: validation by comparison to blood loss and operative time
    Sohail K Mirza
    Department of Orthopedics and Sports Medicine, Center for Cost and Outcomes Research, and University of Washington, Seattle, WA, USA
    Spine (Phila Pa 1976) 33:2651-61; discussion 2662. 2008
    ..Prospective cohort study...
  28. ncbi request reprint Screening for Auditory Impairment-Which Hearing Assessment Test (SAI-WHAT): RCT design and baseline characteristics
    Bevan Yueh
    Health Services Research and Development Service, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Contemp Clin Trials 28:303-15. 2007
    ..We describe the rationale and design of the first randomized clinical trial to study the long-term effects of routine screening for hearing loss. We also describe the baseline characteristics of the randomized cohort...
  29. pmc Genetic and nongenetic sources of variation in phospholipid transfer protein activity
    Gail P Jarvik
    Department of Medicine Division of Medical Genetics, University of Washington, Seattle, WA, USA
    J Lipid Res 51:983-90. 2010
    ..These results demonstrate that PLTP activity is strongly influenced by PLTP region polymorphisms and metabolic factors...
  30. ncbi request reprint The relationship between electrodiagnostic findings and patient symptoms and function in carpal tunnel syndrome
    Leighton Chan
    Department of Rehabilitation Medicine, University of Washington, Seattle, WA, USA
    Arch Phys Med Rehabil 88:19-24. 2007
    ....
  31. doi request reprint Magnetic resonance imaging compared with electrodiagnostic studies in patients with suspected carpal tunnel syndrome: predicting symptoms, function, and surgical benefit at 1 year
    Jeffrey G Jarvik
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    J Neurosurg 108:541-50. 2008
    ....
  32. doi request reprint Marginal mark regression analysis of recurrent marked point process data
    Benjamin French
    Department of Biostatistics, University of Washington, Seattle, Washington 98195 7232, USA
    Biometrics 65:415-22. 2009
    ..We conclude with the recommendation that analysts carefully explore both the exposure and event time processes prior to implementing a repeated measures analysis of recurrent marked point process data...
  33. doi request reprint Including injured workers without compensated time loss in Cox regression models: analyzing time loss using all available data
    Jeanne M Sears
    Department of Health Services, School of Public Health and Community Medicine, University of Washington, Box 357660, Seattle, WA 98195, USA
    J Occup Rehabil 18:225-32. 2008
    ..We present a novel technique based on standard survival analysis methods to allow for the inclusion of all cases when appropriate...
  34. pmc Analysis of longitudinal data to evaluate a policy change
    Benjamin French
    Department of Biostatistics, University of Washington, Seattle, WA 98195 7232, USA
    Stat Med 27:5005-25. 2008
    ..Analysts must carefully decide which methods are appropriate for their application and must be aware of the differences between methods to select a procedure that generates valid inference...
  35. ncbi request reprint The association between pain and disability
    Judith A Turner
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195 6560, USA
    Pain 112:307-14. 2004
    ....
  36. ncbi request reprint A comparison between audio computer-assisted self-interviews and clinician interviews for obtaining the sexual history
    Ann E Kurth
    Center for AIDS and STD, University of Washington, Seattle, Washington 98195 7266, USA
    Sex Transm Dis 31:719-26. 2004
    ..The objective of this study was to compare reporting between audio computer-assisted self-interview (ACASI) and clinician-administered sexual histories...
  37. ncbi request reprint Vitamin C and E intake is associated with increased paraoxonase activity
    Gail P Jarvik
    Department of Medicine, Division of Medical Genetics, University of Washington 98195, USA
    Arterioscler Thromb Vasc Biol 22:1329-33. 2002
    ..Vitamins C and E, dietary antioxidants, scavenge free-oxygen radical products that may depress PON1 activity. Therefore, we evaluated the relationship between dietary vitamin C and E intake and PON1 activity...
  38. ncbi request reprint The effect of alcohol consumption on the prevalence of iron overload, iron deficiency, and iron deficiency anemia
    George N Ioannou
    Department of Medicine and Division of Gastroenterology, University of Washington Medical Center, and VA Medical Center, 1660 S Columbian Way, Seattle, WA 98108, USA
    Gastroenterology 126:1293-301. 2004
    ..Our aim was to investigate the relationship between alcohol consumption and iron overload, iron deficiency, or iron deficiency anemia in the U.S. population...
  39. ncbi request reprint Directly parameterized regression conditioning on being alive: analysis of longitudinal data truncated by deaths
    Brenda F Kurland
    National Alzheimer s Coordinating Center, University of Washington, 4311 11th Avenue NE 300, Seattle, WA 98105, USA
    Biostatistics 6:241-58. 2005
    ..Simulation studies and an analysis of monthly disability status illustrate potential bias in regression methods that do not explicitly condition on survival...
  40. ncbi request reprint Marginalized transition models for longitudinal binary data with ignorable and non-ignorable drop-out
    Brenda F Kurland
    National Alzheimer s Coordinating Center, University of Washington, Department of Epidemiology, 4311 11th Ave NE 300, Seattle, WA 98105, USA
    Stat Med 23:2673-95. 2004
    ..MTM and IPCW-GEE regression parameters both display misspecification bias for MAR and non-ignorable missing data, and both reduce bias noticeably by improving model fit...
  41. ncbi request reprint Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease
    Gail P Jarvik
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Wash, USA
    Arterioscler Thromb Vasc Biol 23:1465-71. 2003
    ..The effects of paraoxonase (PON1) activity and of genetic variation in the PON1 promoter and coding region on carotid artery disease (CAAD) were investigated...
  42. ncbi request reprint Effect of therapeutic footwear on foot reulceration in patients with diabetes: a randomized controlled trial
    Gayle E Reiber
    VA Puget Sound Health Care System 152, 1660 S Columbian Way, Seattle, WA 98108, USA
    JAMA 287:2552-8. 2002
    ..Many people with diabetes experience lower-limb ulcers. Footwear has been implicated as a primary cause of foot ulcers, yet research is limited on the efficacy of shoe and insert combinations to prevent reulceration...
  43. ncbi request reprint Three-year incidence of low back pain in an initially asymptomatic cohort: clinical and imaging risk factors
    Jeffrey G Jarvik
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    Spine (Phila Pa 1976) 30:1541-8; discussion 1549. 2005
    ..Prospective cohort study of randomly selected Veterans Affairs out-patients without baseline low back pain (LBP)...
  44. ncbi request reprint Colorectal cancer among Asians and Pacific Islanders in the U.S.: survival disadvantage for the foreign-born
    John H Choe
    Department of Medicine, University of Washington School of Medicine, Harborview Medical Center, 325 Ninth Avenue, Box 359780, Seattle, WA 98104, USA
    Cancer Detect Prev 29:361-8. 2005
    ..Asian Americans and Pacific Islanders (AAPI) have better colorectal cancer survival than other racial populations. However, immigrants face challenges that may place them at higher risk for late diagnosis and death...
  45. pmc Interaction between fibrinogen and IL-6 genetic variants and associations with cardiovascular disease risk in the Cardiovascular Health Study
    Cara L Carty
    Department of Epidemiology, University of Washington, Seattle, USA
    Ann Hum Genet 74:1-10. 2010
    ..Although IL-6 responsive binding sites are present in fibrinogen gene promoter regions, we did not find strong evidence of interaction between fibrinogen SNPs and IL6 SNPs or levels influencing CVD...
  46. doi request reprint Statistical approaches to group sequential monitoring of postmarket safety surveillance data: current state of the art for use in the Mini-Sentinel pilot
    Andrea J Cook
    Biostatistics Unit, Group Health Research Institute, Seattle, WA 98101, USA
    Pharmacoepidemiol Drug Saf 21:72-81. 2012
    ....
  47. pmc Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk
    James Ronald
    Department of Medicine, Division of Medical Genetics, University of Washington Medical Center Box 357720, Seattle, WA 98195 7720, USA
    Stroke 42:2-9. 2011
    ..The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown...
  48. ncbi request reprint Validation of case-mix measures derived from self-reports of diagnoses and health
    Vincent S Fan
    Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, Seattle, WA 98108 1597, USA
    J Clin Epidemiol 55:371-80. 2002
    ....
  49. pmc Release from prison--a high risk of death for former inmates
    Ingrid A Binswanger
    Puget Sound Veterans Affairs Medical Center, Seattle, USA
    N Engl J Med 356:157-65. 2007
    ..The period immediately after release may be challenging for former inmates and may involve substantial health risks. We studied the risk of death among former inmates soon after their release from Washington State prisons...
  50. ncbi request reprint TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects
    Christopher S Carlson
    Division of Public Health Sciences, The Fred Hutchinson Cancer Research Center, The University of Washington, Seattle, WA, USA
    Hum Genet 121:65-75. 2007
    ..The NFKBIA and IL10RA expression levels significantly differed between subjects with CAAD and controls. These results support a role for genetic variation related to inflammation in CAAD and a causal role for specific gene products...
  51. ncbi request reprint Regression analysis of longitudinal binary data with time-dependent environmental covariates: bias and efficiency
    Jonathan S Schildcrout
    Department of Biostatistics, Vanderbilt University, S 2323 Medical Center North, Nashville, TN 37232 2158, USA
    Biostatistics 6:633-52. 2005
    ..We find that the impact of covariance model choice depends highly on the specific structure of the data features, and that key aspects should be examined before choosing a weighting scheme...
  52. ncbi request reprint Inflammatory response after influenza vaccination in men with and without carotid artery disease
    Cara L Carty
    University of Washington, Department of Epidemiology, Seattle, Wash, USA
    Arterioscler Thromb Vasc Biol 26:2738-44. 2006
    ..We evaluated whether the APR magnitude in men with severe carotid artery disease (CAAD) (>80% stenosis) differed from that of men without stenosis (<15% stenosis)...
  53. ncbi request reprint Racial differences in the relationship between hepatitis C infection and iron stores
    George N Ioannou
    Department of Medicine and Division of Gastroenterology, University of Washington, Seattle, WA 98195, USA
    Hepatology 37:795-801. 2003
    ..This finding may partly explain the reduced response of HCV-positive African-Americans to antiviral treatment...
  54. ncbi request reprint Marginal modeling of nonnested multilevel data using standard software
    Diana L Miglioretti
    Group Health Center for Health Studies, Seattle, WA 98101, USA
    Am J Epidemiol 165:453-63. 2007
    ..Performance with a small number of clusters is discussed. Both the simulations and the example demonstrate the importance of accounting for the correlation within all levels of clustering for proper inference...
  55. ncbi request reprint Elevated prevalence of hepatitis C infection in users of United States veterans medical centers
    Jason A Dominitz
    Epidemiologic Research and Information Center VA Puget Sound Health Care System, Seattle, WA 98108 1597, USA
    Hepatology 41:88-96. 2005
    ..In conclusion, the prevalence of hepatitis C in these subjects exceeds the estimate from the general US population by more than 2-fold, likely reflecting more exposure to traditional risk factors among these veterans...
  56. doi request reprint Surgery versus non-surgical therapy for carpal tunnel syndrome: a randomised parallel-group trial
    Jeffrey G Jarvik
    Department of Radiology, School of Medicine, University of Washington, Seattle, WA, USA
    Lancet 374:1074-81. 2009
    ..Our aim was to compare surgical versus multi-modality, non-surgical treatment for patients with carpal tunnel syndrome without denervation. We hypothesised that surgery would result in improved functional and symptom outcomes...
  57. pmc Study protocol- Lumbar Epidural steroid injections for Spinal Stenosis (LESS): a double-blind randomized controlled trial of epidural steroid injections for lumbar spinal stenosis among older adults
    Janna L Friedly
    Comparative Effectiveness, Cost and Outcomes Research Center, University of Washington, Seattle, USA
    BMC Musculoskelet Disord 13:48. 2012
    ....
  58. ncbi request reprint Dialectical behavior therapy versus comprehensive validation therapy plus 12-step for the treatment of opioid dependent women meeting criteria for borderline personality disorder
    Marsha M Linehan
    Behavioral Research and Therapy Clinics, Department of Psychology, University of Washington, Box 351525, Seattle, WA 98195 1525, USA
    Drug Alcohol Depend 67:13-26. 2002
    ..A noteworthy secondary finding was that DBT participants were significantly more accurate in their self-report of opiate use than were those assigned to CVT + 12S...
  59. pmc Effectiveness of collaborative care depression treatment in Veterans' Affairs primary care
    Susan C Hedrick
    Health Services Research and Development Center of Excellence, the VA Puget Sound Health Care System, Seattle, Wash 98108, USA
    J Gen Intern Med 18:9-16. 2003
    ..In CL care, study clinicians informed the primary care provider of the diagnosis and facilitated referrals to psychiatry residents practicing in the primary care clinic...
  60. ncbi request reprint VA community-based outpatient clinics: quality of care performance measures
    Ashley N Hedeen
    Health Services Research and Development, Northwest Center for Outcomes Research in Older Adults, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    Med Care 40:570-7. 2002
    ..The Veterans Health Administration (VHA) recently initiated a system of Community-Based Outpatient Clinics (CBOCs) to enhance delivery of primary care to veterans...
  61. pmc A genetic expression profile associated with oral cancer identifies a group of patients at high risk of poor survival
    Eduardo Mendez
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA 98109 1024, USA
    Clin Cancer Res 15:1353-61. 2009
    ..To determine if gene expression signature of invasive oral squamous cell carcinoma (OSCC) can subclassify OSCC based on survival...
  62. doi request reprint Safety and efficacy of video-assisted versus conventional lung resection for lung cancer
    Farhood Farjah
    Department of Surgery, Surgical Outcomes Research Center, University of Washington, Seattle, Wash 98195 6310, USA
    J Thorac Cardiovasc Surg 137:1415-21. 2009
    ..We sought to evaluate the use of video-assisted thoracoscopy among patients with lung cancer and its safety and effectiveness relative to conventional resection...
  63. ncbi request reprint The nationwide frequency of major adverse outcomes in antireflux surgery and the role of surgeon experience, 1992-1997
    David R Flum
    Department of Surgery, University of Washington, Seattle 98195 7183, USA
    J Am Coll Surg 195:611-8. 2002
    ..The population level frequency of adverse events after antireflux procedures and its relationship to surgical experience has not been well studied...
  64. ncbi request reprint Motor cortex organization after stroke is related to side of stroke and level of recovery
    Anna C Zemke
    Department of Neurology, University of Washington, Seattle, USA
    Stroke 34:e23-8. 2003
    ..The present study hypothesized that side of stroke and level of recovery influence motor system organization after stroke...
  65. ncbi request reprint Hospital volume and the outcomes of mechanical ventilation
    Jeremy M Kahn
    Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle 98104, USA
    N Engl J Med 355:41-50. 2006
    ..The relationship between the number of patients admitted (hospital volume) and outcome among patients with critical illnesses is unknown...
  66. ncbi request reprint Safety and acceptability of the Reality condom for anal sex among men who have sex with men
    Cristina Renzi
    Department of Medicine, University of Washington, Seattle 98104, USA
    AIDS 17:727-31. 2003
    ..To assess safety and acceptability of Reality condoms for anal sex among men who have sex with men...
  67. ncbi request reprint Population-based trends in volumes and rates of ambulatory lumbar spine surgery
    Darryl T Gray
    Center for Quality Improvement and Patient Safety, Agency for Healthcare Research and Quality, Rockville, MD 20850, USA
    Spine (Phila Pa 1976) 31:1957-63; discussion 1964. 2006
    ..Sequential cross-sectional study...
  68. pmc INvestigational Vertebroplasty Efficacy and Safety Trial (INVEST): a randomized controlled trial of percutaneous vertebroplasty
    Leigh A Gray
    Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA
    BMC Musculoskelet Disord 8:126. 2007
    ....
  69. ncbi request reprint Marginal modeling of multilevel binary data with time-varying covariates
    Diana L Miglioretti
    Center for Health Studies, Group Health Cooperative, USA
    Biostatistics 5:381-98. 2004
    ..Implications of time-varying endogenous covariates are addressed. The methods are illustrated using data from the Breast Cancer Surveillance Consortium to estimate mammography accuracy from a repeatedly screened population...
  70. ncbi request reprint A common VLDLR polymorphism interacts with APOE genotype in the prediction of carotid artery disease risk
    Dana C Crawford
    Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, TN, USA
    J Lipid Res 49:588-96. 2008
    ..These findings may further our understanding of VLDLR function, its ligand APOE, and ultimately the pathogenesis of CAAD in the general population...
  71. ncbi request reprint Potential confounding by exposure history and prior outcomes: an example from perinatal epidemiology
    Penelope P Howards
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, Maryland 20892, USA
    Epidemiology 18:544-51. 2007
    ..There is no single answer as to whether reproductive history should be included in the model; the decision depends on the research question and the underlying DAG...
  72. ncbi request reprint Apolipoprotein E genotype and neurodevelopmental sequelae of infant cardiac surgery
    J William Gaynor
    Division of Cardiothoracic Surgery, The Children s Hospital of Philadelphia, PA 19104, USA
    J Thorac Cardiovasc Surg 126:1736-45. 2003
    ..Polymorphisms of apolipoprotein E have been identified as a risk factor for worse neurologic recovery after central nervous system injury...
  73. ncbi request reprint Medicaid acceptance and availability of timely follow-up for newborns with Medicaid
    Alison A Galbraith
    Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care, Harvard Medical School, Boston, MA 02215, USA
    Pediatrics 116:1148-54. 2005
    ....
  74. ncbi request reprint Daily weight-bearing activity does not increase the risk of diabetic foot ulcers
    Joseph W Lemaster
    Department of Family and Community Medicine, University of Missouri, Columbia, MO 65212, USA
    Med Sci Sports Exerc 35:1093-9. 2003
    ....
  75. ncbi request reprint Sexual risk, nitrite inhalant use, and lack of circumcision associated with HIV seroconversion in men who have sex with men in the United States
    Susan P Buchbinder
    AIDS Office, San Francisco Department of Public Health, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 39:82-9. 2005
    ..8, PAR = 7%). Having a large number of male sex partners, nitrite inhalant use, and engaging in receptive anal sex explained the majority of infections in this cohort and should be targeted in prevention strategies for MSM...
  76. ncbi request reprint Analysis of repeated pregnancy outcomes
    Germaine Buck Louis
    Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852, USA
    Stat Methods Med Res 15:103-26. 2006
    ..We illustrate the issues by analysing a sample from the Collaborative Perinatal Project dataset, demonstrating how the statistical model impacts summary statistics and inferences when assessing etiologic determinants of birth weight...

Research Grants4

  1. STATISTICAL METHODS FOR LONGITUDINAL STUDIES
    Patrick Heagerty; Fiscal Year: 2006
    ..This aim will develop flexible likelihood-based estimation methods for categorical longitudinal data. ..