W G Haynes

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Receptor-mediated regional sympathetic nerve activation by leptin
    W G Haynes
    Hypertension Genetics Specialized Center of Research, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Clin Invest 100:270-8. 1997
  2. ncbi request reprint Sympathetic and cardiorenal actions of leptin
    W G Haynes
    Hypertension Genetics Specialized Center of Research, and Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City 52242, USA
    Hypertension 30:619-23. 1997
  3. ncbi request reprint Does leptin stimulate nitric oxide to oppose the effects of sympathetic activation?
    J L Mitchell
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center, Diabetes Endocrine Research Center, University of Iowa College of Medicine, Iowa City, USA
    Hypertension 38:1081-6. 2001
  4. ncbi request reprint Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure
    M L Correia
    Specialized Center of Research in Hypertension Genetics, The Cardiovascular Center and Department of Internal Medicine, The University of Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Hypertension 37:936-42. 2001
  5. ncbi request reprint Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    W G Haynes
    Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 33:542-7. 1999
  6. ncbi request reprint Role of corticotrophin-releasing factor in effects of leptin on sympathetic nerve activity and arterial pressure
    M L Correia
    Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Hypertension 38:384-8. 2001
  7. ncbi request reprint Does leptin cause functional peripheral sympatholysis?
    A Jalali
    Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City 52242, USA
    Am J Hypertens 14:615-8. 2001
  8. ncbi request reprint Cardiovascular consequences of obesity: role of leptin
    W G Haynes
    Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City 52242, USA
    Clin Exp Pharmacol Physiol 25:65-9. 1998
  9. ncbi request reprint Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats
    W I Sivitz
    Department of Internal Medicine, Division of Adult and Pediatric Endocrinology, University of Iowa, Iowa City, Iowa 52246, USA
    Am J Physiol 277:E668-77. 1999
  10. ncbi request reprint A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat
    A L Mark
    Specialized Center of Research in Hypertension Genetics, The Department of Internal Medicine, Lucille A Carver College of Medicine, and the Veterans Administration Medical Center, Iowa City, IA 52242 1101, USA
    Acta Physiol Scand 177:345-9. 2003

Collaborators

Detail Information

Publications15

  1. pmc Receptor-mediated regional sympathetic nerve activation by leptin
    W G Haynes
    Hypertension Genetics Specialized Center of Research, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Clin Invest 100:270-8. 1997
    ..These data demonstrate that leptin increases thermogenic sympathetic nerve activity and reveal an unexpected stimulatory effect of leptin on overall sympathetic nerve traffic...
  2. ncbi request reprint Sympathetic and cardiorenal actions of leptin
    W G Haynes
    Hypertension Genetics Specialized Center of Research, and Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City 52242, USA
    Hypertension 30:619-23. 1997
    ..Although we are at an early stage of understanding, we speculate that abnormalities in the actions of leptin may have implications for the sympathetic, cardiovascular, and renal changes associated with obesity...
  3. ncbi request reprint Does leptin stimulate nitric oxide to oppose the effects of sympathetic activation?
    J L Mitchell
    Hypertension Genetics Specialized Center of Research, Cardiovascular Center, Diabetes Endocrine Research Center, University of Iowa College of Medicine, Iowa City, USA
    Hypertension 38:1081-6. 2001
    ..These data support the concept that the chronic hemodynamic actions of leptin are likely to be related to sympathetic activation...
  4. ncbi request reprint Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure
    M L Correia
    Specialized Center of Research in Hypertension Genetics, The Cardiovascular Center and Department of Internal Medicine, The University of Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Hypertension 37:936-42. 2001
    ..Leptin appears to oppose the depressor effect of weight loss...
  5. ncbi request reprint Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    W G Haynes
    Hypertension Genetics Specialized Center of Research, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Hypertension 33:542-7. 1999
    ..Our data also suggest that leptin increases renal SNA through activation of hypothalamic melanocortin receptors. In contrast, sympathoactivation to thermogenic BAT by leptin appears to be independent of the melanocortin system...
  6. ncbi request reprint Role of corticotrophin-releasing factor in effects of leptin on sympathetic nerve activity and arterial pressure
    M L Correia
    Specialized Center of Research in Hypertension Genetics, Department of Internal Medicine, University of Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    Hypertension 38:384-8. 2001
    ..These results suggest that corticotrophin-releasing factor may mediate the sympathoexcitatory effect of leptin on thermogenic tissue without altering its cardiovascular actions...
  7. ncbi request reprint Does leptin cause functional peripheral sympatholysis?
    A Jalali
    Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City 52242, USA
    Am J Hypertens 14:615-8. 2001
    ..Thus, we conclude that leptin does not change regional blood flows, and that leptin also does not appear to have vascular or neural actions to cause peripheral functional sympatholysis...
  8. ncbi request reprint Cardiovascular consequences of obesity: role of leptin
    W G Haynes
    Department of Internal Medicine, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City 52242, USA
    Clin Exp Pharmacol Physiol 25:65-9. 1998
    ..Alterations in leptin generation or action may, in part, underlie the sympathetic, endocrine and renal consequences of obesity...
  9. ncbi request reprint Sympathetic inhibition, leptin, and uncoupling protein subtype expression in normal fasting rats
    W I Sivitz
    Department of Internal Medicine, Division of Adult and Pediatric Endocrinology, University of Iowa, Iowa City, Iowa 52246, USA
    Am J Physiol 277:E668-77. 1999
    ..However, the in vivo modulation of leptin and UCPs appears complex and, beyond a causal effect of SNA per se, may depend on concurrent changes in plasma insulin, glucose, and circulatory hemodynamics...
  10. ncbi request reprint A leptin-sympathetic-leptin feedback loop: potential implications for regulation of arterial pressure and body fat
    A L Mark
    Specialized Center of Research in Hypertension Genetics, The Department of Internal Medicine, Lucille A Carver College of Medicine, and the Veterans Administration Medical Center, Iowa City, IA 52242 1101, USA
    Acta Physiol Scand 177:345-9. 2003
    ..This manuscript briefly reviews evidence and potential implications of a leptin-sympathetic-leptin feedback loop...
  11. ncbi request reprint Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice
    A L Mark
    Specialized Center of Research in Hypertension Genetics and the Cardiovascular Center, Department of Internal Medicine, University of Iowa, Iowa City, USA
    J Hypertens 17:1949-53. 1999
    ..In contrast, agouti yellow obese(Ay) mice have overexpression of an agouti peptide that blocks melanocortin receptors. Stimulation of melanocortin receptors by alpha-melanocyte-stimulating hormone decreases arterial pressure...
  12. ncbi request reprint Effect of vitamin E on resistance vessel endothelial dysfunction induced by methionine
    G Raghuveer
    Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Cardiol 88:285-90. 2001
    ....
  13. ncbi request reprint Lessons from Leptin's molecular biology: Potential therapeutic actions of recombinant leptin and leptin-related compounds
    M L G Correia
    General Clinical Research Center, Department of Internal Medicine 157 MRF, University of Iowa, Iowa City, IA, 52242, USA
    Mini Rev Med Chem 7:31-8. 2007
    ..As human obesity is characterized by hyperleptinemia and leptin resistance, increasing leptin sensitivity is an attractive target for obesity treatment...
  14. ncbi request reprint Endothelin as a regulator of cardiovascular function in health and disease
    W G Haynes
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    J Hypertens 16:1081-98. 1998
    ..Development of such agents will increase knowledge of the physiological and pathological roles of the endothelins, and should generate drugs with novel benefits...
  15. ncbi request reprint Leptin signaling pathways in the central nervous system: interactions between neuropeptide Y and melanocortins
    K Rahmouni
    Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Bioessays 23:1095-9. 2001
    ..These data add complexity to the mechanisms by which leptin achieves its effects in the central nervous system, but they also offer potential mechanisms to explain the phenomenon of leptin resistance observed in obesity...