Thomas S Hays
Affiliation: University of Minnesota
McIntosh J, Hays T. A Brief History of Research on Mitotic Mechanisms. Biology (Basel). 2016;5: pubmed publisher
..Our goal is to provide modern scientists with an appreciation of the work that has laid the foundations for their current work and interests. ..
Neisch A, Neufeld T, Hays T. A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation. J Cell Biol. 2017;216:441-461 pubmed publisher
..In addition, CKA-deficient flies exhibit PP2A-dependent motor coordination defects. CKA function within the STRIPAK complex is crucial to prevent transport defects that may contribute to neurodegeneration. ..
Avery A, Thomas D, Hays T. ?-III-spectrin spinocerebellar ataxia type 5 mutation reveals a dominant cytoskeletal mechanism that underlies dendritic arborization. Proc Natl Acad Sci U S A. 2017;114:E9376-E9385 pubmed publisher
Avery A, Fealey M, Wang F, Orlova A, Thompson A, Thomas D, et al
. Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation. Nat Commun. 2017;8:1350 pubmed publisher
..Collectively, these results shed light on the mechanism by which β-III-spectrin, and likely similar actin-binding proteins, interact with actin, and how this mechanism can be perturbed to cause disease. ..