Christy L Haynes

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Exploring inflammatory disease drug effects on neutrophil function
    Xiaojie Wu
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    Analyst 139:4056-63. 2014
  2. pmc Microfluidic-SERS devices for one shot limit-of-detection
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    Analyst 139:3227-34. 2014
  3. ncbi request reprint Facile method to stain the bacterial cell surface for super-resolution fluorescence microscopy
    Ian L Gunsolus
    Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, MN 55455, USA
    Analyst 139:3174-8. 2014
  4. doi request reprint On-chip evaluation of platelet adhesion and aggregation upon exposure to mesoporous silica nanoparticles
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, Minnesota 55455, USA
    Analyst 139:906-13. 2014
  5. pmc The role of p38 MAPK in neutrophil functions: single cell chemotaxis and surface marker expression
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, Minnesota 55455, USA
    Analyst 138:6826-33. 2013
  6. doi request reprint Isotope-dilution UPLC-MS/MS determination of cell-secreted bioactive lipids
    Audrey F Meyer
    University of Minnesota, Department of Chemistry, 207 Pleasant St SE, Minneapolis, MN 55455, USA
    Analyst 138:5697-705. 2013
  7. ncbi request reprint Examining changes in cellular communication in neuroendocrine cells after noble metal nanoparticle exposure
    Sara A Love
    207 Pleasant Street SE, Smith and Kolthoff Halls, Minneapolis, Minnesota, USA
    Analyst 137:3004-10. 2012
  8. doi request reprint Self-assembled plasmonic nanoring cavity arrays for SERS and LSPR biosensing
    Hyungsoon Im
    Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Adv Mater 25:2678-85. 2013
  9. ncbi request reprint Development of screening assays for nanoparticle toxicity assessment in human blood: preliminary studies with charged Au nanoparticles
    Sara A Love
    Department of Chemistry, University of Minnesota, Kolthoff and Smith Halls, 207 Pleasant Street SE, Minneapolis, MN 55455, USA
    Nanomedicine (Lond) 7:1355-64. 2012
  10. pmc Dynamin-related protein-1 controls fusion pore dynamics during platelet granule exocytosis
    Secil Koseoglu
    Department of Chemistry, University of Minnesota, Minneapolis, MN, USA
    Arterioscler Thromb Vasc Biol 33:481-8. 2013

Collaborators

  • Catherine J Murphy
  • Joseph J Dalluge
  • Zhen Liu
  • Chad A Mirkin
  • Galya Orr
  • Ozge Kurtuluş
  • James G White
  • Kalpna Gupta
  • Robert P Hebbel
  • Donghyuk Kim
  • Melissa A Maurer-Jones
  • Sara A Love
  • Shencheng Ge
  • Yu Shen Lin
  • Secil Koseoglu
  • Bryce J Marquis
  • Kyle C Bantz
  • Hyungsoon Im
  • Audrey F Meyer
  • Si Hoon Lee
  • Ian L Gunsolus
  • John W Thompson
  • Benjamin M Manning
  • Sang Hyun Oh
  • Xiaojie Wu
  • Sarah M Gruba
  • Nathan J Wittenberg
  • John D Chan
  • Ashlyn T Young
  • Yiwen Wang
  • Timothy W Johnson
  • Katie R Hurley
  • Keqiang Xie
  • Nardine Abadeer
  • Emily Woo
  • Ken Hsuan Liao
  • Nathan C Lindquist
  • Solaire Finkenstaedt-Quinn
  • Dehong Hu
  • Nathan D Burrows
  • Richard P Van Duyne
  • Jonathan S Marchant
  • Marco D Torelli
  • Timothy A Day
  • Zhe Gao
  • Antonio R Campos
  • Prince N Agbedanu
  • Robert J Hamers
  • Cosmin Mihai
  • Mostafa Zamanian
  • Nathan G Greeneltch
  • Chang Soo Lee
  • Matthew Rycenga
  • Catherine J Murhpy
  • Joseph T Buchman
  • Samuel E Lohse
  • Ashish Datt
  • Joseph E Italiano
  • Cole J Christenson
  • Jennifer L Fitch-Tewfik
  • Nathalie A Fadel
  • Christian G Peters
  • James R Dilks
  • Robert Flaumenhaft
  • Ben M Meyer
  • Reema Jasuja
  • Kenneth J Renner
  • Robert L Meisel
  • Victoria E Collins
  • Rafael Lujan
  • Kirill A Martemyanov
  • Christopher W Macosko
  • Kathy L Braun
  • Katherine L Braun

Detail Information

Publications43

  1. ncbi request reprint Exploring inflammatory disease drug effects on neutrophil function
    Xiaojie Wu
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    Analyst 139:4056-63. 2014
    ..This study provides mechanistic insight into the drug effects on neutrophil function, facilitating comparison of current and potential pharmaceutical approaches. ..
  2. pmc Microfluidic-SERS devices for one shot limit-of-detection
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    Analyst 139:3227-34. 2014
    ..The results indicate, with varying sensitivities, that either flexible or inflexible devices can be easily used to create a calibration curve and perform a limit of detection study with a single experiment. ..
  3. ncbi request reprint Facile method to stain the bacterial cell surface for super-resolution fluorescence microscopy
    Ian L Gunsolus
    Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, MN 55455, USA
    Analyst 139:3174-8. 2014
    ..We further use this method to identify localization patterns of nanomaterials, specifically cadmium selenide quantum dots, following interaction with bacterial cells. ..
  4. doi request reprint On-chip evaluation of platelet adhesion and aggregation upon exposure to mesoporous silica nanoparticles
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, Minnesota 55455, USA
    Analyst 139:906-13. 2014
    ..This simple and highly adaptable analytical platform will be useful for further nanotoxicity studies involving other nanoparticle and cell types. ..
  5. pmc The role of p38 MAPK in neutrophil functions: single cell chemotaxis and surface marker expression
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, Minnesota 55455, USA
    Analyst 138:6826-33. 2013
    ....
  6. doi request reprint Isotope-dilution UPLC-MS/MS determination of cell-secreted bioactive lipids
    Audrey F Meyer
    University of Minnesota, Department of Chemistry, 207 Pleasant St SE, Minneapolis, MN 55455, USA
    Analyst 138:5697-705. 2013
    ..0348 ng mL(-1) to 0.803 ng mL(-1). This method was applied to the determination of lipid secretion from mast cells and platelets, demonstrating broad applicability for lipid measurement in primary culture biological systems. ..
  7. ncbi request reprint Examining changes in cellular communication in neuroendocrine cells after noble metal nanoparticle exposure
    Sara A Love
    207 Pleasant Street SE, Smith and Kolthoff Halls, Minneapolis, Minnesota, USA
    Analyst 137:3004-10. 2012
    ..Overall, it is clear that various nanoparticle physicochemical properties, including size and surface coating, do modulate changes in cellular communication via exocytosis...
  8. doi request reprint Self-assembled plasmonic nanoring cavity arrays for SERS and LSPR biosensing
    Hyungsoon Im
    Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Adv Mater 25:2678-85. 2013
    ..These substrates are used for SERS detection of the biological analyte, adenine, followed by concurrent localized surface plasmon resonance sensing...
  9. ncbi request reprint Development of screening assays for nanoparticle toxicity assessment in human blood: preliminary studies with charged Au nanoparticles
    Sara A Love
    Department of Chemistry, University of Minnesota, Kolthoff and Smith Halls, 207 Pleasant Street SE, Minneapolis, MN 55455, USA
    Nanomedicine (Lond) 7:1355-64. 2012
    ..Optical monitoring of platelet aggregation revealed that none of the examined nanoparticles induced aggregation upon short-term exposure...
  10. pmc Dynamin-related protein-1 controls fusion pore dynamics during platelet granule exocytosis
    Secil Koseoglu
    Department of Chemistry, University of Minnesota, Minneapolis, MN, USA
    Arterioscler Thromb Vasc Biol 33:481-8. 2013
    ..However, the molecular mechanisms that control platelet fusion pore expansion and collapse are not known...
  11. doi request reprint Functional assessment of metal oxide nanoparticle toxicity in immune cells
    Melissa A Maurer-Jones
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    ACS Nano 4:3363-73. 2010
    ..The varying immune cell response following exposure to nonporous SiO(2) and nonporous TiO(2) indicates that the nanoparticle-cell interactions are also modulated by surface chemistry...
  12. pmc Electrochemical measurement of endogenous serotonin release from human blood platelets
    Shencheng Ge
    Department of Chemistry, College of Science and Engineering, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Anal Chem 83:2598-604. 2011
    ....
  13. ncbi request reprint Toxicity of engineered nanoparticles in the environment
    Melissa A Maurer-Jones
    Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States
    Anal Chem 85:3036-49. 2013
    ....
  14. pmc Impact of TiO2 nanoparticles on growth, biofilm formation, and flavin secretion in Shewanella oneidensis
    Melissa A Maurer-Jones
    Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, Minnesota 55455, USA
    Anal Chem 85:5810-8. 2013
    ....
  15. pmc Time- and concentration-dependent effects of exogenous serotonin and inflammatory cytokines on mast cell function
    Sarah M Gruba
    Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, Minnesota 55455, United States
    ACS Chem Biol 9:503-9. 2014
    ..These results highlight the importance of selecting an appropriate mast cell model when studying mast cell involvement in allergic response and inflammation. ..
  16. pmc Electroanalytical eavesdropping on single cell communication
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Anal Chem 83:7242-9. 2011
    ..This article reviews measurement of single cell exocytosis with microelectrodes, covering history, basic instrumentation, cell types investigated, and fundamental insight gained...
  17. doi request reprint Self-Assembled Plasmonic Nanoring Cavity Arrays for SERS and LSPR Biosensing (Adv. Mater. 19/2013)
    Hyungsoon Im
    Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Adv Mater 25:2677. 2013
    ..The resulting hybrid nanostructure boosts coupling efficiency of light into plasmons, and shows improved SERS detection limit. Further details can be found on page 2678 in the article by Sang-Hyun Oh, Christy L. Haynes, and co-workers...
  18. doi request reprint Stability of small mesoporous silica nanoparticles in biological media
    Yu Shen Lin
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    Chem Commun (Camb) 47:532-4. 2011
    ....
  19. pmc On-chip evaluation of neutrophil activation and neutrophil-endothelial cell interaction during neutrophil chemotaxis
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, United States
    Anal Chem 85:10787-96. 2013
    ..This study brings new knowledge about neutrophil chemotaxis in the context of cell-to-cell communications, yielding both fundamental and therapeutically relevant insight...
  20. doi request reprint Assessing nanoparticle toxicity
    Sara A Love
    Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Anal Chem (Palo Alto Calif) 5:181-205. 2012
    ..Additionally, we present three case studies (of silver, titanium dioxide, and carbon nanotube toxicity) to highlight the important toxicological considerations of these commonly used nanoparticles...
  21. pmc Carbon-fiber microelectrode amperometry reveals sickle-cell-induced inflammation and chronic morphine effects on single mast cells
    Benjamin M Manning
    Department of Chemistry, Division of Hematology, University of Minnesota, Minneapolis, Minnesota 55455, United States
    ACS Chem Biol 7:543-51. 2012
    ..Furthermore, morphine was shown to significantly increase the serotonin released from HbA-BERK mast cells and demonstrated the capacity to reverse the observed sickle-cell-induced changes in mast cell function...
  22. doi request reprint Cytoskeletal F-actin, not the circumferential coil of microtubules, regulates platelet dense-body granule secretion
    Shencheng Ge
    Department of Chemistry, College of Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Platelets 23:259-63. 2012
    ..This study also demonstrates the promise of microelectrochemistry for giving important insight into platelet quantal secretion mechanisms in future studies...
  23. ncbi request reprint Self-assembled plasmonic nanohole arrays
    Si Hoon Lee
    Department of Biomedical Engineering, 312 Church Street SE, University of Minnesota, Twin Cities, Minneapolis, Minnesota 55455, USA
    Langmuir 25:13685-93. 2009
    ..The periodic nanohole arrays produced using this tunable self-assembly method show great promise as inexpensive SERS substrates as well as surface plasmon resonance biosensing platforms...
  24. ncbi request reprint Analytical methods to assess nanoparticle toxicity
    Bryce J Marquis
    Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA
    Analyst 134:425-39. 2009
    ....
  25. doi request reprint Assessment of functional changes in nanoparticle-exposed neuroendocrine cells with amperometry: exploring the generalizability of nanoparticle-vesicle matrix interactions
    Sara A Love
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Twin Cities, Minneapolis, MN 55455, USA
    Anal Bioanal Chem 398:677-88. 2010
    ....
  26. pmc Neutrophil chemotaxis within a competing gradient of chemoattractants
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States
    Anal Chem 84:6070-8. 2012
    ..These results yield insight about how each chemoattractant contributes to overall neutrophil chemotaxis within complex physiological environments...
  27. pmc Microfluidics-based in vivo mimetic systems for the study of cellular biology
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, 207 Pleasant Street Southeast, Minneapolis, Minnesota 55455, United States
    Acc Chem Res 47:1165-73. 2014
    ..Researchers have monitored cellular behaviors in these biomimetic microfluidic environments, producing validated model systems to understand human pathophysiology and to support the development of new therapeutics. ..
  28. ncbi request reprint Investigation of noble metal nanoparticle ζ-potential effects on single-cell exocytosis function in vitro with carbon-fiber microelectrode amperometry
    Bryce J Marquis
    Department of Chemistry, University of Minnesota, Minneapolis, Minnesota, USA
    Analyst 136:3478-86. 2011
    ....
  29. doi request reprint Toward correlation in in vivo and in vitro nanotoxicology studies
    Melissa A Maurer-Jones
    University of Minnesota, MN, USA
    J Law Med Ethics 40:795-801. 2012
    ..Additionally, this comparison aims to identify clear and unique toxicity responses caused by nanoparticles, which informs our perspective on pre-clinical nanotherapeutic oversight...
  30. doi request reprint Ultrastable, redispersible, small, and highly organomodified mesoporous silica nanotherapeutics
    Yu Shen Lin
    Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Am Chem Soc 133:20444-57. 2011
    ..These results suggest that highly stable, redispersible, and small mesoporous silica nanoparticles are promising agents for in vivo biomedical applications...
  31. pmc Quantal regulation and exocytosis of platelet dense-body granules
    Shencheng Ge
    Department of Chemistry, College of Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA
    Biophys J 101:2351-9. 2011
    ....
  32. doi request reprint Cytotoxicity of graphene oxide and graphene in human erythrocytes and skin fibroblasts
    Ken Hsuan Liao
    Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455, United States
    ACS Appl Mater Interfaces 3:2607-15. 2011
    ..Clearly, the toxicity of graphene and graphene oxide depends on the exposure environment (i.e., whether or not aggregation occurs) and mode of interaction with cells (i.e., suspension versus adherent cell types)...
  33. ncbi request reprint Bioanalytical tools for single-cell study of exocytosis
    Shencheng Ge
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455, USA
    Anal Bioanal Chem 397:3281-304. 2010
    ..Lastly, an analytical chemist's perspective on potential future developments in this exciting field is discussed...
  34. ncbi request reprint Impacts of mesoporous silica nanoparticle size, pore ordering, and pore integrity on hemolytic activity
    Yu Shen Lin
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455, USA
    J Am Chem Soc 132:4834-42. 2010
    ....
  35. pmc 'Death and axes': unexpected Ca²⁺ entry phenologs predict new anti-schistosomal agents
    John D Chan
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Pathog 10:e1003942. 2014
    ..Surprisingly, basic research into axis patterning mechanisms provides an unexpected route for discovering novel antischistosomal agents...
  36. doi request reprint Cholesterol effects on vesicle pools in chromaffin cells revealed by carbon-fiber microelectrode amperometry
    Secil Koseoglu
    Department of Chemistry, University of Minnesota, Minneapolis, 55455 0240, USA
    Anal Bioanal Chem 400:2963-71. 2011
    ..Finally, diverging effects of cholesterol on RRP and the older reserve pool vesicle release suggest two different mechanisms for the release of these two vesicular pools...
  37. pmc Recent progress in SERS biosensing
    Kyle C Bantz
    Department of Chemistry, University of Minnesota, Twin Cities, USA
    Phys Chem Chem Phys 13:11551-67. 2011
    ..The progress covered herein shows great promise for widespread adoption of SERS biosensing...
  38. pmc On-chip evaluation of shear stress effect on cytotoxicity of mesoporous silica nanoparticles
    Donghyuk Kim
    Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota, 55455, United States
    Anal Chem 83:8377-82. 2011
    ..This paper clearly demonstrates that shear stress is an important factor to be considered in in vitro nanotoxicology assessments and provides a simple device for pursuing this consideration...
  39. pmc Critical role of membrane cholesterol in exocytosis revealed by single platelet study
    Shencheng Ge
    Department of Chemistry, Institute of Technology, University of Minnesota, Minneapolis, 55455, USA
    ACS Chem Biol 5:819-28. 2010
    ..It is clear from this work that membrane cholesterol plays a critical biophysical, rather than biochemical, role in platelet exocytosis and likely in exocytosis in general...
  40. ncbi request reprint Evaluating the effects of immunotoxicants using carbon fiber microelectrode amperometry
    Bryce J Marquis
    Department of Chemistry, University of Minnesota, 207 Pleasant St SE, Minneapolis, MN 55418, USA
    Anal Bioanal Chem 398:2979-85. 2010
    ..This study illustrates the potential of CFMA as a technique for determining quantitative and biophysical chemical information in in vitro immunotoxicological studies...
  41. doi request reprint Toxicity of therapeutic nanoparticles
    Melissa A Maurer-Jones
    University of Minnesota, Department of Chemistry, 207 Pleasant Street SE, Minneapolis, MN 55455, USA
    Nanomedicine (Lond) 4:219-41. 2009
    ..We end with a perspective section discussing the current technological gaps and promising research aimed at addressing those gaps...
  42. pmc Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems
    Keqiang Xie
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Psychopharmacology (Berl) 219:823-34. 2012
    ....
  43. doi request reprint Using nanoparticles to push the limits of detection
    Nathan J Wittenberg
    Department of Chemistry, University of Minnesota, Minneapolis, MN, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:237-54. 2009
    ....