Yu Ying He

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi request reprint Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 125:560-6. 2005
  2. pmc UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Cancer Res 68:3752-8. 2008
  3. pmc UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes
    M Ming
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Oncogene 29:492-502. 2010
  4. pmc Role of AMPK in UVB-induced DNA damage repair and growth control
    C L Wu
    Department of Radiation Oncology, 4th Affiliated Hospital, China Medical University, Shenyang, China
    Oncogene 32:2682-9. 2013
  5. pmc Deregulation of XPC and CypA by cyclosporin A: an immunosuppression-independent mechanism of skin carcinogenesis
    Weinong Han
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cancer Prev Res (Phila) 5:1155-62. 2012
  6. pmc PTEN positively regulates UVB-induced DNA damage repair
    Mei Ming
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Cancer Res 71:5287-95. 2011
  7. ncbi request reprint Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, FO 06, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:53867-74. 2004
  8. pmc Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair
    Weinong Han
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 286:22825-32. 2011
  9. ncbi request reprint Expression profiling of human keratinocyte response to ultraviolet A: implications in apoptosis
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 122:533-43. 2004
  10. ncbi request reprint Role of reduced glutathione efflux in apoptosis of immortalized human keratinocytes induced by UVA
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:8058-64. 2003

Research Grants

  1. Mechanisms of UVA-induced skin cancer
    Yu Ying He; Fiscal Year: 2010

Detail Information

Publications32

  1. ncbi request reprint Role of phagocyte oxidase in UVA-induced oxidative stress and apoptosis in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 125:560-6. 2005
    ....
  2. pmc UVA-induced cell cycle progression is mediated by a disintegrin and metalloprotease/epidermal growth factor receptor/AKT/Cyclin D1 pathways in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
    Cancer Res 68:3752-8. 2008
    ..Identification of these signaling pathways in UVA-induced cell proliferation will facilitate the development of efficient and safe chemopreventive and therapeutic strategies for skin cancer...
  3. pmc UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes
    M Ming
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Oncogene 29:492-502. 2010
    ..Our identification of PTEN as a critical molecular target of UVB provides new insights into the pathogenesis of skin cancer...
  4. pmc Role of AMPK in UVB-induced DNA damage repair and growth control
    C L Wu
    Department of Radiation Oncology, 4th Affiliated Hospital, China Medical University, Shenyang, China
    Oncogene 32:2682-9. 2013
    ....
  5. pmc Deregulation of XPC and CypA by cyclosporin A: an immunosuppression-independent mechanism of skin carcinogenesis
    Weinong Han
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cancer Prev Res (Phila) 5:1155-62. 2012
    ....
  6. pmc PTEN positively regulates UVB-induced DNA damage repair
    Mei Ming
    Department of Medicine, University of Chicago, Chicago, IL, USA
    Cancer Res 71:5287-95. 2011
    ..Taken together, our findings define PTEN as an essential genomic gatekeeper in the skin through its ability to positively regulate XPC-dependent GG-NER following DNA damage...
  7. ncbi request reprint Delayed and sustained activation of extracellular signal-regulated kinase in human keratinocytes by UVA: implications in carcinogenesis
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, FO 06, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:53867-74. 2004
    ..The delayed and sustained ERK activation provides a survival signal to human HaCaT keratinocytes, which may serve as an important mechanism for cell transformation and potential skin carcinogenesis in vivo caused by UVA exposure...
  8. pmc Caffeine promotes ultraviolet B-induced apoptosis in human keratinocytes without complete DNA repair
    Weinong Han
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 286:22825-32. 2011
    ....
  9. ncbi request reprint Expression profiling of human keratinocyte response to ultraviolet A: implications in apoptosis
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    J Invest Dermatol 122:533-43. 2004
    ..This initial microarray analysis could advance our understanding of cellular responses to ultraviolet A exposure, and provide a platform from which to further study ultraviolet-A-induced apoptosis and carcinogenesis...
  10. ncbi request reprint Role of reduced glutathione efflux in apoptosis of immortalized human keratinocytes induced by UVA
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 278:8058-64. 2003
    ..These provide targets for macrophage recognition and phagocytosis and thus minimize the potential to invoke inflammation or neoplastic transformation...
  11. pmc Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis
    Weinong Han
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:11369-77. 2010
    ..Our findings challenge assumptions about how CsA-associated tumors arise in skin...
  12. ncbi request reprint Epidermal growth factor receptor down-regulation induced by UVA in human keratinocytes does not require the receptor kinase activity
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 278:42457-65. 2003
    ....
  13. pmc Pristine (C60) and hydroxylated [C60(OH)24] fullerene phototoxicity towards HaCaT keratinocytes: type I vs type II mechanisms
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 21:1056-63. 2008
    ..Our results clearly show that the phototoxicity induced by (gamma-CyD) 2/C 60 is mainly mediated by singlet oxygen with a minor contribution from superoxide, while C 60(OH) 24 phototoxicity is mainly due to superoxide...
  14. pmc Enhanced photodynamic efficacy towards melanoma cells by encapsulation of Pc4 in silica nanoparticles
    Baozhong Zhao
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Toxicol Appl Pharmacol 241:163-72. 2009
    ..We expect that modifying the surface of silicon nanoparticles encapsulating the photosensitizers with antibodies specific to melanoma cells will lead to even better early diagnosis and targeted treatment of melanoma in the future...
  15. pmc Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C
    Mei Ming
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 107:22623-8. 2010
    ..Finally, we show that SIRT1 levels are significantly reduced in human skin tumors from Caucasian patients, a population at highest risk. These findings suggest that SIRT1 acts as a tumor suppressor through its role in DNA repair...
  16. doi request reprint Photo-induced reactive oxygen species generation by different water-soluble fullerenes (C) and their cytotoxicity in human keratinocytes
    Baozhong Zhao
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC, USA
    Photochem Photobiol 84:1215-23. 2008
    ..In vitro tests with HaCaT keratinocytes provided evidence that (gamma-CyD)(2)/C(60) phototoxicity is mainly mediated by (1)O(2) (Type II mechanism) with only a minor contribution from free radicals (Type I mechanism)...
  17. pmc Spatial distribution of protein damage by singlet oxygen in keratinocytes
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Photochem Photobiol 84:69-74. 2008
    ..The subcellular localization of the protein DMPO adducts was coincident with that of RB. This approach may provide information on the spatial distribution of singlet oxygen generated in cells...
  18. ncbi request reprint Ultraviolet A sensitivity in Smith-Lemli-Opitz syndrome: Possible involvement of cholesta-5,7,9(11)-trien-3 beta-ol
    Colin F Chignell
    Laboratory of Pharmacology and Chemistry, NIEHS NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 41:339-46. 2006
    ..Finally, we have previously detected 9-DDHC in skin lipids from normal subjects, so this sterol may also be the skin chromophore responsible for skin photoaging and UV-induced skin cancer...
  19. ncbi request reprint Phototoxicity in human lens epithelial cells promoted by St. John's Wort
    Yu Ying He
    Laboratory of Chemistry and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 10023, USA
    Photochem Photobiol 80:583-6. 2004
    ..Thus, ingested SJW is potentially phototoxic to the eye and could contribute to early cataractogenesis. Precautions should be taken to protect the eye from intense sunlight while taking SJW...
  20. pmc PTEN in DNA damage repair
    Mei Ming
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cancer Lett 319:125-9. 2012
    ..We will focus on the newly discovered mechanisms and the potential implications in cancer prevention and therapeutic intervention...
  21. pmc UVB-Induced p21 degradation promotes apoptosis of human keratinocytes
    Xia Lei
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL, USA
    Photochem Photobiol Sci 9:1640-8. 2010
    ....
  22. pmc Nrf1 CNC-bZIP protein promotes cell survival and nucleotide excision repair through maintaining glutathione homeostasis
    Weinong Han
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 287:18788-95. 2012
    ..These results indicate a novel role of Nrf1 in UVB-induced DNA damage repair and suggest Nrf1 as a tumor suppressor in the skin...
  23. ncbi request reprint UVA-ketoprofen-induced hemoglobin radicals detected by immuno-spin trapping
    Yu Ying He
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Photochem Photobiol 77:585-91. 2003
    ..The successful detection of protein radical formation caused by KP photosensitization could help further understand the photoallergic effect of this NSAID...
  24. pmc PTEN: new insights into its regulation and function in skin cancer
    Mei Ming
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    J Invest Dermatol 129:2109-12. 2009
    ....
  25. pmc Recent advances in the prevention and treatment of skin cancer using photodynamic therapy
    Baozhong Zhao
    Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Expert Rev Anticancer Ther 10:1797-809. 2010
    ..This article summarizes the main principles of PDT and its current clinical use in the management of non-melanoma skin cancers, as well as recent developments and possible future research directions...
  26. pmc Requirement for metalloproteinase-dependent ERK and AKT activation in UVB-induced G1-S cell cycle progression of human keratinocytes
    Weinong Han
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL, USA
    Photochem Photobiol 85:997-1003. 2009
    ....
  27. ncbi request reprint Limited protective role of V-PYRRO/NO against cholestasis produced by alpha-naphthylisothiocyanate in mice
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F0 09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Biochem Pharmacol 70:144-51. 2005
    ..Thus, the liver-selective NO donor, V-PYRRO/NO, was partially protective against ANIT-induced liver injury, without affecting ANIT-induced cholestasis and cholestasis-related gene expression...
  28. pmc Difference in phototoxicity of cyclodextrin complexed fullerene [(gamma-CyD)2/C60] and its aggregated derivatives toward human lens epithelial cells
    Baozhong Zhao
    Laboratory of Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Chem Res Toxicol 22:660-7. 2009
    ..Our results also demonstrate that UVA-blocking sunglasses can limit the ocular phototoxicity of this nanomaterial, while nontoxic endogenous antioxidants like lutein or Trolox cannot provide adequate protection...
  29. ncbi request reprint Reactive oxygen species and UV-B: effect on cyanobacteria
    Yu Ying He
    Institut fur Botanik und Pharmazeutische Biologie, Friedrich Alexander Universitat, Staudtstr 5, D 91058 Erlangen, Germany
    Photochem Photobiol Sci 1:729-36. 2002
    ....
  30. ncbi request reprint Adaptation of cyanobacteria to UV-B stress correlated with oxidative stress and oxidative damage
    Yu Ying He
    Institut fur Botanik und Pharmazeutische Biologie, Friedrich Alexander Universitat, Erlangen, German
    Photochem Photobiol 76:188-96. 2002
    ..to UV-B stress in our work. The adaptation of the cyanobacterium correlated with and could be caused by the oxidative stress and oxidative damage...
  31. ncbi request reprint UV-B-induced formation of reactive oxygen species and oxidative damage of the cyanobacterium Anabaena sp.: protective effects of ascorbic acid and N-acetyl-L-cysteine
    Yu Ying He
    Institut fur Botanik und Pharmazeutische Biologie, Friedrich Alexander Universitat, Staudtstrasse 5, D 91058 Erlangen, Germany
    J Photochem Photobiol B 66:115-24. 2002
    ....

Research Grants1

  1. Mechanisms of UVA-induced skin cancer
    Yu Ying He; Fiscal Year: 2010
    ..Understanding how PTEN is regulated when we are exposed to UVA and its consequences in skin cancer will improve our ability to reduce the disease burden of this most common cancer. ..