Jiang He

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment
    Jiang He
    Department of Radiology and Biomedical Imaging, Center for Molecular and Functional Imaging, University of California at San Francisco, San Francisco, California 94143, USA
    J Nucl Med 51:427-32. 2010
  2. pmc Affinity enhancement pretargeting: synthesis and testing of a 99mTc-labeled bivalent MORF
    Jiang He
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Mol Pharm 7:1118-24. 2010
  3. ncbi request reprint Amplification targeting: a modified pretargeting approach with potential for signal amplification-proof of a concept
    Jiang He
    Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Nucl Med 45:1087-95. 2004
  4. ncbi request reprint Radiolabelling morpholinos with 188Re tricarbonyl provides improved in vitro and in vivo stability to re-oxidation
    Jiang He
    Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Nucl Med Commun 25:731-6. 2004
  5. pmc Radiolabeling of MAG3-morpholino oligomers with 188Re at high labeling efficiency and specific radioactivity for tumor pretargeting
    Guozheng Liu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Appl Radiat Isot 64:971-8. 2006
  6. ncbi request reprint Pretargeting in tumored mice with radiolabeled morpholino oligomer showing low kidney uptake
    Guozheng Liu
    Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655 0243, Worcester, USA
    Eur J Nucl Med Mol Imaging 31:417-24. 2004
  7. pmc Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice
    Guozheng Liu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0243, USA
    Eur J Nucl Med Mol Imaging 34:237-46. 2007
  8. ncbi request reprint Improved delivery in cell culture of radiolabeled antisense DNAs by duplex formation
    Xinrong Liu
    Department of Radiology, Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, 01655, USA
    Mol Imaging Biol 8:278-83. 2006
  9. pmc Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas
    Arun K Iyer
    Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    Cancer Res 71:2428-32. 2011
  10. pmc Comparison of several linear fluorophore- and quencher-conjugated oligomer duplexes for stability, fluorescence quenching, and kinetics in vitro and in vivo in mice
    Surong Zhang
    Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Bioconjug Chem 18:1170-5. 2007

Collaborators

Detail Information

Publications38

  1. pmc Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment
    Jiang He
    Department of Radiology and Biomedical Imaging, Center for Molecular and Functional Imaging, University of California at San Francisco, San Francisco, California 94143, USA
    J Nucl Med 51:427-32. 2010
    ..The objective of this study was to evaluate the tumor targeting of an internalizing human antibody fragment, a small-size platform, to provide high contrast in a mouse model of human prostate carcinoma...
  2. pmc Affinity enhancement pretargeting: synthesis and testing of a 99mTc-labeled bivalent MORF
    Jiang He
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Mol Pharm 7:1118-24. 2010
    ..Thus two monovalent MORFs were covalently conjugated into a bivalent MORF effector to improve tumor targeting by both pharmacokinetics and affinity enhancement influences...
  3. ncbi request reprint Amplification targeting: a modified pretargeting approach with potential for signal amplification-proof of a concept
    Jiang He
    Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Nucl Med 45:1087-95. 2004
    ..Amplification targeting is a multistep procedure with the potential to greatly improve target localization of radioactivity (and eventually drugs) through the intermediate use of polymers conjugated with multiple copies of oligomers...
  4. ncbi request reprint Radiolabelling morpholinos with 188Re tricarbonyl provides improved in vitro and in vivo stability to re-oxidation
    Jiang He
    Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Nucl Med Commun 25:731-6. 2004
    ..However, by preparing 188Re-MORFs labelled conventionally with MAG3 as chelator, we have observed unacceptable levels of oxidation to perrhenate in vitro and in vivo in mice...
  5. pmc Radiolabeling of MAG3-morpholino oligomers with 188Re at high labeling efficiency and specific radioactivity for tumor pretargeting
    Guozheng Liu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Appl Radiat Isot 64:971-8. 2006
    ..A labeling efficiency of greater than 90% can be achieved even at a concentration of MAG(3)-cMORF as low as 0.8 microM. The labeled cMORF is stable and capable of hybridizing to its complement...
  6. ncbi request reprint Pretargeting in tumored mice with radiolabeled morpholino oligomer showing low kidney uptake
    Guozheng Liu
    Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655 0243, Worcester, USA
    Eur J Nucl Med Mol Imaging 31:417-24. 2004
    ..The lowering of kidney radioactivity levels in this way may be important to reduce toxicity to this organ in connection with pretargeting radiotherapy studies...
  7. pmc Predicting the biodistribution of radiolabeled cMORF effector in MORF-pretargeted mice
    Guozheng Liu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0243, USA
    Eur J Nucl Med Mol Imaging 34:237-46. 2007
    ....
  8. ncbi request reprint Improved delivery in cell culture of radiolabeled antisense DNAs by duplex formation
    Xinrong Liu
    Department of Radiology, Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, 01655, USA
    Mol Imaging Biol 8:278-83. 2006
    ..We have investigated the mechanism involved to evaluate whether the approach may be useful for antisense radionuclide imaging...
  9. pmc Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas
    Arun K Iyer
    Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    Cancer Res 71:2428-32. 2011
    ....
  10. pmc Comparison of several linear fluorophore- and quencher-conjugated oligomer duplexes for stability, fluorescence quenching, and kinetics in vitro and in vivo in mice
    Surong Zhang
    Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Bioconjug Chem 18:1170-5. 2007
    ..5 may be efficiently and rapidly quenched by Iowa Black when both are conjugated to complementary oligomers and that the resulting inhibition of fluorescence is sufficiently persistent for imaging...
  11. ncbi request reprint Construction of a novel chimera consisting of a chelator-containing Tat peptide conjugated to a morpholino antisense oligomer for technetium-99m labeling and accelerating cellular kinetics
    Yu Min Zhang
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Nucl Med Biol 33:263-9. 2006
    ....
  12. pmc Further investigations of morpholino pretargeting in mice--establishing quantitative relations in tumor
    Guozheng Liu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0243, USA
    Eur J Nucl Med Mol Imaging 32:1115-23. 2005
    ..In the present study, the pharmacokinetics of the antibody and effector were measured under different conditions in mice to establish their quantitative relationships with tumor accumulations by pretargeting...
  13. pmc Successful radiotherapy of tumor in pretargeted mice by 188Re-radiolabeled phosphorodiamidate morpholino oligomer, a synthetic DNA analogue
    Guozheng Liu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Clin Cancer Res 12:4958-64. 2006
    ..Our laboratory has reported on MORF pretargeting for diagnosis using (99m)Tc as radiolabel. We now report on the use of MORF pretargeting for radiotherapy in a mouse tumor model using (188)Re as the therapeutic radiolabel...
  14. ncbi request reprint Optical pretargeting of tumor with fluorescent MORF oligomers
    Jiang He
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Imaging Biol 9:17-23. 2007
    ..The use of linear fluorophore-conjugated oligomer duplexes have been little used in animals, and to our knowledge, have not previously been considered for pretargeting applications...
  15. pmc The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma
    Arun K Iyer
    Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94143, USA
    Biomaterials 32:2605-13. 2011
    ....
  16. ncbi request reprint Pharmacokinetics in mice of four oligomer-conjugated polymers for amplification targeting
    Jiang He
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA
    Cancer Biother Radiopharm 18:941-7. 2003
    ..In particular, the polymer must remain in circulation sufficiently long to permit target localization...
  17. ncbi request reprint Initial observations of 99mTc labelled locked nucleic acids for antisense targeting
    Yumin Zhang
    Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA
    Nucl Med Commun 25:1113-8. 2004
    ..The most recent DNA analogues to become commercially available are known as locked nucleic acids (LNAs). The aim of this study was to evaluate the properties of LNAs for antisense targeting...
  18. ncbi request reprint Evaluation of 99mTc-MAG3-annexin V: influence of the chelate on in vitro and in vivo properties in mice
    Jean Luc Vanderheyden
    Department of Radiology, University of Massachusetts Medical School, Worcester, 01655, USA
    Nucl Med Biol 33:135-44. 2006
    ..Nevertheless, (99m)Tc MAG(3)-annexin may be an attractive alternative to (99m)Tc Hynic-annexin for the in vivo imaging of phosphatidylserine receptors...
  19. ncbi request reprint Affinity enhancement bivalent morpholinos for pretargeting: surface plasmon resonance studies of molecular dimensions
    Jiang He
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Bioconjug Chem 16:1098-104. 2005
    ..The results provide further evidence that the use of bivalent effectors can greatly improve MORF pretargeting and, finally, that bivalent MORFs with reduced equilibrium constants may actually exhibit higher affinity enhancement...
  20. ncbi request reprint Cytosine residues influence kidney accumulations of 99mTc-labeled morpholino oligomers
    Guozheng Liu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Antisense Nucleic Acid Drug Dev 12:393-8. 2002
    ..These results show that the base sequences of MORFs, and probably other oligomers as well, are an important determinant of biodistribution...
  21. pmc Association of cardiac troponin T with left ventricular structure and function in CKD
    Rakesh K Mishra
    University of California, San Francisco, CA, USA
    Am J Kidney Dis 61:701-9. 2013
    ..We evaluated associations of cTnT levels with cardiac structural and functional abnormalities in a cohort of patients with chronic kidney disease (CKD) without heart failure...
  22. ncbi request reprint A comparison of in vitro and in vivo stability in mice of two morpholino duplexes differing in chain length
    Jiang He
    Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Bioconjug Chem 14:1018-23. 2003
    ..The stability of hybridized duplexes is an important criterion for any radiopharmaceutical application of DNAs or their analogues such as phosphorodiamidate morpholinos (MORFs)...
  23. pmc An improved method for covalently conjugating morpholino oligomers to antitumor antibodies
    Jiang He
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Bioconjug Chem 18:983-8. 2007
    ..Using MN14(SANH)-MORF, the influence of the higher gpm on pretargeting permitted lowering the dosages of MN14 administered and may permit administering higher levels of radioactivity in connection with therapy...
  24. ncbi request reprint Affinity enhancement bivalent morpholino for pretargeting: initial evidence by surface plasmon resonance
    Jiang He
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Bioconjug Chem 16:338-45. 2005
    ..These results show that bimolecular binding was occurring in the case of the bivalent MORF and suggest that bivalency may be superior to monovalency in MORF pretargeting applications...
  25. ncbi request reprint Initial mechanistic studies of antisense targeting in cells
    Xinrong Liu
    Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Nucl Med 47:360-8. 2006
    ..The continued development of antisense targeting will require a better understanding of the mechanism...
  26. pmc Preparation and properties of 99mTc(CO)3+-labeled N,N-bis(2-pyridylmethyl)-4-aminobutyric acid
    Guozheng Liu
    Department of Radiology, Division of Nuclear Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Bioconjug Chem 15:1441-6. 2004
    ..Finally, the complex (99m)Tc(CO)(3)(+)-BPABA itself was found to clear exclusively via the hepatobiliary pathway and may have value as a potential hepatobiliary imaging agent...
  27. pmc Biodistributions of 177Lu- and 111In-labeled 7E11 antibodies to prostate-specific membrane antigen in xenograft model of prostate cancer and potential use of 111In-7E11 as a pre-therapeutic agent for 177Lu-7E11 radioimmunotherapy
    Mei Hsiu Pan
    Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA
    Mol Imaging Biol 11:159-66. 2009
    ..To serve as a radioimmunotherapeutic agent, a kinetically inert conjugate is desired to maximize tumor uptake and tumor radiation dose with minimal nonspecific exposure to bone marrow and other major organs...
  28. pmc Predictors of high sensitivity cardiac troponin T in chronic kidney disease patients: a cross-sectional study in the chronic renal insufficiency cohort (CRIC)
    Ruth F Dubin
    San Francisco VA Medical Center, University of California San Francisco, 4150 Clement Street, Box 111A1, San Francisco, CA 94121, USA
    BMC Nephrol 14:229. 2013
    ..We sought to determine the distribution and predictors of hs-TnT in CKD patients without overt cardiovascular disease (CVD)...
  29. pmc Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, San Francisco, California, USA
    Kidney Int 83:909-14. 2013
    ..Thus, while urine NGAL was an independent risk factor of progression among patients with established CKD of diverse etiology, it did not substantially improve prediction of outcome events...
  30. pmc Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma
    Scott Bidlingmaier
    Department of Anesthesia, San Francisco General Hospita, San Francisco, California, USA
    Cancer Res 69:1570-7. 2009
    ....
  31. ncbi request reprint Radiolabeling morpholinos with 90Y, 111In, 188Re and 99mTc
    Chang Bin Liu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA, USA
    Nucl Med Biol 30:207-14. 2003
    ..While we routinely radiolabel with (99m)Tc, we have now labeled MORFs with (111)In, (188)Re and (90)Y in anticipation of therapeutic studies...
  32. ncbi request reprint Electrostatic binding with tat and other cationic peptides increases cell accumulation of 99mTc-antisense DNAs without entrapment
    Yu Min Zhang
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Imaging Biol 5:240-7. 2003
    ..The Tat peptide (Tat), a basic domain of the HIV Tat protein, has been shown to enhance cell accumulation of various biomolecules...
  33. ncbi request reprint In vitro cell studies of technetium-99m labeled RGD-HYNIC peptide, a comparison of tricine and EDDA as co-ligands
    Zi Fen Su
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Nucl Med Biol 30:141-9. 2003
    ..In this research, cyclised peptides containing Arg-Gly-Asp (RGD) and Arg-Gly-Glu (RGE, as control) residues were conjugated with HYNIC and labeled with (99m)Tc...
  34. doi request reprint Intravenous vasopressin for the prevention of nontarget gastrointestinal embolization during liver-directed cancer treatment: experimental study in a porcine model
    Jeremy C Durack
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Vasc Interv Radiol 23:1505-12. 2012
    ..The aim of this study was to evaluate the potential for intravenous vasopressin to reduce the risk of nontarget gastrointestinal embolization during transcatheter liver-directed cancer therapies in a porcine model...
  35. pmc Development of an optimized activatable MMP-14 targeted SPECT imaging probe
    Gregory A Watkins
    Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 185 Berry Street, Suite 350, Box 0946, San Francisco, CA 94107, United States
    Bioorg Med Chem 17:653-9. 2009
    ..The combination of computational chemistry, parallel synthesis and biochemical screening, therefore, shows promise as a set of tools for developing new radiolabeled probes that are sensitive to protease activity...
  36. pmc Symptoms characteristic of heart failure among CKD patients without diagnosed heart failure
    Michael G Shlipak
    University of California, San Francisco, General Internal Medicine, San Francisco VA Medical Center, 4150 Clement St, 111A1, San Francisco, CA 94109, USA
    J Card Fail 17:17-23. 2011
    ..Epidemiological studies typically diagnose heart failure (HF) at the time of hospitalization, and have not evaluated the prevalence of HF symptoms in CKD patients without a prior HF diagnosis...
  37. ncbi request reprint Improving the labeling of S-acetyl NHS-MAG(3)-conjugated morpholino oligomers
    Guozheng Liu
    Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Bioconjug Chem 13:893-7. 2002
    ....
  38. doi request reprint Association of N-terminal pro-B-type natriuretic peptide with left ventricular structure and function in chronic kidney disease (from the Chronic Renal Insufficiency Cohort [CRIC])
    Rakesh K Mishra
    University of California, San Francisco, USA
    Am J Cardiol 111:432-8. 2013
    ..10, 95% CI 0.10 to 0.11; p = 0.07). In conclusion, in this large chronic kidney disease cohort without heart failure, NT-proBNP had strong associations with prevalent LVH and LV systolic dysfunction...

Research Grants3

  1. Targeted liposomal radiotherapy of malignant mesothelioma
    Jiang He; Fiscal Year: 2010
    ..If successfully completed, this novel method will create far-reaching applications in RIT, particularly for high-potent treatments of malignant mesothelioma. ..
  2. Targeted liposomal radiotherapy of malignant mesothelioma
    Jiang He; Fiscal Year: 2008
    ..If successfully completed, this novel method will create far-reaching applications in RIT, particularly for high-potent treatments of malignant mesothelioma. ..
  3. Targeted liposomal radiotherapy of malignant mesothelioma
    Jiang He; Fiscal Year: 2009
    ..If successfully completed, this novel method will create far-reaching applications in RIT, particularly for high-potent treatments of malignant mesothelioma. ..