Biao He

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Gli as a novel therapeutic target in malignant pleural mesothelioma
    Hui Li
    Thoracic Oncology Program, Department of Surgery, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 8:e57346. 2013
  2. pmc Adenoviral delivery of the EMX2 gene suppresses growth in human gastric cancer
    Jie Li
    Protein Science Laboratory of Ministry of Education, School of Life Sciences, Tsinghua University, Beijing, China
    PLoS ONE 7:e45970. 2012
  3. pmc Molecular markers as therapeutic targets in lung cancer
    Hsin Hui Tseng
    Thoracic Oncology Program Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Chin J Cancer 32:59-62. 2013
  4. pmc The role of stem cells in airway repair: implications for the origins of lung cancer
    Michael S Mulvihill
    Thoracic Oncology Program, Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    Chin J Cancer 32:71-4. 2013
  5. ncbi request reprint Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells
    Biao He
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94115, USA
    Cancer Res 65:743-8. 2005
  6. pmc Efficacy of Wnt-1 monoclonal antibody in sarcoma cells
    Iwao Mikami
    Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    BMC Cancer 5:53. 2005
  7. ncbi request reprint Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth
    Yu Ching Lin
    Thoracic Oncology Laboratory, Department of Surgery, University of California, San Francisco, San Francisco, CA 94115, USA
    Hum Gene Ther 18:379-86. 2007
  8. pmc Down-regulation of SIX3 is associated with clinical outcome in lung adenocarcinoma
    Min Li Mo
    School of Life Sciences, Tsinghua University, Beijing, China
    PLoS ONE 8:e71816. 2013
  9. ncbi request reprint Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma
    Amie Y Lee
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Biochem Biophys Res Commun 323:1246-50. 2004
  10. pmc Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients
    Junichi Okamoto
    Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, California Department of Surgery, Division of Thoracic Surgery, Nippon Medical School, Tokyo, Japan
    Clin Lung Cancer 12:237-44. 2011

Collaborators

Detail Information

Publications52

  1. pmc Gli as a novel therapeutic target in malignant pleural mesothelioma
    Hui Li
    Thoracic Oncology Program, Department of Surgery, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 8:e57346. 2013
    ..In summary, Gli activation plays a critical role in MPM. Inhibition of Gli function holds strong potential to become a novel, clinically effective approach to treat MPM...
  2. pmc Adenoviral delivery of the EMX2 gene suppresses growth in human gastric cancer
    Jie Li
    Protein Science Laboratory of Ministry of Education, School of Life Sciences, Tsinghua University, Beijing, China
    PLoS ONE 7:e45970. 2012
    ..Recent studies suggest possible involvement of EMX2 in human cancers; however, the role of EMX2 in carcinogenesis needs further exploration...
  3. pmc Molecular markers as therapeutic targets in lung cancer
    Hsin Hui Tseng
    Thoracic Oncology Program Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Chin J Cancer 32:59-62. 2013
    ..Our understanding of the physiologic processes of tumor development provide a means to design more effective and specific drugs with less toxicity, thereby accelerating the delivery of new drug therapies to the patient's bedside...
  4. pmc The role of stem cells in airway repair: implications for the origins of lung cancer
    Michael S Mulvihill
    Thoracic Oncology Program, Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    Chin J Cancer 32:71-4. 2013
    ..The implications of a stem cell origin of lung cancer are reviewed, and the importance of ongoing research to identify novel therapeutic and prognostic targets is reiterated...
  5. ncbi request reprint Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells
    Biao He
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94115, USA
    Cancer Res 65:743-8. 2005
    ..Our data also suggest that beta-catenin-independent noncanonical pathway(s) may be involved in the apoptotic inhibition caused by activation of Wnt signaling...
  6. pmc Efficacy of Wnt-1 monoclonal antibody in sarcoma cells
    Iwao Mikami
    Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    BMC Cancer 5:53. 2005
    ..Recently, it has been reported that Wnt-1/beta-catenin signaling inhibits apoptosis in several cancers. In this study, we investigated the efficacy of a monoclonal anti-Wnt-1 antibody in sarcoma cells...
  7. ncbi request reprint Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth
    Yu Ching Lin
    Thoracic Oncology Laboratory, Department of Surgery, University of California, San Francisco, San Francisco, CA 94115, USA
    Hum Gene Ther 18:379-86. 2007
    ..Our results suggest the potential for further application of WIF-1 gene therapy in melanoma with WIF-1 silencing...
  8. pmc Down-regulation of SIX3 is associated with clinical outcome in lung adenocarcinoma
    Min Li Mo
    School of Life Sciences, Tsinghua University, Beijing, China
    PLoS ONE 8:e71816. 2013
    ..Little is known about the role of SIX3 in human tumorigenesis. This study is to assess the expression/function of SIX3 and the significance of SIX3 as a prognostic biomarker in lung adenocarcinoma...
  9. ncbi request reprint Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma
    Amie Y Lee
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Biochem Biophys Res Commun 323:1246-50. 2004
    ..Together, our data suggest that Dkk-1 may be able to antagonize Wnt signaling and exert its tumor suppressive effects through beta-catenin-independent non-canonical pathways (i.e., the Wnt/JNK pathway)...
  10. pmc Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients
    Junichi Okamoto
    Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, California Department of Surgery, Division of Thoracic Surgery, Nippon Medical School, Tokyo, Japan
    Clin Lung Cancer 12:237-44. 2011
    ..This study assessed the significance of EMX2 as a prognostic biomarker in lung adenocarcinoma including bronchioloalveolar carcinoma (BAC)...
  11. ncbi request reprint Wnt2 as a new therapeutic target in malignant pleural mesothelioma
    Julien Mazieres
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Int J Cancer 117:326-32. 2005
    ..We thus propose that inhibition of Wnt2 is of therapeutic interest in the development of more effective treatments for MPM...
  12. ncbi request reprint Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus
    Genevieve Clement
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, 2340 Sutter St, San Francisco, CA 94115, USA
    Cancer Sci 99:46-53. 2008
    ..Restoring functional WIF-1 might be used as a new targeted therapy for the treatment of this malignancy...
  13. ncbi request reprint Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines
    Yu Ching Lin
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Biochem Biophys Res Commun 341:635-40. 2006
    ..Our results indicate that aberrant Wnt signaling is a common event in NPC carcinogenesis linked with WIF-1 silencing in at least cell lines. Strategies targeting these molecules should be potentially promising in treating NPC...
  14. ncbi request reprint An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth
    Liang You
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94143 1674, USA
    Cancer Res 64:5385-9. 2004
    ..In an in vivo study, this monoclonal anti-Wnt-2 antibody suppresses tumor growth in a xenograft model. These findings suggest that the anti-Wnt-2 monoclonal antibody may be useful for the treatment of patients with malignant melanoma...
  15. ncbi request reprint Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma
    Sonny Batra
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA, USA
    Biochem Biophys Res Commun 342:1228-32. 2006
    ..New therapies toward inhibition of the Wnt pathway through WIF-1 might be promising for the future treatment of malignant mesothelioma...
  16. pmc SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
    Biao He
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 100:14133-8. 2003
    ..The data also suggest that SOCS-3 therapy may be useful in the treatment of cancer...
  17. ncbi request reprint Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer
    Biao He
    Comprehensive Cancer Center, University of California, San Francisco, USA
    Clin Lung Cancer 5:366-70. 2004
    ..Therefore, methylation silencing of SOCS-3 may be used as a marker for early detection of NSCLC. Suppressor of cytokine signaling-3 therapy may be useful for the treatment of lung cancer...
  18. ncbi request reprint Cloning and characterization of the promoter of human Wnt inhibitory factor-1
    Noemi Reguart
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center University of California, San Francisco, CA 94115, USA
    Biochem Biophys Res Commun 323:229-34. 2004
    ....
  19. ncbi request reprint Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer
    Julien Mazieres
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94115, USA
    Cancer Res 64:4717-20. 2004
    ..Our results suggest that methylation silencing of WIF-1 is a common and likely important mechanism of aberrant activation of the Wnt signaling pathway in lung cancer pathogenesis, raising its therapeutic interest...
  20. ncbi request reprint Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells
    Yihui Shi
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Int J Cancer 121:1175-81. 2007
    ..The combined inhibition of Wnt-2 and Gal-3 may be of superior therapeutic advantage to inhibition by either one of them, giving rise to a potential development of novel drugs for the targeted treatment of colorectal cancer...
  21. ncbi request reprint Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells
    Liang You
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
    Cancer Res 64:3474-8. 2004
    ..Our data suggest that beta-catenin-independent noncanonical pathway(s), i.e., Wnt/JNK pathway, may play a role in the apoptotic inhibition caused by Wnt-1 signaling...
  22. pmc Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma
    Junichi Okamoto
    Thoracic Oncology Laboratory, Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA
    J Thorac Oncol 3:1089-95. 2008
    ..Recently, Hsp90 has emerged as being of prime importance to the growth and survival of cancer cells and its inhibitors have already been used in phase I and II clinical trials...
  23. ncbi request reprint Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis
    Julien Mazieres
    UCSF Comprehensive Cancer Center, San Francisco, CA 94115, USA
    Oncogene 24:5396-400. 2005
    ..We thus propose that Wnt16 plays an important role in leukemogenesis, raising its therapeutic interest...
  24. pmc Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis
    Josephine Chou
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
    Head Neck 30:946-63. 2008
    ..Anti-apoptotic mechanisms are also upregulated. There are multiple abnormalities unique to NPC that are potential targets for novel treatments...
  25. ncbi request reprint Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells
    Liang You
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Oncogene 23:6170-4. 2004
    ....
  26. ncbi request reprint Wnt inhibitory factor inhibits lung cancer cell growth
    Jae Kim
    Thoracic Oncology Laboratory, UCSF Comprehensive Cancer Center, San Francisco, Calif 94143, USA
    J Thorac Cardiovasc Surg 133:733-7. 2007
    ..Wnt inhibitory factor, a secreted Wnt antagonist, is downregulated in non-small cell lung cancer. We hypothesized that restoration of Wnt inhibitory factor function would inhibit lung cancer cell growth...
  27. ncbi request reprint An antagonist of dishevelled protein-protein interaction suppresses beta-catenin-dependent tumor cell growth
    Naoaki Fujii
    Department of Pharmaceutical Chemistry, Thoracic Oncology Labratory, University of California San Francisco, and Department of Structural Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Cancer Res 67:573-9. 2007
    ..FJ9 is thus among the first non-peptide inhibitors to show therapeutic efficacy through disruption of PDZ protein-protein interactions...
  28. pmc SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma
    Yi Zhang
    Department of Surgery, University of California, San Francisco, CA, USA
    J Exp Clin Cancer Res 32:7. 2013
    ..Despite current combined regimen, its prognosis remains dismal, calling for more effective targeted therapies. We investigated whether aberrant Hh activation may play a role in mesothelioma...
  29. ncbi request reprint Inhibition of activated phosphatidylinositol 3-kinase/AKT pathway in malignant pleural mesothelioma leads to G1 cell cycle arrest
    Iwao Mikami
    Department of Surgery, University of California, San Francisco, CA 94115, USA
    Oncol Rep 24:1677-81. 2010
    ..These results confirm that the PI3K/AKT signaling pathway is aberrantly active and plays a critical role for the cell cycle progression in human MM cells...
  30. ncbi request reprint Expression of the secreted frizzled-related protein gene family is downregulated in human mesothelioma
    Amie Y Lee
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Oncogene 23:6672-6. 2004
    ..Our results suggest that methylation silencing of SFRPs may be one of the important mechanisms of aberrant Wnt signaling activation in MM...
  31. pmc A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
    Biao He
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Neoplasia 6:7-14. 2004
    ..Our results indicate that both monoclonal anti-Wnt-1 antibody and Wnt-1 siRNA inhibit Wnt-1 signaling and can induce apoptosis in human cancer cells. These findings hold promise as a novel therapeutic strategy for cancer...
  32. ncbi request reprint Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin
    Kazutsugu Uematsu
    Thoracic Oncology Laboratory, Department of Medicine, University of California San Francisco Cancer Center, San Francisco, CA 94115, USA
    Cancer Res 63:4547-51. 2003
    ..These results demonstrate Dvl overexpression in human cancer and, specifically, that Wnt signaling plays a role in mesothelioma pathogenesis. These data offer possible new avenues for therapeutic intervention...
  33. ncbi request reprint Wnt signaling in stem cells and non-small-cell lung cancer
    Biao He
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94143, USA
    Clin Lung Cancer 7:54-60. 2005
    ....
  34. ncbi request reprint Blockade of Wnt-1 signaling induces apoptosis in human colorectal cancer cells containing downstream mutations
    Biao He
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, 1600 Divisadero St, C322C, Box 1674, San Francisco, CA 94115, USA
    Oncogene 24:3054-8. 2005
    ..Furthermore, our results suggest that blockade of the Wnt signal may have a therapeutic role in the treatment of colorectal cancer...
  35. pmc Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer
    Min Li Mo
    School of Life Sciences, Tsinghua University, Beijing 10084, China
    J Exp Clin Cancer Res 32:29. 2013
    ..E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL). There is no report on E2A-PBX1 fusion transcripts in non-small-cell lung cancer (NSCLC)...
  36. ncbi request reprint The role of cancer stem cells in neoplasia of the lung: past, present and future
    Adam Yagui-Beltran
    Department of Surgery, UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, USA
    Clin Transl Oncol 10:719-25. 2008
    ..It is when these cells undergo genetic mutations which make them acquire the ability to metastasize, that cancer occurs, rendering the concept of "cancer stem cells" a rather attractive one indeed...
  37. ncbi request reprint Wnt signaling in lung cancer
    Julien Mazieres
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, 1600 Divisadero St, C322C, Box 1674, San Francisco, CA 94115, USA
    Cancer Lett 222:1-10. 2005
    ....
  38. ncbi request reprint Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression
    Kazutsugu Uematsu
    Thoracic Oncology Laboratory, UCSF Cancer Center, University of California at San Francisco, San Francisco, CA 94115, USA
    Oncogene 22:7218-21. 2003
    ..Taken together, these data support the novel hypothesis that Dvl overexpression is critical to Wnt signaling activation and cell growth in NSCLC...
  39. ncbi request reprint Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q
    Ronald H Jensen
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Anticancer Res 23:2281-9. 2003
    ..Molecular genetic analysis of 14 freshly resected human mesotheliomas was used to identify regions in the tumor genomes that display DNA copy number alterations, especially the regions that may harbor tumor suppressor genes...
  40. doi request reprint A multigene assay is prognostic of survival in patients with early-stage lung adenocarcinoma
    Dan J Raz
    Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, San Francisco, California 94131, USA
    Clin Cancer Res 14:5565-70. 2008
    ..We sought to generate a real-time PCR (RT-PCR)-based prognostic model in patients with early stage lung adenocarcinoma, the dominant histology of lung cancer in the United States...
  41. ncbi request reprint Wnt-1 signal as a potential cancer therapeutic target
    Liang You
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
    Drug News Perspect 19:27-31. 2006
    ..This review summarizes the recent significant findings and the potentials of Wnt-1 signal as a new therapeutic target for cancer...
  42. doi request reprint Analytical validation of a practical molecular assay prognostic of survival in nonsquamous non-small cell lung cancer
    Johannes R Kratz
    Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, San Francisco, CA, USA
    Diagn Mol Pathol 22:65-9. 2013
    ....
  43. ncbi request reprint Novel therapies targeting signaling pathways in lung cancer
    Adam Yagui-Beltran
    Department of Surgery, University of California San Francisco Comprehensive Cancer Center, 2340 Sutter Street, San Francisco, CA 94143 0128, USA
    Thorac Surg Clin 16:379-96, vi. 2006
    ....
  44. ncbi request reprint Current concepts in bronchioloalveolar carcinoma biology
    Dan J Raz
    Department of Surgery, Division of Cardiothoracic Surgery, University of California, San Francisco, 94143 1724, USA
    Clin Cancer Res 12:3698-704. 2006
  45. ncbi request reprint Roles of secreted frizzled-related proteins in cancer
    Yihui Shi
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Acta Pharmacol Sin 28:1499-504. 2007
    ..However, sFRPs may also promote cell growth in some contexts. Here, we focus on the known knowledge of sFRPs in tumorigenesis...
  46. pmc A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies
    Johannes R Kratz
    University of California, San Francisco, CA 94143 1724, USA
    Lancet 379:823-32. 2012
    ..We aimed to develop and validate a practical, reliable assay that improves risk stratification compared with conventional staging...
  47. ncbi request reprint Update on the molecular biology of malignant mesothelioma
    Amie Y Lee
    Department of Surgery, Division of Cardiothoracic Surgery, University of California, San Francisco, California 94143, USA
    Cancer 109:1454-61. 2007
    ....
  48. pmc Lung cancer therapeutics that target signaling pathways: an update
    M Roshni Ray
    Thoracic Oncology Program, Department of Surgery, University of California, San Francisco, CA 94115, USA
    Expert Rev Respir Med 4:631-45. 2010
    ..This article looks at several areas of interest to lung cancer therapeutics and considers the current state of affairs surrounding the development of these therapies...
  49. ncbi request reprint Future directions: oncolytic viruses
    Liang You
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Clin Lung Cancer 5:226-30. 2004
    ..Much evidence suggests that oncolytic viral therapy works in synergy with standard cancer therapies. In this review, we will focus on the oncolytic viruses that may be beneficial to patients with lung cancer in the near future...
  50. ncbi request reprint Bronchioloalveolar carcinoma: a review
    Dan J Raz
    Department of Surgery, University of California, San Francisco, CA 94131, USA
    Clin Lung Cancer 7:313-22. 2006
    ..Stage for stage, patients with BAC have a higher rate of long-term survival but might have an increased rate of intrathoracic recurrence than patients with other subtypes of NSCLC...
  51. pmc Wnt and hedgehog gene pathway expression in serous ovarian cancer
    Seraina Schmid
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA, USA
    Int J Gynecol Cancer 21:975-80. 2011
    ..Variations in these pathway genes causing proliferation could play a role in the variation in tumor progression and response to therapy...
  52. ncbi request reprint Cloning and characterization of a functional promoter of the human SOCS-3 gene
    Biao He
    Department of Surgery, Thoracic Oncology Laboratory, Comprehensive Cancer Center, University of California, 1600 Divisadero St, C322C, Box 1674, San Francisco, CA 94115, USA
    Biochem Biophys Res Commun 301:386-91. 2003
    ..Cloning of the human SOCS-3 promoter should help uncover mechanisms of regulation of the JAK-STAT pathway in human cancer...

Research Grants2

  1. Small molecule inhibitors of Wnt-2 transcription in NSCLC
    Biao He; Fiscal Year: 2009
    ..The heart of our proposal is translationally focused, specifically the development of novel and innovative small molecule inhibitors of the Wnt transcription as molecular-targeted therapies against lung cancer. ..
  2. Small molecule inhibitors of Wnt-2 transcription in NSCLC
    Biao He; Fiscal Year: 2010
    ..The heart of our proposal is translationally focused, specifically the development of novel and innovative small molecule inhibitors of the Wnt transcription as molecular-targeted therapies against lung cancer. ..