Elizabeth Head

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines
    Elizabeth Head
    Department of Molecular and Biomedical Pharmacology and the Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 20:637-46. 2010
  2. doi request reprint Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain
    D Allan Butterfield
    Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Int J Neuropsychopharmacol 15:981-7. 2012
  3. doi request reprint Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease
    Eugenio Barone
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40506 0055, USA
    J Neurochem 120:135-46. 2012
  4. pmc Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome
    Giovanna Cenini
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0055, USA
    Biochim Biophys Acta 1822:130-8. 2012
  5. pmc Coenzyme Q10 and cognition in atorvastatin treated dogs
    Sarah B Martin
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, United States
    Neurosci Lett 501:92-5. 2011
  6. pmc Antioxidants in the canine model of human aging
    Amy L S Dowling
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    Biochim Biophys Acta 1822:685-9. 2012
  7. ncbi request reprint A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease
    Elizabeth Head
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 32:1029-42. 2012
  8. pmc Neurobiology of the aging dog
    Elizabeth Head
    Sanders Brown Center on Aging, Department of Molecular and Biomedical Pharmacology, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536, USA
    Age (Dordr) 33:485-96. 2011
  9. pmc BACE2 expression increases in human neurodegenerative disease
    Christopher J Holler
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    Am J Pathol 180:337-50. 2012
  10. doi request reprint Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs
    M Paul Murphy
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 405360230, USA
    J Alzheimers Dis 22:135-50. 2010

Collaborators

Detail Information

Publications17

  1. pmc Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines
    Elizabeth Head
    Department of Molecular and Biomedical Pharmacology and the Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 20:637-46. 2010
    ....
  2. doi request reprint Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain
    D Allan Butterfield
    Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Int J Neuropsychopharmacol 15:981-7. 2012
    ..HO-1 up-regulation significantly correlated with lower discrimination learning error scores in aged beagles. Reference to therapeutic applications of atorvastatin in AD is discussed...
  3. doi request reprint Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease
    Eugenio Barone
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40506 0055, USA
    J Neurochem 120:135-46. 2012
    ..Furthermore, BVR-A up-regulation and post-translational modifications significantly correlated with β-secretase protein levels in the brain, suggesting a possible role for BVR-A in Aβ formation...
  4. pmc Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome
    Giovanna Cenini
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0055, USA
    Biochim Biophys Acta 1822:130-8. 2012
    ..Conceivably, treatment with antioxidants may provide a point of intervention to slow pathological alterations in DS...
  5. pmc Coenzyme Q10 and cognition in atorvastatin treated dogs
    Sarah B Martin
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, United States
    Neurosci Lett 501:92-5. 2011
    ..CoQ10 levels in brain may be linked to impaired cognition in response to atorvastatin, in agreement with previous reports that statins may have a negative impact on cognition in the elderly...
  6. pmc Antioxidants in the canine model of human aging
    Amy L S Dowling
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA
    Biochim Biophys Acta 1822:685-9. 2012
    ..These data suggest that antioxidants may be beneficial for human brain aging and for AD, particularly as a preventative intervention. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease...
  7. ncbi request reprint A combination cocktail improves spatial attention in a canine model of human aging and Alzheimer's disease
    Elizabeth Head
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536 0230, USA
    J Alzheimers Dis 32:1029-42. 2012
    ..Our results indicate that this medical food cocktail may be beneficial for improving spatial attention and motivation deficits associated with impaired cognition in aging and AD...
  8. pmc Neurobiology of the aging dog
    Elizabeth Head
    Sanders Brown Center on Aging, Department of Molecular and Biomedical Pharmacology, University of Kentucky, 800 South Limestone Street, Lexington, KY 40536, USA
    Age (Dordr) 33:485-96. 2011
    ..Interestingly, the prefrontal cortex appears to be particularly vulnerable early in the aging process in dogs and this may be reflected in dysfunction in specific cognitive domains with age...
  9. pmc BACE2 expression increases in human neurodegenerative disease
    Christopher J Holler
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536 0230, USA
    Am J Pathol 180:337-50. 2012
    ..A better understanding of the normal functions of BACE1 and BACE2, and how these change in different disease states, is essential for the future development of AD therapeutics...
  10. doi request reprint Changes in cognition and amyloid-β processing with long term cholesterol reduction using atorvastatin in aged dogs
    M Paul Murphy
    Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 405360230, USA
    J Alzheimers Dis 22:135-50. 2010
    ....
  11. pmc Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease: a novel mechanism of action
    Eugenio Barone
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, USA
    Pharmacol Res 63:172-80. 2011
    ..Thus, a novel pharmacological effect of atorvastatin mediated by reducing oxidative damage may be one mechanism underlying benefits of this drug in AD...
  12. pmc Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome
    Elizabeth Head
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 40536, USA
    J Alzheimers Dis 23:399-409. 2011
    ..In summary, plasma Aβ can help predict cognitive function in adults with DS independently of the presence or absence of dementia...
  13. doi request reprint A canine model of human aging and Alzheimer's disease
    Elizabeth Head
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, KY 40536, USA
    Biochim Biophys Acta 1832:1384-9. 2013
    ..These interventions can then be translated into human clinical trials. This article is part of a Special Issue entitled: Animal Models of Disease...
  14. pmc Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model
    Sarah B Martin
    Sanders Brown Center on Aging, University of Kentucky, Lexington KY, USA
    Curr Neuropharmacol 9:651-61. 2011
    ..The current review discusses cognition and neuropathology of the aging canine model and how it has and continues to be useful in further understanding the safety and efficacy of potential AD prevention therapies targeting Aβ...
  15. pmc Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies
    Peter T Nelson
    Department of Pathology, University of Kentucky, Lexington, KY 40536 0230, USA
    Acta Neuropathol 121:571-87. 2011
    ..In conclusion, it may be most fruitful to focus attention on specific pathways involved in AD rather than attributing it to an inevitable consequence of aging...
  16. ncbi request reprint Frontal white matter integrity in adults with Down syndrome with and without dementia
    David Powell
    Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky, Lexington, KY, USA
    Neurobiol Aging 35:1562-9. 2014
    ..DS-related WM integrity reductions in a number of tracts were associated with poorer cognition. These preliminary results suggest that late myelinating frontal pathways may be vulnerable to aging in DS. ..
  17. pmc Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease
    Wycliffe O Opii
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, United States
    Neurobiol Aging 29:51-70. 2008
    ..These results support the combination treatments as a possible therapeutic approach that could be translated to the aging human population who are at risk for age-related neurodegenerative disorders, including Alzheimer's disease...