E Head

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Mol Neurodegener 2:18. 2007
  2. ncbi Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention
    E Head
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    J Alzheimers Dis 11:61-76. 2007
  3. ncbi Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome
    Elizabeth Head
    Institute for Brain Aging and Dementia, University of California at Irvine, Irvine, CA 92697 4540, USA
    Neurosci Lett 330:99-103. 2002
  4. ncbi Nutraceuticals, aging, and cognitive dysfunction
    Elizabeth Head
    Institute for Brain Aging and Dementia, University of California at Irvine, 1259 Gillespie NRF, Irvine, CA 92697 4540, USA
    Vet Clin North Am Small Anim Pract 34:217-28. 2004
  5. ncbi Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome
    E Head
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
    J Neuropathol Exp Neurol 62:917-26. 2003
  6. doi Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging
    Elizabeth Head
    Department of Neurology, Institute for Brain Aging and Dementia, University of California, 1259 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4540, USA
    Neurochem Res 34:670-8. 2009
  7. ncbi Down syndrome and beta-amyloid deposition
    Elizabeth Head
    Institute for Brain Aging and Dementia, Department of Neurology, University of California, Irvine, California, USA
    Curr Opin Neurol 17:95-100. 2004
  8. doi A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta
    Elizabeth Head
    Institute for Brain Aging and Dementia, and Department of Neurology, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 28:3555-66. 2008
  9. ncbi Relapsing polychondritis with features of dementia with Lewy bodies
    Elizabeth Head
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Acta Neuropathol 112:217-25. 2006
  10. ncbi Synaptic proteins, neuropathology and cognitive status in the oldest-old
    Elizabeth Head
    Institute of Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Neurobiol Aging 30:1125-34. 2009

Collaborators

Detail Information

Publications87

  1. pmc Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Mol Neurodegener 2:18. 2007
    ..Conformation dependent antibodies have been reported that specifically recognize distinct assembly states of amyloids, including prefibrillar oligomers and fibrils...
  2. ncbi Possible compensatory events in adult Down syndrome brain prior to the development of Alzheimer disease neuropathology: targets for nonpharmacological intervention
    E Head
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    J Alzheimers Dis 11:61-76. 2007
    ..In combination, adults with DS may be a unique group of individuals well-suited for studies involving the manipulation or upregulation of compensatory responses as an approach to promote successful brain aging in the general population...
  3. ncbi Beta-amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome
    Elizabeth Head
    Institute for Brain Aging and Dementia, University of California at Irvine, Irvine, CA 92697 4540, USA
    Neurosci Lett 330:99-103. 2002
    ..Abeta within or around neurons in addition to contributing to NFT formation may also trigger apoptotic pathways. Caspase activation may lead to the cleavage of critical cellular proteins and neuronal cell death associated with DS...
  4. ncbi Nutraceuticals, aging, and cognitive dysfunction
    Elizabeth Head
    Institute for Brain Aging and Dementia, University of California at Irvine, 1259 Gillespie NRF, Irvine, CA 92697 4540, USA
    Vet Clin North Am Small Anim Pract 34:217-28. 2004
    ....
  5. ncbi Parallel compensatory and pathological events associated with tau pathology in middle aged individuals with Down syndrome
    E Head
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
    J Neuropathol Exp Neurol 62:917-26. 2003
    ..Thus, compensatory growth responses may occur in DS prior to extensive AD pathology and may be one mechanism underlying observations in PET studies of hypermetabolism in the entorhinal cortex of individuals with DS...
  6. doi Oxidative damage and cognitive dysfunction: antioxidant treatments to promote healthy brain aging
    Elizabeth Head
    Department of Neurology, Institute for Brain Aging and Dementia, University of California, 1259 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4540, USA
    Neurochem Res 34:670-8. 2009
    ..In combination, antioxidants may be beneficial for promoting healthy brain aging and reducing the risk of neurodegenerative disease...
  7. ncbi Down syndrome and beta-amyloid deposition
    Elizabeth Head
    Institute for Brain Aging and Dementia, Department of Neurology, University of California, Irvine, California, USA
    Curr Opin Neurol 17:95-100. 2004
    ..The purpose of the current review is therefore to summarize developments and advances in our understanding of beta-amyloid pathogenesis in Down syndrome over the past year...
  8. doi A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta
    Elizabeth Head
    Institute for Brain Aging and Dementia, and Department of Neurology, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 28:3555-66. 2008
    ..Alternatively, clearing preexisting Abeta from the brain in a treatment study may be more efficacious for cognition if combined with a second intervention that restores neuron health...
  9. ncbi Relapsing polychondritis with features of dementia with Lewy bodies
    Elizabeth Head
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Acta Neuropathol 112:217-25. 2006
    ..This study demonstrates that qualitatively similar inflammation-associated neurodegeneration is present in widespread regions of the brain in a RP case presenting clinically as DLB...
  10. ncbi Synaptic proteins, neuropathology and cognitive status in the oldest-old
    Elizabeth Head
    Institute of Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Neurobiol Aging 30:1125-34. 2009
    ..Frontal cortex SYN protein levels may protect neuronal function in oldest-old individuals and reflect compensatory responses that may be involved with maintaining cognition...
  11. ncbi Beta-amyloid deposition and tau phosphorylation in clinically characterized aged cats
    E Head
    Department of Neurology, Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Neurobiol Aging 26:749-63. 2005
    ..Thus, the aged cat brain develops AD-related lesions with important morphological and biochemical differences compared to human brain...
  12. ncbi Combining an antioxidant-fortified diet with behavioral enrichment leads to cognitive improvement and reduced brain pathology in aging canines: strategies for healthy aging
    Elizabeth Head
    Institute for Brain Aging and Dementia, Department of Neurology, University of California at Irvine, 1259 Gillespie NRF, Irvine, CA 92697 4540, USA
    Ann N Y Acad Sci 1114:398-406. 2007
    ..These results suggest that modifying lifestyle factors can have a beneficial impact on the aging process, even in aged individuals with existing cognitive decline and brain pathology...
  13. ncbi Oxidative damage increases with age in a canine model of human brain aging
    E Head
    Institute for Brain Aging and Dementia, University of California, Irvine, California 92697 4540, USA
    J Neurochem 82:375-81. 2002
    ..This evidence of widespread oxidative damage and Abeta deposition is further justification for using the canine model for studying human brain aging and neurodegenerative diseases...
  14. ncbi Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta
    Elizabeth Head
    Institute for Brain Aging and Dementia, Department of Neurology, University of California, 1259 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4540, USA
    Vaccine 24:2824-34. 2006
    ..A nonsignificant increase in CSF Abeta(1-40) and decrease in Abeta(1-40/1-42) in cortex was detected. Canines may be a useful system for testing an Abeta vaccine...
  15. ncbi Region-specific age at onset of beta-amyloid in dogs
    E Head
    Institute for Brain Aging and Dementia, University of California, Research Faculty, 1226 Gillespie Neuroscience, Irvine, CA 92697 4540, USA
    Neurobiol Aging 21:89-96. 2000
    ..We propose that these models will be a useful tool to evaluate interventions that delay the age of onset or slow the rate of accumulation of Abeta in the dog...
  16. ncbi Visual-discrimination learning ability and beta-amyloid accumulation in the dog
    E Head
    Institute for Brain Aging and Dementia, University of California, Irvine, 92697 4540, USA
    Neurobiol Aging 19:415-25. 1998
    ..The results of these studies support an association between cognitive test and the location and extent of beta-amyloid pathology...
  17. ncbi Insights into Abeta and presenilin from a canine model of human brain aging
    Elizabeth Head
    Institute for Brain Aging and Dementia, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, California 92697 4540, USA
    Neurobiol Dis 9:1-10. 2002
    ..These in vivo observations suggest a common site for both Abeta and presenilin supporting the hypothesis that the latter is involved with APP processing...
  18. ncbi Initiation and propagation of molecular cascades in human brain aging: insight from the canine model to promote successful aging
    E Head
    Institute for Brain Aging and Dementia, University of California Irvine, 92697 4540, USA
    Prog Neuropsychopharmacol Biol Psychiatry 24:777-86. 2000
    ..The dog can serve as a useful model for interventions during the initiation stage since dogs develop neuropathology that closely resembles that observed in high pathology human brains...
  19. ncbi Clinical and pathological evidence for a frontal variant of Alzheimer disease
    J K Johnson
    Institute for Brain Aging and Dementia, University of California at Irvine, 92697 4285, USA
    Arch Neurol 56:1233-9. 1999
    ..We hypothesized that these patients would exhibit a greater degree of either neurofibrillary tangle (NFT) or senile plaque pathology in the frontal lobes than would patients with typical AD...
  20. pmc Correlation between caspase activation and neurofibrillary tangle formation in Alzheimer's disease
    T T Rohn
    Institute for Brain Aging and Dementia, University of California at Irvine, 92697-4540, USA
    Am J Pathol 158:189-98. 2001
    ..84). Taken together, these results provide evidence for the activation of apoptotic mechanisms in neurons in the AD brain and suggest that there is an association between NFT formation and the activation of apoptotic pathways in AD...
  21. ncbi Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging
    M Y Su
    Health Sciences Research Imaging Center, University of California, Irvine 92697, USA
    Neurobiol Aging 19:479-85. 1998
    ..These findings indicate that BBB dysfunction detected by magnetic resonance imaging may be useful for predicting and potentially diagnosing early pathological conditions...
  22. ncbi Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome
    E Head
    Institute for Brain Aging and Dementia, University of California, Irvine, California 92697-4540, USA
    Neurobiol Dis 8:252-65. 2001
    ..C1q-positive neurons were associated with activated microglia. These results provide evidence for Abeta-mediated inflammatory factors contributing to the rapid accumulation of neuropathology in DS brain...
  23. pmc Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging
    E Head
    Institute for Brain Aging and Dementia, Department of Neurology, University of California, Irvine, CA, USA
    Exp Neurol 220:171-6. 2009
    ..These results suggest that an antioxidant diet improves cognition by maintaining mitochondrial homeostasis, which may be an independent molecular pathway not engaged by behavioral enrichment...
  24. pmc Neuroimaging of individuals with Down's syndrome at-risk for dementia: evidence for possible compensatory events
    R J Haier
    Department of Pediatrics, University of California, Irvine 92697 4475, USA
    Neuroimage 39:1324-32. 2008
    ..We report functional and structural brain indicators that may precede the onset of dementia in individuals with Down's syndrome (DS)...
  25. ncbi Down syndrome and Alzheimer's disease: a link between development and aging
    I T Lott
    Department of Pediatrics, University of California, Irvine, Orange, CA 92868, USA
    Ment Retard Dev Disabil Res Rev 7:172-8. 2001
    ..Study of the process by which AD evolves in DS affords an opportunity to understand an important link between development and aging. This review will focus on advances in the molecular and clinical basis of this association...
  26. pmc Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice
    Irina Petrushina
    The Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
    J Neurosci 27:12721-31. 2007
    ....
  27. ncbi Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia
    R J Haier
    Department of Pediatrics, University of California, Irvine 92697 5000, USA
    Neurology 61:1673-9. 2003
    ....
  28. ncbi The canine as an animal model of human aging and dementia
    B J Cummings
    Brain Aging Institute, University of California, Irvine 92717 4540, USA
    Neurobiol Aging 17:259-68. 1996
    ..These data indicate that the aged canine is a particularly useful model for studying age-related cognitive dysfunction (ARCD), early neuronal changes associated with aging, and the initial stages of senile plaque formation...
  29. ncbi Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome
    E Head
    Institute for Brain Aging and Dementia, University of California, Irvine, California, 92697-4540, USA
    Neurobiol Dis 8:792-806. 2001
    ..Oxidatively modified Abeta may reflect the efforts of microglial cells to take up and degrade Abeta. Oxidative modification of Abeta may be an early event in Abeta pathogenesis and may be important for plaque biogenesis...
  30. pmc Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines
    Viorela Pop
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
    J Neurosci 30:9831-9. 2010
    ..Overall, the data indicate that multidomain treatments may be a valuable intervention strategy to reduce neuropathology and improve cognitive function in humans...
  31. pmc Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid
    Jiankang Liu
    Division of Biochemistry and Molecular Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:2356-61. 2002
    ..These results suggest that feeding ALCAR and LA to old rats improves performance on memory tasks by lowering oxidative damage and improving mitochondrial function...
  32. ncbi The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches
    Carl W Cotman
    Institute for Brain Aging and Dementia, Department of Neurology, University of California, Irvine, CA 92697 4540, USA
    J Alzheimers Dis 15:685-707. 2008
    ..In addition, combinatorial treatment approaches can be a powerful strategy for improving brain function through enhancement of multiple molecular pathways...
  33. ncbi Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease
    Ming Zhao
    Institute for Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 4540, USA
    Neurobiol Dis 14:391-403. 2003
    ..These findings raise the possibility that the activation of caspase-3 and cleavage of APP may be involved with neuronal degeneration and that pathways characteristic of apoptosis are activated in AD...
  34. ncbi ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons
    Pablo Helguera
    Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697 4550, USA
    J Neurosci 25:2295-303. 2005
    ....
  35. pmc Oxidative stress, aging, and central nervous system disease in the canine model of human brain aging
    Elizabeth Head
    Institute for Brain Aging and Dementia, Department of Neurology, University of California at Irvine, 1259 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4540, USA
    Vet Clin North Am Small Anim Pract 38:167-78, vi. 2008
    ..Reducing oxidative damage through food ingredients rich in a broad spectrum of antioxidants significantly improves, or slows the decline of, learning and memory in aged dogs...
  36. pmc Isolated executive impairment and associated frontal neuropathology
    Julene K Johnson
    Department of Neurology and Memory and Aging Center, University of California, San Francisco, Calif, USA
    Dement Geriatr Cogn Disord 17:360-7. 2004
    ....
  37. pmc A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain
    Floyd Sarsoza
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697, USA
    Acta Neuropathol 118:505-17. 2009
    ....
  38. ncbi Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging
    P Dwight Tapp
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, 164 Irvine Hall, Irvine, CA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:399-406. 2005
    ....
  39. ncbi Open field activity and human interaction as a function of age and breed in dogs
    E Head
    University of Toronto, Scarborough College, Division of Life Sciences, Ontario, Canada
    Physiol Behav 62:963-71. 1997
    ..These findings indicate that OF activity is age-sensitive in dogs, but that breed and test conditions are also essential factors...
  40. pmc Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles
    Lori Ann Christie
    Institute for Brain Aging and Dementia, University of California, Irvine, California 92697 4540, USA
    Exp Gerontol 44:752-9. 2009
    ....
  41. pmc Region specific neuron loss in the aged canine hippocampus is reduced by enrichment
    Christina T Siwak-Tapp
    Institute for Brain Aging and Dementia, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4540, USA
    Neurobiol Aging 29:39-50. 2008
    ..These results suggest that the aged canine hippocampus in the left hemisphere shows selective neuron loss and that behavioral enrichment may reduce this loss...
  42. ncbi Beta-amyloid, oxidative stress and down syndrome
    Ira T Lott
    Department of Pediatrics and Neurology, Alzheimer Disease Research Center, University of California, Irvine, School of Medicine, Irvine, California 92868, USA
    Curr Alzheimer Res 3:521-8. 2006
    ..Since the pathological processes leading to AD are seen across the lifespan in DS, an opportunity is afforded for early pharmacological intervention in the disorder...
  43. pmc Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta
    Vitaly Vasilevko
    The Institute for Memory Impairments and Neurological Disorders, University of California, Irvine 92697 4540, USA
    Neurobiol Dis 39:301-10. 2010
    ..Our findings indicate that prolonged immunization results in distinctive temporal changes in antibody profiles, which may be important for other experimental and clinical settings...
  44. pmc Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function
    Christina T Siwak-Tapp
    Institute for Brain Aging and Dementia, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4540, USA
    Neurobiol Learn Mem 88:249-59. 2007
    ..These results suggest that new neurons in the aged canine dentate gyrus may participate in modulating cognitive functions...
  45. pmc Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype
    Daniel J Berlau
    Institute of Brain Aging and Dementia, University of California, Irvine, 1515 Hewitt Hall, Irvine, CA 92697 1400, USA
    Arch Neurol 64:1193-6. 2007
    ..The apolipoprotein E (APOE) epsilon2 allele has been suggested as having a protective effect and delaying the age at onset of Alzheimer disease...
  46. ncbi Immunotherapy in a natural model of Abeta pathogenesis: the aging beagle
    Vitaly Vasilevko
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    CNS Neurol Disord Drug Targets 8:98-113. 2009
    ..We propose that the canine model complements existing animal models and will be helpful in developing new vaccine approaches to slowing or preventing Abeta pathology that can be translated to human clinical trials...
  47. pmc APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old
    Daniel J Berlau
    Institute of Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 1400, USA
    Neurology 72:829-34. 2009
    ..This would predict, even with advanced age, that APOE2 carriers would be less likely to have dementia and less likely to meet pathologic criteria for AD...
  48. doi Rhinal and dorsolateral prefrontal cortex lesions produce selective impairments in object and spatial learning and memory in canines
    Lori Ann Christie
    Institute for Brain Aging and Dementia, University of California, Irvine, Irvine, California 92697 4540, USA
    J Comp Neurol 511:257-70. 2008
    ....
  49. pmc Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Mol Neurodegener 5:57. 2010
    ..Recent evidence suggests that soluble amyloid oligomers and not the insoluble amyloid fibrils may represent the primary pathological species of protein aggregates...
  50. ncbi Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging
    P Dwight Tapp
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, 164 Irvine Hall, Irvine, CA 92697 5020, USA
    Neuroimage 29:234-44. 2006
    ....
  51. ncbi Learning and memory as a function of age in Down syndrome: a study using animal-based tasks
    Linda Nelson
    Department of Neurology, University of California, Irvine, Medical Center, 101 City Drive, Route 81, Building 53, Room 225, Orange, CA 92868, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:443-53. 2005
    ..These changes may reflect prefrontal and medial temporal lobe dysfunction that is associated with the development of AD pathology in DS...
  52. ncbi BioVision: an application for the automated image analysis of histological sections
    Charles Chubb
    Department of Cognitive Sciences, and Institute for Mathematical Behavioral Sciences, University of California, Irvine, USA
    Neurobiol Aging 27:1462-76. 2006
    ..The tangle counts produced by BioVision proved to be significantly better predictors of the cases' adjusted MMSE scores than any of tangle load, age at death, post mortem interval or the interval between the last MMSE score and death...
  53. ncbi A longitudinal study of brain morphometrics using serial magnetic resonance imaging analysis in a canine model of aging
    Min Ying Su
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California Irvine, CA 92697 5020, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:389-97. 2005
    ..These lesion findings are consistent with other studies in the aging dog that suggest that the frontal lobes may be particularly vulnerable to age-related changes...
  54. ncbi Spatial patterns of mammalian brain aging: distribution of cathepsin D-immunoreactive cell bodies and dystrophic dendrites in aging dogs resembles that in Alzheimer's disease
    Xiaoning Bi
    Department of Psychiatry and Human Behavior, University of California at Irvine, Irvine, California 92697, USA
    J Comp Neurol 464:371-81. 2003
    ..Combined with previous results for rats, these findings indicated that changes in cathepsin D observed in AD, in particular in the temporal lobe, reflect a generalized mammalian pattern of brain aging...
  55. ncbi Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction
    Carl W Cotman
    Institute for Brain Aging and Dementia, University of California, 1226 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4540, USA
    Neurobiol Aging 23:809-18. 2002
    ..Thus, studies in the canine model suggest that oxidative damage impairs cognitive function and that antioxidant treatment can result in significant improvements, supporting the need for further human studies...
  56. ncbi Alzheimer disease and Down syndrome: factors in pathogenesis
    Ira T Lott
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697, USA
    Neurobiol Aging 26:383-9. 2005
    ..The study of individuals with DS may help to identify common pathogenic links as well as a disassociation between vascular disease and AD...
  57. ncbi Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain
    Joseph H Su
    Institute for Brain Aging and Dementia, University of California at Irvine, 92697 4540, USA
    Acta Neuropathol 104:1-6. 2002
    ..A caspase-cleavage product of fodrin that accumulates in many AD and DS neurons is not present in GVD granules. These data support a role for the activation of apoptotic mechanisms in selective compartments exhibiting GVD...
  58. ncbi Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging
    P Dwight Tapp
    Department of Psychology, University of Toronto, Scarborough, Ontario M1C 1A4, Canada
    J Neurosci 24:8205-13. 2004
    ..These findings are consistent with the frontal lobe theory of aging in humans, which suggests that the frontal lobes and functions subserved by this region are compromised early in aging...
  59. ncbi Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697 3900, USA
    Science 300:486-9. 2003
    ..These results indicate that different types of soluble amyloid oligomers have a common structure and suggest they share a common mechanism of toxicity...
  60. ncbi Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia
    Pinar E Coskun
    Mitochondrial and Molecular Medicine and Genetics, University of California Irvine, Irvine, CA, USA
    J Alzheimers Dis 20:S293-310. 2010
    ..Therefore, mtDNA alterations may be responsible for both age-related dementia and the associated neuropathological changes observed in AD and DSAD...
  61. pmc Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
    Jennifer L Tomic
    Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697 3900, USA
    Neurobiol Dis 35:352-8. 2009
    ..These results indicate that fibrillar oligomers may play a key role in the pathology of AD and may be a new target for diagnostic and therapeutic development...
  62. pmc Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer
    Rakez Kayed
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    J Biol Chem 284:4230-7. 2009
    ..The annular anti-protofibril antibody also recognizes heptameric alpha-hemolysin pores, but not monomers, suggesting that the antibody recognizes an epitope that is specific for a beta barrel structural motif...
  63. pmc Gene expression changes in the course of normal brain aging are sexually dimorphic
    Nicole C Berchtold
    Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Proc Natl Acad Sci U S A 105:15605-10. 2008
    ....
  64. pmc Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy
    Vitaly Vasilevko
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, California, USA
    Ann N Y Acad Sci 1207:58-70. 2010
    ..Thus, there is a critical need for new strategies that improve BBB function and limit the development of β-amyloidosis in the cerebral vasculature...
  65. ncbi Response latency in Canis familiaris: mental ability or mental strategy?
    Pria M D Nippak
    Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada
    Behav Neurosci 117:1066-75. 2003
    ..In addition, the slower responding young dogs made fewer errors. Thus, RL appears to reflect the learning strategy applied, rather than the level of mental ability...
  66. ncbi Locomotor activity rhythms in dogs vary with age and cognitive status
    Christina T Siwak
    Institute of Medical Science, University of Toronto, Ontario, Canada
    Behav Neurosci 117:813-24. 2003
    ..The effect of age was less prominent in dogs housed in an indoor/outdoor facility. This suggests that bright sunlight and natural light-dark transitions are better able to consolidate and synchronize the activity rhythms of the dogs...
  67. pmc Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging
    P Dwight Tapp
    Department of Psychology, University of Toronto, Scarborough, Ontario, Canada M1C 1A4
    Learn Mem 10:64-73. 2003
    ..These separate patterns of reversal impairments in the old and senior dogs may reflect different rates of aging in subregions of the frontal cortex...
  68. ncbi Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels as a central target for the development of human AD and AD-like pathology in aged transgenic mice
    Gjumrakch Aliev
    Microscopy Research Center, Department of Anatomy, Case Western Reserve University and University Hospitals of Cleveland, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Ann N Y Acad Sci 977:45-64. 2002
    ..Our observations demonstrate that vascular wall cells, especially their mitochondria, appear to be a central target for oxidative stress-induced damage...
  69. ncbi Caspase-9 activation and caspase cleavage of tau in the Alzheimer's disease brain
    Troy T Rohn
    Department of Biology, Boise State University, Idaho 83725, USA
    Neurobiol Dis 11:341-54. 2002
    ..Taken together, these results demonstrate the activation of caspases and cleavage of tau in the AD brain, events which may precede and lead to the formation of NFTs...
  70. pmc Generation and characterization of the humoral immune response to DNA immunization with a chimeric beta-amyloid-interleukin-4 minigene
    Anahit Ghochikyan
    The Institute for Molecular Medicine, Department of Immunology, Huntington Beach, USA
    Eur J Immunol 33:3232-41. 2003
    ..The DNA minigene-induced anti-Abeta antibodies bound to Abeta plaques in brain tissue from an Alzheimer's disease patient demonstrating functional activity of the antibodies and the potential for therapeutic efficacy...
  71. ncbi Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility
    Alan D F Chan
    Institute of Medical Science, University of Toronto, Ontario, Canada
    Behav Neurosci 116:443-54. 2002
    ..Analysis of the response patterns of individual canines indicated that the deficits were related to the use of ineffective strategies and inflexibility in strategy modification...
  72. pmc Caspase-mediated cleavage of glial fibrillary acidic protein within degenerating astrocytes of the Alzheimer's disease brain
    Peter E Mouser
    Department of Biology, Boise State University, Boise, ID 83725, USA
    Am J Pathol 168:936-46. 2006
    ..These data suggest that the activation of caspases and cleavage of cellular proteins such as GFAP may contribute to astrocyte injury and damage in the AD brain...
  73. ncbi Ageing changes in cat brains demonstrated by beta-amyloid and AT8-immunoreactive phosphorylated tau deposits
    Danielle A Gunn-Moore
    University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin EH25 9RG, UK
    J Feline Med Surg 8:234-42. 2006
    ..There are similarities between these changes and those observed in the brains of aged people and other old mammals...
  74. ncbi Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia
    Christa M Studzinski
    Department of Pharmacology, University of Toronto, 1265 Military Trail, Scarborough, Ont, Canada M1C 1A4
    Neurobiol Learn Mem 86:197-204. 2006
    ....
  75. ncbi Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks
    P Dwight Tapp
    Department of Psychology, University of Toronto, 1265 Military Trail, Scarborough, Ont, Canada M1C 1A4
    Behav Brain Res 153:199-210. 2004
    ..Age impairments in concept learning may account for differences in transfer performance on both 3CSC tests...
  76. ncbi Neuroprotective effects of cognitive enrichment
    Norton W Milgram
    Department of Life Sciences, University of Toronto at Scarborough, Toronto, Ontario, Canada
    Ageing Res Rev 5:354-69. 2006
    ..These results suggest that a combination of behavioral and nutritional or pharmacological interventions may be optimal for reducing the rate of age-dependent cognitive decline...
  77. pmc Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease
    Wycliffe O Opii
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506 0055, United States
    Neurobiol Aging 29:51-70. 2008
    ..These results support the combination treatments as a possible therapeutic approach that could be translated to the aging human population who are at risk for age-related neurodegenerative disorders, including Alzheimer's disease...
  78. ncbi Nutritional management of brain aging in dogs
    Philip Roudebush
    Technical Information Services, Hill s Pet Nutrition Inc, PO Box 148, Topeka, KS 66601, USA
    J Am Vet Med Assoc 227:722-8. 2005
  79. ncbi Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology
    Jodie Newman
    Department of Biology, Boise State University, Boise, Idaho, USA
    Acta Neuropathol 110:135-44. 2005
    ....
  80. ncbi Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs
    Christina T Siwak
    Institute of Medical Science, University of Toronto, Scarborough, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 29:461-9. 2005
    ..Antioxidants improved the performance of aged dogs on the initial learning tests, suggesting a selective improvement of factors related to the aging process and specific cognitive processes rather than general cognitive enhancement...
  81. ncbi A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog
    Lori Ann Christie
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 29:361-9. 2005
    ....
  82. ncbi Reduced neuronal expression of synaptic transmission modulator HNK-1/neural cell adhesion molecule as a potential consequence of amyloid beta-mediated oxidative stress: a proteomic approach
    Stefani N Thomas
    Department of Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA
    J Neurochem 92:705-17. 2005
    ....
  83. doi Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2
    Troy T Rohn
    Department of Biology, Boise State University, Boise, Idaho 83725, USA
    J Neurosci 28:3051-9. 2008
    ..These findings suggest that the activation of apoptotic pathways may be an early event in AD and contributes to the pathological processes that promote the disease mechanisms underlying AD...
  84. ncbi Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs
    Norton W Milgram
    Division of Life Sciences, University of Toronto, 1265 Military Trail, Scarborough, Ont, Canada M1C 1A4
    Exp Gerontol 39:753-65. 2004
    ..These results suggest that the effectiveness of antioxidants in attenuating age-dependent cognitive decline is dependent on behavioral and environmental experience...
  85. ncbi Comparison of the effects of L-carnitine and acetyl-L-carnitine on carnitine levels, ambulatory activity, and oxidative stress biomarkers in the brain of old rats
    Jiankang Liu
    Department of Molecular and Cell Biology, Uniersity of California, Berkeley, CA 94720, USA
    Ann N Y Acad Sci 1033:117-31. 2004
    ..However, ALC was effective, unlike L-carnitine, in decreasing oxidative damage, including MDA, oxo8dG/oxo8G, and nitrotyrosine, in old rat brain. These data suggest that ALC may be a better dietary supplement than L-carnitine...
  86. pmc Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts
    Donald E Kuhn
    Davis Heart and Lung Research Institute, The Ohio State University, DHLRI 515, 473 West 12th Avenue, Columbus, OH 43210, USA
    Biochem Biophys Res Commun 370:473-7. 2008
    ..Importantly, Hsa21-derived miRNAs may provide novel therapeutic targets in the treatment of individuals with DS...
  87. pmc Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy
    Nina Movsesyan
    Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, California, United States of America
    PLoS ONE 3:e2124. 2008
    ....